Intraoperative tranexamic acid reduces blood transfusion in children undergoing craniosynostosis surgery: A randomized double-blind study

Anesthesiology

Volumn 114, Issue 4, 2011, Pages 856-861

  Dadure, Christophe ^a   Sauter, Magali ^a   Bringuier, Sophie ^a   Bigorre, Michelle ^a   Raux, Olivier ^a   Rochette, Alain ^a   Canaud, Nancy ^a   Capdevila, Xavier ^a  

^a LAPEYRONIE HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROPOIETIN; HETASTARCH; IRON; PLACEBO; TRANEXAMIC ACID;

ABSENCE OF SIDE EFFECTS; ARTICLE; BLEEDING; BLOOD TRANSFUSION; CHILD; CLINICAL ARTICLE; COLLOID; CONTINUOUS INFUSION; CONTROLLED STUDY; CRANIOFACIAL SYNOSTOSIS; CRYSTALLOID; DOUBLE BLIND PROCEDURE; DRUG COST; DRUG EFFICACY; DRUG MECHANISM; ERYTHROCYTE CONCENTRATE; FEMALE; HEART SURGERY; HUMAN; INFANT; INTRAOPERATIVE PERIOD; MALE; ORTHOPEDIC SURGERY; PEDIATRIC SURGERY; PERIOPERATIVE COMPLICATION; PREOPERATIVE TREATMENT; PRESCHOOL CHILD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREATMENT RESPONSE;

EID: 79953201596     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/ALN.0b013e318210f9e3     Document Type: Article

References (35)

