Sympathetic hyper-excitation in obesity and pulmonary hypertension: Physiological relevance to the 'obesity paradox'

International Journal of Obesity

Volumn 40, Issue 6, 2016, Pages 938-946

  Diong, C ^a   Jones, P P ^a   Tsuchimochi, H ^b   Gray, E A ^a   Hughes, G ^a   Inagaki, T ^b   Bussey, C T ^a   Fujii, Y ^b   Umetani, K ^c   Shirai, M ^b   Schwenke, D O ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

^b NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^c JAPAN SYNCHROTRON RADIATION RESEARCH INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ATENOLOL; PROPRANOLOL; BETA ADRENERGIC RECEPTOR BLOCKING AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BETA ADRENERGIC RECEPTOR BLOCKING; CONTROLLED STUDY; DRUG EFFECT; ELECTROPHYSIOLOGY; HYPOXIA; HYPOXIC LUNG VASOCONSTRICTION; LUNG CIRCULATION; LUNG INNERVATION; LUNG VASCULAR RESISTANCE; MICROANGIOGRAPHY; MICROCIRCULATION; NONHUMAN; OBESITY; PHYSIOLOGICAL PROCESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY HYPERTENSION; RAT; RECEPTOR DOWN REGULATION; SYMPATHETIC TONE; SYNCHROTRON; VASOCONSTRICTION; WESTERN BLOTTING; ZUCKER FATTY RAT; ZUCKER LEAN RAT; ADRENERGIC SYSTEM; ANIMAL; DISEASE MODEL; LUNG; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; VASCULARIZATION; ZUCKER RAT;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; DISEASE MODELS, ANIMAL; HYPERTENSION, PULMONARY; HYPOXIA; LUNG; MICROCIRCULATION; OBESITY; PROPRANOLOL; RATS; RATS, ZUCKER; SYMPATHETIC NERVOUS SYSTEM; VASOCONSTRICTION;

EID: 84961393727     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/ijo.2016.33     Document Type: Article

References (37)

