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Volumn 21, Issue 4, 2016, Pages 286-294

Is it time to think about the sodium glucose co-transporter 2 sympathetically?

Author keywords

glucose; norepinephrine; sodium glucose co transporter 2; sympathetic nervous system; type 2 diabetes mellitus

Indexed keywords

CANAGLIFLOZIN; DAPAGLIFLOZIN; EMPAGLIFLOZIN; METFORMIN; PHENYLEPHRINE; PRAZOSIN; SODIUM GLUCOSE COTRANSPORTER 2; SODIUM GLUCOSE COTRANSPORTER 2 INHIBITOR; SODIUM PROTON EXCHANGE PROTEIN 3; TOFOGLIFLOZIN; ADRENERGIC RECEPTOR BLOCKING AGENT; ANTIDIABETIC AGENT; SLC5A2 PROTEIN, HUMAN;

EID: 84962165361     PISSN: 13205358     EISSN: 14401797     Source Type: Journal    
DOI: 10.1111/nep.12620     Document Type: Review
Times cited : (20)

References (68)
  • 1
    • 84906882822 scopus 로고    scopus 로고
    • Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: A systematic analysis for the Global Burden of Disease Study 2013
    • Ng M, Fleming T, Robinson M, et al., Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 2014; 384: 766-81.
    • (2014) Lancet , vol.384 , pp. 766-781
    • Ng, M.1    Fleming, T.2    Robinson, M.3
  • 2
    • 0037048167 scopus 로고    scopus 로고
    • Overweight and obesity as determinants of cardiovascular risk: The Framingham experience
    • Wilson PW, D'Agostino RB, Sullivan L, Parise H, Kannel WB,. Overweight and obesity as determinants of cardiovascular risk: the Framingham experience. Arch. Intern. Med. 2002; 162: 1867-72.
    • (2002) Arch. Intern. Med. , vol.162 , pp. 1867-1872
    • Wilson, P.W.1    D'Agostino, R.B.2    Sullivan, L.3    Parise, H.4    Kannel, W.B.5
  • 3
    • 65749095507 scopus 로고    scopus 로고
    • The role of the sympathetic nervous system in obesity-related hypertension
    • da Silva AA, do Carmo J, Dubinion J, Hall JE,. The role of the sympathetic nervous system in obesity-related hypertension. Curr. Hypertens. Rep. 2009; 11: 206-11.
    • (2009) Curr. Hypertens. Rep. , vol.11 , pp. 206-211
    • Da Silva, A.A.1    Do Carmo, J.2    Dubinion, J.3    Hall, J.E.4
  • 5
    • 33747739430 scopus 로고    scopus 로고
    • Body mass index, metabolic syndrome, and risk of type 2 diabetes or cardiovascular disease
    • Meigs JB, Wilson PW, Fox CS, et al., Body mass index, metabolic syndrome, and risk of type 2 diabetes or cardiovascular disease. J. Clin. Endocrinol. Metab. 2006; 91: 2906-12.
    • (2006) J. Clin. Endocrinol. Metab. , vol.91 , pp. 2906-2912
    • Meigs, J.B.1    Wilson, P.W.2    Fox, C.S.3
  • 6
    • 84899862290 scopus 로고    scopus 로고
    • Sodium glucose co-transporter type 2 (SGLT2) inhibitors: Targeting the kidney to improve glycemic control in diabetes mellitus
    • Bays H,. Sodium glucose co-transporter type 2 (SGLT2) inhibitors: targeting the kidney to improve glycemic control in diabetes mellitus. Diabetes Ther 2013; 4: 195-220.
    • (2013) Diabetes Ther , vol.4 , pp. 195-220
    • Bays, H.1
  • 7
    • 84938684785 scopus 로고    scopus 로고
    • Beyond glycosuria: Exploring the intrarenal effects of SGLT-2 inhibition in diabetes
    • Thomas MC, Jandeleit-Dahm K, Bonnet F,. Beyond glycosuria: exploring the intrarenal effects of SGLT-2 inhibition in diabetes. Diabetes Metab. 2014; 40 (6 Suppl 1): S17-22.
    • (2014) Diabetes Metab. , vol.40 , Issue.6 , pp. S17-S22
    • Thomas, M.C.1    Jandeleit-Dahm, K.2    Bonnet, F.3
  • 8
    • 84923527667 scopus 로고    scopus 로고
    • Probing SGLT2 as a therapeutic target for diabetes: Basic physiology and consequences
    • Gallo LA, Wright EM, Vallon V,. Probing SGLT2 as a therapeutic target for diabetes: basic physiology and consequences. Diab. Vasc. Dis. Res. 2015; 12: 78-89.
