Chronic hypoxia increases blood pressure and noradrenaline spillover in healthy humans

Journal of Physiology

Volumn 551, Issue 1, 2003, Pages 379-386

  Calbet, José A L ^a  

^a UNIVERSITY OF LAS PALMAS DE GRAN CANARIA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; NORADRENALIN; OXYGEN; HEMOGLOBIN;

ADRENERGIC SYSTEM; ADULT; ALTITUDE ACCLIMATIZATION; ARTERIAL GAS; ARTERIAL PRESSURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DISEASE ASSOCIATION; FEMALE; HEART OUTPUT; HEMOGLOBIN DETERMINATION; HUMAN; HUMAN EXPERIMENT; HYPERTENSION; HYPOXIA; LEG BLOOD FLOW; MALE; NORADRENALIN BLOOD LEVEL; NORMAL HUMAN; OXYGEN TRANSPORT; PRIORITY JOURNAL; REVIEW; SEA LEVEL; SKELETAL MUSCLE; SYMPATHETIC TONE; SYSTOLIC BLOOD PRESSURE; VASCULARIZATION; ARTICLE; BLOOD PRESSURE MEASUREMENT; CARDIOVASCULAR SYSTEM; CHRONIC HYPOXIA; HEART RATE; HEMOGLOBIN BLOOD LEVEL; MEMBRANE CONDUCTANCE;

ACCLIMATIZATION; ACID-BASE EQUILIBRIUM; ADULT; ALTITUDE; ANOXIA; ARTERIES; BLOOD PRESSURE; CARBON DIOXIDE; CHRONIC DISEASE; EPINEPHRINE; FEMALE; HEART RATE; HUMANS; KINETICS; LEG; MALE; NOREPINEPHRINE; OXYGEN; REGIONAL BLOOD FLOW; SYMPATHETIC NERVOUS SYSTEM;

EID: 0041854177     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.2003.045112     Document Type: Review

References (54)

