-
1
-
-
84867487909
-
Adiposopathy, diabetes mellitus, and primary prevention of atherosclerotic coronary artery disease: Treating "sick fat" through improving fat function with antidiabetes therapies
-
Bays HE. Adiposopathy, diabetes mellitus, and primary prevention of atherosclerotic coronary artery disease: treating "sick fat" through improving fat function with antidiabetes therapies. Am J Cardiol. 2012;110:4B-12B.
-
(2012)
Am J Cardiol
, vol.110
-
-
Bays, H.E.1
-
2
-
-
70549113397
-
Role of glucotoxicity and lipotoxicity in the pathophysiology of Type 2 diabetes mellitus and emerging treatment strategies
-
Del Prato S. Role of glucotoxicity and lipotoxicity in the pathophysiology of Type 2 diabetes mellitus and emerging treatment strategies. Diabet Med. 2009;26:1185-92.
-
(2009)
Diabet Med
, vol.26
, pp. 1185-1192
-
-
Del, P.S.1
-
4
-
-
70349645728
-
Foxo1 links hyperglycemia to LDL oxidation and endothelial nitric oxide synthase dysfunction in vascular endothelial cells
-
Tanaka J, Qiang L, Banks AS, et al. Foxo1 links hyperglycemia to LDL oxidation and endothelial nitric oxide synthase dysfunction in vascular endothelial cells. Diabetes. 2009;58:2344-54.
-
(2009)
Diabetes
, vol.58
, pp. 2344-2354
-
-
Tanaka, J.1
Qiang, L.2
Banks, A.S.3
-
5
-
-
84555188488
-
Sirtuin 1-mediated cellular metabolic memory of high glucose via the LKB1/AMPK/ROS pathway and therapeutic effects of metformin
-
Zheng Z, Chen H, Li J, et al. Sirtuin 1-mediated cellular metabolic memory of high glucose via the LKB1/AMPK/ROS pathway and therapeutic effects of metformin. Diabetes. 2012;61:217-28.
-
(2012)
Diabetes
, vol.61
, pp. 217-228
-
-
Zheng, Z.1
Chen, H.2
Li, J.3
-
6
-
-
53349101264
-
Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia
-
El-Osta A, Brasacchio D, Yao D, et al. Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia. J Exp Med. 2008;205:2409-17.
-
(2008)
J Exp Med
, vol.205
, pp. 2409-2417
-
-
El-Osta, A.1
Brasacchio, D.2
Yao, D.3
-
7
-
-
48249127225
-
Epigenetic histone H3 lysine 9 methylation in metabolic memory and inflammatory phenotype of vascular smooth muscle cells in diabetes
-
Villeneuve LM, Reddy MA, Lanting LL, Wang M, Meng L, Natarajan R. Epigenetic histone H3 lysine 9 methylation in metabolic memory and inflammatory phenotype of vascular smooth muscle cells in diabetes. Proc Natl Acad Sci USA. 2008;105:9047-52.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 9047-9052
-
-
Villeneuve, L.M.1
Reddy, M.A.2
Lanting, L.L.3
Wang, M.4
Meng, L.5
Natarajan, R.6
-
8
-
-
77955267226
-
Abnormal hepatic apolipoprotein B metabolism in type 2 diabetes
-
Verges B. Abnormal hepatic apolipoprotein B metabolism in type 2 diabetes. Atherosclerosis. 2010;211:353-60.
-
(2010)
Atherosclerosis
, vol.211
, pp. 353-360
-
-
Verges, B.1
-
9
-
-
79952119879
-
Transcriptional activation of apolipoprotein CIII expression by glucose may contribute to diabetic dyslipidemia
-
Caron S, Verrijken A, Mertens I, et al. Transcriptional activation of apolipoprotein CIII expression by glucose may contribute to diabetic dyslipidemia. Arterioscler Thromb Vasc Biol. 2011;31:513-9.
-
(2011)
Arterioscler Thromb Vasc Biol
, vol.31
, pp. 513-519
-
-
Caron, S.1
Verrijken, A.2
Mertens, I.3
-
10
-
-
0038222533
-
LDL containing apolipoprotein CIII is an independent risk factor for coronary events in diabetic patients
-
Lee SJ, Campos H, Moye LA, Sacks FM. LDL containing apolipoprotein CIII is an independent risk factor for coronary events in diabetic patients. Arterioscler Thromb Vasc Biol. 2003;23:853-8.
-
(2003)
Arterioscler Thromb Vasc Biol
, vol.23
, pp. 853-858
-
-
Lee, S.J.1
Campos, H.2
Moye, L.A.3
Sacks, F.M.4
-
11
-
-
84880917866
-
Obesity, adiposity, and dyslipidemia: A consensus statement from the National Lipid Association
-
Bays HE, Toth PP, Kris-Etherton PM, et al. Obesity, adiposity, and dyslipidemia: a consensus statement from the National Lipid Association. J Clin Lipidol. 2013;7:304-83.
-
(2013)
J Clin Lipidol
, vol.7
, pp. 304-383
-
-
Bays, H.E.1
Toth, P.P.2
Kris-Etherton, P.M.3
-
12
-
-
0027275397
-
The effect of long-term intensified insulin treatment on the development of microvascular complications of diabetes mellitus
-
Reichard P, Nilsson BY, Rosenqvist U. The effect of long-term intensified insulin treatment on the development of microvascular complications of diabetes mellitus. N Engl J Med. 1993;329:304-9.
-
(1993)
N Engl J Med
, vol.329
, pp. 304-309
-
-
Reichard, P.1
Nilsson, B.Y.2
Rosenqvist, U.3
-
13
-
-
0027370108
-
The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus
-
Diabetes Control and Complications Trial Research (DCCT) group, The Diabetes Control and Complications Trial Research Group
-
Diabetes Control and Complications Trial Research (DCCT) group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group. N Engl J Med. 1993;329:977-86.
-
(1993)
N Engl J Med
, vol.329
, pp. 977-986
-
-
-
14
-
-
0029147687
-
Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: A randomized prospective 6-year study
-
Ohkubo Y, Kishikawa H, Araki E, et al. Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study. Diabetes Res Clin Pract. 1995;28:103-17.
-
(1995)
Diabetes Res Clin Pract
, vol.28
, pp. 103-117
-
-
Ohkubo, Y.1
Kishikawa, H.2
Araki, E.3
-
15
-
-
0032511583
-
Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
-
UK Prospective Diabetes Study (UKPDS) Group, UK Prospective Diabetes Study (UKPDS) Group
-
UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group. Lancet. 1998;352:837-53.
-
(1998)
Lancet
, vol.352
, pp. 837-853
-
-
-
16
-
-
0032511566
-
Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)
-
UK Prospective Diabetes Study (UKPDS) Group, UK Prospective Diabetes Study (UKPDS) Group
-
UK Prospective Diabetes Study (UKPDS) Group. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group. Lancet. 1998;352:854-65.
-
(1998)
Lancet
, vol.352
, pp. 854-865
-
-
-
17
-
-
0034641568
-
Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): Prospective observational study
-
Stratton IM, Adler AI, Neil HA, et al. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ. 2000;321:405-12.
-
(2000)
BMJ
, vol.321
, pp. 405-412
-
-
Stratton, I.M.1
Adler, A.I.2
Neil, H.A.3
-
18
-
-
45149133036
-
Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes
-
Patel A, MacMahon S, Chalmers J, et al. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med. 2008;358:2560-72.
