Association of serum Vitamin D with the risk of incident dementia and subclinical indices of brain aging: The framingham heart study

Journal of Alzheimer's Disease

Volumn 51, Issue 2, 2016, Pages 451-461

  Karakis, Ioannis ^a   Pase, Matthew P ^b,c,d   Beiser, Alexa ^b,c,e   Booth, Sarah L ^f   Jacques, Paul F ^f   Rogers, Gail ^f   DeCarli, Charles ^g   Vasan, Ramachandran S ^b   Wang, Thomas J ^h   Himali, Jayandra J ^b,c   Annweiler, Cedric ^i,j   Seshadri, Sudha ^b,c  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b FRAMINGHAM HEART STUDY   (United States)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d SWINBURNE UNIVERSITY OF TECHNOLOGY   (Australia)

^e BOSTON UNIVERSITY   (United States)

^f TUFTS UNIVERSITY   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

^h VANDERBILT UNIVERSITY   (United States)

ⁱ UNIVERSITÉ D'ANGERS   (France)

^j WESTERN UNIVERSITY   (Canada)

more..

Author keywords

Alzheimer's disease; brain; dementia; diet; lifestyle; magnetic resonance imaging; neuropsychology; nutritional status; risk factors; Vitamin D

Indexed keywords

25 HYDROXYVITAMIN D; VITAMIN D;

ADULT; AGED; AGING; ALZHEIMER DISEASE; ARTICLE; BRAIN; BRAIN INFARCTION; BRAIN SIZE; CLINICAL FEATURE; COGNITION; COGNITIVE DEFECT; COHORT ANALYSIS; CONTROLLED STUDY; DEMENTIA; DEPTH PERCEPTION; DIAGNOSTIC TEST ACCURACY STUDY; DISEASE ASSOCIATION; EXECUTIVE FUNCTION; FEMALE; HIPPOCAMPUS; HOOPER VISUAL ORGANIZATION TEST; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MINI MENTAL STATE EXAMINATION; NEUROIMAGING; NEUROPSYCHOLOGICAL TEST; NEUROPSYCHOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; PREDICTIVE VALUE; PRIORITY JOURNAL; RISK FACTOR; SERUM; STROKE PATIENT; TRAIL MAKING TEST; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY; VITAMIN SUPPLEMENTATION; WHITE MATTER; BLOOD; DIAGNOSTIC IMAGING; MULTIVARIATE ANALYSIS; PATHOLOGY; REGRESSION ANALYSIS; RISK; SENSITIVITY AND SPECIFICITY;

ADULT; AGING; BRAIN; COHORT STUDIES; DEMENTIA; FEMALE; HUMANS; INCIDENCE; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEUROPSYCHOLOGICAL TESTS; REGRESSION ANALYSIS; RISK; SENSITIVITY AND SPECIFICITY; VITAMIN D;

EID: 84961855567     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-150991     Document Type: Article

References (55)