    • (2015) Diab. Vasc. Dis. Res. , vol.12 , pp. 78-89
    • Gallo, L.A.1    Wright, E.M.2    Vallon, V.3
  • 9
    • 84891534541 scopus 로고    scopus 로고
    • Novel hypothesis to explain why SGLT2 inhibitors inhibit only 30-50% of filtered glucose load in humans
    • Abdul-Ghani MA, DeFronzo RA, Norton L,. Novel hypothesis to explain why SGLT2 inhibitors inhibit only 30-50% of filtered glucose load in humans. Diabetes 2013; 62: 3324-8.
    • (2013) Diabetes , vol.62 , pp. 3324-3328
    • Abdul-Ghani, M.A.1    DeFronzo, R.A.2    Norton, L.3
  • 10
    • 78651349221 scopus 로고    scopus 로고
    • Biology of human sodium glucose transporters
    • Wright EM, Loo DD, Hirayama BA,. Biology of human sodium glucose transporters. Physiol. Rev. 2011; 91: 733-94.
    • (2011) Physiol. Rev. , vol.91 , pp. 733-794
    • Wright, E.M.1    Loo, D.D.2    Hirayama, B.A.3
  • 11
    • 0035879385 scopus 로고    scopus 로고
    • Changes in sodium or glucose filtration rate modulate expression of glucose transporters in renal proximal tubular cells of rat
    • Vestri S, Okamoto MM, de Freitas HS, et al., Changes in sodium or glucose filtration rate modulate expression of glucose transporters in renal proximal tubular cells of rat. J. Membr. Biol. 2001; 182: 105-12.
    • (2001) J. Membr. Biol. , vol.182 , pp. 105-112
    • Vestri, S.1    Okamoto, M.M.2    De Freitas, H.S.3
  • 12
    • 56949098667 scopus 로고    scopus 로고
    • Sympathetic nervous system behavior in human obesity
    • Davy KP, Orr JS,. Sympathetic nervous system behavior in human obesity. Neurosci. Biobehav. Rev. 2009; 33: 116-24.
    • (2009) Neurosci. Biobehav. Rev. , vol.33 , pp. 116-124
    • Davy, K.P.1    Orr, J.S.2
  • 13
    • 33748932547 scopus 로고    scopus 로고
    • Adrenoceptors and signal transduction in neurons
    • Hein L,. Adrenoceptors and signal transduction in neurons. Cell Tissue Res. 2006; 326: 541-51.
    • (2006) Cell Tissue Res. , vol.326 , pp. 541-551
    • Hein, L.1
  • 14
    • 0035248116 scopus 로고    scopus 로고
    • The peripheral sympathetic nervous system in human obesity
    • van Baak MA,. The peripheral sympathetic nervous system in human obesity. Obes. Rev. 2001; 2: 3-14.
    • (2001) Obes. Rev. , vol.2 , pp. 3-14
    • Van Baak, M.A.1
  • 15
    • 33744900324 scopus 로고    scopus 로고
    • Subtype-specific α1- and β-adrenoceptor signaling in the heart
    • Xiao R-P, Zhu W, Zheng M, et al., Subtype-specific α1- and β-adrenoceptor signaling in the heart. Trends Pharmacol. Sci. 2006; 27: 330-7.
    • (2006) Trends Pharmacol. Sci. , vol.27 , pp. 330-337
    • Xiao, R.-P.1    Zhu, W.2    Zheng, M.3
  • 16
    • 0029670133 scopus 로고    scopus 로고
    • Alpha 1-adrenoceptors mediating contraction in arteries of normotensive and spontaneously hypertensive rats are of the alpha 1D or alpha 1A subtypes
    • Villalobos-Molina R, Ibarra M,. Alpha 1-adrenoceptors mediating contraction in arteries of normotensive and spontaneously hypertensive rats are of the alpha 1D or alpha 1A subtypes. Eur. J. Pharmacol. 1996; 298: 257-63.
    • (1996) Eur. J. Pharmacol. , vol.298 , pp. 257-263
    • Villalobos-Molina, R.1    Ibarra, M.2
  • 17
    • 0033910849 scopus 로고    scopus 로고
    • Transgenic mice overexpressing alpha2A-adrenoceptors in pancreatic beta-cells show altered regulation of glucose homeostasis
    • Devedjian JC, Pujol A, Cayla C, et al., Transgenic mice overexpressing alpha2A-adrenoceptors in pancreatic beta-cells show altered regulation of glucose homeostasis. Diabetologia 2000; 43: 899-906.