-
(2008)
N Engl J Med
, vol.358
, pp. 2560-2572
-
-
Patel, A.1
Macmahon, S.2
Chalmers, J.3
-
19
-
-
84874662499
-
Intensive glucose control improves kidney outcomes in patients with type 2 diabetes
-
Perkovic V, Heerspink HL, Chalmers J, et al. Intensive glucose control improves kidney outcomes in patients with type 2 diabetes. Kidney Int. 2013;83:517-23.
-
(2013)
Kidney Int
, vol.83
, pp. 517-523
-
-
Perkovic, V.1
Heerspink, H.L.2
Chalmers, J.3
-
20
-
-
70349881450
-
Intensive glucose control and macrovascular outcomes in type 2 diabetes
-
Turnbull FM, Abraira C, Anderson RJ, et al. Intensive glucose control and macrovascular outcomes in type 2 diabetes. Diabetologia. 2009;52:2288-98.
-
(2009)
Diabetologia
, vol.52
, pp. 2288-2298
-
-
Turnbull, F.M.1
Abraira, C.2
Anderson, R.J.3
-
21
-
-
79960959816
-
Effect of intensive glucose lowering treatment on all cause mortality, cardiovascular death, and microvascular events in type 2 diabetes: Meta-analysis of randomised controlled trials
-
Boussageon R, Bejan-Angoulvant T, Saadatian-Elahi M, et al. Effect of intensive glucose lowering treatment on all cause mortality, cardiovascular death, and microvascular events in type 2 diabetes: meta-analysis of randomised controlled trials. BMJ. 2011;343:d4169.
-
(2011)
BMJ
, vol.343
-
-
Boussageon, R.1
Bejan-Angoulvant, T.2
Saadatian-Elahi, M.3
-
22
-
-
82755165018
-
Intensive glycaemic control for patients with type 2 diabetes: Systematic review with meta-analysis and trial sequential analysis of randomised clinical trials
-
Hemmingsen B, Lund SS, Gluud C, et al. Intensive glycaemic control for patients with type 2 diabetes: systematic review with meta-analysis and trial sequential analysis of randomised clinical trials. BMJ. 2011;343:d6898.
-
(2011)
BMJ
, vol.343
-
-
Hemmingsen, B.1
Lund, S.S.2
Gluud, C.3
-
23
-
-
84866609768
-
Glucose control and cardiovascular outcomes in individuals with diabetes mellitus: Lessons learned from the megatrials
-
Avitabile NA, Banka A, Fonseca VA. Glucose control and cardiovascular outcomes in individuals with diabetes mellitus: lessons learned from the megatrials. Heart Fail Clin. 2012;8:513-22.
-
(2012)
Heart Fail Clin
, vol.8
, pp. 513-522
-
-
Avitabile, N.A.1
Banka, A.2
Fonseca, V.A.3
-
24
-
-
65649106228
-
Effect of intensive control of glucose on cardiovascular outcomes and death in patients with diabetes mellitus: A meta-analysis of randomised controlled trials
-
Ray KK, Seshasai SR, Wijesuriya S, et al. Effect of intensive control of glucose on cardiovascular outcomes and death in patients with diabetes mellitus: a meta-analysis of randomised controlled trials. Lancet. 2009;373:1765-72.
-
(2009)
Lancet
, vol.373
, pp. 1765-1772
-
-
Ray, K.K.1
Seshasai, S.R.2
Wijesuriya, S.3
-
25
-
-
84871995815
-
Standards of medical care in diabetes-2013
-
American Diabetes Association
-
American Diabetes Association. Standards of medical care in diabetes-2013. Diabetes Care. 2013;36(Suppl. 1):S11-66.
-
(2013)
Diabetes Care
, vol.36
, Issue.SUPPL. 1
-
-
-
26
-
-
84866268783
-
Management of hyperglycemia in type 2 diabetes: A patient-centered approach: Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
-
Inzucchi SE, Bergenstal RM, Buse JB, et al. Management of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care. 2012;35:1364-79.
-
(2012)
Diabetes Care
, vol.35
, pp. 1364-1379
-
-
Inzucchi, S.E.1
Bergenstal, R.M.2
Buse, J.B.3
-
27
-
-
84875389379
-
-
International Diabetes Federation (IDF), Available at, Accessed 28 February 2013
-
International Diabetes Federation (IDF). Global guidelines for type 2 diabetes. 2012. Available at: https://www.idf.org/guidelines. Accessed 28 February 2013.
-
(2012)
Global Guidelines For Type 2 Diabetes
-
-
-
28
-
-
33745631544
-
Prevalence of inadequate glycemic control among patients with type 2 diabetes in the United Kingdom general practice research database: A series of retrospective analyses of data from 1998 through 2002
-
Fox KM, Gerber RA, Bolinder B, Chen J, Kumar S. Prevalence of inadequate glycemic control among patients with type 2 diabetes in the United Kingdom general practice research database: a series of retrospective analyses of data from 1998 through 2002. Clin Ther. 2006;28:388-95.
-
(2006)
Clin Ther
, vol.28
, pp. 388-395
-
-
Fox, K.M.1
Gerber, R.A.2
Bolinder, B.3
Chen, J.4
Kumar, S.5
-
29
-
-
32644446432
-
Management of type 2 diabetes in the primary care setting: A practice-based research network study
-
Spann SJ, Nutting PA, Galliher JM, et al. Management of type 2 diabetes in the primary care setting: a practice-based research network study. Ann Fam Med. 2006;4:23-31.
-
(2006)
Ann Fam Med
, vol.4
, pp. 23-31
-
-
Spann, S.J.1
Nutting, P.A.2
Galliher, J.M.3
-
30
-
-
84864870066
-
Characteristics associated with poor glycemic control among adults with self-reported diagnosed diabetes-National Health and Nutrition Examination Survey, United States, 2007-2010
-
Centers for Disease Control and Prevention (CDC)
-
Ali MK, Bullard KM, Imperatore G, Barker L, Gregg EW; Centers for Disease Control and Prevention (CDC). Characteristics associated with poor glycemic control among adults with self-reported diagnosed diabetes-National Health and Nutrition Examination Survey, United States, 2007-2010. Morb Mortal Wkly Rep. 2012;61(Suppl.):32-7.
-
(2012)
Morb Mortal Wkly Rep
, vol.61
, Issue.SUPPL.
, pp. 32-37
-
-
Ali, M.K.1
Bullard, K.M.2
Imperatore, G.3
Barker, L.4
Gregg, E.W.5
-
31
-
-
84870403693
-
Factors associated with poor glycemic control or wide glycemic variability among diabetes patients in Hawaii, 2006-2009
-
Juarez DT, Sentell T, Tokumaru S, Goo R, Davis JW, Mau MM. Factors associated with poor glycemic control or wide glycemic variability among diabetes patients in Hawaii, 2006-2009. Prev Chronic Dis. 2012;9:120065.
-
(2012)
Prev Chronic Dis
, vol.9
, pp. 120065
-
-
Juarez, D.T.1
Sentell, T.2
Tokumaru, S.3
Goo, R.4
Davis, J.W.5
Mau, M.M.6
-
32
-
-
84882254968
-
The prevalence of meeting A1C, blood pressure, and LDL goals among people with diabetes, 1988-2010
-
Stark Casagrande S, Fradkin JE, Saydah SH, Rust KF, Cowie CC. The prevalence of meeting A1C, blood pressure, and LDL goals among people with diabetes, 1988-2010. Diabetes Care. 2013;36:2271-9.