1. Cherniack EP, Florez H, RoosBA, Troen BR, Levis S. (2008). HypovitaminosisDin the elderly: From bone to brain. J Nutr Health Aging 12, 366-373.
2. Munger KL, Levin LI, Hollis BW, Howard NS, Ascherio A. (2006). Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. JAMA 296, 2832-2838.
3. Knekt P, Kilkkinen A, Rissanen H, Marniemi J, Saaksjarvi K, Heliovaara M. (2010). Serum vitamin D and the risk of Parkinson disease. Arch Neurol 67, 808-811.
4. Buell JS, Dawson-Hughes B, Scott TM, Weiner DE, Dallal GE, Qui WQ, Bergethon P, Rosenberg IH, FolsteinMF, Patz S, Bhadelia RA, Tucker KL. (2010). 25-Hydroxyvitamin D, dementia, and cerebrovascular pathology in elders receiving home services. Neurology 74, 18-26.
5. Balion C, Griffith LE, Strifler L, Henderson M, Patterson C, Heckman G, Llewellyn DJ, Raina P. (2012). Vitamin D, cognition, and dementia: A systematic review and metaanalysis. Neurology 79, 1397-1405.
6. Annweiler C, Llewellyn DJ, Beauchet O. (2013). Low serum vitamin D concentrations in Alzheimer's disease: A systematic review and meta-Analysis. J Alzheimers Dis 33, 659-674.
7. Annweiler C, Montero-Odasso M, Llewellyn DJ, Richard- Devantoy S, Duque G, Beauchet O. (2013). Meta-Analysis of memory and executive dysfunctions in relation to vitamin D. J Alzheimers Dis 37, 147-171.
8. Kannel WB, Feinleib M, McNamara PM, Garrison RJ, Castelli WP. (1979). An investigation of coronary heart disease in families. The Framingham offspring study. Am J Epidemiol 110, 281-290.
9. Dawber TR, Meadors GF, Moore FE. (1951). Epidemiological approaches to heart disease: The framingham study. Am J Public Health Nations Health 41, 279-286.
10. Rienstra M, Cheng S, Larson MG, McCabe EL, Booth SL, Jacques PF, Lubitz SA, Yin X, Levy D, Magnani JW, Ellinor PT, Benjamin EJ, Wang TJ. (2011). Vitamin D status is not related to development of atrial fibrillation in the community. Am Heart J 162, 538-541.
11. Wang TJ, Pencina MJ, Booth SL, Jacques PF, Ingelsson E, Lanier K, Benjamin EJ, D'Agostino RB, Wolf M, Vasan RS. (2008). Vitamin D deficiency and risk of cardiovascular disease. Circulation 117, 503-511.
12. Holick MF. (2007). Vitamin D deficiency. N Engl J Med 357, 266-281.
13. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. (1984). Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34, 939-944.
14. Wolf PA, Beiser A, Elias MF, Au R, Vasan RS, Seshadri S. (2007). Relation of obesity to cognitive function: Importance of central obesity and synergistic influence of concomitant hypertension. The Framingham Heart Study. Curr Alzheimer Res 4, 111-116.
15. Seshadri S, Beiser A, Selhub J, Jacques PF, Rosenberg IH, D'Agostino RB, Wilson PW, Wolf PA. (2002). Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med 346, 476-483.
16. Strauss E, Sherman EMS, Spreen O. (2006). A Compendium of Neuropsychological Tests: Administration, Norms, and Commentary, Oxford Press, USA
17. Au R, Seshadri S, Wolf PA, Elias M, Elias P, Sullivan L, Beiser A, D'Agostino RB. (2004). New norms for a new generation: Cognitive performance in the framingham offspring cohort. Exp Aging Res 30, 333-358.
18. Seshadri S, Wolf PA, Beiser AS, Selhub J, Au R, Jacques PF, Yoshita M, Rosenberg IH, D'Agostino RB, DeCarli C. (2008). Association of plasma total homocysteine levels with subclinical brain injury: Cerebral volumes, white matter hyperintensity, and silent brain infarcts at volumetric magnetic resonance imaging in the Framingham Offspring Study. Arch Neurol 65, 642-649.
19. Jeerakathil T, Wolf PA, Beiser A, Massaro J, Seshadri S, D'Agostino RB, DeCarli C. (2004). Stroke risk profile predicts white matter hyperintensity volume: The Framingham study. Stroke 35, 1857-1861.
20. WardlawJM, Smith EE, Biessels GJ, Cordonnier C, Fazekas F, Frayne R, Lindley RI, O'Brien JT, Barkhof F, Benavente OR, Black SE, Brayne C, Breteler M, Chabriat H, Decarli C, De Leeuw FE, Doubal F, Duering M, Fox NC, Greenberg S, Hachinski V, Kilimann I, Mok V, Oostenbrugge R, Pantoni L, Speck O, Stephan BC, Teipel S, Viswanathan A, Werring D, Chen C, Smith C, Van Buchem M, Norrving B, Gorelick PB, Dichgans M. (2013). Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration. Lancet Neurol 12, 822-838.
