The efficacy and safety of tranexamic acid in cranio-maxillofacial and plastic surgery

Journal of Craniofacial Surgery

Volumn 27, Issue 2, 2016, Pages 374-379

  Murphy, George Richard Francis ^a   Glass, Graeme Ewan ^b,c   Jain, Abhilash ^b,c  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c CHARING CROSS HOSPITAL   (United Kingdom)

Author keywords

Blood loss; Craniosynostosis; Orthognathic; Tranexamic acid; Transfusion requirement

Indexed keywords

ANTIFIBRINOLYTIC AGENT; TRANEXAMIC ACID;

BLOOD LOSS, SURGICAL; BLOOD TRANSFUSION; FACE; FACIAL BONE; HUMAN; META ANALYSIS; MICROSURGERY; ORTHOGNATHIC SURGERY; PROCEDURES; RANDOMIZED CONTROLLED TRIAL (TOPIC); RECONSTRUCTIVE SURGERY; SAFETY; SKULL; SURGERY; TREATMENT OUTCOME;

ANTIFIBRINOLYTIC AGENTS; BLOOD LOSS, SURGICAL; BLOOD TRANSFUSION; FACE; FACIAL BONES; HUMANS; MICROSURGERY; ORTHOGNATHIC SURGICAL PROCEDURES; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RECONSTRUCTIVE SURGICAL PROCEDURES; SAFETY; SKULL; TRANEXAMIC ACID; TREATMENT OUTCOME;

EID: 84961778241     PISSN: 10492275     EISSN: 15363732     Source Type: Journal    
DOI: 10.1097/SCS.0000000000002250     Document Type: Article

References (46)

