-
1
-
-
79952744346
-
Strategies for conducting ADME studies during lead generation in the drug discovery process
-
J.W. Cramer Strategies for conducting ADME studies during lead generation in the drug discovery process IDrugs 13 2010 857 861
-
(2010)
IDrugs
, vol.13
, pp. 857-861
-
-
Cramer, J.W.1
-
2
-
-
35648944767
-
In vitro-in vivo extrapolation of hepatic clearance: Biological tools, scaling factors, model assumptions and correct concentrations
-
O. Pelkonen, and M. Turpeinen In vitro-in vivo extrapolation of hepatic clearance: biological tools, scaling factors, model assumptions and correct concentrations Xenobiotica 37 2007 1066 1089
-
(2007)
Xenobiotica
, vol.37
, pp. 1066-1089
-
-
Pelkonen, O.1
Turpeinen, M.2
-
3
-
-
79952771693
-
Mechanisms of drug toxicity and relevance to pharmaceutical development
-
F.P. Guengerich Mechanisms of drug toxicity and relevance to pharmaceutical development Drug Metab. Pharmacokinet. 26 2011 3 14
-
(2011)
Drug Metab. Pharmacokinet.
, vol.26
, pp. 3-14
-
-
Guengerich, F.P.1
-
4
-
-
78650018055
-
Strategies for the early detection of drug-induced hepatic steatosis in preclinical drug safety evaluation studies
-
D.E. Amacher Strategies for the early detection of drug-induced hepatic steatosis in preclinical drug safety evaluation studies Toxicology 279 2011 10 18
-
(2011)
Toxicology
, vol.279
, pp. 10-18
-
-
Amacher, D.E.1
-
5
-
-
69249088147
-
Metabolite identification and profiling in drug design: Current practice and future directions
-
Z. Zhang Metabolite identification and profiling in drug design: current practice and future directions Curr. Pharm. Des. 15 2009 2220 2235
-
(2009)
Curr. Pharm. Des.
, vol.15
, pp. 2220-2235
-
-
Zhang, Z.1
-
6
-
-
67650494794
-
Mass defect filter technique and its applications to drug metabolite identification by high-resolution mass spectrometry
-
H. Zhang Mass defect filter technique and its applications to drug metabolite identification by high-resolution mass spectrometry J. Mass Spectrom. 44 2009 999 1016
-
(2009)
J. Mass Spectrom.
, vol.44
, pp. 999-1016
-
-
Zhang, H.1
-
7
-
-
39049090890
-
HPLC-MS/MS in drug metabolism and pharmacokinetic screening
-
Y. Hsieh HPLC-MS/MS in drug metabolism and pharmacokinetic screening Expert Opin. Drug Metab. Toxicol. 4 2008 93 101
-
(2008)
Expert Opin. Drug Metab. Toxicol.
, vol.4
, pp. 93-101
-
-
Hsieh, Y.1
-
8
-
-
78649402523
-
Enhanced metabolite identification with MS(E) and a semi-automated software for structural elucidation
-
B. Bonn Enhanced metabolite identification with MS(E) and a semi-automated software for structural elucidation Rapid Commun. Mass Spectrom. 24 2010 3127 3138
-
(2010)
Rapid Commun. Mass Spectrom.
, vol.24
, pp. 3127-3138
-
-
Bonn, B.1
-
9
-
-
0038440502
-
Predicting drug metabolism: A site of metabolism prediction tool applied to the cytochrome P450 2C9
-
I. Zamora Predicting drug metabolism: a site of metabolism prediction tool applied to the cytochrome P450 2C9 J. Med. Chem. 46 2003 2313 2324
-
(2003)
J. Med. Chem.
, vol.46
, pp. 2313-2324
-
-
Zamora, I.1
-
10
-
-
33847099636
-
Predicting the oxidative metabolism of statins: An application of the MetaSite algorithm
-
G. Caron Predicting the oxidative metabolism of statins: an application of the MetaSite algorithm Pharm. Res. 24 2007 480 501
-
(2007)
Pharm. Res.
, vol.24
, pp. 480-501
-
-
Caron, G.1
-
11
-
-
33646764551
-
Comparison of methods for the prediction of the metabolic sites for CYP3A4-mediated metabolic reactions
-
D. Zhou Comparison of methods for the prediction of the metabolic sites for CYP3A4-mediated metabolic reactions Drug Metab. Dispos. 34 2006 976 983
-
(2006)
Drug Metab. Dispos.