-
(2013)
Diabetes Care
, vol.36
, pp. 2271-2279
-
-
Stark Casagrande, S.1
Fradkin, J.E.2
Saydah, S.H.3
Rust, K.F.4
Cowie, C.C.5
-
34
-
-
0034116810
-
Poor glycaemic control in type 2 diabetes: A conspiracy of disease, suboptimal therapy and attitude
-
Wallace TM, Matthews DR. Poor glycaemic control in type 2 diabetes: a conspiracy of disease, suboptimal therapy and attitude. QJM. 2000;93:369-74.
-
(2000)
QJM
, vol.93
, pp. 369-374
-
-
Wallace, T.M.1
Matthews, D.R.2
-
35
-
-
34147109354
-
Relationship between patient medication adherence and subsequent clinical inertia in type 2 diabetes glycemic management
-
Grant R, Adams AS, Trinacty CM, et al. Relationship between patient medication adherence and subsequent clinical inertia in type 2 diabetes glycemic management. Diabetes Care. 2007;30:807-12.
-
(2007)
Diabetes Care
, vol.30
, pp. 807-812
-
-
Grant, R.1
Adams, A.S.2
Trinacty, C.M.3
-
36
-
-
81255161698
-
Exploring reasons for very poor glycaemic control in patients with Type 2 diabetes
-
Khan H, Lasker SS, Chowdhury TA. Exploring reasons for very poor glycaemic control in patients with Type 2 diabetes. Prim Care Diabetes. 2011;5:251-5.
-
(2011)
Prim Care Diabetes
, vol.5
, pp. 251-255
-
-
Khan, H.1
Lasker, S.S.2
Chowdhury, T.A.3
-
37
-
-
67649359913
-
From victim to ally: The kidney as an emerging target for the treatment of diabetes mellitus
-
Bays H. From victim to ally: the kidney as an emerging target for the treatment of diabetes mellitus. Curr Med Res Opin. 2009;25:671-81.
-
(2009)
Curr Med Res Opin
, vol.25
, pp. 671-681
-
-
Bays, H.1
-
38
-
-
76249133903
-
Role of the kidney in normal glucose homeostasis and in the hyperglycaemia of diabetes mellitus: Therapeutic implications
-
Gerich JE. Role of the kidney in normal glucose homeostasis and in the hyperglycaemia of diabetes mellitus: therapeutic implications. Diabet Med. 2010;27:136-42.
-
(2010)
Diabet Med
, vol.27
, pp. 136-142
-
-
Gerich, J.E.1
-
39
-
-
0027948971
-
Molecular physiology of Sodium-glucose cotransporters
-
Hediger MA, Rhoads DB. Molecular physiology of Sodium-glucose cotransporters. Physiol Rev. 1994;74:993-1026.
-
(1994)
Physiol Rev
, vol.74
, pp. 993-1026
-
-
Hediger, M.A.1
Rhoads, D.B.2
-
40
-
-
78651349221
-
Biology of human sodium glucose transporters
-
Wright EM, Loo DD, Hirayama BA. Biology of human sodium glucose transporters. Physiol Rev. 2011;91:733-94.
-
(2011)
Physiol Rev
, vol.91
, pp. 733-794
-
-
Wright, E.M.1
Loo, D.D.2
Hirayama, B.A.3
-
42
-
-
10944222437
-
Aminoaciduria and glycosuria
-
In: Avner ED, Harmon WE, Niaudet P, editors, 5th ed. Philadelphia: Lippincott Williams & Wilkins
-
Zelikovic I. Aminoaciduria and glycosuria. In: Avner ED, Harmon WE, Niaudet P, editors. Pediatric Nephrology. 5th ed. Philadelphia: Lippincott Williams & Wilkins; 2004. p. 701-28.
-
(2004)
Pediatric Nephrology
, pp. 701-728
-
-
Zelikovic, I.1
-
43
-
-
67649318668
-
Renal handling of organic solutes
-
In: Brenner BM, editor, Philadelphia: Saunders Elsevier
-
Moe OW, Wright SH, Palacín M. Renal handling of organic solutes. In: Brenner BM, editor. Brenner and Rector's The Kidney. Philadelphia: Saunders Elsevier; 2008. p. 214-47.
-
(2008)
Brenner and Rector's the Kidney
, pp. 214-247
-
-
Moe, O.W.1
Wright, S.H.2
Palacín, M.3
-
44
-
-
0001524988
-
Glucose transport in the renal tubule
-
In: Windhager EE, editor, New York: Oxford University Press
-
Silverman M, Turner JR. Glucose transport in the renal tubule. In: Windhager EE, editor. Handbook of Physiology. New York: Oxford University Press; 1992. pp. 2017-38.
-
(1992)
Handbook of Physiology
, pp. 2017-2038
-
-
Silverman, M.1
Turner, J.R.2
-
45
-
-
0015122757
-
Maximum tubular reabsorption capacity for glucose and renal hemodynamics during rapid hypertonic glucose infusion in normal and diabetic subjects
-
Mogensen CE. Maximum tubular reabsorption capacity for glucose and renal hemodynamics during rapid hypertonic glucose infusion in normal and diabetic subjects. Scand J Clin Lab Invest. 1971;28:101-9.
-
(1971)
Scand J Clin Lab Invest
, vol.28
, pp. 101-109
-
-
Mogensen, C.E.1
-
46
-
-
33644688031
-
Glucose transporters in human renal proximal tubular cells isolated from the urine of patients with non-insulin-dependent diabetes
-
Rahmoune H, Thompson PW, Ward JM, Smith CD, Hong G, Brown J. Glucose transporters in human renal proximal tubular cells isolated from the urine of patients with non-insulin-dependent diabetes. Diabetes. 2005;54:3427-34.
-
(2005)
Diabetes
, vol.54
, pp. 3427-3434
-
-
Rahmoune, H.1
Thompson, P.W.2
Ward, J.M.3
Smith, C.D.4
Hong, G.5
Brown, J.6
-
47
-
-
0035879385
-
Changes in sodium or glucose filtration rate modulate expression of glucose transporters in renal proximal tubular cells of rat
-
Vestri S, Okamoto MM, de Freitas HS, et al. Changes in sodium or glucose filtration rate modulate expression of glucose transporters in renal proximal tubular cells of rat. J Membr Biol. 2001;182:105-12.
-
(2001)
J Membr Biol
, vol.182
, pp. 105-112
-
-
Vestri, S.1
Okamoto, M.M.2
de Freitas, H.S.3
-
48
-
-
83655193529
-
The role of the kidneys in glucose homeostasis: A new path towards normalizing glycaemia
-
DeFronzo RA, Davidson JA, Del Prato S. The role of the kidneys in glucose homeostasis: a new path towards normalizing glycaemia. Diabetes Obes Metab. 2012;14:5-14.
-
(2012)
Diabetes Obes Metab
, vol.14
, pp. 5-14
-
-
Defronzo, R.A.1
Davidson, J.A.2
Del, P.S.3
-
50
-
-
10744229025
-
Molecular analysis of the SGLT2 gene in patients with renal glucosuria
-
Santer R, Kinner M, Lassen CL, et al. Molecular analysis of the SGLT2 gene in patients with renal glucosuria. J Am Soc Nephrol. 2003;14:2873-82.
