Changes in macrovessel pulmonary blood flow distribution following chronic hypoxia: Assessed using synchrotron radiation microangiography

Journal of Applied Physiology

Volumn 104, Issue 1, 2008, Pages 88-96

  Schwenke, Daryl O ^a,b   Pearson, James T ^c   Kangawa, Kenji ^a   Umetani, Keiji ^d   Shirai, Mikiyasu ^e  

^a NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^b UNIVERSITY OF OTAGO   (New Zealand)

^c MONASH UNIVERSITY   (Australia)

^d JAPAN SYNCHROTRON RADIATION RESEARCH INSTITUTE   (Japan)

^e HIROSHIMA INTERNATIONAL UNIVERSITY   (Japan)

Author keywords

Hypoxia; Intact chest; Pulmonary microvessels; Rat

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; OXYGEN; PROPRANOLOL;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; HYPOXIA; LUNG BLOOD FLOW; LUNG CIRCULATION; LUNG VASOCONSTRICTION; MALE; MICROANGIOGRAPHY; NONHUMAN; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RAT; SPRAGUE DAWLEY RAT; STATISTICAL SIGNIFICANCE; SYNCHROTRON;

ADRENERGIC BETA-ANTAGONISTS; ANGIOGRAPHY; ANIMALS; ANOXIA; ARTERIOLES; CHRONIC DISEASE; DISEASE MODELS, ANIMAL; LUNG; MALE; PROPRANOLOL; PULMONARY CIRCULATION; RATS; RATS, SPRAGUE-DAWLEY; RESEARCH DESIGN; SYNCHROTRONS; TIME FACTORS; VASOCONSTRICTION;

EID: 38349045165     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00610.2007     Document Type: Article

References (41)

