The protective effect of gangliosides on lead (Pb)-induced neurotoxicity is mediated by autophagic pathways

International Journal of Environmental Research and Public Health

Volumn 13, Issue 4, 2016, Pages

  Meng, Hongtao ^a   Wang, Lan ^a   He, Junhong ^a   Wang, Zhufeng ^a  

^a Armed Police Hospital of Shanxi Province   (China)

Author keywords

Apoptosis; Autophagy; Gangliosides; Lead

Indexed keywords

GANGLIOSIDE; GANGLIOSIDE MIXTURE; MAMMALIAN TARGET OF RAPAMYCIN; UNCLASSIFIED DRUG; LEAD; MTOR PROTEIN, RAT; POLLUTANT; TARGET OF RAPAMYCIN KINASE;

APOPTOSIS; INHIBITION; LEAD; NERVOUS SYSTEM; TOXICITY;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOPHAGY; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; DRUG MECHANISM; DRUG MIXTURE; FEMALE; MALE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PROTEIN EXPRESSION; RAT; REFERENCE MEMORY; SPATIAL MEMORY; ANIMAL; DRUG EFFECTS; HIPPOCAMPUS; METABOLISM; NERVE CELL; POLLUTANT; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; TOXICITY;

MAMMALIA; RATTUS;

ANIMALS; APOPTOSIS; AUTOPHAGY; ENVIRONMENTAL POLLUTANTS; FEMALE; GANGLIOSIDES; HIPPOCAMPUS; LEAD; MALE; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84961680261     PISSN: 16617827     EISSN: 16604601     Source Type: Journal    
DOI: 10.3390/ijerph13040365     Document Type: Article

References (30)

