Evaluation of the efficacy of tranexamic acid on blood loss in orthognathic surgery. A prospective, randomized clinical study

International Journal of Oral and Maxillofacial Surgery

Volumn 41, Issue 6, 2012, Pages 713-717

  Sankar, Duraiswamy ^a   Krishnan, Radhika ^a   Veerabahu, M ^a   Vikraman, B ^a  

^a RAGAS DENTAL COLLEGE AND HOSPITAL   (India)

Author keywords

blood loss; induced hypotension; tranexamic acid

Indexed keywords

GLYCERYL TRINITRATE; TRANEXAMIC ACID;

ADULT; ARTICLE; BLEEDING; BLOOD TRANSFUSION; BOLUS INJECTION; CLINICAL ARTICLE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG DOSE TITRATION; DRUG EFFECT; DRUG EFFICACY; EVALUATION; FEMALE; HUMAN; INDUCED HYPOTENSION; MALE; MAXILLOFACIAL SURGERY; OPERATION DURATION; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

ADOLESCENT; ADULT; ANESTHESIA, INTRAVENOUS; ANTIFIBRINOLYTIC AGENTS; BLOOD LOSS, SURGICAL; BLOOD TRANSFUSION; BLOOD VOLUME; DOUBLE-BLIND METHOD; FEMALE; HEMATOCRIT; HEMOGLOBINS; HUMANS; HYPOTENSION, CONTROLLED; MALE; MONITORING, INTRAOPERATIVE; NITROGLYCERIN; ORTHOGNATHIC SURGICAL PROCEDURES; PLACEBOS; PROSPECTIVE STUDIES; TIME FACTORS; TRANEXAMIC ACID; TREATMENT OUTCOME; VASODILATOR AGENTS; YOUNG ADULT;

EID: 84861335115     PISSN: 09015027     EISSN: 13990020     Source Type: Journal    
DOI: 10.1016/j.ijom.2012.01.008     Document Type: Article

References (25)

1. C.N.F. Yu, T.K. Chow, A.S.K. Kwan, S.L. Wong, and S.C. Fung Intra operative blood loss and operating time in orthognathic surgery using induced hypotensive general anesthesia: prospective study HKMJ 6 2000 307 311
2. T.R. Flood, V. Ilankovan, K.F. Moos, and A. El-Attar Cross-match requirements in orthognathic surgery: an audit Br J Oral Maxillofac Surg 28 1990 292 294
3. N. Samman, L.K. Cheung, A.C. Tong, and H. Tideman Blood loss and transfusion requirements in orthognathic surgery J Oral Maxillofac Surg 54 1996 21 24
4. R.G. Rohling, A.P. Zimmermann, P. Biro, P.E. Haers, and H.F. Sailer Alternative methods for reduction of blood loss during elective orthognathic surgery Int J Adult Orthodon Orthognath Surg 14 1999 77 82
5. T. Kovesi, and D. Royston Pharmacological approaches to reducing allogenic blood exposure Vox Sang 84 2003 2 10
6. C.J. Dunn, and K.L. Goa Tranexamic acid: a review of its use in surgery and other indications Drugs 57 1999 1005 1032
7. W.S. Choi, M.G. Irwin, and N. Samman The effect of tranexamic acid on blood loss during orthognathic surgery: a randomized controlled trial J Oral Maxillofac Surg 67 2009 125 133
8. G. Zellin, L. Rasmusson, J. Pålsson, and K.E. Kahnberg Evaluation of hemorrhage depressors on blood loss during orthognathic surgery: a retrospective study J oral Maxillofac Surg 62 2004 662 666
9. G.A. Fromme, R.A. Mackenzie, A.B. Gould, B.A. Lund, and K.P. Offord Controlled hypotension for orthognathic surgery Anesth Analg 65 1986 683 686
10. D.S. Precious, W. Splinter, and D. Bosco Induced hypotensive anesthesia for adolescent orthognathic surgery patients J Oral Maxillofac Surg 54 1996 680 683
11. The clinical use of blood-handbook 2002 World Health Organization (WHO), Blood Transfusion Safety Geneva 222 pp., 99.3 p. 167-70
12. A. Stewart, L. Newman, K. Sneddon, and M. Harris Aprotinin reduces blood loss and the need for transfusion in orthognathic surgery Br J Oral Maxillofac Surg 39 2001 365 370
13. G.N. Pedersen Salivary fibrinolytic activity before and after oral surgery estimated on different types of fibrin Int J Oral Surg 5 1976 270 275
14. V. Casati, D. Guzzon, M. Oppizzi, F. Bellotti, A. Franco, and C. Gerli Tranexamic acid compared with high dose aprotinin in primary elective operations; effects on perioperative bleeding and allogenic transfusions J Thorac Cardiovasc Surg 120 2000 520 527
15. N.P. Dowd, J.M. Karski, D.C. Cheng, J.A. Carroll, Y. Lin, and R.L. James Pharmacokinetics of tranexamic acid during cardiopulmonary bypass Anesthesiology 97 2002 390 399
16. W.R. Jamelson, P.J. Dryden, J.P. O'Connor, H. Sadeghi, D.M. Ansley, and P.M. Merrick Beneficial effect of both tranexamic acid and aprotinin on blood loss reduction in reoperative valve replacement surgery Circulation 4 1997 96 100
17. R.W. Reid, A.A. Zimmerman, P.C. Laussen, J.E. Mayer, J.B. Gorlin, and F.A. Burrows The efficacy of tranexamic acid versus placebo in decreasing blood loss in pediatric patients undergoing repeat cardiac surgery Anesth Analg 84 1997 990 996
18. L. Andersson, I.M. Nilsoon, S. Colleen, B. Granstrand, and B. Melander Role of urokinase and tissue activator in sustaining bleeding and the management thereof with EACA and AMCA Ann N Y Acad Sci 146 1968 642 658
19. J.C. Horrow, D.F. Van riper, M.D. Strong, K.E. Grunewald, and J.L. Parmet The dose response relationship of tranexamic acid Anesthesiology 82 1995 383 392
20. B.K. Fiechtner, G.A. Nuttall, M.E. Johnson, Y. Dong, N. Sujirattanawimol, and W.C. Oliver Jr. Plasma tranexamic acid concentration during cardio pulmonary bypass Anesth Analg 92 2001 1131 1136
21. R.M. Dolman, K.C. Bentley, T.W. Head, and M. English The effect of hypotensive anesthesia on blood loss and operative time during Lefort I osteotomies J Oral Maxillofac Surg 58 2000 840
22. M.Y. Gai, L.F. Wu, Q.F. Su, and K. Tatsumoto Clinical observation of blood loss reduced by tranexamic acid during and after caesarian section; a multi-centre, randomized trial Eur J Obstet Gynecol Reprod Biol 112 2004 154 157
23. P.S. Wells Safety and efficacy of methods for reducing perioperative allogenic transfusion. A critical review of the literature Am J Ther 9 2002 377 388
24. D.T. Lanigan, J.H. Hey, and R.A. West Major vascular complications of orthognathic surgery J Oral Maxillofac Surg 48 1990 561 573
25. R.D. Marcinni Blood loss and transfusion requirements in orthognathic surgery - discussion J Oral Maxillofac Surg 54 1996 25 26