메뉴 건너뛰기




Volumn 142, Issue 6, 2016, Pages 1261-1271

Effects of paclitaxel on permanent head and neck squamous cell carcinoma cell lines and identification of anti-apoptotic caspase 9b

Author keywords

Apoptosis; Caspase 9b; Caspases; Head and neck cancer; Paclitaxel

Indexed keywords

APOPTOSOME; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CASPASE 10; CASPASE 3; CASPASE 8; CASPASE 9; CASPASE 9B; PACLITAXEL; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; APAF1 PROTEIN, HUMAN; STAUROSPORINE;

EID: 84962148542     PISSN: 01715216     EISSN: 14321335     Source Type: Journal    
DOI: 10.1007/s00432-016-2150-3     Document Type: Article
Times cited : (16)

References (39)
  • 1
    • 0033597923 scopus 로고    scopus 로고
    • Regulation of apoptotic protease activating factor-1 oligomerization and apoptosis by the WD-40 repeat region
    • COI: 1:CAS:528:DyaK1MXkvVKkurk%3D, PID: 10409627
    • Adrain C, Slee EA, Harte MT, Martin SJ (1999) Regulation of apoptotic protease activating factor-1 oligomerization and apoptosis by the WD-40 repeat region. J Biol Chem 274:20855–20860
    • (1999) J Biol Chem , vol.274 , pp. 20855-20860
    • Adrain, C.1    Slee, E.A.2    Harte, M.T.3    Martin, S.J.4
  • 2
    • 84860315254 scopus 로고    scopus 로고
    • Methylation of the APAF-1 and DAPK-1 promoter region correlates with progression of renal cell carcinoma in North Indian population
    • COI: 1:CAS:528:DC%2BC38XjsF2nurg%3D, PID: 21922274
    • Ahmad ST, Arjumand W, Seth A, Saini AK, Sultana S (2012) Methylation of the APAF-1 and DAPK-1 promoter region correlates with progression of renal cell carcinoma in North Indian population. Tumour Biol 33:395–402. doi:10.1007/s13277-011-0235-9
    • (2012) Tumour Biol , vol.33 , pp. 395-402
    • Ahmad, S.T.1    Arjumand, W.2    Seth, A.3    Saini, A.K.4    Sultana, S.5
  • 3
    • 0033623874 scopus 로고    scopus 로고
    • Genetic analysis of the APAF1 gene in male germ cell tumors
    • COI: 1:CAS:528:DC%2BD3cXks1Skt7s%3D, PID: 10862031
    • Bala S et al (2000) Genetic analysis of the APAF1 gene in male germ cell tumors. Genes Chromosom Cancer 28:258–268
    • (2000) Genes Chromosom Cancer , vol.28 , pp. 258-268
    • Bala, S.1
  • 4
    • 0036561649 scopus 로고    scopus 로고
    • Altered methylation patterns in cancer cell genomes: cause or consequence?