-
(2003)
J Am Soc Nephrol
, vol.14
, pp. 2873-2882
-
-
Santer, R.1
Kinner, M.2
Lassen, C.L.3
-
52
-
-
75449091856
-
Apple trees to sodium glucose cotransporter inhibitors: A review of SGLT2 inhibition
-
White JR Jr. Apple trees to sodium glucose cotransporter inhibitors: a review of SGLT2 inhibition. Clin Diabetes. 2010;28:5-10.
-
(2010)
Clin Diabetes
, vol.28
, pp. 5-10
-
-
White Jr., J.R.1
-
53
-
-
0000298609
-
Phlorizin as a competitive inhibitor of the active transport of sugars by hamster small intestine, in vitro
-
Alvarado F, Crane RK. Phlorizin as a competitive inhibitor of the active transport of sugars by hamster small intestine, in vitro. Biochim Biophys Acta. 1962;56:170-2.
-
(1962)
Biochim Biophys Acta
, vol.56
, pp. 170-172
-
-
Alvarado, F.1
Crane, R.K.2
-
54
-
-
0023275573
-
Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats
-
Rossetti L, Smith D, Shulman GI, Papachristou D, DeFronzo RA. Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats. J Clin Invest. 1987;79:1510-5.
-
(1987)
J Clin Invest
, vol.79
, pp. 1510-1515
-
-
Rossetti, L.1
Smith, D.2
Shulman, G.I.3
Papachristou, D.4
Defronzo, R.A.5
-
55
-
-
0023571397
-
Effect of chronic hyperglycemia on in vivo insulin secretion in partially pancreatectomized rats
-
Rossetti L, Shulman GI, Zawalich W, DeFronzo RA. Effect of chronic hyperglycemia on in vivo insulin secretion in partially pancreatectomized rats. J Clin Invest. 1987;80:1037-44.
-
(1987)
J Clin Invest
, vol.80
, pp. 1037-1044
-
-
Rossetti, L.1
Shulman, G.I.2
Zawalich, W.3
Defronzo, R.A.4
-
56
-
-
0032850016
-
T-1095, an inhibitor of renal Na?-glucose cotransporters, may provide a novel approach to treating diabetes
-
Oku A, Ueta K, Arakawa K, et al. T-1095, an inhibitor of renal Na?-glucose cotransporters, may provide a novel approach to treating diabetes. Diabetes. 1999;48:1794-800.
-
(1999)
Diabetes
, vol.48
, pp. 1794-1800
-
-
Oku, A.1
Ueta, K.2
Arakawa, K.3
-
57
-
-
80052819282
-
Development and potential role of type-2 Sodium-glucose transporter inhibitors for management of type 2 diabetes
-
Hardman TC, Dubrey SW. Development and potential role of type-2 Sodium-glucose transporter inhibitors for management of type 2 diabetes. Diabetes Ther. 2011;2:133-45.
-
(2011)
Diabetes Ther
, vol.2
, pp. 133-145
-
-
Hardman, T.C.1
Dubrey, S.W.2
-
58
-
-
77956921439
-
Dapagliflozin monotherapy in type 2 diabetic patients with inadequate glycemic control by diet and exercise: A randomized, double-blind, placebo-controlled, phase 3 trial
-
Ferrannini E, Ramos SJ, Salsali A, Tang W, List JF. Dapagliflozin monotherapy in type 2 diabetic patients with inadequate glycemic control by diet and exercise: a randomized, double-blind, placebo-controlled, phase 3 trial. Diabetes Care. 2010;33:2217-24.
-
(2010)
Diabetes Care
, vol.33
, pp. 2217-2224
-
-
Ferrannini, E.1
Ramos, S.J.2
Salsali, A.3
Tang, W.4
List, J.F.5
-
59
-
-
84860218907
-
Dapagliflozin, metformin XR, or both: Initial pharmacotherapy for type 2 diabetes, a randomised controlled trial
-
Henry RR, Murray AV, Marmolejo MH, Hennicken D, Ptaszynska A, List JF. Dapagliflozin, metformin XR, or both: initial pharmacotherapy for type 2 diabetes, a randomised controlled trial. Int J Clin Pract. 2012;66:446-56.
-
(2012)
Int J Clin Pract
, vol.66
, pp. 446-456
-
-
Henry, R.R.1
Murray, A.V.2
Marmolejo, M.H.3
Hennicken, D.4
Ptaszynska, A.5
List, J.F.6
-
60
-
-
84866003015
-
Dapagliflozin monotherapy in drug-naive patients with diabetes: A randomized-controlled trial of low-dose range
-
Bailey CJ, Iqbal N, T'Joen C, List JF. Dapagliflozin monotherapy in drug-naive patients with diabetes: a randomized-controlled trial of low-dose range. Diabetes Obes Metab. 2012;14:951-9.
-
(2012)
Diabetes Obes Metab
, vol.14
, pp. 951-959
-
-
Bailey, C.J.1
Iqbal, N.2
T'Joen, C.3
List, J.F.4
-
61
-
-
77953857048
-
Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: A randomised, double-blind, placebo-controlled trial
-
Bailey CJ, Gross JL, Pieters A, Bastien A, List JF. Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: a randomised, double-blind, placebo-controlled trial. Lancet. 2010;375: 2223-33.
-
(2010)
Lancet
, vol.375
, pp. 2223-2233
-
-
Bailey, C.J.1
Gross, J.L.2
Pieters, A.3
Bastien, A.4
List, J.F.5
-
62
-
-
84858020943
-
Effects of dapagliflozin on body weight, total fat mass, and regional adipose tissue distribution in patients with type 2 diabetes mellitus with inadequate glycemic control on metformin
-
Bolinder J, Ljunggren O, Kullberg J, et al. Effects of dapagliflozin on body weight, total fat mass, and regional adipose tissue distribution in patients with type 2 diabetes mellitus with inadequate glycemic control on metformin. J Clin Endocrinol Metab. 2012;97:1020-31.
-
(2012)
J Clin Endocrinol Metab
, vol.97
, pp. 1020-1031
-
-
Bolinder, J.1
Ljunggren, O.2
Kullberg, J.3
-
63
-
-
80155124676
-
Dapagliflozin versus glipizide as add-on therapy in patients with type 2 diabetes who have inadequate glycemic control with metformin: A randomized, 52-week, double-blind, active-controlled noninferiority trial
-
Nauck MA, Del Prato S, Meier JJ, et al. Dapagliflozin versus glipizide as add-on therapy in patients with type 2 diabetes who have inadequate glycemic control with metformin: a randomized, 52-week, double-blind, active-controlled noninferiority trial. Diabetes Care. 2011;34:2015-22.
-
(2011)
Diabetes Care
, vol.34
, pp. 2015-2022
-
-
Nauck, M.A.1
Del, P.S.2
Meier, J.J.3
-
64
-
-
80052524011
-
Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with glimepiride: A randomized, 24-week, double-blind, placebo-controlled trial
-
Strojek K, Yoon KH, Hruba V, Elze M, Langkilde AM, Parikh S. Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with glimepiride: a randomized, 24-week, double-blind, placebo-controlled trial. Diabetes Obes Metab. 2011;13:928-38.
