Natural Xanthones from Garcinia mangostana with Multifunctional Activities for the Therapy of Alzheimer’s Disease

Neurochemical Research

Volumn 41, Issue 7, 2016, Pages 1806-1817

  Wang, Sheng nan ^a,b   Li, Qian ^c   Jing, Ming hua ^a   Alba, Espargaró ^d   Yang, Xiao hong ^a,b   Sabaté, Raimon ^d   Han, Yi fan ^e   Pi, Rong biao ^a,b,f   Lan, Wen jian ^a,b   Yang, Xiao bo ^c   Chen, Jing kao ^a,b  

^a SUN YAT SEN UNIVERSITY   (China)

^b International Joint Laboratory (SYSU PolyU HK) of Novel Anti Dementia Drugs of Guangdong   (China)

^c GUANGDONG PROVINCIAL HOSPITAL OF CHINESE MEDICINE   (China)

^d UNIVERSITY OF BARCELONA   (Spain)

^e HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

^f SUN YAT SEN UNIVERSITY   (China)

Author keywords

Alzheimer s disease; Multifunction; Neuroprotection; Oxidative stress; Xanthones

Indexed keywords

8 DEOXYGARTANIN; ALPHA MANGOSTIN; AMYLOID BETA PROTEIN[1-42]; ANTIOXIDANT; BETA SECRETASE 1; GAMMA MANGOSTIN; GARCINONE C; GARTANIN; NEUROPROTECTIVE AGENT; NOOTROPIC AGENT; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; XANTHONE DERIVATIVE; AMYLOID BETA PROTEIN; ASPARTIC PROTEINASE; BACE1 PROTEIN, MOUSE; PLANT EXTRACT; SECRETASE;

ALZHEIMER DISEASE; ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD BRAIN BARRIER; CELL DEATH; CELL PROLIFERATION; CELL VIABILITY; CHEMICAL STRUCTURE; CYTOTOXICITY; DRUG PENETRATION; DRUG SCREENING; DRUG STRUCTURE; ESCHERICHIA COLI; GARCINIA MANGOSTANA; IN VITRO STUDY; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PHARMACOLOGICAL PARAMETERS; PRIORITY JOURNAL; PROTEIN AGGREGATION; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; ISOLATION AND PURIFICATION; METABOLISM; MOUSE;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; CELL LINE; GARCINIA MANGOSTANA; MICE; PLANT EXTRACTS; XANTHONES;

EID: 84962191284     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/s11064-016-1896-y     Document Type: Article

References (34)

