GLP1- and GIP-producing cells rarely overlap and differ by bombesin receptor-2 expression and responsiveness

Journal of Endocrinology

Volumn 228, Issue 1, 2016, Pages 39-48

  Svendsen, Berit ^a,b   Pais, Ramona ^c   Engelstoft, Maja S ^a,d   Milev, Nikolay B ^c   Richards, Paul ^c   Christiansen, Charlotte B ^a,b   Egerod, Kristoffer L ^a,d   Jensen, Signe M ^a,c   Habib, Abdella M ^c   Gribble, Fiona M ^c   Schwartz, Thue W ^a,d   Reimann, Frank ^c   Holst, Jens J ^a,b  

^a Capital Region   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

BB2; Forskolin IBMX; Incretin hormones; Neuromedin C; Perfused mouse intestine

Indexed keywords

BOMBESIN RECEPTOR; CALCIUM; CRE RECOMBINASE; FLUORESCENT DYE; GASTRIC INHIBITORY POLYPEPTIDE; GLUCAGON LIKE PEPTIDE 1; INTEGRASE;

ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CELL CULTURE; CELL SEPARATION; CHEMISTRY; CLASSIFICATION; ENTEROENDOCRINE CELL; FEMALE; FLOW CYTOMETRY; GENETICS; MALE; METABOLISM; MOUSE; SECRETION (PROCESS); TRANSGENIC MOUSE;

ANIMALS; CALCIUM; CELL SEPARATION; CELLS, CULTURED; ENTEROENDOCRINE CELLS; FEMALE; FLOW CYTOMETRY; FLUORESCENT DYES; GASTRIC INHIBITORY POLYPEPTIDE; GLUCAGON-LIKE PEPTIDE 1; INTEGRASES; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; RECEPTORS, BOMBESIN;

EID: 84953226258     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1530/JOE-15-0247     Document Type: Article

References (25)