1. Parameswaran K, Todd DC, Soth M. Altered respiratory physiology in obesity. Can Respir J 2006; 13: 203-210.
2. Sztrymf B, Ioos V, Sitbon O, Parent F, Simonneau G, Humbert M. Pulmonary hypertension and obesity. Rev Pneumol Clin 2002; 58: 104-110.
3. Dela Cruz CS, Matthay RA. Role of obesity in cardiomyopathy and pulmonary hypertension. Clin Chest Med 2009; 30: 509-523 ix.
4. Badheka AO, Rathod A, Kizilbash MA, Garg N, Mohamad T, Afonso L et al. Influence of obesity on outcomes in atrial fibrillation: yet another obesity paradox. Am J Med 2010; 123: 646-651.
5. Strandberg TE, Strandberg AY, Salomaa VV, Pitkala KH, Tilvis RS, Sirola J et al. Explaining the obesity paradox: cardiovascular risk, weight change, and mortality during long-term follow-up in men. Eur Heart J 2009; 30: 1720-1727.
6. Dixon JB, Lambert GW. The obesity paradox-a reality that requires explanation and clinical interpretation. Atherosclerosis 2013; 226: 47-48.
7. Ozeke O, Ozer C, Gungor M, Celenk MK, Dincer H, Ilicin G. Chronic intermittent hypoxia caused by obstructive sleep apnea may play an important role in explaining the morbidity-mortality paradox of obesity. Med Hypotheses 2011; 76: 61-63.
8. Lavie CJ, Milani RV, Artham SM, Patel DA, Ventura HO. The obesity paradox, weight loss, and coronary disease. Am J Med 2009; 122: 1106-1114.
9. Romero-Corral A, Montori VM, Somers VK, Korinek J, Thomas RJ, Allison TG et al. Association of bodyweight with total mortality and with cardiovascular events in coronary artery disease: A systematic review of cohort studies. Lancet 2006; 368: 666-678.
10. Zafrir B, Adir Y, Shehadeh W, Shteinberg M, Salman N, Amir O. The association between obesity, mortality and filling pressures in pulmonary hypertension patients; the "obesity paradox". Respir Med 2013; 107: 139-146.
11. Schwenke DO, Pearson JT, Kangawa K, Umetani K, Shirai M. Changes in macrovessel pulmonary blood flow distribution following chronic hypoxia: Assessed using synchrotron radiation microangiography. J Appl Physiol 2008; 104: 88-96.
12. Mueller PJ, Mischel NA, Scislo TJ. Differential activation of adrenal, renal, and lumbar sympathetic nerves following stimulation of the rostral ventrolateral medulla of the rat. Am J Physiol Regul Integr Comp Physiol 2011; 300: R1230-R1240.
13. Moral-Sanz J, Menendez C, Moreno L, Moreno E, Cogolludo A, Perez-Vizcaino F. Pulmonary arterial dysfunction in insulin resistant obese Zucker rats. Respir Res 2011; 12 51.
14. Shirai M, Tsuchimochi H, Nagai H, Gray E, Pearson JT, Sonobe T et al. Pulmonary vascular tone is dependent on the central modulation of sympathetic nerve activity following chronic intermittent hypoxia. Basic Res Cardiol 2014; 109: 432.
15. Schwenke DO, Tokudome T, Kishimoto I, Horio T, Cragg PA, Shirai M et al. One dose of ghrelin prevents the acute and sustained increase in cardiac sympathetic tone after myocardial infarction. Endocrinology 2012; 153: 2436-2443.
16. Schwenke DO, Tokudome T, Shirai M, Hosoda H, Horio T, Kishimoto I et al. Early ghrelin treatment after myocardial infarction prevents an increase in cardiac sympathetic tone and reduces mortality. Endocrinology 2008; 149: 5172-5176.
17. Shirai M, Schwenke DO, Tsuchimochi H, Umetani K, Yagi N, Pearson JT. Synchrotron radiation imaging for advancing our understanding of cardiovascular function. Circ Res 2013; 112: 209-221.
18. Huber DA, Schreihofer AM. Attenuated baroreflex control of sympathetic nerve activity in obese Zucker rats by central mechanisms. J Physiol 2010; 588: 1515-1525.
19. Alvarez GE, Beske SD, Ballard TP, Davy KP. Sympathetic neural activation in visceral obesity. Circulation 2002; 106: 2533-2536.
20. Calbet JA. Chronic hypoxia increases blood pressure and noradrenaline spillover in healthy humans. J Physiol 2003; 551: 379-386.
21. Hansen J, Sander M. Sympathetic neural overactivity in healthy humans after prolonged exposure to hypobaric hypoxia. J Physiol 2003; 546: 921-929.
22. Moraes DJ, Zoccal DB, Machado BH. Medullary respiratory network drives sympathetic overactivity and hypertension in rats submitted to chronic intermittent hypoxia. Hypertension 2012; 60: 1374-1380.
23. Neubauer JA, Sunderram J. Heme oxygenase-1 and chronic hypoxia. Respir Physiol Neurobiol 2012; 184: 178-185.
24. Costa-Silva JH, Zoccal DB, Machado BH. Chronic intermittent hypoxia alters glutamatergic control of sympathetic and respiratory activities in the commissural NTS of rats. Am J Physiol Regul Integr Comp Physiol 2012; 302: R785-R793.
25. Marina N, Tang F, Figueiredo M, Mastitskaya S, Kasimov V, Mohamed-Ali V et al. Purinergic signalling in the rostral ventro-lateral medulla controls sympathetic drive and contributes to the progression of heart failure following myocardial infarction in rats. Basic Res Cardiol 2013; 108: 317.
26. Sharpe AL, Calderon AS, Andrade MA, Cunningham JT, Mifflin SW, Toney GM. Chronic intermittent hypoxia increases sympathetic control of blood pressure: role of neuronal activity in the hypothalamic paraventricular nucleus. Am J Physiol Heart Circ Physiol 2013; 305: H1772-H1780.
27. Hausberg M, Morgan DA, Mitchell JL, Sivitz WI, Mark AL, Haynes WG. Leptin potentiates thermogenic sympathetic responses to hypothermia: A receptor-mediated effect. Diabetes 2002; 51: 2434-2440.
28. Mark AL, Agassandian K, Morgan DA, Liu X, Cassell MD, Rahmouni K. Leptin signaling in the nucleus tractus solitarii increases sympathetic nerve activity to the kidney. Hypertension 2009; 53: 375-380.
29. Shirai M, Matsukawa K, Nishiura N, Kawaguchi AT, Ninomiya I. Changes in efferent pulmonary sympathetic nerve activity during systemic hypoxia in anesthetized cats. Am J Physiol Regul Integr Comp Physiol 1995; 269: R1404-R1409.
30. Nagai H, Kuwahira I, Schwenke DO, Tsuchimochi H, Nara A, Inagaki T et al. Beta2-adrenergic receptor-dependent attenuation of hypoxic pulmonary vasoconstriction prevents progression of pulmonary arterial hypertension in intermittent hypoxic rats. PLoS One 2014; 9: e110693.
31. Schwenke DO, Pearson JT, Kangawa K, Shirai M. Does central nitric oxide chronically modulate the acute hypoxic ventilatory response in conscious rats? Acta Physiol 2006; 186: 309-318.
32. Bristow MR. Changes in myocardial and vascular receptors in heart failure. J Am Coll Cardiol 1993; 22: 61A-71A.
33. Nikolaev VO, Moshkov A, Lyon AR, Miragoli M, Novak P, Paur H et al. Beta2-adrenergic receptor redistribution in heart failure changes cAMP compartmentation. Science 2010; 327: 1653-1657.
34. Lefkowitz RJ, Rockman HA, Koch WJ. Catecholamines, cardiac beta-adrenergic receptors, and heart failure. Circulation 2000; 101: 1634-1637.
35. Kacimi R, Richalet JP, Corsin A, Abousahl I, Crozatier B. Hypoxia-induced downregulation of beta-adrenergic receptors in rat heart. J Appl Physiol (1985) 1992; 73: 1377-1382.
36. Nijkamp FP, Engels F, Henricks PA, Van Oosterhout AJ. Mechanisms of betaadrenergic receptor regulation in lungs and its implications for physiological responses. Physiol Rev 1992; 72: 323-367.
37. Sharma V, McNeill JH. Parallel effects of beta-adrenoceptor blockade on cardiac function and fatty acid oxidation in the diabetic heart: confronting the maze. World J Cardiol 2011; 3: 281-302.