메뉴 건너뛰기




Volumn 7, Issue , 2016, Pages 112-120

Oxyntomodulin Identified as a Marker of Type 2 Diabetes and Gastric Bypass Surgery by Mass-spectrometry Based Profiling of Human Plasma

Author keywords

GLP 1; Gut hormones; Low abundant peptides; Mass spectrometry; Proteomics

Indexed keywords

BIOLOGICAL MARKER; DIPEPTIDYL PEPTIDASE IV; GLICENTIN; GLUCAGON LIKE PEPTIDE 1; OXYNTOMODULIN;

EID: 84962406909     PISSN: None     EISSN: 23523964     Source Type: Journal    
DOI: 10.1016/j.ebiom.2016.03.034     Document Type: Article
Times cited : (54)

References (45)
  • 1
    • 0037435030 scopus 로고    scopus 로고
    • Mass spectrometry-based proteomics
    • Aebersold R., Mann M. Mass spectrometry-based proteomics. Nature 2003, 422(6928):198-207.
    • (2003) Nature , vol.422 , Issue.6928 , pp. 198-207
    • Aebersold, R.1    Mann, M.2
  • 2
    • 84951066421 scopus 로고    scopus 로고
    • Effect of oxyntomodulin, glucagon, GLP-1 and combined glucagon + GLP-1 infusion on food intake, appetite and resting energy expenditure
    • (p. jc20152335)
    • Bagger J.I., Holst J.J., Hartmann B., Andersen B., Knop F.K., Vilsboll T. Effect of oxyntomodulin, glucagon, GLP-1 and combined glucagon + GLP-1 infusion on food intake, appetite and resting energy expenditure. J. Clin. Endocrinol. Metab. 2015, (p. jc20152335).
    • (2015) J. Clin. Endocrinol. Metab.
    • Bagger, J.I.1    Holst, J.J.2    Hartmann, B.3    Andersen, B.4    Knop, F.K.5    Vilsboll, T.6
  • 3
    • 0023910424 scopus 로고
    • Oxyntomodulin (glicentin-(33-69)): pharmacokinetics, binding to liver cell membranes, effects on isolated perfused pig pancreas, and secretion from isolated perfused lower small intestine of pigs
    • Baldissera F.G., Holst J.J., Knuhtsen S., Hilsted L., Nielsen O.V. Oxyntomodulin (glicentin-(33-69)): pharmacokinetics, binding to liver cell membranes, effects on isolated perfused pig pancreas, and secretion from isolated perfused lower small intestine of pigs. Regul. Pept. 1988, 21(1-2):151-166.
    • (1988) Regul. Pept. , vol.21 , Issue.1-2 , pp. 151-166
    • Baldissera, F.G.1    Holst, J.J.2    Knuhtsen, S.3    Hilsted, L.4    Nielsen, O.V.5
  • 6
    • 84876475252 scopus 로고    scopus 로고
    • Secretion of glucagon-like peptide-1 in patients with type 2 diabetes mellitus: systematic review and meta-analyses of clinical studies
    • Calanna S., Christensen M., Holst J.J., Laferrère B., Gluud L.L., Vilsbøll T., Knop F.K. Secretion of glucagon-like peptide-1 in patients with type 2 diabetes mellitus: systematic review and meta-analyses of clinical studies. Diabetologia 2013, 56(5):965-972.
    • (2013) Diabetologia , vol.56 , Issue.5 , pp. 965-972
    • Calanna, S.1    Christensen, M.2    Holst, J.J.3    Laferrère, B.4    Gluud, L.L.5    Vilsbøll, T.6    Knop, F.K.7
  • 8
    • 57449099865 scopus 로고    scopus 로고
    • MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification
    • Cox J., Mann M. MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification. Nat. Biotechnol. 2008, 26(12):1367-1372.