    • (2000) Diabetologia , vol.43 , pp. 899-906
    • Devedjian, J.C.1    Pujol, A.2    Cayla, C.3
  • 18
    • 84937763347 scopus 로고    scopus 로고
    • Inhibition of the glucose transporter SGLT2 with dapagliflozin in pancreatic alpha cells triggers glucagon secretion
    • Bonner C, Kerr-Conte J, Gmyr V, et al., Inhibition of the glucose transporter SGLT2 with dapagliflozin in pancreatic alpha cells triggers glucagon secretion. Nat. Med. 2015; 21: 512-7.
    • (2015) Nat. Med. , vol.21 , pp. 512-517
    • Bonner, C.1    Kerr-Conte, J.2    Gmyr, V.3
  • 19
    • 0021327070 scopus 로고
    • Beta-adrenergic receptors: Biochemical mechanisms of physiological regulation
    • Stiles GL, Caron MG, Lefkowitz RJ,. Beta-adrenergic receptors: biochemical mechanisms of physiological regulation. Physiol. Rev. 1984; 64: 661-743.
    • (1984) Physiol. Rev. , vol.64 , pp. 661-743
    • Stiles, G.L.1    Caron, M.G.2    Lefkowitz, R.J.3
  • 20
    • 0034077279 scopus 로고    scopus 로고
    • New insights into sympathetic regulation of glucose and fat metabolism
    • Nonogaki K,. New insights into sympathetic regulation of glucose and fat metabolism. Diabetologia 2000; 43: 533-49.
    • (2000) Diabetologia , vol.43 , pp. 533-549
    • Nonogaki, K.1
  • 22
    • 0023132812 scopus 로고
    • Splanchnic neural regulation of insulin and glucagon secretion in the isolated perfused human pancreas
    • Brunicardi FC, Sun YS, Druck P, Goulet RJ, Elahi D, Andersen DK,. Splanchnic neural regulation of insulin and glucagon secretion in the isolated perfused human pancreas. Am. J. Surg. 1987; 153: 34-40.
    • (1987) Am. J. Surg. , vol.153 , pp. 34-40
    • Brunicardi, F.C.1    Sun, Y.S.2    Druck, P.3    Goulet, R.J.4    Elahi, D.5    Andersen, D.K.6
  • 23
    • 23944516469 scopus 로고    scopus 로고
    • Neuroadrenergic and reflex abnormalities in patients with metabolic syndrome
    • Grassi G, Dell'Oro R, Quarti-Trevano F, et al., Neuroadrenergic and reflex abnormalities in patients with metabolic syndrome. Diabetologia 2005; 48: 1359-65.
    • (2005) Diabetologia , vol.48 , pp. 1359-1365
    • Grassi, G.1    Dell'Oro, R.2    Quarti-Trevano, F.3
  • 24
    • 0028939936 scopus 로고
    • Sympathetic activation in obese normotensive subjects
    • Grassi G, Seravalle G, Cattaneo BM, et al., Sympathetic activation in obese normotensive subjects. Hypertension 1995; 25 (4 Pt 1): 560-3.
    • (1995) Hypertension , vol.25 , Issue.4 , pp. 560-563
    • Grassi, G.1    Seravalle, G.2    Cattaneo, B.M.3
  • 25
    • 27744591354 scopus 로고    scopus 로고
    • Effects of dietary weight loss on sympathetic activity and cardiac risk factors associated with the metabolic syndrome
    • Straznicky NE, Lambert EA, Lambert GW, Masuo K, Esler MD, Nestel PJ,. Effects of dietary weight loss on sympathetic activity and cardiac risk factors associated with the metabolic syndrome. J. Clin. Endocrinol. Metab. 2005; 90: 5998-6005.
    • (2005) J. Clin. Endocrinol. Metab. , vol.90 , pp. 5998-6005
    • Straznicky, N.E.1    Lambert, E.A.2    Lambert, G.W.3    Masuo, K.4    Esler, M.D.5    Nestel, P.J.6
  • 26
    • 79952300791 scopus 로고    scopus 로고
    • The effects of weight loss versus weight loss maintenance on sympathetic nervous system activity and metabolic syndrome components
    • Straznicky NE, Grima MT, Eikelis N, et al., The effects of weight loss versus weight loss maintenance on sympathetic nervous system activity and metabolic syndrome components. J. Clin. Endocrinol. Metab. 2011; 96: E503-8.
    • (2011) J. Clin. Endocrinol. Metab. , vol.96 , pp. E503-E508
    • Straznicky, N.E.1    Grima, M.T.2    Eikelis, N.3
  • 27
    • 0032568488 scopus 로고    scopus 로고
    • Body weight reduction, sympathetic nerve traffic, and arterial baroreflex in obese normotensive humans
    • Grassi G, Seravalle G, Colombo M, et al., Body weight reduction, sympathetic nerve traffic, and arterial baroreflex in obese normotensive humans. Circulation 1998; 97: 2037-42.