1. Alexander JK & Grover RF (1983). Mechanism of reduced cardiac stroke volume at high altitude. Clin Cardiol 6, 301-303.
2. Andersen P & Saltin B (1985). Maximal perfusion of skeletal muscle in man. J Physiol 366, 233-249.
3. Antezana AM, Kacimi R, Le Trong JL, Marchal M, Abousahl I, Dubray C & Richalet JP (1994). Adrenergic status of humans during prolonged exposure to the altitude of 6,542 m. J Appl Physiol 76, 1055-1059.
4. Azevedo ER, Newton GE, Floras JS & Parker JD (2000). Reducing cardiac filling pressure lowers norepinephrine spillover in patients with chronic heart failure. Circulation 101, 2053-2059.
5. Boczek-Funcke A, Habler HJ, Janig W & Michaelis M (1992). Respiratory modulation of the activity in sympathetic neurones supplying muscle, skin and pelvic organs in the cat. J Physiol 449, 333-361.
6. Calbet JA (2000). Oxygen tension and content in the regulation of limb blood flow. Acta Physiol Scand 168, 465-472.
7. 2 content? Am J Physiol Regul Integr Comp Physiol 284, R304-316.
8. Carlson JT, Hedner JA, Sellgren J, Elam M & Wallin BG (1996). Depressed baroreflex sensitivity in patients with obstructive sleep apnea. Am J Respir Crit Care Med 154, 1490-1496.
9. Cinar Y, Demir G, Pac M & Cinar AB (1999). Effect of hematocrit on blood pressure via hyperviscosity. Am J Hypertens 12, 739-743.
10. Clar C, Dorrington KL & Robbins PA (1999). Ventilatory effects of 8 h of isocapnic hypoxia with and without beta-blockade in humans. J Appl Physiol 86, 1897-1904.
11. Dempsey JA, Sheel AW, St Croix CM & Morgan BJ (2002). Respiratory influences on sympathetic vasomotor outflow in humans. Respir Physiol Neurobiol 130, 3-20.
12. Dow P (1956). Estimations of cardiac output and central blood volume by dye dilution. Physiol Rev 36, 77-102.
13. Doyle MP & Walker BR (1991). Attentuation of systemic vasoreactivity in chronically hypoxic rats. Am J Physiol 260, R1114-1122.
14. Duplain H, Vollenweider L, Delabays A, Nicod P, Bartsch P & Scherrer U (1999). Augmented sympathetic activation during short-term hypoxia and high-altitude exposure in subjects susceptible to high-altitude pulmonary edema. Circulation 99, 1713-1718.
15. Dwinell MR, Janssen PL, Pizarro J & Bisgard GE (1997). Effects of carotid body hypocapnia during ventilatory acclimatization to hypoxia. J Appl Physiol 82, 118-124.
16. Eisenhofer G, Friberg P, Rundqvist B, Quyyumi AA, Lambert G, Kaye DM, Kopin IJ, Goldstein DS & Esler MD (1996). Cardiac sympathetic nerve function in congestive heart failure. Circulation 93, 1667-1676.
17. Esler M (2000). The sympathetic system and hypertension. Am J Hypertens 13, 99S-105S.
18. Esler M, Jackman G, Bobik A, Kelleher D, Jennings G, Leonard P, Skews H & Korner P (1979). Determination of norepinephrine apparent release rate and clearance in humans. Life Sci 25, 1461-1470.
19. Esler M, Jennings G, Leonard P, Sacharias N, Burke F, Johns J & Blombery P (1984). Contribution of individual organs to total noradrenaline release in humans. Acta Physiol Scand Suppl 527, 11-16.
20. 2 before and after an 8-h exposure to hypoxia in humans. J Appl Physiol 90, 1607-1614.
21. Fletcher EC (2001). Invited review: Physiological consequences of intermittent hypoxia: systemic blood pressure. J Appl Physiol 90, 1600-1605.
22. Gonzalez C, Almaraz L, Obeso A & Rigual R (1994). Carotid body chemoreceptors: from natural stimuli to sensory discharges. Physiol Rev 74, 829-898.
23. Hallman H, Farnebo LO, Hamberger B & Johnsson G (1978). A sensitive method for the determination of plasma catecholamines using liquid chromatography with electrochemical detection. Life Sci 23, 1049-1052.
24. Hansen J & Sander M (2003). Sympathetic neural overactivity in healthy humans after prolonged exposure to hypobaric hypoxia. J Physiol 546, 921-929.
25. Heindl S, Lehnert M, Criee CP, Hasenfuss G & Andreas S (2001). Marked sympathetic activation in patients with chronic respiratory failure. Am J Respir Crit Care Med 164, 597-601.
26. Heistad DD, Abboud FM, Mark AL & Schmid PG (1972). Impaired reflex vasoconstriction in chronically hypoxemic patients. J Clin Invest 51, 331-337.
27. Hilton R & Eichholtz F (1925). The influence of chemical factors on the coronary circulation. J Physiol 59, 413-425.
28. Imadojemu VA, Gleeson K, Gray KS, Sinoway LI & Leuenberger UA (2002). Obstructive apnea during sleep is associated with peripheral vasoconstriction. Am J Respir Crit Care Med 165, 61-66.
29. Jie K, van Brummelen P, Vermey P, Timmermans PB & van Zwieten PA (1987). Modulation of noradrenaline release by peripheral presynaptic alpha 2-adrenoceptors in humans. J Cardiovasc Pharmacol 9, 407-413.