21. DeCarli C, Massaro J, Harvey D, Hald J, TullbergM, Au R, Beiser A, D'Agostino R, Wolf PA. (2005). Measures of brain morphology and infarction in the framingham heart study: Establishing what is normal. Neurobiol Aging 26, 491-510.
22. DeCarli C, Maisog J, Murphy DG, Teichberg D, Rapoport SI, Horwitz B. (1992). Method for quantification of brain, ventricular, and subarachnoid CSF volumes from MR images. J Comput Assist Tomogr 16, 274-284.
23. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, JonesDW, Materson BJ, Oparil S, Wright JT Jr, Roccella EJ. (2003). Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension 42, 1206-1252.
24. Rimm EB, Giovannucci EL, Stampfer MJ, Colditz GA, Litin LB, Willett WC. (1992). Reproducibility and validity of an expanded self-Administered semiquantitative food frequency questionnaire among male health professionals. Am J Epidemiol 135, 1114-1126; discussion 1127-1136.
25. Committee to Review Dietary Reference Intakes for Vitamin D and Calcium; Food and Nutrition Board; Institute of Medicine. (2010). Dietary reference intakes for calcium and vitamin D, National Academic Press, Washington DC.
26. Littlejohns TJ, Henley WE, Lang IA, Annweiler C, Beauchet O, Chaves PHM, Fried L, Kestenbaum BR, Kuller LH, Langa KM, Lopez OL, Kos K, Soni M, Llewellyn DJ. (2014). Vitamin D and the risk of dementia and Alzheimer disease. Neurology 83, 920-928.
27. Afzal S, Bojesen SE, Nordestgaard BG. (2014). Reduced 25-hydroxyvitamin D and risk of Alzheimer's disease and vascular dementia. Alzheimers Dement 10, 296-302.
28. Annweiler C, Rolland Y, Schott AM, Blain H, Vellas B, Beauchet O. (2011). Serum vitamin D deficiency as a predictor of incident non-Alzheimer dementias: A 7-year longitudinal study. Dement Geriatr Cogn Disord 32, 273-278.
29. Annweiler C, Rolland Y, Schott AM, Blain H, Vellas B, Herrmann FR, Beauchet O. (2012). Higher vitamin D dietary intake is associated with lower risk of alzheimer's disease: A7-year follow-up. J Gerontol A Biol Sci Med Sci 67, 1205-1211.
30. Buell JS, Scott TM, Dawson-Hughes B, Dallal GE, Rosenberg IH, Folstein MF, Tucker KL. (2009). Vitamin D is associated with cognitive function in elders receiving home health services. J Gerontol A Biol Sci Med Sci 64, 888-895.
31. Menant JC, Close JC, Delbaere K, Sturnieks DL, Trollor J, Sachdev PS, Brodaty H, Lord SR. (2012). Relationships between serum vitamin D levels, neuromuscular and neuropsychological function and falls in older men and women. Osteoporos Int 23, 981-989.
32. Llewellyn DJ, Lang IA, Langa KM, Muniz-Terrera G, Phillips CL, Cherubini A, Ferrucci L, MelzerD(2010)Vitamin D and risk of cognitive decline in elderly persons. Arch Intern Med 170, 1135-1141.
33. Jorde R, Waterloo K, Saleh F, Haug E, Svartberg J. (2006). Neuropsychological function in relation to serum parathyroid hormone and serum 25-hydroxyvitamin D levels. The Tromso study. J Neurol 253, 464-470.
34. McGrath J, Scragg R, Chant D, Eyles D, Burne T, Obradovic D. (2007). No association between serum 25- hydroxyvitamin D3 level and performance on psychometric tests in NHANES III. Neuroepidemiology 29, 49-54.
35. Tolppanen AM, Williams DM, LawlorDA(2011). The association of serum ionized calcium and vitamin D with adult cognitive performance. Epidemiology 22, 113-117.
36. Risacher SL, Saykin AJ, West JD, Shen L, Firpi HA, McDonald BC. (2009). Baseline MRI predictors of conversion from MCI to probable AD in the ADNI cohort. Curr Alzheimer Res 6, 347-361.