    • (1998) Circulation , vol.97 , pp. 2037-2042
    • Grassi, G.1    Seravalle, G.2    Colombo, M.3
  • 28
    • 35848940260 scopus 로고    scopus 로고
    • Differing pattern of sympathoexcitation in normal-weight and obesity-related hypertension
    • Lambert E, Straznicky N, Schlaich M, et al., Differing pattern of sympathoexcitation in normal-weight and obesity-related hypertension. Hypertension 2007; 50: 862-8.
    • (2007) Hypertension , vol.50 , pp. 862-868
    • Lambert, E.1    Straznicky, N.2    Schlaich, M.3
  • 29
    • 0027514229 scopus 로고
    • Reflex sympathetic activation induces acute insulin resistance in the human forearm
    • Jamerson KA, Julius S, Gudbrandsson T, Andersson O, Brant DO,. Reflex sympathetic activation induces acute insulin resistance in the human forearm. Hypertension 1993; 21: 618-23.
    • (1993) Hypertension , vol.21 , pp. 618-623
    • Jamerson, K.A.1    Julius, S.2    Gudbrandsson, T.3    Andersson, O.4    Brant, D.O.5
  • 30
    • 0032710789 scopus 로고    scopus 로고
    • Metabolic characteristics of individuals with impaired fasting glucose and/or impaired glucose tolerance
    • Weyer C, Bogardus C, Pratley RE,. Metabolic characteristics of individuals with impaired fasting glucose and/or impaired glucose tolerance. Diabetes 1999; 48: 2197-203.
    • (1999) Diabetes , vol.48 , pp. 2197-2203
    • Weyer, C.1    Bogardus, C.2    Pratley, R.E.3
  • 31
    • 0030025673 scopus 로고    scopus 로고
    • Hypertension and associated metabolic abnormalities-The role of insulin resistance and the sympathoadrenal system
    • Reaven GM, Lithell H, Landsberg L,. Hypertension and associated metabolic abnormalities-the role of insulin resistance and the sympathoadrenal system. N. Engl. J. Med. 1996; 334: 374-81.
    • (1996) N. Engl. J. Med. , vol.334 , pp. 374-381
    • Reaven, G.M.1    Lithell, H.2    Landsberg, L.3
  • 32
    • 0026518984 scopus 로고
    • Insulin increases sympathetic activity but not blood pressure in borderline hypertensive humans
    • Anderson EA, Balon TW, Hoffman RP, Sinkey CA, Mark AL,. Insulin increases sympathetic activity but not blood pressure in borderline hypertensive humans. Hypertension 1992; 19 (6 Pt 2): 621-7.
    • (1992) Hypertension , vol.19 , Issue.6 , pp. 621-627
    • Anderson, E.A.1    Balon, T.W.2    Hoffman, R.P.3    Sinkey, C.A.4    Mark, A.L.5
  • 33
    • 23944448775 scopus 로고    scopus 로고
    • Physiology in perspective: The wisdom of the body. Neural control of the kidney
    • DiBona GF,. Physiology in perspective: the wisdom of the body. Neural control of the kidney. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2005; 289: R633-41.
    • (2005) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.289 , pp. R633-R641
    • DiBona, G.F.1
  • 34
    • 84893459294 scopus 로고    scopus 로고
    • The adrenergic regulation of proximal tubular Na(+)/H(+) exchanger 3 in the rat
    • Healy V, Thompson C, Johns EJ,. The adrenergic regulation of proximal tubular Na(+)/H(+) exchanger 3 in the rat. Acta Physiol (Oxf.) 2014; 210: 678-89.
    • (2014) Acta Physiol (Oxf.) , vol.210 , pp. 678-689
    • Healy, V.1    Thompson, C.2    Johns, E.J.3
  • 35
    • 0028245533 scopus 로고
    • Neural control of renal function in health and disease
    • DiBona GF,. Neural control of renal function in health and disease. Clin. Auton. Res. 1994; 4: 69-74.
    • (1994) Clin. Auton. Res. , vol.4 , pp. 69-74
    • DiBona, G.F.1
  • 36
    • 0028872833 scopus 로고
    • Uptake and release of glucose by the human kidney. Postabsorptive rates and responses to epinephrine
    • Stumvoll M, Chintalapudi U, Perriello G, Welle S, Gutierrez O, Gerich J,. Uptake and release of glucose by the human kidney. Postabsorptive rates and responses to epinephrine. J. Clin. Invest. 1995; 96: 2528-33.
