4-Hydroxyisoleucine attenuates the inflammation-mediated insulin resistance by the activation of AMPK and suppression of SOCS-3 coimmunoprecipitation with both the IR-β subunit as well as IRS-1

Molecular and Cellular Biochemistry

Volumn 414, Issue 1-2, 2016, Pages 95-104

  Gautam, Sudeep ^a   Ishrat, Nayab ^a   Yadav, Pragya ^a   Singh, Rohit ^a   Narender, Tadigoppula ^a   Srivastava, Arvind K ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

4 HIL; C2C12 myotubes; Glucose uptake; Insulin resistance; TNF ; Trigonella foenum graecum

Indexed keywords

4 HYDROXYISOLEUCINE; GLUCOSE TRANSPORTER 4; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR BETA; INSULIN RECEPTOR SUBSTRATE 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SERINE; SUPPRESSOR OF CYTOKINE SIGNALING 3; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; WORTMANNIN; 4-HYDROXYISOLEUCINE; ADENYLATE KINASE; ANDROSTANE DERIVATIVE; DEOXYGLUCOSE; INSULIN RECEPTOR SUBSTRATE; ISOLEUCINE; SLC2A4 PROTEIN, MOUSE; SOCS3 PROTEIN, MOUSE; TUMOR NECROSIS FACTOR;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG MECHANISM; ENZYME ACTIVATION; FENUGREEK; GLUCOSE TRANSPORT; IMMUNOPRECIPITATION; IN VITRO STUDY; INSULIN RESISTANCE; INSULIN SENSITIVITY; MYOTUBE; NONHUMAN; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ANALOGS AND DERIVATIVES; ANIMAL; CELL LINE; DRUG EFFECTS; INFLAMMATION; METABOLISM; MOUSE; PHOSPHORYLATION; SKELETAL MUSCLE CELL;

ADENYLATE KINASE; ANDROSTADIENES; ANIMALS; CELL LINE; DEOXYGLUCOSE; ENZYME ACTIVATION; GLUCOSE TRANSPORTER TYPE 4; IMMUNOPRECIPITATION; INFLAMMATION; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN RESISTANCE; ISOLEUCINE; MICE; MUSCLE FIBERS, SKELETAL; PHOSPHORYLATION; SUPPRESSOR OF CYTOKINE SIGNALING 3 PROTEIN; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84962195672     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-016-2662-9     Document Type: Article

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