1. Egerod KL, Engelstoft MS, Grunddal KV, Nohr MK, Secher A, Sakata I, Pedersen J, Windelov JA, Fuchtbauer EM, Olsen J et al. 2012 A major lineage of enteroendocrine cells coexpress CCK, secretin, GIP, GLP1, PYY, and neurotensin but not somatostatin. Endocrinology 153 5782-5795. (doi:10.1210/en.2012-1595)
2. Eissele R, Goke R, Willemer S, Harthus HP, Vermeer H, Arnold R&Goke B 1992 Glucagon-like peptide-1 cells in the gastrointestinal tract and pancreas of rat, pig and man. European Journal of Clinical Investigation 22 283-291. (doi:10.1111/j.1365-2362.1992.tb01464.x)
3. Engelstoft MS, Park WM, Sakata I, Kristensen LV, Husted AS, Osborne-Lawrence S, Piper PK, Walker AK, Pedersen MH, Nohr MK et al. 2013 Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells. Molecular Metabolism 2 376-392. (doi:10.1016/j.molmet.2013.08.006)
4. Erspamer V&Melchiorri P 1976 Proceedings: Amphibian skin polypeptides active on the gut. Journal of Endocrinology 70(Suppl 3) 12P-13P (available at: http://joe.endocrinology-journals.org/content/70/3_Suppl.toc)
5. Habib AM, Richards P, Cairns LS, Rogers GJ, Bannon CA, Parker HE, Morley TC, Yeo GS, Reimann F&Gribble FM 2012 Overlap of endocrine hormone expression in the mouse intestine revealed by transcriptional profiling and flow cytometry. Endocrinology 153 3054-3065. (doi:10.1210/en.2011-2170)
6. Hansen L&Holst JJ 2002 The effects of duodenal peptides on glucagon-like peptide-1 secretion from the ileum. A duodeno-ileal loop? Regulatory Peptides 110 39-45. (doi:10.1016/S0167-0115(02)00157-X)
7. Hauge M, Vestmar MA, Husted AS, Ekberg JP, Wright MJ, Di SJ, Weinglass AB, Engelstoft MS, Madsen AN, Luckmann M et al. 2014 GPR40 (FFAR1) - combined Gs and Gq signaling in vitro is associated with robust incretin secretagogue action ex vivo and in vivo. Molecular Metabolism 4 3-14. (doi:10.1016/j.molmet.2014.10.002)
8. Knop FK, Vilsboll T, Larsen S, Hojberg PV, Volund A, Madsbad S, Holst JJ & Krarup T 2007 Increased postprandial responses of GLP1 and GIP in patients with chronic pancreatitis and steatorrhea following pancreatic enzyme substitution. American Journal of Physiology. Endocrinology and Metabolism 292 E324-E330. (doi:10.1152/ajpendo.00059.2006)
9. Lindgren O, Carr RD, Deacon CF, Holst JJ, Pacini G, Mari A&Ahren B 2011 Incretin hormone and insulin responses to oral versus intravenous lipid administration in humans. Journal of Clinical Endocrinology and Metabolism 96 2519-2524. (doi:10.1210/jc.2011-0266)
10. Mortensen K, Christensen LL, Holst JJ&Orskov C 2003 GLP1 and GIP are colocalized in a subset of endocrine cells in the small intestine. Regulatory Peptides 114 189-196. (doi:10.1016/S0167-0115(03)00125-3)
11. Moss CE, Marsh WJ, Parker HE, Ogunnowo-Bada E, Riches CH, Habib AM, Evans ML, Gribble FM&Reimann F 2012 Somatostatin receptor 5 and cannabinoid receptor 1 activation inhibit secretion of glucosedependent insulinotropic polypeptide from intestinal K cells in rodents. Diabetologia 55 3094-3103. (doi:10.1007/s00125-012-2663-5)
12. Orskov C, Rabenhoj L, Wettergren A, Kofod H&Holst JJ 1994 Tissue and plasma concentrations of amidated and glycine-extended glucagon-like peptide I in humans. Diabetes 43 535-539. (doi:10.2337/diab.43.4.535)
13. Panaro BL, Tough IR, Engelstoft MS, Matthews RT, Digby GJ, Moller CL, Svendsen B, Gribble F, Reimann F, Holst JJ et al. 2014 The melanocortin-4 receptor is expressed in enteroendocrine L cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo. Cell Metabolism 20 1018-1029. (doi:10.1016/j.cmet.2014.10.004)
14. Parker HE, Habib A, Rogers G, Gribble F&Reimann F 2009 Nutrient-dependent secretion of glucose-dependent insulinotropic polypeptide from primary murine K cells. Diabetologia 52 289-298. (doi:10.1007/s00125-008-1202-x)
15. Parker HE, Adriaenssens A, Rogers G, Richards P, Koepsell H, Reimann F & Gribble FM 2012 Predominant role of active versus facilitative glucose transport for glucagon-like peptide-1 secretion. Diabetologia 55 2445-2455. (doi:10.1007/s00125-012-2585-2)
16. Pedersen J, Ugleholdt RK, Jorgensen SM, Windelov JA, Grunddal KV, Schwartz TW, Fuchtbauer EM, Poulsen SS, Holst PJ&Holst JJ 2013 Glucose metabolism is altered after loss of L cells and alpha-cells but not influenced by loss of K cells. American Journal of Physiology. Endocrinology and Metabolism 304 E60-E73. (doi:10.1152/ajpendo.00547.2011)
17. Plaisancie P, Bernard C, Chayvialle JA&Cuber JC 1994 Regulation of glucagon-like peptide-1-(7-36) amide secretion by intestinal neurotransmitters and hormones in the isolated vascularly perfused rat colon. Endocrinology 135 2398-2403. (doi:10.1210/endo.135.6.7988423)
18. Reimann F, Habib AM, Tolhurst G, Parker HE, Rogers GJ&Gribble FM 2008 Glucose sensing in L cells: a primary cell study. Cell Metabolism 8 532-539. (doi:10.1016/j.cmet.2008.11.002)
19. Rocca AS&Brubaker PL 1999 Role of the vagus nerve in mediating proximal nutrient-induced glucagon-like peptide-1 secretion. Endocrinology 140 1687-1694. (doi:10.1210/endo.140.4.6643)
20. Simpson AK, Ward PS, Wong KY, Collord GJ, Habib AM, Reimann F & Gribble FM 2007 Cyclic AMP triggers glucagon-like peptide-1 secretion from the GLUTag enteroendocrine cell line. Diabetologia 50 2181-2189. (doi:10.1007/s00125-007-0750-9)
21. Sjolund K, Sanden G, Hakanson R&Sundler F 1983 Endocrine cells in human intestine: an immunocytochemical study. Gastroenterology 85 1120-1130. (doi:10.1016/S0016-5085(83)80080-8)
22. Snow ND, Prpic V, Mangel AW, Sharara AI, McVey DC, Hurst LJ, Vigna SR & Liddle RA 1994 Regulation of cholecystokinin secretion by bombesin in STC-1 cells. American Journal of Physiology 267 G859-G865.
23. Svendsen B, Pedersen J, Albrechtsen NJ, Hartmann B, Torang S, Rehfeld JF, Poulsen SS&Holst JJ 2015 An analysis of cosecretion and coexpression of gut hormones from male rat proximal and distal small intestine. Endocrinology 156 847-857. (doi:10.1210/en.2014-1710)
24. Sykaras AG, Demenis C, Cheng L, Pisitkun T, Mclaughlin JT, Fenton RA & Smith CP 2014 Duodenal CCK cells from male mice express multiple hormones including ghrelin. Endocrinology 155 3339-3351. (doi:10.1210/en.2013-2165)
25. Theodorakis MJ, Carlson O, Michopoulos S, Doyle ME, Juhaszova M, Petraki K&Egan JM 2006 Human duodenal enteroendocrine cells: source of both incretin peptides, GLP1 and GIP. American Journal of Physiology. Endocrinology and Metabolism 290 E550-E559. (doi:10.1152/ajpendo.00326.2004)