    • (1995) J. Clin. Invest. , vol.96 , pp. 2528-2533
    • Stumvoll, M.1    Chintalapudi, U.2    Perriello, G.3    Welle, S.4    Gutierrez, O.5    Gerich, J.6
  • 37
    • 0035146344 scopus 로고    scopus 로고
    • Renal gluconeogenesis: Its importance in human glucose homeostasis
    • Gerich JE, Meyer C, Woerle HJ, Stumvoll M,. Renal gluconeogenesis: its importance in human glucose homeostasis. Diabetes Care 2001; 24: 382-91.
    • (2001) Diabetes Care , vol.24 , pp. 382-391
    • Gerich, J.E.1    Meyer, C.2    Woerle, H.J.3    Stumvoll, M.4
  • 38
    • 0031720736 scopus 로고    scopus 로고
    • Effects of glucagon on renal and hepatic glutamine gluconeogenesis in normal postabsorptive humans
    • Stumvoll M, Meyer C, Kreider M, Perriello G, Gerich J,. Effects of glucagon on renal and hepatic glutamine gluconeogenesis in normal postabsorptive humans. Metabolism 1998; 47: 1227-32.
    • (1998) Metabolism , vol.47 , pp. 1227-1232
    • Stumvoll, M.1    Meyer, C.2    Kreider, M.3    Perriello, G.4    Gerich, J.5
  • 39
    • 84892959743 scopus 로고    scopus 로고
    • The effect of empagliflozin on arterial stiffness and heart rate variability in subjects with uncomplicated type 1 diabetes mellitus
    • Cherney DZ, Perkins BA, Soleymanlou N, et al., The effect of empagliflozin on arterial stiffness and heart rate variability in subjects with uncomplicated type 1 diabetes mellitus. Cardiovasc. Diabetol. 2014; 13: 28.
    • (2014) Cardiovasc. Diabetol. , vol.13 , pp. 28
    • Cherney, D.Z.1    Perkins, B.A.2    Soleymanlou, N.3
  • 40
    • 84893214045 scopus 로고    scopus 로고
    • Renal hemodynamic effect of sodium-glucose cotransporter 2 inhibition in patients with type 1 diabetes mellitus
    • Cherney DZ, Perkins BA, Soleymanlou N, et al., Renal hemodynamic effect of sodium-glucose cotransporter 2 inhibition in patients with type 1 diabetes mellitus. Circulation 2014; 129: 587-97.
    • (2014) Circulation , vol.129 , pp. 587-597
    • Cherney, D.Z.1    Perkins, B.A.2    Soleymanlou, N.3
  • 41
    • 48249146624 scopus 로고    scopus 로고
    • Dapagliflozin, a selective SGLT2 inhibitor, improves glucose homeostasis in normal and diabetic rats
    • Han S, Hagan DL, Taylor JR, et al., Dapagliflozin, a selective SGLT2 inhibitor, improves glucose homeostasis in normal and diabetic rats. Diabetes 2008; 57: 1723-9.
    • (2008) Diabetes , vol.57 , pp. 1723-1729
    • Han, S.1    Hagan, D.L.2    Taylor, J.R.3
  • 42
    • 84891784200 scopus 로고    scopus 로고
    • Canagliflozin compared with sitagliptin for patients with type 2 diabetes who do not have adequate glycemic control with metformin plus sulfonylurea: A 52-week randomized trial
    • Schernthaner G, Gross JL, Rosenstock J, et al., Canagliflozin compared with sitagliptin for patients with type 2 diabetes who do not have adequate glycemic control with metformin plus sulfonylurea: a 52-week randomized trial. Diabetes Care 2013; 36: 2508-15.
    • (2013) Diabetes Care , vol.36 , pp. 2508-2515
    • Schernthaner, G.1    Gross, J.L.2    Rosenstock, J.3
  • 43
    • 84874291673 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin monotherapy in subjects with type 2 diabetes mellitus inadequately controlled with diet and exercise
    • Stenlof K, Cefalu WT, Kim KA, et al., Efficacy and safety of canagliflozin monotherapy in subjects with type 2 diabetes mellitus inadequately controlled with diet and exercise. Diabetes Obes. Metab. 2013; 15: 372-82.
    • (2013) Diabetes Obes. Metab. , vol.15 , pp. 372-382
    • Stenlof, K.1    Cefalu, W.T.2    Kim, K.A.3
  • 44
    • 84862875221 scopus 로고    scopus 로고
    • Effects of dapagliflozin, an SGLT2 inhibitor, on HbA(1c), body weight, and hypoglycemia risk in patients with type 2 diabetes inadequately controlled on pioglitazone monotherapy
    • Rosenstock J, Vico M, Wei L, Salsali A, List JF,. Effects of dapagliflozin, an SGLT2 inhibitor, on HbA(1c), body weight, and hypoglycemia risk in patients with type 2 diabetes inadequately controlled on pioglitazone monotherapy. Diabetes Care 2012; 35: 1473-8.