    • (2008) Nat. Biotechnol. , vol.26 , Issue.12 , pp. 1367-1372
    • Cox, J.1    Mann, M.2
  • 11
    • 79961212595 scopus 로고    scopus 로고
    • Improvements In proteomic metrics of low abundance proteins through proteome equalization using ProteoMiner prior to MudPIT
    • Fonslow B.R., Carvalho P.C., Academia K., Freeby S., Xu T., Nakorchevsky A., Paulus A., Yates J.R. Improvements In proteomic metrics of low abundance proteins through proteome equalization using ProteoMiner prior to MudPIT. J. Proteome Res. 2011, 10(8):3690-3700.
    • (2011) J. Proteome Res. , vol.10 , Issue.8 , pp. 3690-3700
    • Fonslow, B.R.1    Carvalho, P.C.2    Academia, K.3    Freeby, S.4    Xu, T.5    Nakorchevsky, A.6    Paulus, A.7    Yates, J.R.8
  • 12
    • 84871983086 scopus 로고    scopus 로고
    • Quantitative analysis of peptides and proteins in biomedicine by targeted mass spectrometry
    • Gillette M.A., Carr S.A. Quantitative analysis of peptides and proteins in biomedicine by targeted mass spectrometry. Nat. Methods 2013, 10(1):28-34.
    • (2013) Nat. Methods , vol.10 , Issue.1 , pp. 28-34
    • Gillette, M.A.1    Carr, S.A.2
  • 13
    • 84871983086 scopus 로고    scopus 로고
    • Quantitative analysis of peptides and proteins in biomedicine by targeted mass spectrometry
    • Gillette M.A., Carr S.A. Quantitative analysis of peptides and proteins in biomedicine by targeted mass spectrometry. Nat. Methods 2013, 10(1):28-34.
    • (2013) Nat. Methods , vol.10 , Issue.1 , pp. 28-34
    • Gillette, M.A.1    Carr, S.A.2
  • 14
    • 0033303516 scopus 로고    scopus 로고
    • Glucagon-like peptide-1-(7-36)amide is transformed to glucagon-like peptide-1-(9-36)amide by dipeptidyl peptidase IV in the capillaries supplying the L cells of the porcine intestine
    • Hansen L., Deacon C.F., Orskov C., Holst J.J. Glucagon-like peptide-1-(7-36)amide is transformed to glucagon-like peptide-1-(9-36)amide by dipeptidyl peptidase IV in the capillaries supplying the L cells of the porcine intestine. Endocrinology 1999, 140(11):5356-5363.
    • (1999) Endocrinology , vol.140 , Issue.11 , pp. 5356-5363
    • Hansen, L.1    Deacon, C.F.2    Orskov, C.3    Holst, J.J.4
  • 16
    • 79960900778 scopus 로고    scopus 로고
    • 'Dipeptidyl peptidase-4 inhibition increases portal concentrations of intact glucagon-like peptide-1 (GLP-1) to a greater extent than peripheral concentrations in anaesthetised pigs'
    • Hjollund, KR, Deacon, CF & Holst, JJ 2011, 'Dipeptidyl peptidase-4 inhibition increases portal concentrations of intact glucagon-like peptide-1 (GLP-1) to a greater extent than peripheral concentrations in anaesthetised pigs', paper presented to Diabetologia, 2011, <>. doi:10.1007/s00125-011-2168-7.
    • (2011) paper presented to Diabetologia 2011
    • Hjollund, K.R.1    Deacon, C.F.2    Holst, J.J.3
  • 17
    • 84888199705 scopus 로고    scopus 로고
    • Enteroendocrine secretion of gut hormones in diabetes, obesity and after bariatric surgery
    • Holst J.J. Enteroendocrine secretion of gut hormones in diabetes, obesity and after bariatric surgery. Curr. Opin. Pharmacol. 2013.
    • (2013) Curr. Opin. Pharmacol.
