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Bioorganic and Medicinal Chemistry Letters

Volumn 26, Issue 9, 2016, Pages 2297-2302

Hit-to-lead evaluation of a novel class of sphingosine 1-phosphate lyase inhibitors

(11) Dinges, Jurgen a Harris, Christopher M a Wallace, Grier A a Argiriadi, Maria A a Queeney, Kara L a Perron, Denise C a Dominguez, Eric a Kebede, Tegest a Desino, Kelly E a Patel, Hetal a Vasudevan, Anil a

a ABBVIE INC (United States)

Author keywords

Hit to lead; Inhibitor; Parallel synthesis; Sphingosine 1 phosphate lyase; Structure based design

Indexed keywords

LYASE INHIBITOR; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE LYASE INHIBITOR; UNCLASSIFIED DRUG; ENZYME INHIBITOR; LYASE; SPHINGOSINE 1-PHOSPHATE LYASE (ALDOLASE);

ARTICLE; DEALKYLATION; DRUG SCREENING; ENZYME ACTIVITY; HIGH THROUGHPUT SCREENING; IC50; IN VITRO STUDY; LIVER MICROSOME; METABOLIC STABILITY; MITSUNOBU REACTION; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY; ANTAGONISTS AND INHIBITORS; CHEMISTRY; HUMAN; SYNTHESIS;

ALDEHYDE-LYASES; ENZYME INHIBITORS; HUMANS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84962150634 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2016.03.043 Document Type: Article

Times cited : (12)

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