Alpha-lipoic acid treatment reverses 2-deoxy-D-ribose-induced oxidative damage and suppression of insulin expression in pancreatic beta-cells

Biological and Pharmaceutical Bulletin

Volumn 36, Issue 10, 2013, Pages 1570-1576

  Koh, Gwanpyo ^a   Yang, Eun Jin ^a   Kim, Min Kyoung ^b   Lee, Sang Ah ^a   Lee, Dae Ho ^c  

^a Jeju National University School of Medicine   (South Korea)

^b Multimedia Research Team   (South Korea)

^c Wonkwang University School of Medicine   (South Korea)

Author keywords

2 deoxy D ribose; Alpha lipoic acid; Glutathione; Oxidative stress; Pancreatic beta cell

Indexed keywords

2 DEOXYRIBOSE; BUTHIONINE SULFOXIMINE; GLUTATHIONE; GLUTATHIONE DISULFIDE; HYDROXYL RADICAL; INSULIN; MESSENGER RNA; REACTIVE OXYGEN METABOLITE; THIOCTIC ACID; TRANSCRIPTION FACTOR PDX 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL LEVEL; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; DRUG TARGETING; ENZYME ACTIVATION; ENZYME SYNTHESIS; FENTON REACTION; INSULIN SYNTHESIS; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PROTEIN DEPLETION; PROTEIN SYNTHESIS INHIBITION; RAT;

ANIMALS; ANTIOXIDANTS; BUTHIONINE SULFOXIMINE; DEOXYRIBOSE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; GLUCOSE; GLUTATHIONE; HOMEODOMAIN PROTEINS; INSULIN; INSULIN-SECRETING CELLS; OXIDATION-REDUCTION; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; THIOCTIC ACID;

EID: 84887060521     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.b13-00292     Document Type: Article

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