-
(2011)
Diabetes Obes Metab
, vol.13
, pp. 928-938
-
-
Strojek, K.1
Yoon, K.H.2
Hruba, V.3
Elze, M.4
Langkilde, A.M.5
Parikh, S.6
-
65
-
-
84862875221
-
Effects of dapagliflozin, an SGLT2 inhibitor, on HbA(1c), body weight, and hypoglycemia risk in patients with type 2 diabetes inadequately controlled on pioglitazone monotherapy
-
Rosenstock J, Vico M, Wei L, Salsali A, List JF. Effects of dapagliflozin, an SGLT2 inhibitor, on HbA(1c), body weight, and hypoglycemia risk in patients with type 2 diabetes inadequately controlled on pioglitazone monotherapy. Diabetes Care. 2012;35:1473-8.
-
(2012)
Diabetes Care
, vol.35
, pp. 1473-1478
-
-
Rosenstock, J.1
Vico, M.2
Wei, L.3
Salsali, A.4
List, J.F.5
-
66
-
-
69549095914
-
A study of dapagliflozin in patients with type 2 diabetes receiving high doses of insulin plus insulin sensitizers: Applicability of a novel insulin-independent treatment
-
Wilding JP, Norwood P, T'Joen C, Bastien A, List JF, Fiedorek FT. A study of dapagliflozin in patients with type 2 diabetes receiving high doses of insulin plus insulin sensitizers: applicability of a novel insulin-independent treatment. Diabetes Care. 2009;32:1656-62.
-
(2009)
Diabetes Care
, vol.32
, pp. 1656-1662
-
-
Wilding, J.P.1
Norwood, P.2
T'Joen, C.3
Bastien, A.4
List, J.F.5
Fiedorek, F.T.6
-
67
-
-
84858323889
-
Long-term efficacy of dapagliflozin in patients with type 2 diabetes mellitus receiving high doses of insulin: A randomized trial
-
Wilding JP, Woo V, Soler NG, et al. Long-term efficacy of dapagliflozin in patients with type 2 diabetes mellitus receiving high doses of insulin: a randomized trial. Ann Intern Med. 2012;156:405-15.
-
(2012)
Ann Intern Med
, vol.156
, pp. 405-415
-
-
Wilding, J.P.1
Woo, V.2
Soler, N.G.3
-
68
-
-
84892488179
-
Dapagliflozin in patients with type 2 diabetes receiving high doses of insulin: Efficacy and safety over 2 years
-
doi:10.1111/dom.12187
-
Wilding JP, Woo V, Rohwedder K, Sugg J, Parikh S. Dapagliflozin in patients with type 2 diabetes receiving high doses of insulin: efficacy and safety over 2 years. Diabetes Obes Metab. 2013. doi:10.1111/dom.12187.
-
(2013)
Diabetes Obes Metab
-
-
Wilding, J.P.1
Woo, V.2
Rohwedder, K.3
Sugg, J.4
Parikh, S.5
-
69
-
-
65349196064
-
Sodium-glucose cotransport inhibition with dapagliflozin in type 2 diabetes
-
List JF, Woo V, Morales E, Tang W, Fiedorek FT. Sodium-glucose cotransport inhibition with dapagliflozin in type 2 diabetes. Diabetes Care. 2009;32:650-7.
-
(2009)
Diabetes Care
, vol.32
, pp. 650-657
-
-
List, J.F.1
Woo, V.2
Morales, E.3
Tang, W.4
Fiedorek, F.T.5
-
70
-
-
84875134980
-
Safety of dapagliflozin in clinical trials for T2DM
-
(Abstract 1011-P)
-
Ptaszynska A, Johnsson KM, Apanovitch A-M, Sugg J, Parikh S, List J. Safety of dapagliflozin in clinical trials for T2DM. Diabetes. 2012;61(Suppl.):A258 (Abstract 1011-P).
-
(2012)
Diabetes
, vol.61
, Issue.SUPPL.
-
-
Ptaszynska, A.1
Johnsson, K.M.2
Apanovitch, A.-M.3
Sugg, J.4
Parikh, S.5
List, J.6
-
71
-
-
84877924519
-
-
Bristol-Myers Squibb and AstraZeneca EEIG, European Medicines Agency (18 September, EMA/689976/2012. Available at, Accessed 17 July 2013
-
Bristol-Myers Squibb and AstraZeneca EEIG. Assessment report: Forxiga (dapagliflozin). European Medicines Agency (18 September 2012). EMA/689976/2012. Available at: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Public_assessment_report/human/002322/WC500136024.pdf. Accessed 17 July 2013.
-
(2012)
Assessment Report: Forxiga (dapagliflozin)
-
-
-
72
-
-
84875175116
-
Effect of dapagliflozin on renal function
-
(Abstract 1098-P)
-
Ptaszynska A, Chalamandaris AG, Sugg JE, Johnsson KM, Parikh S, List JL. Effect of dapagliflozin on renal function Diabetes. 2012;61(Suppl.):A283 (Abstract 1098-P).
-
(2012)
Diabetes
, vol.61
, Issue.SUPPL.
-
-
Ptaszynska, A.1
Chalamandaris, A.G.2
Sugg, J.E.3
Johnsson, K.M.4
Parikh, S.5
List, J.L.6
-
73
-
-
4644224760
-
-
Bristol Myers Squibb and AstraZeneca EEIG, Electronic Medicines Compendium, Available at, Accessed 17 July 2013
-
Bristol Myers Squibb and AstraZeneca EEIG. Summary of Product Characteristics: Forxiga 5 mg & 10 mg film coated tablets. Electronic Medicines Compendium 2012. Available at: http://www.medicines.org.uk/emc/medicine/27188/SPC/Forxiga?5mg??%26?10?mg?film?coated?tablets/. Accessed 17 July 2013.
-
(2012)
Summary of Product Characteristics: Forxiga 5 Mg & 10 Mg Film Coated Tablets
-
-
-
74
-
-
84883799810
-
Vulvovaginitis and balanitis in patients with diabetes treated with dapagliflozin
-
Johnsson KM, Ptaszynska A, Schmitz B, Sugg J, Parikh SJ, List JF. Vulvovaginitis and balanitis in patients with diabetes treated with dapagliflozin. J Diabetes Complicat. 2013;27:479-84.
-
(2013)
J Diabetes Complicat
, vol.27
, pp. 479-484
-
-
Johnsson, K.M.1
Ptaszynska, A.2
Schmitz, B.3
Sugg, J.4
Parikh, S.J.5
List, J.F.6
-
75
-
-
84883810898
-
Urinary tract infections in patients with diabetes treated with dapagliflozin
-
Johnsson KM, Ptaszynska A, Schmitz B, Sugg J, Parikh SJ, List JF. Urinary tract infections in patients with diabetes treated with dapagliflozin. J Diabetes Complicat. 2013;27:473-8.
-
(2013)
J Diabetes Complicat
, vol.27
, pp. 473-478
-
-
Johnsson, K.M.1
Ptaszynska, A.2
Schmitz, B.3
Sugg, J.4
Parikh, S.J.5
List, J.F.6
-
76
-
-
84874291673
-
Efficacy and safety of canagliflozin monotherapy in subjects with type 2 diabetes mellitus inadequately controlled with diet and exercise
-
Stenlof K, Cefalu WT, Kim KA, et al. Efficacy and safety of canagliflozin monotherapy in subjects with type 2 diabetes mellitus inadequately controlled with diet and exercise. Diabetes Obes Metab. 2013;15:372-82.
