Mitochondrial calpain-1 disrupts ATP synthase and induces superoxide generation in type 1 diabetic hearts: A novel mechanism contributing to diabetic cardiomyopathy

Diabetes

Volumn 65, Issue 1, 2016, Pages 255-268

  Ni, Rui ^a,b   Zheng, Dong ^a,b   Xiong, Sidong ^a   Hill, David J ^b   Sun, Tao ^b   Gardiner, Richard B ^b   Fan, Guo Chang ^c   Lu, Yanrong ^d   Abel, E Dale ^e   Greer, Peter A ^f,g   Peng, Tianqing ^a,b  

^a SOOCHOW UNIVERSITY   (China)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

^c UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^d SICHUAN UNIVERSITY   (China)

^e UNIVERSITY OF IOWA   (United States)

^f QUEEN S UNIVERSITY   (Canada)

^g QUEEN S UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CALPAIN 1; CALPASTATIN; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; CALCIUM BINDING PROTEIN; CALPAIN; CAPN1 PROTEIN, MOUSE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; DIABETIC CARDIOMYOPATHY; HEART MUSCLE CELL; INSULIN DEPENDENT DIABETES MELLITUS; MALE; MITOCHONDRION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN CLEAVAGE; UPREGULATION; ANIMAL; CARDIAC MUSCLE; CARDIAC MUSCLE CELL; COMPLICATION; DIABETIC CARDIOMYOPATHIES; DISEASE MODEL; EXPERIMENTAL DIABETES MELLITUS; GENETICS; HEART MITOCHONDRION; METABOLISM; TRANSGENIC MOUSE;

ANIMALS; APOPTOSIS; CALCIUM-BINDING PROTEINS; CALPAIN; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; DIABETIC CARDIOMYOPATHIES; DISEASE MODELS, ANIMAL; MICE; MICE, TRANSGENIC; MITOCHONDRIA, HEART; MITOCHONDRIAL PROTON-TRANSLOCATING ATPASES; MYOCARDIUM; MYOCYTES, CARDIAC; REACTIVE OXYGEN SPECIES; SUPEROXIDES;

EID: 84962191233     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db15-0963     Document Type: Article

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