    • COI: 1:CAS:528:DC%2BD38XktlSrtL8%3D, PID: 12086841
    • Baylin S, Bestor TH (2002) Altered methylation patterns in cancer cell genomes: cause or consequence? Cancer Cell 1:299–305
    • (2002) Cancer Cell , vol.1 , pp. 299-305
    • Baylin, S.1    Bestor, T.H.2
  • 5
    • 0030045450 scopus 로고    scopus 로고
    • Paclitaxel-induced apoptosis in human gastric carcinoma cell lines
    • COI: 1:CAS:528:DyaK28XlsV2guw%3D%3D, PID: 8630921
    • Chang YF, Li LL, Wu CW, Liu TY, Lui WY, P’Eng FK, Chi CW (1996) Paclitaxel-induced apoptosis in human gastric carcinoma cell lines. Cancer 77:14–18
    • (1996) Cancer , vol.77 , pp. 14-18
    • Chang, Y.F.1    Li, L.L.2    Wu, C.W.3    Liu, T.Y.4    Lui, W.Y.5    P’Eng, F.K.6    Chi, C.W.7
  • 6
    • 18644381327 scopus 로고    scopus 로고
    • Apaf-1 is a mediator of E2F-1-induced apoptosis
    • COI: 1:CAS:528:DC%2BD38XnvVeiu7Y%3D, PID: 12149244
    • Furukawa Y et al (2002) Apaf-1 is a mediator of E2F-1-induced apoptosis. J Biol Chem 277:39760–39768
    • (2002) J Biol Chem , vol.277 , pp. 39760-39768
    • Furukawa, Y.1
  • 8
    • 0032493870 scopus 로고    scopus 로고
    • Differential requirement for caspase 9 in apoptotic pathways in vivo
    • COI: 1:CAS:528:DyaK1cXlsVWjs7s%3D, PID: 9708736
    • Hakem R et al (1998) Differential requirement for caspase 9 in apoptotic pathways in vivo. Cell 94:339–352
    • (1998) Cell , vol.94 , pp. 339-352
    • Hakem, R.1
  • 9
    • 34250793839 scopus 로고    scopus 로고
    • EZH2 polycomb transcriptional repressor expression correlates with methylation of the APAF-1 gene in superficial transitional cell carcinoma of the bladder
    • COI: 1:CAS:528:DC%2BD2sXmvFSmsbc%3D, PID: 17541304
    • Hinz S, Kempkensteffen C, Weikert S, Schostak M, Schrader M, Miller K, Christoph F (2007) EZH2 polycomb transcriptional repressor expression correlates with methylation of the APAF-1 gene in superficial transitional cell carcinoma of the bladder. Tumour Biol 28:151–157. doi:10.1159/000103380
    • (2007) Tumour Biol , vol.28 , pp. 151-157
    • Hinz, S.1    Kempkensteffen, C.2    Weikert, S.3    Schostak, M.4    Schrader, M.5    Miller, K.6    Christoph, F.7
  • 10
    • 0344348821 scopus 로고    scopus 로고
    • Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis
    • COI: 1:CAS:528:DyaK1MXksFKlsbc%3D, PID: 10393175
    • Hu Y, Benedict MA, Ding L, Nunez G (1999) Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis. EMBO J 18:3586–3595. doi:10.1093/emboj/18.13.3586
    • (1999) EMBO J , vol.18 , pp. 3586-3595
    • Hu, Y.1    Benedict, M.A.2    Ding, L.3    Nunez, G.4
  • 11
    • 0031762486 scopus 로고    scopus 로고
    • Temporal relationship of CDK1 activation and mitotic arrest to cytosolic accumulation of cytochrome C and caspase-3 activity during Taxol-induced apoptosis of human AML HL-60 cells
    • COI: 1:CAS:528:DyaK1MXktFOhsg%3D%3D, PID: 9844922
    • Ibrado AM, Kim CN, Bhalla K (1998) Temporal relationship of CDK1 activation and mitotic arrest to cytosolic accumulation of cytochrome C and caspase-3 activity during Taxol-induced apoptosis of human AML HL-60 cells. Leukemia 12:1930–1936
    • (1998) Leukemia , vol.12 , pp. 1930-1936
    • Ibrado, A.M.1    Kim, C.N.2    Bhalla, K.3
  • 12
    • 0032493910 scopus 로고    scopus 로고
    • Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9
    • COI: 1:CAS:528:DyaK1cXlsVWjs7o%3D, PID: 9708735
    • Kuida K et al (1998) Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell 94:325–337
    • (1998) Cell , vol.94 , pp. 325-337
    • Kuida, K.1
  • 13
    • 0030715323 scopus 로고    scopus 로고
    • Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
    • COI: 1:CAS:528:DyaK2sXnsFGls70%3D, PID: 9390557
    • Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES, Wang X (1997) Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91:479–489
    • (1997) Cell , vol.91 , pp. 479-489
    • Li, P.1    Nijhawan, D.2    Budihardjo, I.3    Srinivasula, S.M.4    Ahmad, M.5    Alnemri, E.S.6    Wang, X.7
  • 14
    • 0027309218 scopus 로고
    • Glutathione depletion by L-buthionine sulfoximine antagonizes taxol cytotoxicity
    • COI: 1:CAS:528:DyaK3sXktVSntLk%3D, PID: 8097674
    • Liebmann JE, Hahn SM, Cook JA, Lipschultz C, Mitchell JB, Kaufman DC (1993) Glutathione depletion by L-buthionine sulfoximine antagonizes taxol cytotoxicity. Cancer Res 53:2066–2070
    • (1993) Cancer Res , vol.53 , pp. 2066-2070
    • Liebmann, J.E.1    Hahn, S.M.2    Cook, J.A.3    Lipschultz, C.4    Mitchell, J.B.5    Kaufman, D.C.6
  • 15
    • 0031762622 scopus 로고    scopus 로고
    • Submicromolar paclitaxel induces apoptosis in human gastric cancer cells at early G1 phase
    • COI: 1:CAS:528:DyaK1MXntFCm, PID: 9858922
    • Lin HL, Chang YF, Liu TY, Wu CW, Chi CW (1998) Submicromolar paclitaxel induces apoptosis in human gastric cancer cells at early G1 phase. Anticancer Res 18:3443–3449
    • (1998) Anticancer Res , vol.18 , pp. 3443-3449
    • Lin, H.L.1    Chang, Y.F.2    Liu, T.Y.3    Wu, C.W.4    Chi, C.W.5
  • 16
    • 0036468550 scopus 로고    scopus 로고
    • Dysfunctional apoptosome activation in ovarian cancer: implications for chemoresistance
    • COI: 1:CAS:528:DC%2BD38Xht1Kqsrc%3D, PID: 11830553
    • Liu JR, Opipari AW, Tan L, Jiang Y, Zhang Y, Tang H, Nunez G (2002) Dysfunctional apoptosome activation in ovarian cancer: implications for chemoresistance. Cancer Res 62:924–931
    • (2002) Cancer Res , vol.62 , pp. 924-931
    • Liu, J.R.1    Opipari, A.W.2    Tan, L.3    Jiang, Y.4    Zhang, Y.5    Tang, H.6    Nunez, G.7
  • 17
    • 67650455882 scopus 로고    scopus 로고
    • The Apaf-1*procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer
    • COI: 1:CAS:528:DC%2BD1MXmslCmtLs%3D, PID: 19494828
    • Malladi S, Challa-Malladi M, Fearnhead HO, Bratton SB (2009) The Apaf-1*procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer. EMBO J 28:1916–1925
    • (2009) EMBO J , vol.28 , pp. 1916-1925
    • Malladi, S.1    Challa-Malladi, M.2    Fearnhead, H.O.3    Bratton, S.B.4
  • 18
    • 80052666457 scopus 로고    scopus 로고
    • Triggering of a novel intrinsic apoptosis pathway by the kinase inhibitor staurosporine: activation of caspase-9 in the absence of Apaf-1
    • COI: 1:CAS:528:DC%2BC3MXhtFOht7jP, PID: 21659556
    • Manns J et al (2011) Triggering of a novel intrinsic apoptosis pathway by the kinase inhibitor staurosporine: activation of caspase-9 in the absence of Apaf-1. FASEB J 25:3250–3261. doi:10.1096/fj.10-177527
    • (2011) FASEB J , vol.25 , pp. 3250-3261
    • Manns, J.1
  • 19