-
(2013)
Diabetes Obes Metab
, vol.15
, pp. 372-382
-
-
Stenlof, K.1
Cefalu, W.T.2
Kim, K.A.3
-
77
-
-
84861781220
-
Doseranging effects of canagliflozin, a sodium-glucose cotransporter 2 inhibitor, as add-on to metformin in subjects with type 2 diabetes
-
Rosenstock J, Aggarwal N, Polidori D, et al. Doseranging effects of canagliflozin, a sodium-glucose cotransporter 2 inhibitor, as add-on to metformin in subjects with type 2 diabetes. Diabetes Care. 2012;35:1232-8.
-
(2012)
Diabetes Care
, vol.35
, pp. 1232-1238
-
-
Rosenstock, J.1
Aggarwal, N.2
Polidori, D.3
-
78
-
-
84876335746
-
Canagliflozin, a sodium glucose co-transporter 2 inhibitor, improves glycaemia in subjects with type diabetes inadequatley controlled with metformin plus sulphonylurea
-
(Abstract 766)
-
Wilding J, Mathieu C, Deng L, et al. Canagliflozin, a sodium glucose co-transporter 2 inhibitor, improves glycaemia in subjects with type diabetes inadequatley controlled with metformin plus sulphonylurea. Diabetologia. 2012;55(Suppl. 1):S315 (Abstract 766).
-
(2012)
Diabetologia
, vol.55
, Issue.SUPPL. 1
-
-
Wilding, J.1
Mathieu, C.2
Deng, L.3
-
79
-
-
84884167643
-
Efficacy and safety of canagliflozin versus glimepiride in patients with type 2 diabetes inadequately controlled with metformin (CANTATA-SU): 52 week results from a randomised, double-blind, phase 3 non-inferiority trial
-
Cefalu WT, Leiter LA, Yoon KH, et al. Efficacy and safety of canagliflozin versus glimepiride in patients with type 2 diabetes inadequately controlled with metformin (CANTATA-SU): 52 week results from a randomised, double-blind, phase 3 non-inferiority trial. Lancet. 2013;382:941-50.
-
(2013)
Lancet
, vol.382
, pp. 941-950
-
-
Cefalu, W.T.1
Leiter, L.A.2
Yoon, K.H.3
-
80
-
-
84891784200
-
Canagliflozin compared with sitagliptin for patients with type 2 diabetes who do not have adequate glycemic control with metformin plus sulfonylurea: A 52-week randomized trial
-
Schernthaner G, Gross JL, Rosenstock J, et al. Canagliflozin compared with sitagliptin for patients with type 2 diabetes who do not have adequate glycemic control with metformin plus sulfonylurea: a 52-week randomized trial. Diabetes Care. 2013;36:2508-15.
-
(2013)
Diabetes Care
, vol.36
, pp. 2508-2515
-
-
Schernthaner, G.1
Gross, J.L.2
Rosenstock, J.3
-
81
-
-
84876311251
-
Efficacy and safety of canagliflozin in subjects with type 2 diabetes and chronic kidney disease
-
Yale JF, Bakris G, Cariou B, et al. Efficacy and safety of canagliflozin in subjects with type 2 diabetes and chronic kidney disease. Diabetes Obes Metab. 2013;15:463-73.
-
(2013)
Diabetes Obes Metab
, vol.15
, pp. 463-473
-
-
Yale, J.F.1
Bakris, G.2
Cariou, B.3
-
82
-
-
84880543926
-
Efficacy and safety of canagliflozin treatment in older subjects with type 2 diabetes mellitus: A randomized trial
-
Bode B, Stenlof K, Sullivan D, Fung A, Usiskin K. Efficacy and safety of canagliflozin treatment in older subjects with type 2 diabetes mellitus: a randomized trial. Hosp Pract (1995). 2013;41(2):72-84.
-
(2013)
Hosp Pract (1995)
, vol.41
, Issue.2
, pp. 72-84
-
-
Bode, B.1
Stenlof, K.2
Sullivan, D.3
Fung, A.4
Usiskin, K.5
-
83
-
-
84899843153
-
Efficacy and safety of canagliflozin (CANA) in subjects with type 2 diabetes mellitus (T2DM) on metformin (MET) and pioglitazone (PIO) over 52 weeks
-
(Abstract 1098-P)
-
Forst T, Guthrie R, Goldenberg R, et al. Efficacy and safety of canagliflozin (CANA) in subjects with type 2 diabetes mellitus (T2DM) on metformin (MET) and pioglitazone (PIO) over 52 weeks. Diabetes. 2013;62(Suppl. 1):A284 (Abstract 1098-P).
-
(2013)
Diabetes
, vol.62
, Issue.SUPPL. 1
-
-
Forst, T.1
Guthrie, R.2
Goldenberg, R.3
-
84
-
-
84860252876
-
Canagliflozin improves glycaemic control over 28 days in subjects with type 2 diabetes not optimally controlled on insulin
-
Devineni D, Morrow L, Hompesch M, et al. Canagliflozin improves glycaemic control over 28 days in subjects with type 2 diabetes not optimally controlled on insulin. Diabetes Obes Metab. 2012;14:539-45.
-
(2012)
Diabetes Obes Metab
, vol.14
, pp. 539-545
-
-
Devineni, D.1
Morrow, L.2
Hompesch, M.3
-
85
-
-
84879471749
-
Efficacy and safety of canagliflozin (CANA), an inhibitor of sodium glucose co-transporter 2 (SGLT2), added-on to insulin therapy ± oral agents in type 2 diabetes
-
(Abstract 764)
-
Matthews DR, Fulcher G, Perkovic V, et al. Efficacy and safety of canagliflozin (CANA), an inhibitor of sodium glucose co-transporter 2 (SGLT2), added-on to insulin therapy ± oral agents in type 2 diabetes. Diabetologia. 2012;55(Suppl. 1):S314 (Abstract 764).
-
(2012)
Diabetologia
, vol.55
, Issue.SUPPL. 1
-
-
Matthews, D.R.1
Fulcher, G.2
Perkovic, V.3
-
86
-
-
84899852101
-
Lower blood pressure (BP) with canagliflozin (CANA) in subjects with type 2 diabetes mellitus (T2DM)
-
(Abstract 1077-P)
-
Weir MR, Januszewicz A, Gilbert RE, Lavalle Gonzalez FJ, Meininger G. Lower blood pressure (BP) with canagliflozin (CANA) in subjects with type 2 diabetes mellitus (T2DM). Diabetes. 2013;62(Suppl. 1):A278 (Abstract 1077-P).
-
(2013)
Diabetes
, vol.62
, Issue.SUPPL. 1
-
-
Weir, M.R.1
Januszewicz, A.2
Gilbert, R.E.3
Lavalle, G.F.J.4
Meininger, G.5
-
87
-
-
84899821662
-
-
Janssen Pharmaceuticals Inc, Prescribing information (issued March, 2013. Available at, Accessed 17 July 2013
-
Janssen Pharmaceuticals Inc. INVOKANA™ (canagliflozin) tablets, for oral use. Prescribing information (issued March 2013). 2013. Available at: http://www.invokanahcp.com/prescribing-information.pdf. Accessed 17 July 2013.