30. Kanstrup IL, Poulsen TD, Hansen JM, Andersen LJ, Bestle MH, Christensen NJ & Olsen NV (1999). Blood pressure and plasma catecholamines in acute and prolonged hypoxia: effects of local hypothermia. J Appl Physiol 87, 2053-2058.
31. Kaye DM, Lefkovits J, Jennings GL, Bergin P, Broughton A & Esler MD (1995). Adverse consequences of high sympathetic nervous activity in the failing human heart. J Am Coll Cardiol 26, 1257-1263.
32. 2 flow in peripheral chemoreceptor excitation. Fed Proc 39, 2648-2652.
33. Laughlin MH, Korthuis RJ, Duncker DJ & Bache RJ (1996). Control of blood flow to cardiac and skeletal muscle during exercise. In Handbook of Physiology. Exercise: Regulation and Integration of Multiple Systems, vol. 12, ed. Rowell LB & Shepherd JT, pp. 705-769. American Physiological Society, Bethesda, MD, USA.
34. Leuenberger U, Gleeson K, Wroblewski K, Prophet S, Zelis R, Zwillich C & Sinoway L (1991). Norepinephrine clearance is increased during acute hypoxemia in humans. Am J Physiol 261, H1659-1664.
35. Marshall JM (1994). Peripheral chemoreceptors and cardiovascular regulation. Physiol Rev 74, 543-594.
36. Mazzeo RS, Bender PR, Brooks GA, Butterfield GE, Groves BM, Sutton JR, Wolfel EE & Reeves JT (1991). Arterial catecholamine responses during exercise with acute and chronic high-altitude exposure. Am J Physiol 261, E419-424.
37. Mazzeo RS, Brooks GA, Butterfield GE, Podolin DA, Wolfel EE & Reeves JT (1995). Acclimatization to high altitude increases muscle sympathetic activity both at rest and during exercise. Am J Physiol 269, R201-207.
38. Narkiewicz K, van de Borne PJ, Pesek CA, Dyken ME, Montano N & Somers VK (1999). Selective potentiation of peripheral chemoreflex sensitivity in obstructive sleep apnea. Circulation 99, 1183-1189.
39. Pawelczyk JA, Zuckerman JH, Blomqvist CG & Levine BD (2001). Regulation of muscle sympathetic nerve activity after bed rest deconditioning. Am J Physiol Heart Circ Physiol 280, H2230-2239.
40. Pawloski JR, Hess DT & Stamler JS (2001). Export by red blood cells of nitric oxide bioactivity. Nature 409, 622-626.
41. Reis DJ, Golanov EV, Ruggiero DA & Sun MK (1994). Sympathoexcitatory neurons of the rostral ventrolateral medulla are oxygen sensors and essential elements in the tonic and reflex control of the systemic and cerebral circulations. J Hypertens Suppl 12, S159-180.
42. Richalet JP, Larmignat P, Rathat C, Keromes A, Baud P & Lhoste F (1988). Decreased cardiac response to isoproterenol infusion in acute and chronic hypoxia. J Appl Physiol 65, 1957-1961.
43. Rostrup M (1998). Catecholamines, hypoxia and high altitude. Acta Physiol Scand 162, 389-399.
44. Rowell LB, Johnson DG, Chase PB, Comess KA & Seals DR (1989). Hypoxemia raises muscle sympathetic activity but not norepinephrine in resting humans. J Appl Physiol 66, 1736-1743.
45. Seals DR, Suwarno NO & Dempsey JA (1990). Influence of lung volume on sympathetic nerve discharge in normal humans. Circ Res 67, 130-141.
46. Somers VK, Mark AL & Abboud FM (1991). Interaction of baroreceptor and chemoreceptor reflex control of sympathetic nerve activity in normal humans. J Clin Invest 87, 1953-1957.
47. Sun MK & Reis DJ (1995). Decerebration does not alter hypoxic sympathoexcitatory responses in rats. J Auton Nerv Syst 53, 77-81.
48. Trzebski A, Tafil M, Zoltowski M & Przybylski J (1982). Increased sensitivity of the arterial chemoreceptor drive in young men with mild hypertension. Cardiovasc Res 16, 163-172.
49. van Hall G, Calbet JA, Sondergaard H & Saltin B (2001). The re-establishment of the normal blood lactate response to exercise in humans after prolonged acclimatization to altitude. J Physiol 536, 963-975.
50. Wagner PD, Araoz M, Boushel R, Calbet JA, Jessen B, Radegran G, Spielvogel H, Sondegaard H, Wagner H & Saltin B (2002). Pulmonary gas exchange and acid-base state at 5,260 m in high-altitude Bolivians and acclimatized lowlanders. J Appl Physiol 92, 1393-1400.
51. Weisbrod CJ, Minson CT, Joyner MJ & Halliwill JR (2001). Effects of regional phentolamine on hypoxic vasodilatation in healthy humans. J Physiol 537, 613-621.
52. Xie A, Skatrud JB, Puleo DS & Morgan BJ (2001). Exposure to hypoxia produces long-lasting sympathetic activation in humans. J Appl Physiol 91, 1555-1562.
53. Young PM, Sutton JR, Green HJ, Reeves JT, Rock PB, Houston CS & Cymerman A (1992). Operation Everest II: metabolic and hormonal responses to incremental exercise to exhaustion. J Appl Physiol 73, 2574-2579.
54. Zoccali C, Mallamaci F, Parlongo S, Cutrupi S, Benedetto FA, Tripepi G, Bonanno G, Rapisarda F, Fatuzzo P, Seminara G, Cataliotti A, Stancanelli B, Malatino LS & Cateliotti A (2002). Plasma norepinephrine predicts survival and incident cardiovascular events in patients with end-stage renal disease. Circulation 105, 1354-1359.