    • 70349974226 scopus 로고    scopus 로고
    • Paclitaxel promotes a caspase 8-mediated apoptosis through death effector domain association with microtubules
    • COI: 1:CAS:528:DC%2BD1MXps1ahu7k%3D, PID: 19668227
    • Mielgo A, Torres VA, Clair K, Barbero S, Stupack DG (2009) Paclitaxel promotes a caspase 8-mediated apoptosis through death effector domain association with microtubules. Oncogene 28:3551–3562
    • (2009) Oncogene , vol.28 , pp. 3551-3562
    • Mielgo, A.1    Torres, V.A.2    Clair, K.3    Barbero, S.4    Stupack, D.G.5
  • 20
    • 2342459790 scopus 로고    scopus 로고
    • DNA damage-induced apoptosis
    • COI: 1:CAS:528:DC%2BD2cXivFKmsLY%3D, PID: 15077143
    • Norbury CJ, Zhivotovsky B (2004) DNA damage-induced apoptosis. Oncogene 23:2797–2808
    • (2004) Oncogene , vol.23 , pp. 2797-2808
    • Norbury, C.J.1    Zhivotovsky, B.2
  • 21
    • 10944257440 scopus 로고    scopus 로고
    • Taxol induces caspase-10-dependent apoptosis
    • COI: 1:CAS:528:DC%2BD2cXhtVaqsr3M, PID: 15452117
    • Park SJ, Wu CH, Gordon JD, Zhong X, Emami A, Safa AR (2004) Taxol induces caspase-10-dependent apoptosis. J Biol Chem 279:51057–51067. doi:10.1074/jbc.M406543200
    • (2004) J Biol Chem , vol.279 , pp. 51057-51067
    • Park, S.J.1    Wu, C.H.2    Gordon, J.D.3    Zhong, X.4    Emami, A.5    Safa, A.R.6
  • 22
    • 84930440762 scopus 로고    scopus 로고
    • Aberrant methylation patterns in cancer: a clinical view
    • Paska AV, Hudler P (2015) Aberrant methylation patterns in cancer: a clinical view. Biochem Med 25:161–176. doi:10.11613/BM.2015.017
    • (2015) Biochem Med , vol.25 , pp. 161-176
    • Paska, A.V.1    Hudler, P.2
  • 23
    • 0034654517 scopus 로고    scopus 로고
    • The role of Apaf-1, caspase-9, and bid proteins in etoposide- or paclitaxel-induced mitochondrial events during apoptosis
    • COI: 1:CAS:528:DC%2BD3cXit1aqtLs%3D, PID: 10749135
    • Perkins CL, Fang G, Kim CN, Bhalla KN (2000) The role of Apaf-1, caspase-9, and bid proteins in etoposide- or paclitaxel-induced mitochondrial events during apoptosis. Cancer Res 60:1645–1653
    • (2000) Cancer Res , vol.60 , pp. 1645-1653
    • Perkins, C.L.1    Fang, G.2    Kim, C.N.3    Bhalla, K.N.4
  • 24
    • 34347215518 scopus 로고    scopus 로고
    • Analysis of apoptosis by propidium iodide staining and flow cytometry
    • COI: 1:CAS:528:DC%2BD28Xht1eitL7K, PID: 17406435
    • Riccardi C, Nicoletti I (2006) Analysis of apoptosis by propidium iodide staining and flow cytometry. Nat Protoc 1(3):1458–1461. doi:10.1038/nprot.2006.238
    • (2006) Nat Protoc , vol.1 , pp. 1458-1461
    • Riccardi, C.1    Nicoletti, I.2
  • 25
    • 84994521433 scopus 로고
    • Paclitaxel (taxol)
    • COI: 1:STN:280:DyaK2M7ptFKisg%3D%3D, PID: 7885406
    • Rowinsky EK, Donehower RC (1995) Paclitaxel (taxol). N Engl J Med 332:1004–1014
    • (1995) N Engl J Med , vol.332 , pp. 1004-1014
    • Rowinsky, E.K.1    Donehower, R.C.2
  • 26
    • 0018387446 scopus 로고
    • Promotion of microtubule assembly in vitro by taxol
    • COI: 1:CAS:528:DyaE1MXkvVCitrY%3D, PID: 423966
    • Schiff PB, Fant J, Horwitz SB (1979) Promotion of microtubule assembly in vitro by taxol. Nature 277:665–667
    • (1979) Nature , vol.277 , pp. 665-667
    • Schiff, P.B.1    Fant, J.2    Horwitz, S.B.3
