Polyphenols from the mangosteen (Garcinia mangostana) fruit for breast and prostate cancer

Frontiers in Pharmacology

Volumn 4 JUN, Issue , 2013, Pages

  Li, Gongbo ^a   Thomas, Stacey ^a   Johnson, Jeremy J ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Mangostin; Extract; Mangosteen; Prostate cancer; Xanthone

Indexed keywords

3,3' DIINDOLYLMETHANE; 8 DEOXYGARTANIN; 9 HYDROXYCALABAXANTHON; ALPHA MANGOSTIN; ANTINEOPLASTIC AGENT; EPIGALLOCATECHIN GALLATE; GAMMA MANGOSTIN; GARCINIA MANGOSTANA EXTRACT; GARCINONE D; GARCINONE E; GARTANIN; GENISTEIN; POLYPHENOL DERIVATIVE; UNCLASSIFIED DRUG; XANTHONE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; BREAST CANCER; CANCER CELL; CANCER INHIBITION; CANCER PREVENTION; CELL CYCLE; CELL PROLIFERATION; CHEMOPROPHYLAXIS; CONCENTRATION RESPONSE; DIETARY INTAKE; DRUG ISOLATION; FOOD COMPOSITION; FRUIT; GARCINIA MANGOSTANA; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MALIGNANT NEOPLASTIC DISEASE; NONHUMAN; PHYSICAL CHEMISTRY; PROSTATE CANCER; SHORT SURVEY; SIGNAL TRANSDUCTION;

EID: 84881618017     PISSN: None     EISSN: 16639812     Source Type: Journal    
DOI: 10.3389/fphar.2013.00080     Document Type: Short Survey

References (23)