1. Shah MD, Goldstein DP, McCluskey SA, et al. Blood transfusion prediction in patients undergoing major head and neck surgery with free-flap reconstruction. Arch Otolaryngol Head Neck Surg 2010;136:1199-1204
2. Fenner M, Vairaktaris E, Nkenke E, et al. Prognostic impact of blood transfusion in patients undergoing primary surgery and free-flap reconstruction for oral squamous cell carcinoma. Cancer 2009;115:1481-1488
3. Szakmany T, Dodd M, Dempsey GA, et al. The influence of allogenic blood transfusion in patients having free-flap primary surgery for oral and oropharyngeal squamous cell carcinoma. Br J Cancer 2006;94: 647-653
4. Appleton SE, Ngan A, Kent B, et al. Risk factors influencing transfusion rates in DIEP flap breast reconstruction. Plast Reconstr Surg 2011;127:1773-1782
5. Rinker BD, Bowling JT, Vasconez HC. Blood transfusion and risk of metastatic disease or recurrence in patients undergoing immediate TRAM flap breast reconstruction: a clinical study and meta-analysis. Plast Reconstr Surg 2007;119:2001-2007
6. Tzilinis A, Lofman AM, Tzarnas CD. Transfusion requirements for TRAM flap postmastectomy breast reconstruction. Ann Plast Surg 2003;50:623-627
7. Choi WS, Irwin MG, Samman N. The effect of tranexamic acid on blood loss during orthognathic surgery: a randomized controlled trial. J Oral Maxillofac Surg 2009;67:125-133
8. Dadure C, Sauter M, Bringuier S, et al. Intraoperative tranexamic acid reduces blood transfusion in children undergoing craniosynostosis surgery: a randomized double-blind study. Anesthesiology 2011;114:856-861
9. Goobie SM, Meier PM, Pereira LM, et al. Efficacy of tranexamic acid in pediatric craniosynostosis surgery: a double-blind, placebo-controlled trial. Anesthesiology 2011;114:862-871
10. Sankar D, Krishnan R, Veerabahu M, et al. Evaluation of the efficacy of tranexamic acid on blood loss in orthognathic surgery. A prospective, randomized clinical study. Int J Oral Maxillofac Surg 2012;41:713-717
11. Hidalgo DA, Rekow A. A review of 60 consecutive fibula free flap mandible reconstructions. Plast Reconstr Surg 1995;96:585-596
12. Rossmiller SR, Cannady SB, Ghanem TA, et al. Transfusion criteria in free flap surgery. Otolaryngol Head Neck Surg 2010;142:359-364
13. Czerwinski M, Hopper RA, Gruss J, et al. Major morbidity and mortality rates in craniofacial surgery: an analysis of 8101 major procedures. Plast Reconstr Surg 2010;126:181-186
14. Goodnough LT, Brecher ME, Kanter MH, et al. Transfusion medicine. First of two parts-blood transfusion. N Engl J Med 1999;340:438-447
15. Gohel MS, Bulbulia RA, Slim FJ, et al. How to approach major surgery where patients refuse blood transfusion (including Jehovah's Witnesses). Ann R Coll Surg Engl 2005;87:3-14
16. McCormack PL. Tranexamic acid: a review of its use in the treatment of hyperfibrinolysis. Drugs 2012;72:585-617
17. Slaughter TF, Greenberg CS. Antifibrinolytic drugs and perioperative hemostasis. Am J Hematol 1997;56:32-36
18. Soslau G, Horrow J, Brodsky I. Effect of tranexamic acid on platelet ADP during extracorporeal circulation. Am J Hematol 1991;38:113-119
19. Godier A, Roberts I, Hunt BJ. Tranexamic acid: less bleeding and less thrombosis? Crit Care 2012;16:135
20. Amara U, Flierl MA, Rittirsch D, et al. Molecular intercommunication between the complement and coagulation systems. J Immunol 2010;185:5628-5636
21. Ogiwara K, Nogami K, Nishiya K, et al. Plasmin-induced procoagulant effects in the blood coagulation: a crucial role of coagulation factors V and VIII. Blood Coagul Fibrinolysis 2010;21:568-576
22. Henry DA, Carless PA, Moxey AJ, et al. Anti-fibrinolytic use for minimizing perioperative allogeneic blood transfusion. Cochrane Database Syst Rev 2011:CD001886
23. Perel P, Ker K, Morales Uribe CH, et al. Tranexamic acid for reducing mortality in emergency and urgent surgery. Cochrane Database Syst Rev 2013;1:CD010245
24. Ker K, Edwards P, Perel P, et al. Effect of tranexamic acid on surgical bleeding: systematic review and cumulative meta-analysis. BMJ 2012;344:e3054
25. Shakur H, Roberts I, Bautista R, et al. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomized, placebo-controlled trial. Lancet 2010;376:23-32
26. Roberts I, Shakur H, Afolabi A, et al. The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomized controlled trial. Lancet 2011;377:1096-1101
27. Horrow JC, Van Riper DF, Strong MD, et al. Hemostatic effects of tranexamic acid and desmopressin during cardiac surgery. Circulation 1991;84:2063-2070
28. Benoni G, Fredin H. Fibrinolytic inhibition with tranexamic acid reduces blood loss and blood transfusion after knee arthroplasty: a prospective, randomized, double-blind study of 86 patients. J Bone Joint Surg Br 1996;78:434-440
29. Tzortzopoulou A, Cepeda MS, Schumann R, et al. Antifibrinolytic agents for reducing blood loss in scoliosis surgery in children. Cochrane Database Syst Rev 2008:CD006883
30. Song G, Yang P, Zhu S, et al. Tranexamic acid reducing blood transfusion in children undergoing craniosynostosis surgery. J Craniofac Surg 2013;24:299-303
31. Song G, Yang P, Hu J, et al. The effect of tranexamic acid on blood loss in orthognathic surgery: a meta-analysis of randomized controlled trials. Oral Surg Oral Med Oral Pathol Oral Radiol 2013;115:595-600
32. Higgins JP, Altman DG, Gotzsche PC, et al. The Cochrane Collaboration's tool for assessing risk of bias in randomized trials. BMJ 2011;343:d5928
33. Duran de la Fuente P, Garcia-Fernandez J, Perez-Lopez C, et al. Usefulness of tranexamic acid in cranial remodeling surgery. Rev Esp Anestesiol Reanim 2003;50:388-394
34. Hanna MG, Refaie A, Gouda N, et al. Reductionof peri-operative bleeding in craniofacial surgeries in pediatrics; comparison between recombinant factor VII and tranexamic acid. Egypt J Anaesth 2010;26:53-61
35. Kaewpradub P, Apipan B, Rummasak D. Does tranexamic acid in an irrigating fluid reduce intraoperative blood loss in orthognathic surgery? A double-blind, randomized clinical trial. J Oral Maxillofac Surg 2011;69:e186-189
36. Karimi A, Mohammadi SS, Hasheminasab M. Efficacy of tranexamic acid on blood loss during bimaxilary osteotomy: a randomized double blind clinical trial. Saudi J Anaesth 2012;6:41-45
37. Chen CC, Wang CC, Wang CP, et al. Prospective, randomized, controlled trial of tranexamic acid in patients who undergo head and neck procedures. Otolaryngol Head Neck Surg 2008;138: 762-767
38. Oertli D, Laffer U, Haberthuer F, et al. Perioperative and postoperative tranexamic acid reduces the local wound complication rate after surgery for breast cancer. Br J Surg 1994;81:856-859
39. Kanechorn Na Ayuthaya P, Niumphradit N, Manosroi A, et al. Topical 5% tranexamic acid for the treatment of melasma in Asians: a double-blind randomized controlled clinical trial. J Cosmet Laser Ther 2012;14:150-154
40. Kato H, Araki J, Eto H, et al. Aprospective randomized controlled studyof oral tranexamic acid for preventing postinflammatory hyperpigmentation after Q-switched ruby laser. Dermatol Surg 2011;37:605-610
41. Abstracts of the Australasian College of Dermatologists 46th Annual Scientific Meeting. May 19-22, 2013. Sydney, New South Wales, Australia. Australas J Dermatol 2013;54:43
42. Shin JU, Park J, Oh SH, et al. Oral tranexamic acid enhances the efficacy of low-fluence 1064-nm quality-switched neodymium-doped yttrium aluminum garnet laser treatment for melasma in Koreans: a randomized, prospective trial. Dermatol Surg 2013;39:435-442
43. Namazi MR. Practice pearl: a novel anesthetic solution for decreasing the blood loss at the recipient site of hair transplantation (Namazi Solution). Aesthetic Plast Surg 2007;31:415
44. Namazi MR. Practice pearl: Using 'Namazi solution' for decreasing the formation of bruises in liposuction. J Cutan Aesthet Surg 2014;7:69-70
45. Tang YMJ, Chapman TWL, Brooks P. Use of tranexamic acid to reduce bleedinginburnssurgery. J Plast Reconstr Aesthet Surg 2012;65:684-686
46. Eriksson O, Kjellman H, Pilbrant A, et al. Pharmacokinetics of tranexamic acid after intravenous administration to normal volunteers. Eur J Clin Pharmacol 1974;7:375-380