37. Bateman RJ, Xiong C, Benzinger TL, Fagan AM, Goate A, Fox NC, Marcus DS, Cairns NJ, Xie X, Blazey TM, Holtzman DM, Santacruz A, Buckles V, Oliver A, Moulder K, Aisen PS, Ghetti B, Klunk WE, McDade E, Martins RN, Masters CL, Mayeux R, Ringman JM, Rossor MN, Schofield PR, Sperling RA, Salloway S, Morris JC. (2012). Clinical and biomarker changes in dominantly inherited Alzheimer's disease. N Engl J Med 367, 795-804.
38. Laakso MP, Partanen K, Riekkinen P Jr, Lehtovirta M, Helkala EL, Hallikainen M, H'anninen T, Vainio P, Soininen H. (1996). Hippocampal volumes in Alzheimer's disease, Parkinson's disease with and without dementia, and in vascular dementia: An MRI study. Neurology 46, 678-681.
39. Kassi E, Adamopoulos C, Basdra EK, Papavassiliou AG. (2013). Role of vitamin D in atherosclerosis. Circulation 128, 2517-2531.
40. Juonala M, Voipio A, Pahkala K, Viikari JS, Mikkila V, Kahonen M, Hutri-Kahonen N, Jula A, Burgner D, Sabin MA, Marniemi J, Loo BM, Laitinen T, Jokinen E, Taittonen L, Magnussen CG, Raitakari OT. (2015). Childhood 25-OH vitamin D levels and carotid intima-media thickness in adulthood: The cardiovascular risk in young Finns study. J Clin Endocrinol Metab 100, 1469-1476.
41. KalueffAV, Tuohimaa P. (2007). Neurosteroid hormone vitamin D and its utility in clinical nutrition. Curr Opin Clin Nutr Metab Care 10, 12-19.
42. McCann JC, AmesBN(2008). Is there convincing biological or behavioral evidence linking vitaminDdeficiency to brain dysfunction'. FASEB J 22, 982-1001.
43. Eyles DW, Smith S, Kinobe R, Hewison M, McGrath JJ. (2005). Distribution of the vitamin D receptor and 1 alphahydroxylase in human brain. J Chem Neuroanat 29, 21-30.
44. Buell JS, Dawson-Hughes B. (2008). Vitamin D and neurocognitive dysfunction: Preventing "D"ecline'. Mol Aspects Med 29, 415-422.
45. Aranow C. (2011). Vitamin D and the immune system. J Investig Med 59, 881-886.
46. Heppner FL, Ransohoff RM, Becher B. (2015). Immune attack: The role of inflammation in Alzheimer disease. Nat Rev Neurosci 16, 358-372.
47. Kiraly SJ, Kiraly MA, Hawe RD, Makhani N. (2006). Vitamin D as a neuroactive substance: Review. Scientific- WorldJournal 6, 125-139.
48. Brewer LD, Thibault V, Chen KC, Langub MC, Landfield PW, Porter NM. (2001). Vitamin D hormone confers neuroprotection in parallel with downregulation of L-type calcium channel expression in hippocampal neurons. J Neurosci 21, 98-108.
49. Dursun E, Gezen-Ak D, Yilmazer S. (2011). A novel perspective for Alzheimer's disease: Vitamin D receptor suppression by amyloid-beta and preventing the amyloidbeta induced alterations by vitamin D in cortical neurons. J Alzheimers Dis 23, 207-219.
50. Masoumi A, Goldenson B, Ghirmai S, Avagyan H, Zaghi J, Abel K, Zheng X, Espinosa-Jeffrey A, Mahanian M, Liu PT, Hewison M, Mizwickie M, Cashman J, Fiala M. (2009 1alpha, 25-dihydroxyvitamin D3 interacts with curcuminoids to stimulate amyloid-beta clearance by macrophages of Alzheimer's disease patients. J Alzheimers Dis 17, 703-717.
51. Ito S, Ohtsuki S, NezuY, KoitabashiY, Murata S, Terasaki T. (2011). 1alpha, 25-Dihydroxyvitamin D3 enhances cerebral clearance of human amyloid-beta peptide(1-40). from mouse brain across the blood-brain barrier. Fluids Barriers CNS 8, 20.
52. Yu J, Gattoni-Celli M, Zhu H, Bhat NR, Sambamurti K, Gattoni-Celli S, KindyMS(2011)Vitamin D3-enriched diet correlates with a decrease of amyloid plaques in the brain of AbetaPP transgenic mice. J Alzheimers Dis 25, 295-307.
53. Sutherland MK, Somerville MJ, Yoong LK, Bergeron C, Haussler MR, McLachlan DR. (1992). Reduction of vitamin D hormone receptor mRNA levels in Alzheimer as compared to Huntington hippocampus: Correlation with calbindin-28k mRNA levels. Brain Res Mol Brain Res 13, 239-250.
54. Forrest KY, Stuhldreher WL. (2011). Prevalence and correlates of vitamin D deficiency in US adults. Nutr Res 31, 48-54.
55. Daly RM, Gagnon C, Lu ZX, Magliano DJ, Dunstan DW, Sikaris KA, Zimmet PZ, Ebeling PR, Shaw JE. (2012). Prevalence of vitamin D deficiency and its determinants in Australian adults aged 25 years and older: A national, population-based study. Clin Endocrinol. (Oxf). 77, 26-35.