    • (2012) Diabetes Care , vol.35 , pp. 1473-1478
    • Rosenstock, J.1    Vico, M.2    Wei, L.3    Salsali, A.4    List, J.F.5
  • 45
    • 84861781220 scopus 로고    scopus 로고
    • Dose-ranging effects of canagliflozin, a sodium-glucose cotransporter 2 inhibitor, as add-on to metformin in subjects with type 2 diabetes
    • Rosenstock J, Aggarwal N, Polidori D, et al., Dose-ranging effects of canagliflozin, a sodium-glucose cotransporter 2 inhibitor, as add-on to metformin in subjects with type 2 diabetes. Diabetes Care 2012; 35: 1232-8.
    • (2012) Diabetes Care , vol.35 , pp. 1232-1238
    • Rosenstock, J.1    Aggarwal, N.2    Polidori, D.3
  • 46
    • 84885476895 scopus 로고    scopus 로고
    • Effects of SGLT2 selective inhibitor ipragliflozin on hyperglycemia, hyperlipidemia, hepatic steatosis, oxidative stress, inflammation, and obesity in type 2 diabetic mice
    • Tahara A, Kurosaki E, Yokono M, et al., Effects of SGLT2 selective inhibitor ipragliflozin on hyperglycemia, hyperlipidemia, hepatic steatosis, oxidative stress, inflammation, and obesity in type 2 diabetic mice. Eur. J. Pharmacol. 2013; 715: 246-55.
    • (2013) Eur. J. Pharmacol. , vol.715 , pp. 246-255
    • Tahara, A.1    Kurosaki, E.2    Yokono, M.3
  • 47
    • 84893872877 scopus 로고    scopus 로고
    • Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients
    • Ferrannini E, Muscelli E, Frascerra S, et al., Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients. J. Clin. Invest. 2014; 124: 499-508.
    • (2014) J. Clin. Invest. , vol.124 , pp. 499-508
    • Ferrannini, E.1    Muscelli, E.2    Frascerra, S.3
  • 48
    • 84906795005 scopus 로고    scopus 로고
    • Hyperglycemia causes cellular senescence via a SGLT2- and p21-dependent pathway in proximal tubules in the early stage of diabetic nephropathy
    • Kitada K, Nakano D, Ohsaki H, et al., Hyperglycemia causes cellular senescence via a SGLT2- and p21-dependent pathway in proximal tubules in the early stage of diabetic nephropathy. J. Diabetes Complications 2014; 28: 604-11.
    • (2014) J. Diabetes Complications , vol.28 , pp. 604-611
    • Kitada, K.1    Nakano, D.2    Ohsaki, H.3
  • 49
    • 84898854471 scopus 로고    scopus 로고
    • Effects of sodium-glucose co-transporter 2 inhibitors on blood pressure: A systematic review and meta-analysis
    • e9
    • Baker WL, Smyth LR, Riche DM, Bourret EM, Chamberlin KW, White WB,. Effects of sodium-glucose co-transporter 2 inhibitors on blood pressure: a systematic review and meta-analysis. J. Am. Soc. Hypertens. 2014; 8: 262-75 e9.
    • (2014) J. Am. Soc. Hypertens. , vol.8 , pp. 262-275
    • Baker, W.L.1    Smyth, L.R.2    Riche, D.M.3    Bourret, E.M.4    Chamberlin, K.W.5    White, W.B.6
  • 50
    • 84962170992 scopus 로고    scopus 로고
    • fda.gov. United States: United States Food and Drug Administration; 2015 [updated March 2015; cited 2015 19 August]
    • fda.gov. United States: United States Food and Drug Administration; 2015 [updated March 2015; cited 2015 19 August]. Available from: http://www.accessdata.fda.gov/drugsatfda-docs/label/2015/204042s005lbl.pdf.
  • 51
    • 84906837116 scopus 로고    scopus 로고
    • Effect of canagliflozin on serum electrolytes in patients with type 2 diabetes in relation to estimated glomerular filtration rate (EGFR)
    • Weir MR, Kline I, Xie J, Edwards R, Usiskin K,. Effect of canagliflozin on serum electrolytes in patients with type 2 diabetes in relation to estimated glomerular filtration rate (eGFR). Curr. Med. Res. Opin. 2014; 30: 1759-68.
