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The unfolded protein response (UPR)-activated transcription factor X-box-binding protein 1 (XBP1) induces microRNA-346 expression that targets the human antigen peptide transporter 1 (TAP1) mRNA and governs immune regulatory genes
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This is one of the first papers demonstrating a link between microRNAs and the UPR pathway. They show that microRNA-346 is a transcriptional target of XBP-1
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• Bartoszewski, R et al (2011) The unfolded protein response (UPR)-activated transcription factor X-box-binding protein 1 (XBP1) induces microRNA-346 expression that targets the human antigen peptide transporter 1 (TAP1) mRNA and governs immune regulatory genes. J Biol Chem 286(48):41862–41870. This is one of the first papers demonstrating a link between microRNAs and the UPR pathway. They show that microRNA-346 is a transcriptional target of XBP-1
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This study demonstrates that microRNA-708 is a direct transcriptional target of CHOP, and shows a prosurvival role for CHOP under ER stress conditions by limiting the syntehsis of the ER folded protein rhodopsin
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• Behrman, S, Acosta-Alvear D, Walter P (2011) A CHOP-regulated microRNA controls rhodopsin expression. J Cell Biol 192(6):919–927. This study demonstrates that microRNA-708 is a direct transcriptional target of CHOP, and shows a prosurvival role for CHOP under ER stress conditions by limiting the syntehsis of the ER folded protein rhodopsin
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miR-211 is a prosurvival microRNA that regulates chop expression in a PERK-dependent manner
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MicroRNA-30c-2* limits expression of proadaptive factor XBP1 in the unfolded protein response
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In one of the earlier papers in the field the authors show that the PERK branch of the UPR induces microRNA-30c-2p, which represses XBP-1 expression, thus regulating the IRE1α branch of the UPR
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IRE1alpha induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress
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IRE1alpha cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2
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