    • Holst, J.J.1
  • 18
    • 84883754628 scopus 로고    scopus 로고
    • Incretin hormones and the satiation signal
    • Holst J.J. Incretin hormones and the satiation signal. Int. J. Obes. (Lond) 2013, 37(9):1161-1168.
    • (2013) Int. J. Obes. (Lond) , vol.37 , Issue.9 , pp. 1161-1168
    • Holst, J.J.1
  • 19
    • 38349068918 scopus 로고    scopus 로고
    • Quantitative, multiplexed assays for low abundance proteins in plasma by targeted mass spectrometry and stable isotope dilution
    • Keshishian H., Addona T., Burgess M., Kuhn E., Carr S.A. Quantitative, multiplexed assays for low abundance proteins in plasma by targeted mass spectrometry and stable isotope dilution. Mol. Cell. Proteomics 2007, 6(12):2212-2229.
    • (2007) Mol. Cell. Proteomics , vol.6 , Issue.12 , pp. 2212-2229
    • Keshishian, H.1    Addona, T.2    Burgess, M.3    Kuhn, E.4    Carr, S.A.5
  • 20
    • 38349068918 scopus 로고    scopus 로고
    • Quantitative, multiplexed assays for low abundance proteins in plasma by targeted mass spectrometry and stable isotope dilution
    • Keshishian H., Addona T., Burgess M., Kuhn E., Carr S.A. Quantitative, multiplexed assays for low abundance proteins in plasma by targeted mass spectrometry and stable isotope dilution. Mol. Cell. Proteomics 2007, 6(12):2212-2229.
    • (2007) Mol. Cell. Proteomics , vol.6 , Issue.12 , pp. 2212-2229
    • Keshishian, H.1    Addona, T.2    Burgess, M.3    Kuhn, E.4    Carr, S.A.5
  • 22
    • 84896768407 scopus 로고    scopus 로고
    • GLP-1 amidation efficiency along the length of the intestine in mice, rats and pigs and in GLP-1 secreting cell lines
    • Kuhre R.E., Albrechtsen N.W., Windelov J.A., Svendsen B., Hartmann B., Holst J.J. GLP-1 amidation efficiency along the length of the intestine in mice, rats and pigs and in GLP-1 secreting cell lines. Peptides 2014, 55:52-57.
    • (2014) Peptides , vol.55 , pp. 52-57
    • Kuhre, R.E.1    Albrechtsen, N.W.2    Windelov, J.A.3    Svendsen, B.4    Hartmann, B.5    Holst, J.J.6
  • 23
    • 84895538371 scopus 로고    scopus 로고
    • Minimal, encapsulated proteomic-sample processing applied to copy-number estimation in eukaryotic cells
    • Kulak N.A., Pichler G., Paron I., Nagaraj N., Mann M. Minimal, encapsulated proteomic-sample processing applied to copy-number estimation in eukaryotic cells. Nat. Methods 2014, 11(3):319-324.
    • (2014) Nat. Methods , vol.11 , Issue.3 , pp. 319-324
    • Kulak, N.A.1    Pichler, G.2    Paron, I.3    Nagaraj, N.4    Mann, M.5
  • 25
    • 70350099073 scopus 로고    scopus 로고
    • Deep depletion of abundant serum proteins reveals low-abundant proteins as potential biomarkers for human ovarian cancer
    • Lin B., White J.T., Wu J., Lele S., Old L.J., Hood L., Odunsi K. Deep depletion of abundant serum proteins reveals low-abundant proteins as potential biomarkers for human ovarian cancer. Proteomics Clin. Appl. 2009, 3(7):853-861.
    • (2009) Proteomics Clin. Appl. , vol.3 , Issue.7 , pp. 853-861
    • Lin, B.1    White, J.T.2    Wu, J.3    Lele, S.4    Old, L.J.5    Hood, L.6    Odunsi, K.7
  • 26
    • 84893363785 scopus 로고    scopus 로고
    • Mechanisms of changes in glucose metabolism and bodyweight after bariatric surgery
    • Madsbad S., Dirksen C., Holst J.J. Mechanisms of changes in glucose metabolism and bodyweight after bariatric surgery. Lancet Diabetes Endocrinol. 2014, 2(2):152-164.