    • (2014) Curr. Med. Res. Opin. , vol.30 , pp. 1759-1768
    • Weir, M.R.1    Kline, I.2    Xie, J.3    Edwards, R.4    Usiskin, K.5
  • 52
    • 84962154687 scopus 로고    scopus 로고
    • 4B.01: Contrasting influences of renal function on blood pressure and hba1c reductions with empagliflozin in patients with type 2 diabetes and hypertension
    • Cherney D, Cooper M, Tikkanen I, et al., 4B.01: contrasting influences of renal function on blood pressure and hba1c reductions with empagliflozin in patients with type 2 diabetes and hypertension. J. Hypertens. 2015; 33 (Suppl 1): e53.
    • (2015) J. Hypertens. , vol.33 , pp. e53
    • Cherney, D.1    Cooper, M.2    Tikkanen, I.3
  • 54
    • 84940594950 scopus 로고    scopus 로고
    • Case of ketoacidosis by a sodium-glucose cotransporter 2 inhibitor in a diabetic patient with a low-carbohydrate diet
    • Hayami T, Kato Y, Kamiya H, et al,. Case of ketoacidosis by a sodium-glucose cotransporter 2 inhibitor in a diabetic patient with a low-carbohydrate diet. J Diabetes Invest 2015; 6: 587-90.
    • (2015) J Diabetes Invest , vol.6 , pp. 587-590
    • Hayami, T.1    Kato, Y.2    Kamiya, H.3    Al, E.4
  • 55
    • 84899558137 scopus 로고    scopus 로고
    • Efficacy and safety of monotherapy with the novel sodium/glucose cotransporter-2 inhibitor tofogliflozin in Japanese patients with type 2 diabetes mellitus: A combined Phase 2 and 3 randomized, placebo-controlled, double-blind, parallel-group comparative study
    • Kaku K, Watada H, Iwamoto Y, et al., Efficacy and safety of monotherapy with the novel sodium/glucose cotransporter-2 inhibitor tofogliflozin in Japanese patients with type 2 diabetes mellitus: a combined Phase 2 and 3 randomized, placebo-controlled, double-blind, parallel-group comparative study. Cardiovasc. Diabetol. 2014; 13: 65.
    • (2014) Cardiovasc. Diabetol. , vol.13 , pp. 65
    • Kaku, K.1    Watada, H.2    Iwamoto, Y.3
  • 56
    • 84944597723 scopus 로고    scopus 로고
    • Durability and tolerability of dapagliflozin over 52 weeks as add-on to metformin and sulphonylurea in type 2 diabetes
    • Jul 25
    • Matthaei S, Bowering K, Rohwedder K, Sugg J, Parikh S, Johnsson E,. Durability and tolerability of dapagliflozin over 52 weeks as add-on to metformin and sulphonylurea in type 2 diabetes. Diabetes Obes. Metab. 2015; Jul 25 doi: 10.1111/dom.12543.
    • (2015) Diabetes Obes. Metab.
    • Matthaei, S.1    Bowering, K.2    Rohwedder, K.3    Sugg, J.4    Parikh, S.5    Johnsson, E.6
  • 57
    • 84964240560 scopus 로고    scopus 로고
    • Long-term efficacy and safety of canagliflozin over 104 weeks in patients aged 55-80 years with type 2 diabetes
    • Bode B, Stenlof K, Harris S, et al., Long-term efficacy and safety of canagliflozin over 104 weeks in patients aged 55-80 years with type 2 diabetes. Diabetes Obes. Metab. 2015; 17: 294-303.
    • (2015) Diabetes Obes. Metab. , vol.17 , pp. 294-303
    • Bode, B.1    Stenlof, K.2    Harris, S.3
  • 59
    • 28944441781 scopus 로고    scopus 로고
    • Oligonucleotide microarray analysis of differential transporter regulation in the regenerating rat liver
    • Dransfeld O, Gehrmann T, Kohrer K, et al., Oligonucleotide microarray analysis of differential transporter regulation in the regenerating rat liver. Liver Int. 2005; 25: 1243-58.
    • (2005) Liver Int. , vol.25 , pp. 1243-1258
    • Dransfeld, O.1    Gehrmann, T.2    Kohrer, K.3
  • 60
    • 0034820481 scopus 로고    scopus 로고
    • SGLT gene expression in primary lung cancers and their metastatic lesions
    • Ishikawa N, Oguri T, Isobe T, Fujitaka K, Kohno N,. SGLT gene expression in primary lung cancers and their metastatic lesions. Jpn. J. Cancer Res. 2001; 92: 874-9.
