Association of plasma total homocysteine levels with subclinical brain injury: Cerebral volumes, white matter hyperintensity, and silent brain infarcts at volumetric magnetic resonance imaging in the Framingham Offspring Study

Archives of Neurology

Volumn 65, Issue 5, 2008, Pages 642-649

  Seshadri, Sudha ^a   Wolf, Philip A ^a   Beiser, Alexa S ^a,b   Selhub, Jacob ^d   Au, Rhoda ^a   Jacques, Paul F ^d   Yoshita, Mitsuhiro ^e   Rosenberg, Irwin H ^d   D'Agostino, Ralph B ^c   DeCarli, Charles ^e  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BOSTON UNIVERSITY   (United States)

^c Boston University   (United States)

^d TUFTS UNIVERSITY   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HOMOCYSTEINE;

ADULT; AGED; ARTICLE; BRAIN INFARCTION; BRAIN INJURY; BRAIN SIZE; CONTROLLED STUDY; DEMENTIA; FEMALE; FRONTAL LOBE; HUMAN; MAJOR CLINICAL STUDY; MALE; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; PREVALENCE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; STROKE; TEMPORAL LOBE; WHITE MATTER;

AGED; ATROPHY; BIOLOGICAL MARKERS; BRAIN INFARCTION; CEREBRAL CORTEX; COHORT STUDIES; COMORBIDITY; FEMALE; HOMOCYSTEINE; HUMANS; HYPERHOMOCYSTEINEMIA; MAGNETIC RESONANCE IMAGING; MALE; MASSACHUSETTS; MIDDLE AGED; NERVE DEGENERATION; NERVE FIBERS, MYELINATED; PREDICTIVE VALUE OF TESTS; PROGNOSIS;

EID: 43549091613     PISSN: 00039942     EISSN: 15383687     Source Type: Journal    
DOI: 10.1001/archneur.65.5.642     Document Type: Article

References (35)

