The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation

Nature

Volumn 531, Issue 7595, 2016, Pages 523-527

  Ravindran, Rajesh ^a   Loebbermann, Jens ^a   Nakaya, Helder I ^b   Khan, Nooruddin ^c   Ma, Hualing ^a   Gama, Leonardo ^b   Machiah, Deepa K ^a   Lawson, Benton ^a   Hakimpour, Paul ^a   Wang, Yi Chong ^a   Li, Shuzhao ^a   Sharma, Prachi ^a   Kaufman, Randal J ^d   Martinez, Jennifer ^e   Pulendran, Bali ^a  

^a EMORY UNIVERSITY   (United States)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c UNIVERSITY OF HYDERABAD   (India)

^d BURNHAM INSTITUTE   (United States)

^e NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; GENERAL CONTROLLED NON REPRESSED KINASE 2; INFLAMMASOME; INTERLEUKIN 1BETA; PHOSPHOTRANSFERASE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; ATG5 PROTEIN, HUMAN; ATG7 PROTEIN, HUMAN; AUTOPHAGY RELATED PROTEIN 5; AUTOPHAGY RELATED PROTEIN 7; EIF2AK4 PROTEIN, MOUSE; MICROTUBULE ASSOCIATED PROTEIN; PROTEIN SERINE THREONINE KINASE; UBIQUITIN PROTEIN LIGASE;

AMINO ACID; CELLS AND CELL COMPONENTS; DIGESTIVE SYSTEM; HOMEOSTASIS; OXYGEN; RODENT; SENSOR;

ANIMAL CELL; ANIMAL TISSUE; ANTIGEN PRESENTING CELL; ARTICLE; AUTOPHAGY; CONTROLLED STUDY; ENTERITIS; EPITHELIUM CELL; FEMALE; GENE DELETION; INTESTINE EPITHELIUM CELL; KWASHIORKOR; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN FUNCTION; TH17 CELL; ANIMAL; ANTAGONISTS AND INHIBITORS; COLITIS; DEFICIENCY; DISEASE MODEL; GENETICS; HUMAN; IMMUNOLOGY; INFLAMMATION; INTESTINE; METABOLISM; PATHOLOGY; PHYSIOLOGICAL STRESS;

EUKARYOTA; MUS;

AMINO ACIDS; ANIMALS; ANTIGEN-PRESENTING CELLS; AUTOPHAGY; AUTOPHAGY-RELATED PROTEIN 5; AUTOPHAGY-RELATED PROTEIN 7; COLITIS; DISEASE MODELS, ANIMAL; EPITHELIAL CELLS; FEMALE; HUMANS; INFLAMMASOMES; INFLAMMATION; INTERLEUKIN-1BETA; INTESTINES; MALE; MICE; MICROTUBULE-ASSOCIATED PROTEINS; PROTEIN-SERINE-THREONINE KINASES; REACTIVE OXYGEN SPECIES; STRESS, PHYSIOLOGICAL; TH17 CELLS; UBIQUITIN-ACTIVATING ENZYMES;

EID: 84961721972     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature17186     Document Type: Article

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