    • (2001) Jpn. J. Cancer Res. , vol.92 , pp. 874-879
    • Ishikawa, N.1    Oguri, T.2    Isobe, T.3    Fujitaka, K.4    Kohno, N.5
  • 61
    • 84859739099 scopus 로고    scopus 로고
    • Expression of Na + -D-glucose cotransporter SGLT2 in rodents is kidney-specific and exhibits sex and species differences
    • Sabolic I, Vrhovac I, Eror DB, et al., Expression of Na + -D-glucose cotransporter SGLT2 in rodents is kidney-specific and exhibits sex and species differences. Am. J. Physiol. Cell Physiol. 2012; 302: C1174-88.
    • (2012) Am. J. Physiol. Cell Physiol. , vol.302 , pp. C1174-C1188
    • Sabolic, I.1    Vrhovac, I.2    Eror, D.B.3
  • 62
    • 79957455422 scopus 로고    scopus 로고
    • Glucose-induced regulation of NHEs activity and SGLTs expression involves the PKA signaling pathway
    • Beloto-Silva O, Machado UF, Oliveira-Souza M,. Glucose-induced regulation of NHEs activity and SGLTs expression involves the PKA signaling pathway. J. Membr. Biol. 2011; 239: 157-65.
    • (2011) J. Membr. Biol. , vol.239 , pp. 157-165
    • Beloto-Silva, O.1    Machado, U.F.2    Oliveira-Souza, M.3
  • 63
    • 0027175343 scopus 로고
    • Regulation of the ovine intestinal Na+/glucose co-transporter (SGLT1) is dissociated from mRNA abundance
    • Lescale-Matys L, Dyer J, Scott D, Freeman TC, Wright EM, Shirazi-Beechey SP,. Regulation of the ovine intestinal Na+/glucose co-transporter (SGLT1) is dissociated from mRNA abundance. Biochem. J. 1993; 291 (Pt 2): 435-40.
    • (1993) Biochem. J. , vol.291 , pp. 435-440
    • Lescale-Matys, L.1    Dyer, J.2    Scott, D.3    Freeman, T.C.4    Wright, E.M.5    Shirazi-Beechey, S.P.6
  • 64
    • 0034304925 scopus 로고    scopus 로고
    • HNF1alpha controls renal glucose reabsorption in mouse and man
    • Pontoglio M, Prie D, Cheret C, et al., HNF1alpha controls renal glucose reabsorption in mouse and man. EMBO Rep. 2000; 1: 359-65.
    • (2000) EMBO Rep. , vol.1 , pp. 359-365
    • Pontoglio, M.1    Prie, D.2    Cheret, C.3
  • 65
    • 38549182041 scopus 로고    scopus 로고
    • Na(+)-glucose transporter-2 messenger ribonucleic acid expression in kidney of diabetic rats correlates with glycemic levels: Involvement of hepatocyte nuclear factor-1alpha expression and activity
    • Freitas HS, Anhe GF, Melo KF, et al., Na(+)-glucose transporter-2 messenger ribonucleic acid expression in kidney of diabetic rats correlates with glycemic levels: involvement of hepatocyte nuclear factor-1alpha expression and activity. Endocrinology 2008; 149: 717-24.
    • (2008) Endocrinology , vol.149 , pp. 717-724
    • Freitas, H.S.1    Anhe, G.F.2    Melo, K.F.3
  • 66
    • 84864510447 scopus 로고    scopus 로고
    • Regulation of the human Na + -dependent glucose cotransporter hSGLT2
    • Ghezzi C, Wright EM,. Regulation of the human Na + -dependent glucose cotransporter hSGLT2. Am. J. Physiol. Cell Physiol. 2012; 303: C348-54.
    • (2012) Am. J. Physiol. Cell Physiol. , vol.303 , pp. C348-C354
    • Ghezzi, C.1    Wright, E.M.2
  • 67
    • 79955755012 scopus 로고    scopus 로고
    • Effect of renal sympathetic denervation on glucose metabolism in patients with resistant hypertension: A pilot study
    • Mahfoud F, Schlaich M, Kindermann I, et al., Effect of renal sympathetic denervation on glucose metabolism in patients with resistant hypertension: a pilot study. Circulation 2011; 123: 1940-6.
    • (2011) Circulation , vol.123 , pp. 1940-1946
    • Mahfoud, F.1    Schlaich, M.2    Kindermann, I.3
  • 68
    • 84962186619 scopus 로고    scopus 로고
    • Sympathetic nervous system activation in the metabolic syndrome
    • Schlaich M,. Sympathetic nervous system activation in the metabolic syndrome. Gen. Pract. 2008; 8: 8-11.
    • (2008) Gen. Pract. , vol.8 , pp. 8-11
    • Schlaich, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.