-
(2013)
INVOKANA™ (canagliflozin) Tablets, For Oral Use
-
-
-
88
-
-
84899890888
-
Genital mycotic infections with canagliflozin (CANA) in subjects with type 2 diabetes mellitus (T2DM)
-
(Abstract 1069-P)
-
Nyirjesy P, Sobel J, Fung A, Gassmann-Meyer C, Ways K, Usiskin K. Genital mycotic infections with canagliflozin (CANA) in subjects with type 2 diabetes mellitus (T2DM). Diabetes. 2013;62(Suppl. 1):A276 (Abstract 1069-P).
-
(2013)
Diabetes
, vol.62
, Issue.SUPPL. 1
-
-
Nyirjesy, P.1
Sobel, J.2
Fung, A.3
Gassmann-Meyer, C.4
Ways, K.5
Usiskin, K.6
-
89
-
-
84888011650
-
Urinary tract infection (UTI) with canagliflozin (CANA) in subjects with type 2 diabetes mellitus (T2DM)
-
(Abstract 1139-P)
-
Nicolle LE, Capuano G, Fung A, Usiskin K. Urinary tract infection (UTI) with canagliflozin (CANA) in subjects with type 2 diabetes mellitus (T2DM). Diabetes. 2013;62(Suppl. 1):A296 (Abstract 1139-P).
-
(2013)
Diabetes
, vol.62
, Issue.SUPPL. 1
-
-
Nicolle, L.E.1
Capuano, G.2
Fung, A.3
Usiskin, K.4
-
90
-
-
84879795546
-
A phase IIb, randomised, placebo-controlled study of the SGLT2 inhibitor empagliflozin in patients with type 2 diabetes
-
Ferrannini E, Seman L, Seewaldt-Becker E, Hantel S, Pinnetti S, Woerle H. A phase IIb, randomised, placebo-controlled study of the SGLT2 inhibitor empagliflozin in patients with type 2 diabetes. Diabetes Obes Metab. 2013;15:721-8.
-
(2013)
Diabetes Obes Metab
, vol.15
, pp. 721-728
-
-
Ferrannini, E.1
Seman, L.2
Seewaldt-Becker, E.3
Hantel, S.4
Pinnetti, S.5
Woerle, H.6
-
91
-
-
84885954870
-
Empagliflozin monotherapy with sitagliptin as an active comparator in patients with type 2 diabetes: A randomised, double-blind, placebo-controlled, phase 3 trial
-
doi:10.1016/S2213-8587(13)70084-6
-
Roden M, Weng J, Eilbracht J, et al. Empagliflozin monotherapy with sitagliptin as an active comparator in patients with type 2 diabetes: a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Diabetes Endocrinol. 2013. doi:10.1016/S2213-8587(13)70084-6.
-
(2013)
Lancet Diabetes Endocrinol
-
-
Roden, M.1
Weng, J.2
Eilbracht, J.3
-
92
-
-
84887191925
-
Efficacy and safety of empagliflozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor, as add-on to metformin in type 2 diabetes with mild hyperglycaemia
-
doi: 10.1111/dom.12185
-
Rosenstock J, Seman LJ, Jelaska A, et al. Efficacy and safety of empagliflozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor, as add-on to metformin in type 2 diabetes with mild hyperglycaemia. Diabetes Obes Metab. 2013. doi: 10.1111/dom.12185.
-
(2013)
Diabetes Obes Metab
-
-
Rosenstock, J.1
Seman, L.J.2
Jelaska, A.3
-
93
-
-
84875204252
-
Safety and efficacy of empagliflozin as monotherapy or add-on to metformin in a 78-week open-label extension study in patients with type 2 diabetes
-
(Abstract 49-LB)
-
Woerle HJ, Ferrannini E, Berk A, Manun'ebo M, Pinnetti S, Broedl UC. Safety and efficacy of empagliflozin as monotherapy or add-on to metformin in a 78-week open-label extension study in patients with type 2 diabetes. Diabetes. 2012;61(Suppl.):LB13 (Abstract 49-LB).
-
(2012)
Diabetes
, vol.61
, Issue.SUPPL.
-
-
Woerle, H.J.1
Ferrannini, E.2
Berk, A.3
Manun'Ebo, M.4
Pinnetti, S.5
Broedl, U.C.6
-
94
-
-
84885952950
-
Empagliflozin as add-on to metformin plus sulfonylurea in patients with type 2 diabetes: A 24-week randomized, double-blind, placebo-controlled trial
-
doi: 10.2337/dc12-2673
-
Häring HU, Merker L, Seewaldt-Becker E, et al. Empagliflozin as add-on to metformin plus sulfonylurea in patients with type 2 diabetes: a 24-week randomized, double-blind, placebo-controlled trial. Diabetes Care. 2013. doi: 10.2337/dc12-2673.
-
(2013)
Diabetes Care
-
-
Häring, H.U.1
Merker, L.2
Seewaldt-Becker, E.3
-
95
-
-
84884205144
-
Empagliflozin as add-on to metformin for 24 weeks improves glycemic control in patients with type 2 diabetes (T2DM)
-
Häring HU, Merker L, Seewaldt-Becker E, Weimer M, Meinicke T. Empagliflozin as add-on to metformin for 24 weeks improves glycemic control in patients with type 2 diabetes (T2DM). Diabetes. 2013;62(Suppl. 1):A282 (Abstract 1092-P).
-
(2013)
Diabetes
, vol.62
, Issue.SUPPL. 1
-
-
Häring, H.U.1
Merker, L.2
Seewaldt-Becker, E.3
Weimer, M.4
Meinicke, T.5
-
96
-
-
84892477577
-
Empagliflozin improves glycaemic and weight control as add-on therapy to pioglitazone or pioglitazone plus metformin in patients with type 2 diabetes: A 24-week, randomized, placebo-controlled trial
-
doi:10.1111/dom.12188
-
Kovacs CS, Seshiah V, Swallow R, et al. Empagliflozin improves glycaemic and weight control as add-on therapy to pioglitazone or pioglitazone plus metformin in patients with type 2 diabetes: a 24-week, randomized, placebo-controlled trial. Diabetes Obes Metab. 2013. doi:10.1111/dom.12188.
-
(2013)
Diabetes Obes Metab
-
-
Kovacs, C.S.1
Seshiah, V.2
Swallow, R.3
-
97
-
-
84884205365
-
Empagliflozin as add-on to basal insulin for 78 weeks improves glycemic control with weight loss in insulin-treated type 2 diabetes (T2DM)
-
(Abstract 1102-P)
-
Rosenstock J, Jelaska A, Kim G, Broedl UC, Woerle HJ. Empagliflozin as add-on to basal insulin for 78 weeks improves glycemic control with weight loss in insulin-treated type 2 diabetes (T2DM). Diabetes. 2013;62(Suppl. 1):A285 (Abstract 1102-P).
-
(2013)
Diabetes
, vol.62
, Issue.SUPPL. 1
-
-
Rosenstock, J.1
Jelaska, A.2
Kim, G.3
Broedl, U.C.4
Woerle, H.J.5
-
98
-
-
84896856867
-
Empagliflozin (EMPA) increases genital infections but not urinary tract infections (UTIs) in pooled data from four pivotal phase III trials
-
(Abstract 74-LB)
-
Kim G, Gerich JE, Salsali A, et al. Empagliflozin (EMPA) increases genital infections but not urinary tract infections (UTIs) in pooled data from four pivotal phase III trials. Diabetes. 2013;62(Suppl. 1):LB21 (Abstract 74-LB).