1. Pande, M.; Flora, S.J. Lead induced oxidative damage and its response to combined administration of alpha-lipoic acid and succimers in rats. Toxicology 2002, 177, 187-196.[CrossRef]
2. Nieboer, E.; Tsuji, L.J.; Martin, I.D.; Liberda, E.N. Human biomonitoring issues related to lead exposure. Environ. Sci. Process. Impacts 2013, 15, 1824-1829.[CrossRef] [PubMed]
3. Warniment, C.; Tsang, K.; Galazka, S.S. Lead poisoning in children. Am. Fam. Physician 2010, 81, 751-757. [PubMed]
4. Liu, K.S.; Hao, J.H.; Zeng, Y.; Dai, F.C.; Gu, P.Q. Neurotoxicity and biomarkers of lead exposure: A review. Chin. Med. Sci. J. 2013, 28, 178-188.[CrossRef]
5. Nava-Ruiz, C.; Mendez-Armenta, M.; Rios, C. Lead neurotoxicity: Effects on brain nitric oxide synthase. J. Mol. Histol. 2012, 43, 553-563.[CrossRef] [PubMed]
6. Suszkiw, J.B. Presynaptic disruption of transmitter release by lead. Neurotoxicology 2004, 25, 599-604.[CrossRef] [PubMed]
7. Zhang, J.; Cai, T.; Zhao, F.; Yao, T.; Chen, Y.; Liu, X.; Luo, W.; Chen, J. The role of alpha-synuclein and tau hyperphosphorylation-mediated autophagy and apoptosis in lead-induced learning and memory injury. Int. J. Biol. Sci. 2012, 8, 935-944.[CrossRef] [PubMed]
8. Wang, Q.; Luo, W.; Zhang, W.; Dai, Z.; Chen, Y.; Chen, J. Iron supplementation protects against lead-induced apoptosis through MAPK pathway in weanling rat cortex. Neurotoxicology 2007, 28, 850-859.[CrossRef] [PubMed]
9. Su, P.; Zhao, F.; Cao, Z.; Zhang, J.; Aschner, M.; Luo, W. Mir-203-mediated tricellulin mediates lead-induced in vitro loss of blood-cerebrospinal fluid barrier (BCB) function. Toxicol. In Vitro 2015, 29, 1185-1194.[CrossRef] [PubMed]
10. Yu, R.K.; Nakatani, Y.; Yanagisawa, M. The role of glycosphingolipid metabolism in the developing brain. J. Lipid Res. 2009, 50, S440-S445.[CrossRef] [PubMed]
11. Ledeen, R.W.; Wu, G. Nuclear sphingolipids: Metabolism and signaling. J. Lipid Res. 2008, 49, 1176-1186.[CrossRef] [PubMed]
12. Nezuo, M.; Shogomori, H.; Hoshi, M.; Yamamoto, T.; Teshima, T.; Shiba, T.; Chiba, K. Developmental changes in localization of the main gangliosides during sea urchin embryogenesis. Glycobiology 2000, 10, 1243-1247.[CrossRef] [PubMed]
13. Cuello, A.C. Gangliosides, NGF, brain aging and disease: A mini-review with personal reflections. Neurochem. Res. 2012, 37, 1256-1260.[CrossRef] [PubMed]
14. Taki, T. An approach to glycobiology from glycolipidomics: Gangliosides molecular scanning in the brains of patients with Alzheimer’s disease by TLC-blot/matrix assisted laser desorption/ionization-time of flight MS. Biol. Pharm. Bull. 2012, 35, 1642-1647.[CrossRef] [PubMed]
15. Yanagisawa, K. Role of gangliosides in Alzheimer’s disease. Biochim. Biophys. Acta 2007, 1768, 1943-1951.[CrossRef] [PubMed]
16. Yu, R.K.; Tsai, Y.T.; Ariga, T. Functional roles of gangliosides in neurodevelopment: An overview of recent advances. Neurochem. Res. 2012, 37, 1230-1244.[CrossRef] [PubMed]
17. Cox, T.M.; Cachon-Gonzalez, M.B. The cellular pathology of lysosomal diseases. J. Pathol. 2012, 226, 241-254.[CrossRef] [PubMed]
18. Orr, C.F.; Rowe, D.B.; Halliday, G.M. An inflammatory review of Parkinson’s disease. Prog. Neurobiol. 2002, 68, 325-340.[CrossRef]
19. She, J.Q.; Wang, M.; Zhu, D.M.; Sun, L.G.; Ruan, D.Y. Effect of gangliosides on synaptic plasticity of hippocampus in lead-exposed rats in vivo. Brain Res. 2005, 1060, 162-169.[CrossRef] [PubMed]
20. Jung, C.H.; Ro, S.H.; Cao, J.; Otto, N.M.; Kim, D.H. mTOR regulation of autophagy. FEBS Lett. 2010, 584, 1287-1295.[CrossRef] [PubMed]
21. Lopes, A.C.; Peixe, T.S.; Mesas, A.E.; Paoliello, M.M. Lead Exposure and Oxidative Stress: A Systematic Review. Rev. Environ. Contam. Toxicol. 2016, 236, 193-238.[PubMed]
22. Zhai, Q.; Narbad, A.; Chen, W. Dietary strategies for the treatment of cadmium and lead toxicity. Nutrients 2015, 7, 552-571.[CrossRef] [PubMed]
23. Mei, Z.T.; Zheng, J.Z. Effects of exogenous gangliosides on learning and memory in rats. Jpn. J. Physiol. 1993, 43, S295-S299. [PubMed]
24. She, J.Q.; Wang, M.; Zhu, D.M.; Tang, M.; Chen, J.T.; Wang, L.; Ruan, D.Y. Monosialoanglioside (GM1) prevents lead-induced neurotoxicity on long-term potentiation, SOD activity, MDA levels, and intracellular calcium levels of hippocampus in rats. Naunyn Schmiedebergs Arch. Pharmacol. 2009, 379, 517-524.[CrossRef] [PubMed]
25. Cappelletti, C.; Galbardi, B.; Kapetis, D.; Vattemi, G.; Guglielmi, V.; Tonin, P.; Salerno, F.; Morandi, L.; Tomelleri, G.; Mantegazza, R. et al. Autophagy, inflammation and innate immunity in inflammatory myopathies. PLoS ONE 2014, 9.[CrossRef] [PubMed]
26. Alirezaei, M.; Kemball, C.C.; Whitton, J.L. Autophagy, inflammation and neurodegenerative disease. Eur. J. Neurosci. 2011, 33, 197-204.[CrossRef] [PubMed]
27. Jiang, P.; Mizushima, N. Autophagy and human diseases. Cell Res. 2014, 24, 69-79.[CrossRef] [PubMed]
28. Hwang, J.; Lee, S.; Lee, J.T.; Kwon, T.K.; Kim, D.R.; Kim, H.; Park, H.C.; Suk, K. Gangliosides induce autophagic cell death in astrocytes. Br. J. Pharmacol. 2010, 159, 586-603.[CrossRef] [PubMed]
29. Hwang, J.; Lee, H.J.; Lee, W.H.; Suk, K. NF-kappaB as a common signaling pathway in ganglioside-induced autophagic cell death and activation of astrocytes. J. Neuroimmunol. 2010, 226, 66-72.[CrossRef] [PubMed]
30. Takamura, A.; Higaki, K.; Kajimaki, K.; Otsuka, S.; Ninomiya, H.; Matsuda, J.; Ohno, K.; Suzuki, Y.; Nanba, E. Enhanced autophagy and mitochondrial aberrations in murine G(M1)-gangliosidosis. Biochem. Biophys. Res. Commun. 2008, 367, 616-622.[CrossRef] [PubMed]