  • 27
    • 0033593201 scopus 로고    scopus 로고
    • A caspase-9 variant missing the catalytic site is an endogenous inhibitor of apoptosis
    • COI: 1:CAS:528:DyaK1MXovVGnsg%3D%3D, PID: 9890966
    • Seol DW, Billiar TR (1999) A caspase-9 variant missing the catalytic site is an endogenous inhibitor of apoptosis. J Biol Chem 274:2072–2076
    • (1999) J Biol Chem , vol.274 , pp. 2072-2076
    • Seol, D.W.1    Billiar, T.R.2
  • 28
    • 78549234102 scopus 로고    scopus 로고
    • Alternative splicing of caspase 9 is modulated by the phosphoinositide 3-kinase/Akt pathway via phosphorylation of SRp30a
    • COI: 1:CAS:528:DC%2BC3cXhsVWmsLvO, PID: 21045158
    • Shultz JC, Goehe RW, Wijesinghe DS, Murudkar C, Hawkins AJ, Shay JW, Minna JD, Chalfant CE (2010) Alternative splicing of caspase 9 is modulated by the phosphoinositide 3-kinase/Akt pathway via phosphorylation of SRp30a. Cancer Res 70(2):9185–9196. doi:10.1158/0008-5472.CAN-10-1545
    • (2010) Cancer Res , vol.70 , pp. 9185-9196
    • Shultz, J.C.1    Goehe, R.W.2    Wijesinghe, D.S.3    Murudkar, C.4    Hawkins, A.J.5    Shay, J.W.6    Minna, J.D.7    Chalfant, C.E.8
  • 29
    • 0035843169 scopus 로고    scopus 로고
    • Inactivation of the apoptosis effector Apaf-1 in malignant melanoma
    • COI: 1:CAS:528:DC%2BD3MXlvFSrsA%3D%3D, PID: 11196646
    • Soengas MS et al (2001) Inactivation of the apoptosis effector Apaf-1 in malignant melanoma. Nature 409:207–211. doi:10.1038/35051606
    • (2001) Nature , vol.409 , pp. 207-211
    • Soengas, M.S.1
  • 30
    • 0032085941 scopus 로고    scopus 로고
    • Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization
    • COI: 1:CAS:528:DyaK1cXktlKlt74%3D, PID: 9651578
    • Srinivasula SM, Ahmad M, Fernandes-Alnemri T, Alnemri ES (1998) Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization. Mol Cell 1:949–957
    • (1998) Mol Cell , vol.1 , pp. 949-957
    • Srinivasula, S.M.1    Ahmad, M.2    Fernandes-Alnemri, T.3    Alnemri, E.S.4
  • 31
    • 0033104331 scopus 로고    scopus 로고
    • Identification of an endogenous dominant-negative short isoform of caspase-9 that can regulate apoptosis
    • COI: 1:CAS:528:DyaK1MXhslemtLg%3D, PID: 10070954
    • Srinivasula SM, Ahmad M, Guo Y, Zhan Y, Lazebnik Y, Fernandes-Alnemri T, Alnemri ES (1999) Identification of an endogenous dominant-negative short isoform of caspase-9 that can regulate apoptosis. Cancer Res 59:999–1002
    • (1999) Cancer Res , vol.59 , pp. 999-1002
    • Srinivasula, S.M.1    Ahmad, M.2    Guo, Y.3    Zhan, Y.4    Lazebnik, Y.5    Fernandes-Alnemri, T.6    Alnemri, E.S.7
  • 32
    • 0035826163 scopus 로고    scopus 로고
    • Staurosporine and conventional anticancer drugs induce overlapping, yet distinct pathways of apoptosis and caspase activation
    • COI: 1:CAS:528:DC%2BD3MXit1OitLk%3D, PID: 11313863
    • Stepczynska A, Lauber K, Engels IH, Janssen O, Kabelitz D, Wesselborg S, Schulze-Osthoff K (2001) Staurosporine and conventional anticancer drugs induce overlapping, yet distinct pathways of apoptosis and caspase activation. Oncogene 20:1193–1202. doi:10.1038/sj.onc.1204221
    • (2001) Oncogene , vol.20 , pp. 1193-1202
    • Stepczynska, A.1    Lauber, K.2    Engels, I.H.3    Janssen, O.4    Kabelitz, D.5    Wesselborg, S.6    Schulze-Osthoff, K.7