    • (2014) Lancet Diabetes Endocrinol. , vol.2 , Issue.2 , pp. 152-164
    • Madsbad, S.1    Dirksen, C.2    Holst, J.J.3
  • 27
    • 84907481867 scopus 로고    scopus 로고
    • GLP-1 as a mediator in the remission of type 2 diabetes after gastric bypass and sleeve gastrectomy surgery
    • Madsbad S., Holst J.J. GLP-1 as a mediator in the remission of type 2 diabetes after gastric bypass and sleeve gastrectomy surgery. Diabetes 2014, 63(10):3172-3174.
    • (2014) Diabetes , vol.63 , Issue.10 , pp. 3172-3174
    • Madsbad, S.1    Holst, J.J.2
  • 28
    • 84874232489 scopus 로고    scopus 로고
    • The coming age of complete, accurate, and ubiquitous proteomes
    • Mann M., Kulak N., Nagaraj N., Cox Jr The coming age of complete, accurate, and ubiquitous proteomes. Mol. Cell 2013, 49(4):583-590.
    • (2013) Mol. Cell , vol.49 , Issue.4 , pp. 583-590
    • Mann, M.1    Kulak, N.2    Nagaraj, N.3    Cox, J.4
  • 29
    • 77951793008 scopus 로고    scopus 로고
    • Is the diminished incretin effect in type 2 diabetes just an epi-phenomenon of impaired β-cell function?
    • Meier J.J., Nauck M.A. Is the diminished incretin effect in type 2 diabetes just an epi-phenomenon of impaired β-cell function?. Diabetes 2010, 59(5):1117-1125.
    • (2010) Diabetes , vol.59 , Issue.5 , pp. 1117-1125
    • Meier, J.J.1    Nauck, M.A.2
  • 30
    • 84876541392 scopus 로고    scopus 로고
    • Direct proteomic quantification of the secretome of activated immune cells
    • Meissner F., Scheltema R.A., Mollenkopf H.J., Mann M. Direct proteomic quantification of the secretome of activated immune cells. Science 2013, 340(6131):475-478.
    • (2013) Science , vol.340 , Issue.6131 , pp. 475-478
    • Meissner, F.1    Scheltema, R.A.2    Mollenkopf, H.J.3    Mann, M.4
  • 31
    • 82355185805 scopus 로고    scopus 로고
    • Low abundance protein enrichment for discovery of candidate plasma protein biomarkers for early detection of breast cancer
    • Meng R., Gormley M., Bhat V.B., Rosenberg A., Quong A.A. Low abundance protein enrichment for discovery of candidate plasma protein biomarkers for early detection of breast cancer. J. Proteomics 2011, 75(2):366-374.
    • (2011) J. Proteomics , vol.75 , Issue.2 , pp. 366-374
    • Meng, R.1    Gormley, M.2    Bhat, V.B.3    Rosenberg, A.4    Quong, A.A.5
  • 32
    • 79952310049 scopus 로고    scopus 로고
    • Secretion of glucagon-like peptide-1 (GLP-1) In type 2 diabetes: what is up, what is down?
    • Nauck M.A., Vardarli I., Deacon C.F., Holst J.J., Meier J.J. Secretion of glucagon-like peptide-1 (GLP-1) In type 2 diabetes: what is up, what is down?. Diabetologia 2011, 54(1):10-18.
    • (2011) Diabetologia , vol.54 , Issue.1 , pp. 10-18
    • Nauck, M.A.1    Vardarli, I.2    Deacon, C.F.3    Holst, J.J.4    Meier, J.J.5
  • 33
    • 34548336772 scopus 로고    scopus 로고
    • Higher-energy C-trap dissociation for peptide modification analysis
    • Olsen J.V., Macek B., Lange O., Makarov A., Horning S., Mann M. Higher-energy C-trap dissociation for peptide modification analysis. Nat. Methods 2007, 4(9):709-712.
