Alpha lipoic acid attenuates high-fructose-induced pancreatic toxicity

Pancreatology

Volumn 16, Issue 3, 2016, Pages 347-352

  Topsakal, Senay ^a   Ozmen, Ozlem ^b   Cankara, Fatma Nihan ^c   Yesilot, Sukriye ^b   Bayram, Dilek ^c   Genç Özdamar, Nilüfer ^c   Kayan, Sümeyra ^c  

^a Department of Endocrinology and Metabolism   (Turkey)

^b MEHMET AKIF ERSOY UNIVERSITY   (Turkey)

^c SULEYMAN DEMIREL UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

Author keywords

Alpha lipoic acid; High fructose corn syrup; Immunohistochemistry; Oxidative stress; Pancreas; Pathology

Indexed keywords

AMYLASE; BIOCHEMICAL MARKER; CASPASE 3; CATALASE; CORN SYRUP; FRUCTOSE; GLUCAGON; GLUCOSE; INSULIN; MALONALDEHYDE; THIOCTIC ACID; TRIACYLGLYCEROL LIPASE; ANTIOXIDANT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCHEMICAL ANALYSIS; CELL DEGENERATION; CONTROLLED STUDY; DRUG EFFECT; FEMALE; GLUCAGON RELEASE; GLUCOSE BLOOD LEVEL; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INFLAMMATORY INFILTRATE; INSULIN RESISTANCE; NONHUMAN; PANCREAS CELL; PANCREAS INJURY; PANCREAS ISLET CELL; PANCREAS NECROSIS; PANCREATIC TISSUE; PANCREATIC TOXICITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SINGLE DRUG DOSE; ANIMAL; DRUG EFFECTS; METABOLISM; OXIDATIVE STRESS; PANCREAS; PATHOLOGY; RANDOMIZATION; WISTAR RAT;

ANIMALS; ANTIOXIDANTS; FEMALE; HIGH FRUCTOSE CORN SYRUP; IMMUNOHISTOCHEMISTRY; OXIDATIVE STRESS; PANCREAS; RANDOM ALLOCATION; RATS; RATS, WISTAR; THIOCTIC ACID;

EID: 84961792771     PISSN: 14243903     EISSN: 14243911     Source Type: Journal    
DOI: 10.1016/j.pan.2016.03.001     Document Type: Article

References (45)