1. Al-Tinawi A, Krenz GS, Rickaby DA, Linehan JH, Dawson CA. Influence of hypoxia and serotonin on small pulmonary vessels. J Appl Physiol 76: 56-64, 1994.
2. Archer S, Rich S. Primary pulmonary hypertension: a vascular biology and translational research "Work in progress." Circulation 102: 2781-2791, 2000.
3. Birnkrant DJ, Davis PB, Ernsberger P. Visualization of high- and low-affinity β-adrenergic receptors in rat lung: upregulation by chronic hypoxia. Am J Physiol Lung Cell Mol Physiol 265: L389-L394, 1993.
4. Chiong MA, Hatcher JD. The sympathoadrenergic system in the cardiovascular responses to hypoxia in the dog. Can J Physiol Pharmacol 50: 674-683, 1972.
5. Clini E, Cremona G, Campana M, Scotti C, Pagani M, Bianchi L, Giordano A, Ambrosino N. Production of endogenous nitric oxide in chronic obstructive pulmonary disease and patients with cor pulmonale. Correlates with echo-Doppler assessment. Am J Respir Crit Care Med 162: 446-450, 2000.
6. Diaz-Flores L, Gutierrez R, Varela H. Angiogenesis: an update. Histol Histopathol 9: 807-843, 1994.
7. Emery CJ, Bee D, Barer GR. Mechanical properties and reactivity of vessels in isolated perfused lungs of chronically hypoxic rats. Clin Sci (Lond) 61: 569-580, 1981.
8. Fried R, Reid LM. Early recovery from hypoxic pulmonary hypertension: a structural and functional study. J Appl Physiol 57: 1247-1253, 1984.
9. Hampl V, Archer SL, Nelson DP, Weir EK. Chronic EDRF inhibition and hypoxia: effects on pulmonary circulation and systemic blood pressure. J Appl Physiol 75: 1748-1757, 1993.
10. Hillier SC, Graham JA, Hanger CC, Godbey PS, Glenny RW, Wagner WWJ. Hypoxic vasoconstriction in pulmonary arterioles and venules. J Appl Physiol 82: 1084-1090, 1997.
11. Hislop A, Reid L. New findings in pulmonary arteries of rats with hypoxia-induced pulmonary hypertension. Br J Exp Pathol 57: 542-554, 1976.
12. Hislop A, Reid L. Normal structure and dimensions of the pulmonary arteries in the rat. J Anat 125: 71-83, 1978.
13. Hopkins N, McLoughlin P. The structural basis of pulmonary hypertension in chronic lung disease: remodelling, rarefaction or angiogenesis? J Anat 201: 335-348, 2002.
14. Howell K, Preston RJ, McLoughlin P. Chronic hypoxia causes angiogenesis in addition to remodelling in the adult rat pulmonary circulation. J Physiol 547: 133-145, 2003.
15. Huang KL, Wu CP, Kang BH, Lin YC. Chronic hypoxia attenuates nitric oxide-dependent hemodynamic responses to acute hypoxia. J Biomed Sci 9: 206-212, 2002.
16. Hyvelin J, Howell K, Nichol A, Costello CM, Preston RJ, McLoughlin P. Inhibition of Rho-kinase attenuates hypoxia-induced angiogenesis in the pulmonary circulation. Circ Res 97: 185-191, 2005.
17. Ikai A, Shirai M, Nishimura K, Ikeda T, Kameyama T, Ueyama K, Komeda M. Maintenance of pulmonary vasculature tone by blood derived from the inferior vena cava in a rabbit model of cavopulmonary shunt. J Thorac Cardiovasc Surg 129: 199-206, 2005.
18. Karamsetty VS, MacLean MR, McCulloch KM, Kane KA, Wadsworth RM. Hypoxic constrictor response in the isolated pulmonary artery from chronically hypoxic rats. Respir Physiol 105: 85-93, 1996.
19. Kelly DA, Hislop AA, Hall SM, Haworth SG. Relationship between structural remodeling and reactivity in pulmonary resistance arteries from hypertensive piglets. Pediatr Res 58: 525-530, 2005.
20. Kontos HA, Lower RR. Role of β-adrenergic receptors in the circulatory response to hypoxia. Am J Physiol 217: 756-763, 1969.
21. Le Cras TD, Markham NE, Tuder RM, Voelkel NF, Abman SH. Treatment of newborn rats with a VEGF receptor inhibitor causes pulmonary hypertension and abnormal lung structure. Am J Physiol Lung Cell Mol Physiol 283: L555-L562, 2002.
22. McMurtry IF, Petrun MD, Reeves JT. Lungs from chronically hypoxic rats have decreased pressor response to acute hypoxia. Am J Physiol Heart Circ Physiol 235: H104-H109, 1978.
23. Meyrick B, Fujiwara K, Reid L. Smooth muscle myosin in precursor and mature smooth muscle cells in normal pulmonary arteries and the effect of hypoxia. Exp Lung Res 2: 303-313, 1981.
24. Meyrick B, Hislop A, Reid L. Pulmonary arteries of the normal rat: the thick walled oblique muscle segment. J Anat 125: 209-221, 1978.
25. Meyrick B, Reid L. The effect of continued hypoxia on rat pulmonary arterial circulation. An ultrastructural study. Lab Invest 38: 188-200, 1978.
26. Moudgil R, Michelakis ED, Archer SL. Hypoxic pulmonary vasoconstriction. J Appl Physiol 98: 390-403, 2005.
27. Nagasaka Y, Bhattacharya J, Nanjo S, Gropper MA, Staub NC. Micropuncture measurement of lung microvascular pressure profile during hypoxia in cats. Circ Res 54: 90-95, 1984.
28. Patan S. Vasculogenesis and angiogenesis. Cancer Treat Res 117: 3-32, 2004.
29. Patan S, Munn LL, Tanda S, Roberge S, Jain RK, Jones RC. Vascular morphogenesis and remodeling in a model of tissue repair: blood vessel formation and growth in the ovarian pedicle after ovariectomy. Circ Res 89: 723-731, 2001.
30. Rabinovitch M, Gamble W, Nadas AS, Miettinen OS, Reid L. Rat pulmonary circulation after chronic hypoxia: hemodynamic and structural features. Am J Physiol Heart Circ Physiol 236: H818-H827, 1979.
31. Sasaki S, Kobayashi N, Dambara T, Kira S, Sakai T. Structural organization of pulmonary arteries in the rat lung. Anat Embryol (Berl) 191: 477-489, 1995.
32. Schwenke DO, Pearson JT, Kangawa K, Umetani K, Shirai M. Imaging of the pulmonary circulation in the closed-chest rat using synchrotron radiation microangiography. J Appl Physiol 102: 787-793, 2007.
33. Shirai M, Matsukawa K, Nishiura N, Kawaguchi AT, Ninomiya I. Changes in efferent pulmonary sympathetic nerve activity during systemic hypoxia in anesthetized cats. Am J Physiol Regul Integr Comp Physiol 269: R1404-R1409, 1995.
34. Shirai M, Shimouchi A, Kawaguchi AT, Sunagawa K, Ninomiya I. Inhaled nitric oxide: diameter response patterns in feline small pulmonary arteries and veins. Am J Physiol Heart Circ Physiol 270: H974-H980, 1996.
35. Shirai M, Shindo T, Ninomiya I. β-Adrenergic mechanisms attenuated hypoxic pulmonary vasoconstriction during systemic hypoxia in cats. Am J Physiol Heart Circ Physiol 266: H1777-H1785, 1994.
36. Tanaka A, Mori H, Tanaka E, Mohammed MU, Tanaka Y, Sekka T, Ito K, Shinozaki Y, Hyodo K, Ando M, Umetani K, Tanioka K, Kubota M, Abe S, Handa S, Nakazawa H. Branching patterns of intramural coronary vessels determined by microangiography using synchrotron radiation. Am J Physiol Heart Circ Physiol 276: H2262-H2267, 1999.
37. Tokiya R, Umetani K, Imai S, Yamashita T, Hiratsuka J, Imajo Y. Observation of microvasculatures in athymic nude rat transplanted tumor using synchrotron radiation microangiography system. Acad Radiol 11: 1039-1046, 2004.
38. Weissmann N, Nollen M, Gerigk B, Ardeschir Ghofrani H, Schermuly RT, Gunther A, Quanz K, Fink L, Hanze J, Rose F, Seeger W, Grimminger F. Downregulation of hypoxic vasoconstriction by chronic hypoxia in rabbits: effects of nitric oxide. Am J Physiol Heart Circ Physiol 284: H931-H938, 2003.
39. Winter RJ, Dickinson KE, Rudd RM, Sever PS. Tissue specific modulation of β-adrenoceptor number in rats with chronic hypoxia with an attenuated response to down-regulation by salbutamol. Clin Sci (Lond) 70: 159-165, 1986.
40. Yamashita T, Kawashima S, Ozaki M, Namiki M, Shinohara M, Inoue N, Hirata K, Umetani K, Yokoyama M. In vivo angiographic detection of vascular lesions in apolipoprotein E-knockout mice using a synchrotron radiation microangiography system. Circ J 66: 1057-1059, 2002.
41. Zhao L, Crawley DE, Hughes JM, Evans TW, Winter RJ. Endothelium-derived relaxing factor activity in rat lung during hypoxic pulmonary vascular remodeling. J Appl Physiol 74: 1061-1065, 1993.