1. Aviv RI, Rodger E, Hall CM: Craniosynostosis Clin Radiol 2002; 57:93-102
2. Cohen MM Jr: Craniosynostosis and syndromes with craniosynostosis: Incidence, genetics, penetrance, variability, and new syndrome updating. Birth Defects Orig Artic Ser 1979; 15:13-63 (Pubitemid 10183906)
3. Jimenez DF, Barone CM: Intraoperative autologous blood transfusion in the surgical correction of craniosynostosis. Neurosurgery 1995; 37:1075-9
4. Czerwinski M, Hopper RA, Gruss J, Fearon JA: Major morbidity and mortality rates in craniofacial surgery: An analysis of 8,101 major procedures. Plast Reconstr Surg 2010; 126: 181-6
5. Kneyber MC, Hersi MI, Twisk JW, Markhorst DG, Plotz FB: Red blood cell transfusion in critically ill children is independently associated with increased mortality. Intensive Care Med 2007; 33:1414-22 (Pubitemid 47101723)
6. Longatti PL, Paccagnella F, Agostini S, Nieri A, Carteri A: Autologous hemodonation in the corrective surgery of craniostenosis. Childs Nerv Syst 1991; 7:40-2
7. Hans P, Collin V, Bonhomme V, Damas F, Born JD, Lamy M: Evaluation of acute normovolemic hemodilution for surgical repair of craniosynostosis. J Neurosurg Anesthesiol 2000; 12:33-6 (Pubitemid 30040839)
8. Dahmani S, Orliaguet GA, Meyer PG, Blanot S, Renier D, Carli PA: Perioperative blood salvage during surgical correction of craniosynostosis in infants. Br J Anaesth 2000; 85:550-5
9. Helfaer MA, Carson BS, James CS, Gates J, Della-Lana D, Vander Kolk C: Increased hematocrit and decreased transfusion requirements in children given erythropoietin before undergoing craniofacial surgery. J Neurosurg 1998; 88:704-8 (Pubitemid 28145214)
10. Fearon JA, Weinthal J: The use of recombinant erythropoietin in the reduction of blood transfusion rates in craniosynostosis repair in infants and children. Plast Reconstr Surg 2002; 109:2190-6 (Pubitemid 34556189)
11. Meneghini L, Zadra N, Aneloni V, Metrangolo S, Faggin R, Giusti F: Erthropoeitin therapy and acute preoperative normovolaemic haemodilution in infants undergoing craniosynostosis surgery. Paediatr Anaesth 2003; 13:392-6 (Pubitemid 36774018)
12. Slaughter TF, Greenberg CS: Antifibrinolytic drugs and perioperative hemostasis. Am J Hematol 1997; 56:32-6 (Pubitemid 27398056)
13. Chauhan S, Bisoi A, Modi R, Gharde P, Rajesh MR: Tranexamic acid in paediatric cardiac surgery. Indian J Med Res 2003; 118:86-9 (Pubitemid 37493015)
14. Chauhan S, Das SN, Bisoi A, Kale S, Kiran U: Comparison of epsilon aminocaproic acid and tranexamic acid in pediatric cardiac surgery. J Cardiothorac Vasc Anesth 2004; 18:141-3 (Pubitemid 38506857)
15. Levin E, Wu J, Devine DV, Alexander J, Reichart C, Sett S, Seear M: Hemostatic parameters and platelet activation marker expression in cyanotic and acyanotic pediatric patients undergoing cardiac surgery in the presence of tranexamic acid. Thromb Haemost 2000; 83:54-9 (Pubitemid 30045477)
16. Bulutcu FS, Ozbek U, Polat B, Yalcin Y, Karaci AR, Bayindir O: Which may be effective to reduce blood loss after cardiac operations in cyanotic children: Tranexamic acid, aprotinin or a combination? Paediatr Anaesth 2005; 15:41-6 (Pubitemid 40188791)
17. Reid RW, Zimmerman AA, Laussen PC, Mayer JE, Gorlin JB, Burrows FA: The efficacy of tranexamic acid versus placebo in decreasing blood loss in pediatric patients undergoing repeat cardiac surgery. Anesth Analg 1997; 84:990-6 (Pubitemid 27197656)
18. Chauhan S, Bisoi A, Kumar N, Mittal D, Kale S, Kiran U, Venugopal P: Dose comparison of tranexamic acid in pediatric cardiac surgery. Asian Cardiovasc Thorac Ann 2004; 12:121-4 (Pubitemid 39010972)
19. Neilipovitz DT, Murto K, Hall L, Barrowman NJ, Splinter WM: A randomized trial of tranexamic acid to reduce blood transfusion for scoliosis surgery. Anesth Analg 2001; 93:82-7 (Pubitemid 32601158)
20. Sethna NF, Zurakowski D, Brustowicz RM, Bacsik J, Sullivan LJ, Shapiro F: Tranexamic acid reduces intraoperative blood loss in pediatric patients undergoing scoliosis surgery. ANESTHESIOLOGY 2005; 102:727-32 (Pubitemid 40462851)
21. Grant JA, Howard J, Luntley J, Harder J, Aleissa S, Parsons D: Perioperative blood transfusion requirements in pediatric scoliosis surgery: The efficacy of tranexamic acid. J Pediatr Orthop 2009; 29:300-4
22. D'Errico CC, Munro HM, Buchman SR, Wagner D, Muraszko KM: Efficacy of aprotinin in children undergoing craniofacial surgery. J Neurosurg 2003; 99:287-90 (Pubitemid 36900123)
23. Durán de la Fuente P, García-Fernández J, Péréz-López C, Carceller F, Gilsanz Rodriguez F: Usefulness of tranexamic acid in cranial remodeling surgery [in Spanish]. Rev Esp Anestesiol Reanim 2003; 50:388-94
24. Camboulives J, Paut O, Marti JY: Anesthésie du nourrisson et de l'enfant. In Encylopédie-Médico-Chirurgicale, Anesthésie- Réanimation, 36-640-A-20. Paris, Elsevier, 1996
25. Schouten ES, Van de Pol AC, Schouten AN, Turner NM, Jansen NJ, Bollen CW: The effect of aprotinin, tranexamic acid, and aminocaproic acid on blood loss and use of blood products in major pediatric surgery: A meta-analysis. Pediatr Crit Care Med 2009; 10:182-90
26. Orth VH, Rehm M, Thiel M, Kreimeier U, Haller M, Brechtelsbauer H, Finsterer U: First clinical implications of perioperative red cell volume measurement with a nonradioactive marker (sodium fluorescein). Anesth Analg 1998; 87:1234-8 (Pubitemid 28549482)
27. Elwatidy S, Jamjoom Z, Elgamal E, Zakaria A, Turkistani A, El-Dawlatly A: Efficacy and safety of prophylactic large dose of tranexamic acid in spine surgery: A prospective, randomized, double-blind, placebo-controlled study. Spine 2008; 33:2577-80
28. Agnelli G, Gresele P, De Cunto M, Gallai V, Nenci GG: Tranexamic acid, intrauterine contraceptive devices and fatal cerebral arterial thrombosis: Case report. Br J Obstet Gynaecol 1982; 89:681-2 (Pubitemid 12039934)
29. Woo KS, Tse LK, Woo JL, Vallance-Owen J: Massive pulmonary thromboembolism after tranexamic acid antifibrinolytic therapy. Br J Clin Pract 1989; 43:465-6 (Pubitemid 20017351)
30. Taparia M, Cordingley FT, Leahy MF: Pulmonary embolism associated with tranexamic acid in severe acquired haemophilia. Eur J Haematol 2002; 68:307-9
31. Parsons MR, Merritt DR, Ramsay RC: Retinal artery occlusion associated with tranexamic acid therapy. Am J Ophthalmol 1988; 105:688-9
32. Molenaar IQ, Warnaar N, Groen H, Tenvergert EM, Slooff MJ, Porte RJ: Efficacy and safety of antifibrinolytic drugs in liver transplantation: A systematic review and meta-analysis. Am J Transplant 2007; 7:185-94 (Pubitemid 44952872)
33. Schlag MG, Hopf R, Zifko U: Epileptic seizures following cortical application of fibrin sealants containing tranexamic acid in rats. Acta Neurochir 2002; 144:63-9 (Pubitemid 34117850)
34. Yeh HM, Lau HP, Lin PL, Sun WZ, Mok MS: Convulsion and refractory ventricular fibrillation after intrathecal injection of a massive dose of tranexamic acid. ANESTHESIOLOGY 2003; 98:270-2 (Pubitemid 36043438)
35. Murkin JM, Falter F, Granton J, Young B, Burt C, Chu M: High-dose tranexamic acid is associated with non-ischemic clinical seizure in cardiac surgical patients. Anesth Analg 2010; 110:350-3