1. Rosini M, Simoni E, Minarini A, Melchiorre C (2014) Multi-target design strategies in the context of Alzheimer’s disease: acetylcholinesterase inhibition and NMDA receptor antagonism as the driving forces. Neurochem Res 39(10):1914–1923
2. Carreiras MC, Mendes E, Perry MJ, Francisco AP, Marco-Contelles J (2013) The multifactorial nature of Alzheimer’s disease for developing potential therapeutics. Curr Top Med Chem 13(15):1745–1770
3. Kim HG, Oh MS (2012) Herbal medicines for the prevention and treatment of Alzheimer’s disease. Curr Pharm Des 18(1):57–75
4. Wu TY, Chen CP, Jinn TR (2011) Traditional Chinese medicines and Alzheimer’s disease. Taiwan J Obst Gynecol 50(2):131–135
5. Kim MH, Kim SH, Yang WM (2014) Mechanisms of action of phytochemicals from medicinal herbs in the treatment of Alzheimer’s disease. Planta Med 80(15):1249–1258
6. Bajda M, Guzior N, Ignasik M, Malawska B (2011) Multi-target-directed ligands in Alzheimer’s disease treatment. Curr Med Chem 18(32):4949–4975
7. Guzior N, Wieckowska A, Panek D, Malawska B (2015) Recent development of multifunctional agents as potential drug candidates for the treatment of Alzheimer’s disease. Curr Med Chem 22(3):373–404
8. Suttirak W, Manurakchinakorn S (2014) In vitro antioxidant properties of mangosteen peel extract. J Food Sci Technol 51(12):3546–3558
9. Li G, Thomas S, Johnson JJ (2013) Polyphenols from the mangosteen (Garcinia mangostana) fruit for breast and prostate cancer. Front Pharmacol 4:80
10. Kosem N, Ichikawa K, Utsumi H, Moongkarndi P (2013) In vivo toxicity and antitumor activity of mangosteen extract. J Nat Med 67(2):255–263
11. Dharmaratne HR, Sakagami Y, Piyasena KG, Thevanesam V (2013) Antibacterial activity of xanthones from Garcinia mangostana (L.) and their structure-activity relationship studies. Nat Prod Res 27(10):938–941
12. Wang Y, Xia Z, Xu JR, Wang YX, Hou LN, Qiu Y, Chen HZ (2012) Alpha-mangostin, a polyphenolic xanthone derivative from mangosteen, attenuates beta-amyloid oligomers-induced neurotoxicity by inhibiting amyloid aggregation. Neuropharmacology 62(2):871–881
13. Bumrungpert A, Kalpravidh RW, Chuang CC, Overman A, Martinez K, Kennedy A, McIntosh M (2010) Xanthones from mangosteen inhibit inflammation in human macrophages and in human adipocytes exposed to macrophage-conditioned media. J Nutr 140(4):842–847
14. Huang HJ, Chen WL, Hsieh RH, Hsieh-Li HM (2014) Multifunctional effects of mangosteen pericarp on cognition in C57BL/6J and triple transgenic Alzheimer’s mice. Evid-Based Complement Altern Med eCAM 2014:813672
15. Xu Z, Huang L, Chen XH, Zhu XF, Qian XJ, Feng GK, Lan WJ, Li HJ (2014) Cytotoxic prenylated xanthones from the pericarps of Garcinia mangostana. Molecules 19(2):1820–1827 (Basel, Switzerland)
16. Di L, Kerns EH, Fan K, McConnell OJ, Carter GT (2003) High throughput artificial membrane permeability assay for blood-brain barrier. Eur J Med Chem 38(3):223–232
17. Hardy J, Selkoe DJ (2002) The amyloid hypothesis of Alzheimer’s disease: progress and problems on the road to therapeutics. Science 297(5580):353–356
18. Biancalana M, Makabe K, Koide A, Koide S (2009) Molecular mechanism of thioflavin-T binding to the surface of beta-rich peptide self-assemblies. J Mol Biol 385(4):1052–1063
19. Fodera V, Groenning M, Vetri V, Librizzi F, Spagnolo S, Cornett C, Olsen L, van de Weert M, Leone M (2008) Thioflavin T hydroxylation at basic pH and its effect on amyloid fibril detection. J Phys Chem B 112(47):15174–15181
20. Pouplana S, Espargaro A, Galdeano C, Viayna E, Sola I, Ventura S, Munoz-Torrero D, Sabate R (2014) Thioflavin-S staining of bacterial inclusion bodies for the fast, simple, and inexpensive screening of amyloid aggregation inhibitors. Curr Med Chem 21(9):1152–1159
21. Luo Y, Bolon B, Kahn S, Bennett BD, Babu-Khan S, Denis P, Fan W, Kha H, Zhang J, Gong Y, Martin L, Louis JC, Yan Q, Richards WG, Citron M, Vassar R (2001) Mice deficient in BACE1, the Alzheimer’s beta-secretase, have normal phenotype and abolished beta-amyloid generation. Nat Neurosci 4(3):231–232
22. Yan R, Vassar R (2014) Targeting the beta secretase BACE1 for Alzheimer’s disease therapy. Lancet Neurol 13(3):319–329
23. Padurariu M, Ciobica A, Lefter R, Serban IL, Stefanescu C, Chirita R (2013) The oxidative stress hypothesis in Alzheimer’s disease. Psychiatr Danub 25(4):401–409
24. Azizi G, Navabi SS, Al-Shukaili A, Seyedzadeh MH, Yazdani R, Mirshafiey A (2015) The Role of Inflammatory Mediators in the Pathogenesis of Alzheimer’s Disease. Sultan Qaboos Univ Med J 15(3):e305–e316
25. Buendia I, Michalska P, Navarro E, Gameiro I, Egea J, Leon R (2016) Nrf2-ARE pathway: an emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases. Pharmacol Ther 157:84–104
26. Biswas C, Shah N, Muthu M, La P, Fernando AP, Sengupta S, Yang G, Dennery PA (2014) Nuclear heme oxygenase-1 (HO-1) modulates subcellular distribution and activation of Nrf2, impacting metabolic and anti-oxidant defenses. J Biol Chem 289(39):26882–26894
27. Lim JL, Wilhelmus MM, de Vries HE, Drukarch B, Hoozemans JJ, van Horssen J (2014) Antioxidative defense mechanisms controlled by Nrf2: state-of-the-art and clinical perspectives in neurodegenerative diseases. Arch Toxicol 88(10):1773–1786
28. Schipper HM (2007) Biomarker potential of heme oxygenase-1 in Alzheimer’s disease and mild cognitive impairment. Biomark Med 1(3):375–385
29. Calabrese V, Cornelius C, Dinkova-Kostova AT, Calabrese EJ, Mattson MP (2010) Cellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disorders. Antioxid Redox Signal 13(11):1763–1811
30. Trovato Salinaro A, Cornelius C, Koverech G, Koverech A, Scuto M, Lodato F, Fronte V, Muccilli V, Reibaldi M, Longo A, Uva MG, Calabrese V (2014) Cellular stress response, redox status, and vitagenes in glaucoma: a systemic oxidant disorder linked to Alzheimer’s disease. Front Pharmacol 5:129
31. Calabrese V, Cornelius C, Mancuso C, Pennisi G, Calafato S, Bellia F, Bates TE, Giuffrida Stella AM, Schapira T, Dinkova Kostova AT, Rizzarelli E (2008) Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity. Neurochem Res 33(12):2444–2471
32. Calabrese V, Cornelius C, Dinkova-Kostova AT, Iavicoli I, Di Paola R, Koverech A, Cuzzocrea S, Rizzarelli E (1822) Calabrese EJ (2012) cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity. Biochim Biophys Acta 5:753–783
33. Viayna E, Sola I, Bartolini M, De Simone A, Tapia-Rojas C, Serrano FG, Sabate R, Juarez-Jimenez J, Perez B, Luque FJ, Andrisano V, Clos MV, Inestrosa NC, Munoz-Torrero D (2014) Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents. J Med Chem 57(6):2549–2567
34. Khaw KY, Choi SB, Tan SC, Wahab HA, Chan KL, Murugaiyah V (2014) Prenylated xanthones from mangosteen as promising cholinesterase inhibitors and their molecular docking studies. Phytomed Int J Phytother Phytopharmacol 21(11):1303–1309