Prospective, randomized, controlled trial of tranexamic acid in patients who undergo head and neck procedures

Otolaryngology - Head and Neck Surgery

Volumn 138, Issue 6, 2008, Pages 762-767

  Chen, Chih Cheng ^a   Wang, Chen Chi ^a,b   Wang, Ching Ping ^a,b   Lin, Tseng Hsi ^a   Lin, Whe Dar ^c   Liu, Shih An ^a,b  

^a TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c OVERSEAS CHINESE INSTITUTE OF TECHNOLOGY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

SODIUM CHLORIDE; TRANEXAMIC ACID;

ADULT; AGED; ARTICLE; BLEEDING; BLOOD CLOTTING; BLOOD SAMPLING; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE COURSE; DOUBLE BLIND PROCEDURE; FEMALE; HEAD AND NECK SURGERY; HUMAN; MALE; NECK DISSECTION; OPERATION DURATION; PAROTIDECTOMY; PERIOPERATIVE PERIOD; PROPHYLAXIS; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SURGICAL DRAINAGE; THYROIDECTOMY; WOUND INFECTION;

ADULT; AGED; AGED, 80 AND OVER; ANTIFIBRINOLYTIC AGENTS; DOUBLE-BLIND METHOD; DRAINAGE; FEMALE; HUMANS; MALE; MIDDLE AGED; OTORHINOLARYNGOLOGIC SURGICAL PROCEDURES; POSTOPERATIVE CARE; POSTOPERATIVE HEMORRHAGE; PROSPECTIVE STUDIES; THYROIDECTOMY; TIME FACTORS; TRANEXAMIC ACID;

EID: 43949128736     PISSN: 01945998     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.otohns.2008.02.022     Document Type: Article

References (20)

1. Williams J., Toews D., and Prince M. Survey of the use of suction drains in head and neck surgery and analysis of their biomechanical properties. J Otolaryngol 32 (2003) 16-22
2. Urquhart A.C., and Berg R.L. Neck dissections: predicting postoperative drainage. Laryngoscope 112 (2002) 1294-1298
3. Vilar-Compte D., Jacquemin B., Robles-Vidal C., et al. Surgical site infections in breast surgery: case-control study. World J Surg 28 (2004) 242-246
4. Patel V.P., Walsh M., Sehgal B., et al. Factors associated with prolonged wound drainage after primary total hip and knee arthroplasty. J Bone Joint Surg Am 89 (2007) 33-38
5. Porte R.J., and Leebeek F.W.G. Pharmacological strategies to decrease transfusion requirements in patients undergoing surgery. Drugs 62 (2002) 2193-2211
6. Neilipovitz D.T. Tranexamic acid for major spinal surgery. Eur Spine J 13 Suppl.1 (2004) S62-S65
7. Zabeeda D., Medalion B., Sverdlov M., et al. Tranexamic acid reduces bleeding and the need for blood transfusion in primary myocardial revascularization. Ann Thorac Surg 74 (2002) 733-738
8. Yamasaki S., Masuhara K., and Fuji T. Tranexamic acid reduces blood loss after cementless total hip arthroplasty: prospective randomized study in 40 cases. Int Orthop 28 (2004) 69-73
9. Camarasa M.A., Olle G., Serra-Prat M., et al. Efficacy of aminocaproic, tranexamic acids in the control of bleeding during total knee replacement: a randomized clinical trial. Br J Anaesth 96 (2006) 576-582
10. Su H.Y., Ding D.C., Chen D.C., et al. Prospective randomized comparison of single-dose versus 1-day cefazolin for prophylaxis in gynecologic surgery. Acta Obstet Gynecol Scand 84 (2005) 384-389
11. Benoni G., Lethagen S., Nilsson P., et al. Tranexamic acid, given at the end of the operation, does not reduce postoperative blood loss in hip arthroplasty. Acta Orthop Scand 71 (2000) 250-254
12. Koh M.B.C., and Hunt B.J. The management of peri-operative bleeding. Blood Rev 17 (2003) 179-185
13. Dalloglio M.F., Srougi M., Antunes A.A., et al. An improved technique for controlling bleeding during simple retropubic prostatectomy: a randomized controlled study. BJU Int 98 (2006) 384-387
14. Fergusson D., Blair A., Henry D., et al. Technologies to minimize blood transfustion in cardiac and orthopedic surgery: results of a practice variation survey in nine countries. International Study of Peri-operative Transfusion (ISPOT) Investigators. Int J Technol Assess Health Care 15 (1999) 717-728
15. Benoni G., Bjorkman S., and Fredin H. Application of pharmacokinetic data from healthy volunteers for the prediction of plasma concentrations of traexamic acid in surgical patients. Clin Drug Invest 10 (1995) 280-287
16. Orpen N.M., Little C., Walker G., et al. Tranexamic acid reduces early post-operative blood loss after total knee arthroplasty: a prospective randomized controlled trial of 29 patients. Knee 13 (2006) 106-110
17. Horrow J.C., Van Riper D.F., Strong M.D., et al. The dose-response relationship of tranexamic acid. Anesthesiology 82 (1995) 383-392
18. Armellin G., Casella S., Guzzinati S., et al. Tranexamic acid in aortic valve replacement. J Cardiothorac Vasc Anesth 15 (2001) 331-335
19. Casati V., Sandrelli L., Speziali G., et al. Hemostatic effects of tranexamic acid in elective thoracic aortic surgery: a prospective, randomized, double-blind, placebo-controlled study. J Thorac Cardiovasc Surg 123 (2002) 1084-1091
20. Benoni G., Lethagen S., and Fredin H. The effect of tranexamic acid on local and plasma fibrinolysis during total knee arthroplasty. Thromb Res 85 (1997) 195-206