1. Bostom AG, Rosenberg IH, Silbershatz H, et al. Nonfasting plasma total homocysteine levels and stroke incidence in elderly persons: the Framingham Study. Ann Intern Med. 1999;131(5):352-355.
2. Seshadri S, Beiser A, Selhub J, et al. Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med. 2002;346(7):476-483.
3. Vermeer SE, Den Heijer T, Koudstaal PJ, Oudkerk M, Hofman A, Breteler MM; Rotterdam Scan Study. Incidence and risk factors of silent brain infarcts in the population-based Rotterdam Scan Study. Stroke. 2003;34(2):392-396.
4. Seshadri S, Wolf PA, Beiser A, et al. Stroke risk profile, brain volume, and cognitive function: the Framingham Offspring Study. Neurology. 2004;63(9):1591-1599.
5. Longstreth WT Jr, Katz R, Olson J, et al. Plasma total homocysteine levels and cranial magnetic resonance imaging findings in elderly persons: the Cardiovascular Health Study. Arch Neurol. 2004;61(1):67-72.
6. Matsui T, Arai H, Yuzuriha T, et al. Elevated plasma homocysteine levels and risk of silent brain infarction in elderly people. Stroke. 2001;32(5):1116-1119.
7. Sachdev P, Parslow R, Salonikas C, et al. Homocysteine and the brain in mid-adult life: evidence for an increased risk of leukoaraiosis in men [published correction appears in Arch Neurol. 2005;62(4):691]. Arch Neurol. 2004;61(9):1369-1376.
8. Sachdev P. Homocysteine, cerebrovascular disease and brain atrophy. J Neurol Sci. 2004;226(1-2):25-29.
9. Sachdev PS, Valenzuela M, Wang XL, Looi JC, Brodaty H. Relationship between plasma homocysteine levels and brain atrophy in healthy elderly individuals. Neurology. 2002;58(10):1539-1541.
10. Scott TM, Tucker KL, Bbadelia A, et al. Homocysteine and B vitamins relate to brain volume and white-matter changes in geriatric patients with psychiatric disorders. Am J Geriatr Psychiatry. 2004;12(6):631-638.
11. Whalley LJ, Staff RT, Murray AD, et al. Plasma vitamin C, cholesterol and homocysteine are associated with grey matter volume determined by MRI in non-demented old people. Neurosci Lett. 2003;341(3):173-176.
12. Wright CB, Paik MC, Brown TR, et al. Total homocysteine is associated with white matter hyperintensity volume: the Northern Manhattan Study. Stroke. 2005;36(6):1207-1211.
13. Wong A, Mok V, Fan YH, Lam WW, Liang KS, Wong KS. Hyperhomocysteinemia is associated with volumetric white matter change in patients with small vessel disease. J Neurol. 2006;253(4):441-447.
14. den Heijer T, Vermeer SE, Clarke R, et al. Homocysteine and brain atrophy on MRI of non-demented elderly. Brain. 2003;126(pt 1):170-175.
15. Vermeer SE, van Dijk EJ, Koudstaal PJ, et al. Homocysteine, silent brain infarcts, and white matter lesions: the Rotterdam Scan Study. Ann Neurol. 2002;51(3):285-289.
16. Feinleib M, Garrison RJ, Stallones L, Kannel WB, Castelli WP, McNamara PM. A comparison of blood pressure, total cholesterol and cigarette smoking in parents in 1950 and their children in 1970. Am J Epidemiol. 1979;110(3):291-303.
17. Araki A, Sako Y. Determination of free and total homocysteine in human plasma by high-performance liquid chromatography with fluorescence detection. J Chromatogr. 1987;422:43-52.
18. Selhub J, Jacques PF, Wilson PW, Rush D, Rosenberg IH. Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. JAMA. 1993;270(22):2693-2698.
19. Jacques PF, Selhub J, Bostom AG, Wilson PW, Rosenberg IH. The effect of folic acid fortification on plasma folate and total homocysteine concentrations. N Engl J Med. 1999;340(19):1449-1454.
20. DeCarli C, Maisog J, Murphy DG, Teichberg D, Rapoport SI, Horwitz B. Method for quantification of brain, ventricular, and subarachnoid CSF volumes from MR images. J Comput Assist Tomogr. 1992;16(2):274-284.
21. DeCarli C, Massaro J, Harvey D, et al. Measures of brain morphology and infarction in the Framingham Heart Study: establishing what is normal. Neurobiol Aging. 2005;26(4):491-510.
22. Jeerakathil T, Wolf PA, Beiser A, et al. Stroke risk profile predicts white matter hyperintensity volume: the Framingham Study. Stroke. 2004;35(8):1857-1861.
23. DeCarli C, Miller BL, Swan GE, et al. Predictors of brain morphology for the men of the NHLBI twin study. Stroke. 1999;30(3):529-536.
24. D'Agostino RB, Wolf PA, Belanger AJ, Kannel WB. Stroke risk profile: adjustment for antihypertensive medication: the Framingham Study. Stroke. 1994;25(1):40-43.
25. Wolf PA, D'Agostino RB, Belanger AJ, Kannel WB. Probability of stroke: a risk profile from the Framingham Study. Stroke. 1991;22(3):312-318.
26. Verhoef P, Hennekens CH, Malinow MR, Kok FJ, Willett WC, Stampfer MJ. A prospective study of plasma homocyst(e)ine and risk of ischemic stroke. Stroke. 1994;25(10):1924-1930.
27. Sacco RL, Anand K, Lee HS, et al. Homocysteine and the risk of ischemic stroke in a triethnic cohort: the NOrthern MAnhattan Study. Stroke. 2004;35(10):2263-2269.
28. Kittner SJ, Giles WH, Macko RF, et al. Homocyst(e)ine and risk of cerebral infarction in a biracial population: the Stroke Prevention in Young Women Study. Stroke. 1999;30(8):1554-1560.
29. Eikelboom JW, Hankey GJ, Anand SS, Lofthouse E, Staples N, Baker RI. Association between high homocyst(e)ine and ischemic stroke due to large- and small-artery disease but not other etiologic subtypes of ischemic stroke. Stroke. 2000;31(5):1069-1075.
30. Elias MF, Sullivan LM, D'Agostino RB, et al. Homocysteine and cognitive performance in the Framingham Offspring Study: age is important. Am J Epidemiol. 2005;162(7):644-653.
31. Bleich S, Sperling W, Degner D, et al. Lack of association between hippocampal volume reduction and first-onset alcohol withdrawal seizure: a volumetric MRI study. Alcohol Alcohol. 2003;38(1):40-44.
32. Williams JH, Pereira EA, Budge MM, Bradley KM. Minimal hippocampal width relates to plasma homocysteine in community-dwelling older people. Age Ageing. 2002;31(6):440-444.
33. Kohara K, Fujisawa M, Ando F, et al. MTHFR gene polymorphism as a risk factor for silent brain infarcts and white matter lesions in the Japanese general population: the NILS-LSA Study. Stroke. 2003;34(5):1130-1135.
34. Fazekas F, Schmidt R, Scheltens P. Pathophysiologic mechanisms in the development of age-related white matter changes of the brain. Dement Geriatr Cogn Disord. 1998;9(suppl 1):2-5.
35. Hogervorst E, Ribeiro HM, Molyneux A, Budge M, Smith AD. Plasma homocysteine levels, cerebrovascular risk factors, and cerebral white matter changes (leukoaraiosis) in patients with Alzheimer disease. Arch Neurol. 2002;59(5):787-793.