1. B.P. Marriott, N. Cole, and E. Lee National estimates of dietary fructose intake increased from 1977 to 2004 in the United States J Nutr 139 2009 1228 1235
2. R.J. Johnson, M.S. Segal, Y. Sautin, T. Nakagawa, D.I. Feig, D. Kang, and et al. Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease Am J Clin Nutr 86 2007 899 906
3. B. Isomaa A major health hazard: the metabolic syndrome Life Sci 73 2003 2395 2411
4. I. Dhar, A. Dhar, and L. Wu Increased methylglyoxal formation with upregulation of renin angiotensin system in fructose fed Sprague Dawley rats PLoS One 8 2013 e74212
5. H. Wang, Q.H. Meng, J.R. Gordon, H. Khandwala, and L. Wu Proinflammatory and proapoptotic effects of methylglyoxal on neutrophils from patients with type 2 diabetes mellitus Clin Biochem 40 2007 1232 1239
6. A. Ceriello, and E. Motz Is oxidative stress the pathogenic mechanism underlying insulin resistance, diabetes, and cardiovascular disease? the common soil hypothesis revisited Arterioscler Thromb Vasc Biol 24 2004 816 823
7. A. Salehi, E. Vieira, and E. Gylfe Paradoxical stimulation of glucagon secretion by high glucose concentrations Diabetes 55 2006 2318 2323
8. E. Vieira, A. Salehi, and E. Gylfe Glucose inhibits glucagon secretion by a direct effect on mouse pancreatic a cells Diabetologia 50 2007 370 379
9. A.U. Kabir, M.B. Samad, A. Ahmed, M.R. Jahan, F. Akhter, J. Tasnim, and et al. Aqueous fraction of Beta vulgaris ameliorates hyperglycemia in diabetic mice due to enhanced glucose stimulated insulin secretion, mediated by acetylcholine and GLP-1, and elevated glucose uptake via increased membrane bound GLUT4 transporters PLoS One 10 2015 e0116546
10. A.M. Arafat, P. Kaczmarek, M. Skrzypski, E. Pruszynska-Oszmalek, P. Kołodziejski, D. Szczepankiewicz, and et al. Glucagon increases circulating fibroblast growth factor 21 independently of endogenous insulin levels: a novel mechanism of glucagon-stimulated lipolysis? Diabetologia 56 2013 588 597
11. P.E. Cryer Minireview: glucagon in the pathogenesis of hypoglycemia and hyperglycemia in diabetes Endocrinology 153 2012 1039 1048
12. K.K. Nickander, B.R. McPhee, P.A. Low, and H. Tritschler Alpha-lipoic acid: antioxidant potency against lipid peroxidationof neural tissues in vitro and implications for diabeticneuropathy Free Radic Biol Med 21 1996 631 639
13. E.A. Muellenbach, C.J. Diehl, M.K. Teachey, K.A. Lindborg, T.L. Archuleta, N.B. Harrell, and et al. Interactions of the advanced glycation end product inhibitor pyridoxamine and the antioxidant alpha-lipoicacidon insulin resistance in the obese Zucker rat Metabolism 57 2008 1465 1472
14. K.L. Teff, S.S. Elliott, M. Tschop, T.J. Kieffer, D. Rader, M. Heiman, and et al. Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women J Clin Endocrinol Metab 89 2004 2963 2972
15. H. Basciano, L. Federico, and K. Adeli Fructose, insulin resistance, and metabolic dyslipidemia Nutr Metab 2 2005 1 14
16. F. Akar, O. Uludag, A. AydIn, Y.A. Aytekin, S. Elbeg, M. Tuzcu, and et al. High-fructose corn syrup causes vascular dysfunction associated with metabolic disturbance in rats: protective effect of resveratrol Food Chem Toxicol 50 2012 2135 2141
17. E.E. Ventura, J.N. Davis, and M.I. Goran Sugar content of popular sweetened beverages based on objective laboratory analysis: focus on fructose content Obesity 19 2011 784 868
18. A. Gunes, O. Ozmen, M. SaygIn, H. AscI, L. Tok, O. Tok, and et al. Lens and cornea lesions of rats fed corn syrup and the protective effects of alpha lipoic acid Cutan Ocul Toxicol 35 2016 31 35
19. S.C. Micili, A. Goker, O. Sayin, P. Akokay, and B.U. Ergur The effect of lipoic acid on wound healing in a full thickness uterine injury model in rats J Mol Histol 44 2013 339 435
20. A.W. Thorburn, L.H. Storlien, A.B. Jenkins, S. Khouri, and E.W. Kraegen Fructose-induced in vivo insulin resistance and elevated plasma triglyceride levels in rats Am J Clin Nutr 49 1989 1155 1163
21. H. Aebi Catalase in vitro Methods Enzymol 105 1984 121 126
22. M.M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal Biochem 72 1976 248 254
23. H.H. Drapper, and M. Hadley Malondialdehyde determination as index of lipid peroxidation Methods Enzymol 186 1990 421 431
24. M.A. Abdel-Wahhab, S.A. Nada, and M.S. Arbid Ochratoxicosis: prevention of developmental toxicity by L-methionine in rats J Appl Toxicol 19 1999 7 12