  • 33
    • 1642484904 scopus 로고    scopus 로고
    • Mechanisms of paclitaxel-induced apoptosis in an ovarian cancer cell line and its paclitaxel-resistant clone
    • COI: 1:CAS:528:DC%2BD2cXitlyitLY%3D, PID: 15031599
    • Sugimura M, Sagae S, Ishioka S, Nishioka Y, Tsukada K, Kudo R (2004) Mechanisms of paclitaxel-induced apoptosis in an ovarian cancer cell line and its paclitaxel-resistant clone. Oncology 66:53–61. doi:10.1159/000076335
    • (2004) Oncology , vol.66 , pp. 53-61
    • Sugimura, M.1    Sagae, S.2    Ishioka, S.3    Nishioka, Y.4    Tsukada, K.5    Kudo, R.6
  • 34
    • 84055182529 scopus 로고    scopus 로고
    • A short caspase-3 isoform inhibits chemotherapy-induced apoptosis by blocking apoptosome assembly
    • COI: 1:CAS:528:DC%2BC38XltFelsQ%3D%3D, PID: 22216167
    • Vegran F, Boidot R, Solary E, Lizard-Nacol S (2011) A short caspase-3 isoform inhibits chemotherapy-induced apoptosis by blocking apoptosome assembly. PLoS ONE 6:e29058. doi:10.1371/journal.pone.0029058
    • (2011) PLoS ONE , vol.6 , pp. 29058
    • Vegran, F.1    Boidot, R.2    Solary, E.3    Lizard-Nacol, S.4
  • 35
    • 21344466795 scopus 로고    scopus 로고
    • Medical treatment in head and neck cancer
    • PID: 15958469
    • Vermorken JB (2005) Medical treatment in head and neck cancer. Ann Oncol 16(Suppl. 2):ii258–ii264. doi:10.1093/annonc/mdi735
    • (2005) Ann Oncol , vol.16 , pp. ii258-ii264
    • Vermorken, J.B.1
  • 36
    • 0034212385 scopus 로고    scopus 로고
    • Paclitaxel-induced cell death: where the cell cycle and apoptosis come together
    • COI: 1:CAS:528:DC%2BD3cXktFGjsLc%3D, PID: 10861441
    • Wang TH, Wang HS, Soong YK (2000) Paclitaxel-induced cell death: where the cell cycle and apoptosis come together. Cancer 88:2619–2628
    • (2000) Cancer , vol.88 , pp. 2619-2628
    • Wang, T.H.1    Wang, H.S.2    Soong, Y.K.3
  • 37
    • 0242667892 scopus 로고    scopus 로고
    • Frequent LOH at chromosome 12q22-23 and Apaf-1 inactivation in glioblastoma
    • COI: 1:CAS:528:DC%2BD3sXpslCgtb0%3D, PID: 14655749
    • Watanabe T et al (2003) Frequent LOH at chromosome 12q22-23 and Apaf-1 inactivation in glioblastoma. Brain Pathol 13:431–439
    • (2003) Brain Pathol , vol.13 , pp. 431-439
    • Watanabe, T.1
  • 38
    • 0034055156 scopus 로고    scopus 로고
    • Frameshift mutations in Fas, Apaf-1, and Bcl-10 in gastro-intestinal cancer of the microsatellite mutator phenotype
    • COI: 1:CAS:528:DC%2BD3cXis1aku74%3D, PID: 10819600
    • Yamamoto H, Gil J, Schwartz S Jr, Perucho M (2000) Frameshift mutations in Fas, Apaf-1, and Bcl-10 in gastro-intestinal cancer of the microsatellite mutator phenotype. Cell Death Differ 7:238–239
    • (2000) Cell Death Differ , vol.7 , pp. 238-239
    • Yamamoto, H.1    Gil, J.2    Schwartz, S.3    Perucho, M.4
  • 39
    • 3042707323 scopus 로고    scopus 로고
    • Methylation profiling of twenty promoter-CpG islands of genes which may contribute to hepatocellular carcinogenesis
    • PID: 12433278
    • Yu J et al (2002) Methylation profiling of twenty promoter-CpG islands of genes which may contribute to hepatocellular carcinogenesis. BMC Cancer 2:29
    • (2002) BMC Cancer , vol.2 , pp. 29
    • Yu, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.