A2B adenosine receptor blockade inhibits growth of prostate cancer cells

Purinergic Signalling

Volumn 9, Issue 2, 2013, Pages 271-280

  Wei, Qiang ^a,b   Costanzi, Stefano ^a,c   Balasubramanian, Ramachandran ^a   Gao, Zhan Guo ^a   Jacobson, Kenneth A ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b SOUTHERN MEDICAL UNIVERSITY   (China)

^c AMERICAN UNIVERSITY   (United States)

Author keywords

A2B; Adenosine receptor; Cancer; Cell proliferation; G protein coupled receptor (GPCR); Prostate cancer

Indexed keywords

ADENOSINE A1 RECEPTOR; ADENOSINE A2A RECEPTOR; ADENOSINE A2B RECEPTOR; ADENOSINE A3 RECEPTOR; CASPASE 3; CYCLIC AMP; LACTATE DEHYDROGENASE; ADENOSINE A2 RECEPTOR ANTAGONIST;

APOPTOSIS; ARTICLE; CANCER GROWTH; CELL DEATH; CELL PROLIFERATION; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; POLYMERASE CHAIN REACTION; PROSTATE CANCER; PROTEIN EXPRESSION; WESTERN BLOTTING; CONFOCAL MICROSCOPY; DRUG EFFECT; MALE; METABOLISM; PROSTATE TUMOR; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL LINE; DRUG EFFECTS;

ADENOSINE A2 RECEPTOR ANTAGONISTS; APOPTOSIS; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; MALE; MICROSCOPY, CONFOCAL; PROSTATIC NEOPLASMS; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTOR, ADENOSINE A2B; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84877595430     PISSN: 15739538     EISSN: 15739546     Source Type: Journal    
DOI: 10.1007/s11302-012-9350-3     Document Type: Article

References (21)

1. Damber JE, Aus G (2008) Prostate Cancer 371: 1710-1721.
2. Lappano R, Maggiolini M (2011) G protein-coupled receptors: novel targets for drug discovery in cancer. Nat Rev Drug Discov 10: 47-60.
3. Dorsam RT, Gutkind JS (2007) G-protein-coupled receptors and cancer. Nat Rev Cancer 7: 79-94.
4. 1 receptor induces apoptosis and inhibits proliferation of prostate cancer cells. Biochem Pharmacol 82: 418-425.
5. Li S, Huang S, Peng SB (2005) Overexpression of G protein-coupled receptors in cancer cells: involvement in tumor progression. Int J Oncol 27: 1329-1339.
6. 2B receptor modulates proliferation of colon carcinoma cells. Hum Pathol 41: 1550-1557.
7. Stagg J, Divisekera U, McLaughlin N, Sharkey J, Pommey S, Denoyer D, Dwyer KM, Smyth MJ (2010) Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis. Proc Natl Acad Sci USA 107: 1547-1552.
8. 2B adenosine receptors promote carcinoma growth. Neoplasia 10: 987-995.
9. 2B receptor blockade slows growth of bladder and breast tumors. J Immunol 188: 198-205.
10. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25: 402-408.
11. Blom WM, de Bont HJ, Meijerman I, Mulder GJ, Nagelkerke JF (1999) Prevention of cycloheximide-induced apoptosis in hepatocytes by adenosine and by caspase inhibitors. Biochem Pharmacol 58: 1891-1898.
12. Das A, Durrant D, Mitchell C, Mayton E, Hoke NN, Salloum FN, Park MA, Qureshi I, Lee R, Dent P, Kukreja RC (2010) Sildenafil increases chemotherapeutic efficacy of doxorubicin in prostate cancer and ameliorates cardiac dysfunction. Proc Natl Acad Sci USA 107: 18202-18207.
13. Janssens R, Boeynaems JM (2001) Effects of extracellular nucleotides and nucleosides on prostate carcinoma cells. Br J Pharmacol 132: 536-546.
14. Aghaei M, Karami-Tehrani F, Panjehpour M, Salami S, Fallahian F (2011) Adenosine induces cell-cycle arrest and apoptosis in androgen-dependent and -independent prostate cancer cell lines, LNcap-FGC-10, DU-145, and PC3. Prostate 72: 361-375.
15. Minelli A, Bellezza I, Tucci A, Rambotti MG, Conte C, Culig Z (2009) Differential involvement of reactive oxygen species and nucleoside transporters in cytotoxicity induced by two adenosine analogues in human prostate cancer cells. Prostate 69: 538-547.
16. Panjehpour M, Movahedian A, Sadeghi H, Eghbali B, Yekdaneh A (2010) Adenosine receptor expression in two different human cancer lines at molecular level. Iranian J Cancer Prevention 3: 111-116.
17. 3AR agonist. Anticancer Res 23: 2077-2083.
18. 2B receptor expression in neuroendocrine tumours: potential targets for therapy. Purinergic Signal 8: 265-274.
19. Hastie C, Saxton M, Akpan A, Cramer R, Masters JR, Naaby-Hansen S (2005) Combined affinity labelling and mass spectrometry analysis of differential cell surface protein expression in normal and prostate cancer cells. Oncogene 24: 5905-5913.
20. Stagg J, Beavis PA, Divisekera U, Liu MC, Moeller A, Darcy PK, Smyth MJ (2012) CD73-deficient mice are resistant to carcinogenesis. Cancer Res 72: 2190-2196.
21. Feng L, Sun X, Csizmadia E, Han L, Bian S, Murakami T, Wang X, Robson SC, Wu Y (2011) Vascular CD39/ENTPD1 directly promotes tumor cell growth by scavenging extracellular adenosine triphosphate. Neoplasia 13: 206-216.