25. S.Z. Sun, G.H. Anderson, B.D. Flickinger, P.S. Williamson-Hughes, and M.W. Empie Fructose and non-fructose sugar intakes in the US population and their associations with indicators of metabolic syndrome Food Chem Toxicol 49 2011 2875 2882
26. R.W. Walker, K.A. Dumke, and M.I. Goran Fructose content in popular beverages made with and without high-fructose corn syrup Nutrition 30 2014 928 935
27. X. Ouyang, P. Cirillo, Y. Sautin, S. McCall, J.L. Bruchette, A.M. Diehl, and et al. Fructose consumption as a risk factor for non-alcoholic fatty liver disease J Hepatol 48 2008 993 999
28. L. Ferder, M.D. Ferder, and F. Inserra The role of high-fructose corn syrup in metabolic syndrome and hypertension Curr Hypertens Rep 12 2010 105 112
29. W. Zhang, M. Wang, H.Y. Xie, L. Zhou, X.Q. Meng, J. Shi, and et al. Role of reactive oxygen species in mediating hepatic ischemia-reperfusion injury and its therapeutic applications in liver transplantation Transpl Proc 39 2007 1332 1337
30. L. Guan, H. Feng, D. Gong, X. Zhao, L. Cai, Q. Wu, and et al. Genipin ameliorates age-related insulin resistance through inhibiting hepatic oxidative stress and mitochondrial dysfunction Exp Gerontol 48 2013 1387 1394
31. B. Diesel, S. Kulhanek-Heinze, M. Höltje, B. Brandt, H.D. Höltje, A.M. Vollmar, and et al. Alpha-lipoic acid as a directly binding activator of the insulin receptor: protection from hepatocyte apoptosis Biochemistry 46 2007 2146 2155
32. S.S. Elliott, N.L. Keim, J.S. Stern, K. Teff, and P.J. Havel Fructose, weight gain, and the insulin resistance syndrome Am J Clin Nutr 76 2002 911 922
33. C.Y. Zou, Y. Gong, and J. Liang Metabolic signaling of insulin secretion by pancreatic β-cell and its derangement in type 2 diabetes Eur Rev Med Pharmacol Sci 18 2014 2215 2227
34. A. Siafarikas, R.J. Johnston, M.K. Bulsara, P. O'Leary, T.W. Jones, and E.A. Davis Early loss of the glucagon response to hypoglycemia in adolescents with type 1 diabetes Diabetes Care 35 2012 1757 1762
35. S. He, D. Wang, Y. Lu, Y. Chen, X. Jin, C. Wang, and et al. Increasing glucagon secretion could antagonize the action of exogenous insulin for glycemic control in streptozocin-induced diabetic rhesus monkeys Exp Biol Med (Maywood) 238 2013 385 391
36. R.W. Gelling, P.M. Vuguin, X.Q. Du, L. Cui, J. Romer, R.A. Pederson, and et al. Pancreatic b-cell overexpression of the glucagon receptor gene results in enhanced b-cell function and mass Am J Physiol Endocrinol Metab 297 2009 E695 E707
37. S.M. Alwahsh, M. Xu, H.A. Seyhan, S. Ahmad, S. Mihm, G. Ramadori, and et al. Diet high in fructose leads to an overexpression of lipocalin-2 in rat fatty liver World J Gastroenterol 20 2014 1807 1821
38. S. Dinneen, A. Alzaid, D. Turk, and R. Rizza Failure of glucagon suppression contributes to postprandial hyperglycaemia in IDDM Diabetologia 38 1995 337 343
39. P. Shah, A. Vella, A. Basu, R. Basu, W.F. Schwenk, and R.A. Rizza Lack of suppression of glucagon contributes to postprandial hyperglycemia in subjects with type 2 diabetes mellitus J Clin Endocrinol Metab 85 2000 4053 4059
40. M.A. Nauck, M.M. Heimesaat, K. Behle, J.J. Holst, M.S. Nauck, R. Ritzel, and et al. Effects of glucagon-like peptide 1 on counterregulatory hormone responses, cognitive functions, and insulin secretion during hyperinsulinemic, stepped hypoglycemic clamp experiments in healthy volunteers J Clin Endocrinol Metab 87 2002 1239 1246
41. J. Dupre, M.T. Behme, and T.J. McDonald Exendin-4 normalized postcibal glycemic excursions in type 1 diabetes J Clin Endocrinol Metab 89 2004 3469 3473
42. B.W. Lee, S.J. Kwon, H.Y. Chae, J.G. Kang, C.S. Kim, S.J. Lee, and et al. Dose-related cytoprotective effect of alpha-lipoic acid on hydrogen peroxide-induced oxidative stress to pancreatic beta cells Free Radic Res 43 2009 68 77
43. Y. Yang, W. Wang, Y. Liu, T. Guo, P. Chen, K. Ma, and et al. α-lipoic acid inhibits high glucose-induced apoptosis in HIT-T15 cells Dev Growth Diffe 54 2012 557 565
44. G. Koh, E.J. Yang, M.K. Kim, S.A. Lee, and D.H. Lee Alpha-lipoic acid treatment reverses 2-deoxy-D-ribose-induced oxidative damage and suppression of insulin expression in pancreatic beta-cells Biol Pharm Bull 36 2013 1570 1576
45. A. Marchioro, A.O. Mallmann, A. Diel, P. Dilkin, R.H. Rauber, F.J. Blazquez, and et al. Effects of aflatoxins on performance and exocrine pancreas of broiler chickens Avian Dis 57 2013 280 284