1. Arcangeli, S., Pinzi, V., and Arcangeli, G. (2012). Epidemiology of prostate cancer and treatment remarks. World J. Radiol. 4, 241-246. doi: 10.4329/wjr.v4.i6.241.
2. Balunas, M. J., Su, B., Brueggemeier, R. W., and Kinghorn, A. D. (2008). Xanthones from the botanical dietary supplement mangosteen (Garcinia mangostana) with aromatase inhibitory activity. J. Nat. Prod. 71, 1161-1166. doi: 10.1021/np8000255.
3. Carter, B. S., Beaty, T. H., Steinberg, G. D., Childs, B., and Walsh, P. C. (1992). Mendelian inheritance of familial prostate cancer. Proc. Natl. Acad. Sci. U.S.A. 89, 3367-3371. doi: 10.1073/pnas.89.8.3367.
4. Chin, Y. W., and Kinghorn, A. D. (2008). Structural characterization, biological effects, and synthetic studies on xanthones from mangosteen (Garcinia mangostana), a popular botanical dietary supplement. Mini Rev. Org. Chem. 5, 355-364. doi: 10.2174/157019308786242223.
5. Han, A. R., Kim, J. A., Lantvit, D. D., Kardono, L. B., Riswan, S., Chai, H., et al. (2009). Cytotoxic xanthone constituents of the stem bark of Garcinia mangostana (mangosteen). J. Nat. Prod. 72, 2028-2031. doi: 10.1021/np900517h.
6. Hung, S. H., Shen, K. H., Wu, C. H., Liu, C. L., and Shih, Y. W. (2009). Alpha-mangostin suppresses PC-3 human prostate carcinoma cell metastasis by inhibiting matrix metalloproteinase-2/9 and urokinase-plasminogen expression through the JNK signaling pathway. J. Agric. Food Chem. 57, 1291-1298. doi: 10.1021/jf8032683.
7. Johnson, J. J., Petiwala, S. M., Syed, D. N., Rasmussen, J. T., Adhami, V. M., Siddiqui, I. A., et al. (2012). Alpha-mangostin, a xanthone from mangosteen fruit, promotes cell cycle arrest in prostate cancer and decreases xenograft tumor growth. Carcinogenesis 33, 413-419. doi: 10.1093/carcin/bgr291.
8. Johnson, J. J., Syed, D. N., Heren, C. R., Suh, Y., Adhami, V. M., and Mukhtar, H. (2008). Carnosol, a dietary diterpene, displays growth inhibitory effects in human prostate cancer PC3 cells leading to G2-phase cell cycle arrest and targets the 5′-AMP-activated protein kinase (AMPK) pathway. Pharm. Res. 25, 2125-2134. doi: 10.1007/s11095-008-9552-0.
9. Jung, H. A., Su, B. N., Keller, W. J., Mehta, R. G., and Kinghorn, A. D. (2006). Antioxidant xanthones from the pericarp of Garcinia mangostana (Mangosteen). J. Agric. Food Chem. 54, 2077-2082. doi: 10.1021/jf052649z.
10. Katayose, Y., Kim, M., Rakkar, A. N., Li, Z., Cowan, K. H., and Seth, P. (1997). Promoting apoptosis: a novel activity associated with the cyclin-dependent kinase inhibitor p27. Cancer Res. 57, 5441-5445..
11. Khan, N., and Mukhtar, H. (2012). Modulation of signaling pathways in prostate cancer by green tea polyphenols. Biochem. Pharmacol. 85, 667-672. doi: 10.1016/j.bcp.2012.09.027.
12. Kurose, H., Shibata, M. A., Iinuma, M., and Otsuki, Y. (2012). Alterations in cell cycle and induction of apoptotic cell death in breast cancer cells treated with alpha-mangostin extracted from mangosteen pericarp. J. Biomed. Biotechnol. 2012, 672428. doi: 10.1155/2012/672428.
13. Matsumoto, K., Akao, Y., Kobayashi, E., Ohguchi, K., Ito, T., Tanaka, T., et al. (2003). Induction of apoptosis by xanthones from mangosteen in human leukemia cell lines. J. Nat. Prod. 66, 1124-1127. doi: 10.1021/np020546u.
14. Matsumoto, K., Akao, Y., Ohguchi, K., Ito, T., Tanaka, T., Iinuma, M., et al. (2005). Xanthones induce cell-cycle arrest and apoptosis in human colon cancer DLD-1 cells. Bioorg. Med. Chem. 13, 6064-6069. doi: 10.1016/j.bmc.2005.06.065.
15. Matsumoto, K., Akao, Y., Yi, H., Ohguchi, K., Ito, T., Tanaka, T., et al. (2004). Preferential target is mitochondria in alpha-mangostin-induced apoptosis in human leukemia HL60 cells. Bioorg. Med. Chem. 12, 5799-5806. doi: 10.1016/j.bmc.2004.08.034.
16. Moongkarndi, P., Kosem, N., Kaslungka, S., Luanratana, O., Pongpan, N., and Neungton, N. (2004a). Antiproliferation, antioxidation and induction of apoptosis by Garcinia mangostana (mangosteen) on SKBR3 human breast cancer cell line. J. Ethnopharmacol. 90, 161-166. doi: 10.1016/j.jep.2003.09.048.
17. Moongkarndi, P., Kosem, N., Luanratana, O., Jongsomboonkusol, S., and Pongpan, N. (2004b). Antiproliferative activity of Thai medicinal plant extracts on human breast adenocarcinoma cell line. Fitoterapia 75, 375-377. doi: 10.1016/j.fitote.2004.01.010.
18. Obolskiy, D., Pischel, I., Siriwatanametanon, N., and Heinrich, M. (2009). Garcinia mangostana L.: a phytochemical and pharmacological review. Phytother. Res. 23, 1047-1065. doi: 10.1002/ptr.2730.
19. Shan, T., Ma, Q., Guo, K., Liu, J., Li, W., Wang, F., et al. (2011). Xanthones from mangosteen extracts as natural chemopreventive agents: potential anticancer drugs. Curr. Mol. Med. 11, 666-677. doi: 10.2174/156652411797536679.
20. Shibata, M. A., Iinuma, M., Morimoto, J., Kurose, H., Akamatsu, K., Okuno, Y., et al. (2011). Alpha-Mangostin extracted from the pericarp of the mangosteen (Garcinia mangostana Linn) reduces tumor growth and lymph node metastasis in an immunocompetent xenograft model of metastatic mammary cancer carrying a p53 mutation. BMC Med. 9:69. doi: 10.1186/1741-7015-9-69.
21. Suksamrarn, S., Komutiban, O., Ratananukul, P., Chimnoi, N., Lartpornmatulee, N., and Suksamrarn, A. (2006). Cytotoxic prenylated xanthones from the young fruit of Garcinia mangostana. Chem. Pharm. Bull. (Tokyo) 54, 301-305. doi: 10.1248/cpb.54.301.
22. Wang, J. J., Sanderson, B. J., and Zhang, W. (2012). Significant anti-invasive activities of alpha-mangostin from the mangosteen pericarp on two human skin cancer cell lines. Anticancer Res. 32, 3805-3816..
23. Wang, X., Gorospe, M., Huang, Y., and Holbrook, N. J. (1997). p27Kip1 overexpression causes apoptotic death of mammalian cells. Oncogene 15, 2991-2997. doi: 10.1038/sj.onc.1201450.