β2-adrenergic receptor-dependent attenuation of hypoxic pulmonary vasoconstriction prevents progression of pulmonary arterial hypertension in intermittent hypoxic rats

PLoS ONE

Volumn 9, Issue 10, 2014, Pages

  Nagai, Hisashi ^a,b   Kuwahira, Ichiro ^c   Schwenke, Daryl O ^d   Tsuchimochi, Hirotsugu ^e   Nara, Akina ^b   Inagaki, Tadakatsu ^e   Ogura, Sayoko ^b,f   Fujii, Yutaka ^e   Umetani, Keiji ^g   Shimosawa, Tatsuo ^b   Yoshida, Kenichi ^b,h   Pearson, James T ^i,j   Uemura, Koichi ^a   Shirai, Mikiyasu ^e  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c TOKAI UNIVERSITY TOKYO HOSPITAL   (Japan)

^d UNIVERSITY OF OTAGO   (New Zealand)

^e NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^f NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^g JAPAN SYNCHROTRON RADIATION RESEARCH INSTITUTE   (Japan)

^h TOKYO MEDICAL UNIVERSITY   (Japan)

ⁱ MONASH UNIVERSITY   (Australia)

^j AUSTRALIAN SYNCHROTRON   (Australia)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ATENOLOL; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; ENDOTHELIAL NITRIC OXIDE SYNTHASE; NADOLOL; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; BETA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE 3 KINASE;

ADRENERGIC RECEPTOR BLOCKING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY DIAMETER; ARTICLE; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; DISEASE COURSE; DOWN REGULATION; DRUG EFFECT; DRUG SELECTIVITY; HEART RIGHT VENTRICLE HYPERTROPHY; HEMODYNAMICS; HYPOXIC LUNG VASOCONSTRICTION; INTERMITTENT HYPOXIA; LONG TERM EXPOSURE; MALE; MICROANGIOGRAPHY; MORPHOMETRICS; NONHUMAN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PULMONARY ARTERY; PULMONARY HYPERTENSION; RAT; RAT MODEL; SIGNAL TRANSDUCTION; SYNCHROTRON RADIATION; SYSTOLIC BLOOD PRESSURE; TISSUE DISTRIBUTION; ANIMAL; ANOXIA; BLOOD PRESSURE; DISEASE MODEL; DRUG EFFECTS; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHOSPHORYLATION; TIME; VASOCONSTRICTION;

RATTUS;

ADRENERGIC BETA-2 RECEPTOR ANTAGONISTS; ANIMALS; ANOXIA; BLOOD PRESSURE; CLASS IA PHOSPHATIDYLINOSITOL 3-KINASE; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; HYPERTENSION, PULMONARY; HYPERTROPHY, RIGHT VENTRICULAR; MALE; NADOLOL; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PULMONARY ARTERY; RATS; RECEPTORS, ADRENERGIC, BETA-1; RECEPTORS, ADRENERGIC, BETA-2; TIME FACTORS; VASOCONSTRICTION;

EID: 84908530400     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0110693     Document Type: Article

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