    • (2007) Nat. Methods , vol.4 , Issue.9 , pp. 709-712
    • Olsen, J.V.1    Macek, B.2    Lange, O.3    Makarov, A.4    Horning, S.5    Mann, M.6
  • 34
    • 84906716279 scopus 로고    scopus 로고
    • Mass spectrometry based biomarker discovery, verification, and validation - quality assurance and control of protein biomarker assays
    • Parker C.E., Borchers C.H. Mass spectrometry based biomarker discovery, verification, and validation - quality assurance and control of protein biomarker assays. Mol. Oncol. 2014, 8(4):840-858.
    • (2014) Mol. Oncol. , vol.8 , Issue.4 , pp. 840-858
    • Parker, C.E.1    Borchers, C.H.2
  • 35
    • 84897116945 scopus 로고    scopus 로고
    • Action and therapeutic potential of oxyntomodulin
    • Pocai A. Action and therapeutic potential of oxyntomodulin. Mol. Metab. 2014, 3(3):241-251.
    • (2014) Mol. Metab. , vol.3 , Issue.3 , pp. 241-251
    • Pocai, A.1
  • 36
    • 34548183872 scopus 로고    scopus 로고
    • Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips
    • Rappsilber J., Mann M., Ishihama Y. Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips. Nat. Protoc. 2007, 2(8):1896-1906.
    • (2007) Nat. Protoc. , vol.2 , Issue.8 , pp. 1896-1906
    • Rappsilber, J.1    Mann, M.2    Ishihama, Y.3
  • 38
    • 84879414291 scopus 로고    scopus 로고
    • Emerging combinatorial hormone therapies for the treatment of obesity and T2DM
    • Sadry S.A., Drucker D.J. Emerging combinatorial hormone therapies for the treatment of obesity and T2DM. Nat. Rev. Endocrinol. 2013, 9(7):425-433.
    • (2013) Nat. Rev. Endocrinol. , vol.9 , Issue.7 , pp. 425-433
    • Sadry, S.A.1    Drucker, D.J.2
  • 40
    • 84925881208 scopus 로고    scopus 로고
    • The Q exactive HF, a benchtop mass spectrometer with a pre-filter, high-performance quadrupole and an ultra-high-field orbitrap analyzer
    • Scheltema R.A., Hauschild J.-P., Lange O., Hornburg D., Denisov E., Damoc E., Kuehn A., Makarov A., Mann M. The Q exactive HF, a benchtop mass spectrometer with a pre-filter, high-performance quadrupole and an ultra-high-field orbitrap analyzer. Mol. Cell. Proteomics 2014, 13(12):3698-3708.
    • (2014) Mol. Cell. Proteomics , vol.13 , Issue.12 , pp. 3698-3708
    • Scheltema, R.A.1    Hauschild, J.-P.2    Lange, O.3    Hornburg, D.4    Denisov, E.5    Damoc, E.6    Kuehn, A.7    Makarov, A.8    Mann, M.9
  • 41
    • 0023714388 scopus 로고
    • Oxyntomodulin: a potential hormone from the distal gut. Pharmacokinetics and effects on gastric acid and Insulin secretion in man
    • Schjoldager B.T., Baldissera F.G., Mortensen P.E., Holst J.J., Christiansen J. Oxyntomodulin: a potential hormone from the distal gut. Pharmacokinetics and effects on gastric acid and Insulin secretion in man. Eur. J. Clin. Invest. 1988, 18(5):499-503.
    • (1988) Eur. J. Clin. Invest. , vol.18 , Issue.5 , pp. 499-503
    • Schjoldager, B.T.1    Baldissera, F.G.2    Mortensen, P.E.3    Holst, J.J.4    Christiansen, J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.