, vol.34
, pp. 976-983
-
-
Zhou, D.1
-
12
-
-
33444465313
-
-
B. Testa, S. Kraemer, H. Wunderli-Allenspach, G. Folkers, Wiley-VHCA
-
G. Cruciani B. Testa, S. Kraemer, H. Wunderli-Allenspach, G. Folkers, Pharmacokinetic Profiling in Drug Research: Biological, Physicochemical and Computational Strategies 2005 Wiley-VHCA 367
-
(2005)
Pharmacokinetic Profiling in Drug Research: Biological, Physicochemical and Computational Strategies
, pp. 367
-
-
Cruciani, G.1
-
13
-
-
27444434892
-
MetaSite: Understanding metabolism in human cytochromes from the perspective of the chemist
-
G. Cruciani MetaSite: understanding metabolism in human cytochromes from the perspective of the chemist J. Med. Chem. 48 2005 6970 6979
-
(2005)
J. Med. Chem.
, vol.48
, pp. 6970-6979
-
-
Cruciani, G.1
-
14
-
-
80053232023
-
High-resolution chromatography/time-of-flight MSE with in silico data mining is an information-rich approach to reactive metabolite screening
-
J.E. Barbara, and J.M. Castro-Perez High-resolution chromatography/time- of-flight MSE with in silico data mining is an information-rich approach to reactive metabolite screening Rapid Commun. Mass Spectrom. 25 2011 3029 3040
-
(2011)
Rapid Commun. Mass Spectrom.
, vol.25
, pp. 3029-3040
-
-
Barbara, J.E.1
Castro-Perez, J.M.2
-
15
-
-
77953362009
-
Coupling liquid chromatography to Orbitrap mass spectrometry
-
A. Makarov, and M. Scigelova Coupling liquid chromatography to Orbitrap mass spectrometry J. Chromatogr. A 1217 2010 3938 3945
-
(2010)
J. Chromatogr. A
, vol.1217
, pp. 3938-3945
-
-
Makarov, A.1
Scigelova, M.2
-
16
-
-
84860230344
-
General unknown screening in hair by liquid chromatography-hybrid quadrupole time-of-flight mass spectrometry (LC-QTOF-MS)
-
S. Broecker General unknown screening in hair by liquid chromatography-hybrid quadrupole time-of-flight mass spectrometry (LC-QTOF-MS) Forensic Sci. Int. 218 2012 68 81
-
(2012)
Forensic Sci. Int.
, vol.218
, pp. 68-81
-
-
Broecker, S.1
-
17
-
-
0042856256
-
Strategy for structural elucidation of drugs and drug metabolites using (MS)n fragmentation in an electrospray ion trap
-
Z. Tozuka Strategy for structural elucidation of drugs and drug metabolites using (MS)n fragmentation in an electrospray ion trap J. Mass Spectrom. 38 2003 793 808
-
(2003)
J. Mass Spectrom.
, vol.38
, pp. 793-808
-
-
Tozuka, Z.1
-
18
-
-
77949592420
-
Comparison of triple quadrupole, hybrid linear ion trap triple quadrupole, time-of-flight and LTQ-Orbitrap mass spectrometers in drug discovery phase metabolite screening and identification in vitro-amitriptyline and verapamil as model compounds
-
T. Rousu Comparison of triple quadrupole, hybrid linear ion trap triple quadrupole, time-of-flight and LTQ-Orbitrap mass spectrometers in drug discovery phase metabolite screening and identification in vitro-amitriptyline and verapamil as model compounds Rapid Commun. Mass Spectrom. 24 2010 939 957
-
(2010)
Rapid Commun. Mass Spectrom.
, vol.24
, pp. 939-957
-
-
Rousu, T.1
-
19
-
-
84859107186
-
High-resolution mass spectrometry for integrated qualitative and quantitative analysis of pharmaceuticals in biological matrices
-
G.G. Hopfgartner High-resolution mass spectrometry for integrated qualitative and quantitative analysis of pharmaceuticals in biological matrices Anal. Bioanal. Chem. 402 2012 2587 2596
-
(2012)
Anal. Bioanal. Chem.
, vol.402
, pp. 2587-2596
-
-
Hopfgartner, G.G.1
|