-
(2013)
Diabetes
, vol.62
, Issue.SUPPL. 1
-
-
Kim, G.1
Gerich, J.E.2
Salsali, A.3
-
99
-
-
82455213037
-
Safety, pharmacokinetic, and pharmacodynamic profiles of ipragliflozin (ASP1941), a novel and selective inhibitor of sodium-dependent glucose co-transporter 2, in patients with type 2 diabetes mellitus
-
Schwartz SL, Akinlade B, Klasen S, Kowalski D, Zhang W, Wilpshaar W. Safety, pharmacokinetic, and pharmacodynamic profiles of ipragliflozin (ASP1941), a novel and selective inhibitor of sodium-dependent glucose co-transporter 2, in patients with type 2 diabetes mellitus. Diabetes Technol Ther. 2011;13:1219-27.
-
(2011)
Diabetes Technol Ther
, vol.13
, pp. 1219-1227
-
-
Schwartz, S.L.1
Akinlade, B.2
Klasen, S.3
Kowalski, D.4
Zhang, W.5
Wilpshaar, W.6
-
100
-
-
84864283546
-
Ipragliflozin improved glycaemic control with additional benefits of reductions of body weight and blood pressure in Japanese patients with type 2 diabetes mellitus: BRIGHTEN Study
-
Kashiwagi A, Takinami Y, Kazuta K, Yoshida S, Utsuno A, Nagase I. Ipragliflozin improved glycaemic control with additional benefits of reductions of body weight and blood pressure in Japanese patients with type 2 diabetes mellitus: BRIGHTEN Study. Diabetologia. 2011;54(Suppl. 1):S68 (Abstract 149).
-
(2011)
Diabetologia
, vol.54
, Issue.SUPPL. 1
-
-
Kashiwagi, A.1
Takinami, Y.2
Kazuta, K.3
Yoshida, S.4
Utsuno, A.5
Nagase, I.6
-
101
-
-
84876344111
-
Efficacy and safety of ipragliflozin in patients with type 2 diabetes inadequately controlled on metformin: A dose-finding study
-
Wilding JP, Ferrannini E, Fonseca VA, Wilpshaar W, Dhanjal P, Houzer A. Efficacy and safety of ipragliflozin in patients with type 2 diabetes inadequately controlled on metformin: a dose-finding study. Diabetes Obes Metab. 2013;15:403-9.
-
(2013)
Diabetes Obes Metab
, vol.15
, pp. 403-409
-
-
Wilding, J.P.1
Ferrannini, E.2
Fonseca, V.A.3
Wilpshaar, W.4
Dhanjal, P.5
Houzer, A.6
-
102
-
-
84892486720
-
Ipragliflozin reduced HbA1c and body weight in Japanese type 2 diabetes patients who have inadequate glycaemic control on sulfonylurea or pioglitazone alone
-
(Abstract 739)
-
Kashiwagi A, Shiga T, Akiyama N, et al. Ipragliflozin reduced HbA1c and body weight in Japanese type 2 diabetes patients who have inadequate glycaemic control on sulfonylurea or pioglitazone alone. Diabetologia. 2012;55(Suppl. 1):S302 (Abstract 739).
-
(2012)
Diabetologia
, vol.55
, Issue.SUPPL. 1
-
-
Kashiwagi, A.1
Shiga, T.2
Akiyama, N.3
-
103
-
-
84876938443
-
The potential of sodium glucose cotransporter 2 (SGLT2) inhibitors to reduce cardiovascular risk in patients with type 2 diabetes (T2DM)
-
Basile JN. The potential of sodium glucose cotransporter 2 (SGLT2) inhibitors to reduce cardiovascular risk in patients with type 2 diabetes (T2DM). J Diabetes Complicat. 2013;27:280-6.
-
(2013)
J Diabetes Complicat
, vol.27
, pp. 280-286
-
-
Basile, J.N.1
-
104
-
-
84861079280
-
Effects of SGLT2 inhibitors on cardiovascular outcomes
-
Foote C, Perkovic V, Neal B. Effects of SGLT2 inhibitors on cardiovascular outcomes. Diab Vasc Dis Res. 2012;9:117-23.
-
(2012)
Diab Vasc Dis Res
, vol.9
, pp. 117-123
-
-
Foote, C.1
Perkovic, V.2
Neal, B.3
-
105
-
-
84899823547
-
-
Bristol Myers Squibb-AstraZeneca, FDA Briefing Document, July 19), Endocrinologic and Metabolic Drugs Advisory Committee. Available at, Accessed 17 July 2013
-
Bristol Myers Squibb-AstraZeneca. NDA 202293, Dapaglifozin tablets, 5 and 10 mg. FDA Briefing Document (2011, July 19), Endocrinologic and Metabolic Drugs Advisory Committee. Available at: http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/drugs/EndocrinologicandMetabolicDrugsAdvisoryCommittee/ucm262994.pdf. Accessed 17 July 2013.
-
(2011)
NDA 202293, Dapaglifozin Tablets, 5 and 10 Mg
-
-
-
106
-
-
84888018295
-
-
Janssen Research & Development LLC, JNJ-28431754 (Canagliflozin) NDA 204042. FDA Briefing Document (2013, January 10), Endocrinologic and Metabolic Drugs Advisory Committee. Available at, Accessed 7 August 2013
-
Janssen Research & Development LLC. Canagliflozin as an adjunctive treatment to diet and exercise alone or co-administered with other antihyperglycemic agents to improve glycemic control in adults with type 2 diabetes mellitus. JNJ-28431754 (Canagliflozin) NDA 204042. FDA Briefing Document (2013, January 10), Endocrinologic and Metabolic Drugs Advisory Committee. Available at: http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/EndocrinologicandMetabolicDrugsAdvisoryCommittee/UCM334551.pdf. Accessed 7 August 2013.
-
Canagliflozin As An Adjunctive Treatment to Diet and Exercise Alone Or Co-administered With Other Antihyperglycemic Agents to Improve Glycemic Control In Adults With Type 2 Diabetes Mellitus
-
-
-
107
-
-
84884209217
-
Empagliflozin in patients with type 2 diabetes mellitus and renal impairment
-
(Abstract 1104-P)
-
Barnett AH, Mithal A, Manassie J, Rattunde H, Woerle HJ, Broedl UC. Empagliflozin in patients with type 2 diabetes mellitus and renal impairment. Diabetes. 2013;62(Suppl. 1):A286 (Abstract 1104-P).
-
(2013)
Diabetes
, vol.62
, Issue.SUPPL. 1
-
-
Barnett, A.H.1
Mithal, A.2
Manassie, J.3
Rattunde, H.4
Woerle, H.J.5
Broedl, U.C.6
-
108
-
-
84899857239
-
Canagliflozin (CANA) compared with sitagliptin (SITA) in subjects with type 2 diabetes mellitus (T2DM) on Metformin (MET) over 52 weeks
-
(Abstract 238-OR)
-
Lavalle Gonzalez FJ, Januszewicz A, Davidson JA, Qiu R, Tong C, Meininger G. Canagliflozin (CANA) compared with sitagliptin (SITA) in subjects with type 2 diabetes mellitus (T2DM) on Metformin (MET) over 52 weeks. Diabetes. 2013;62(Suppl. 1):A61 (Abstract 238-OR).
-
(2013)
Diabetes
, vol.62
, Issue.SUPPL. 1
-
-
Lavalle, G.F.J.1
Januszewicz, A.2
Davidson, J.A.3
Qiu, R.4
Tong, C.5
Meininger, G.6
|