Differences in hypothalamic type 2 deiodinase ubiquitination explain localized sensitivity to thyroxine

Journal of Clinical Investigation

Volumn 125, Issue 2, 2015, Pages 769-781

  De Castro, Joao Pedro Werneck ^a,b   Fonseca, Tatiana L ^a,b   Ueta, Cintia B ^a   McAninch, Elizabeth A ^a,b   Abdalla, Sherine ^a   Wittmann, Gabor ^c   Lechan, Ronald M ^c   Gereben, Balazs ^d   Bianco, Antonio C ^a,b  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b RUSH UNIVERSITY   (United States)

^c TUFTS MEDICAL CENTER   (United States)

^d INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

LIOTHYRONINE; PLACEBO; THYROXINE; THYROXINE DEIODINASE; TISSUE EXTRACT; IODIDE PEROXIDASE; IODOTHYRONINE DEIODINASE TYPE II; THYROTROPIN; UBIQUITIN PROTEIN LIGASE; WSB1 PROTEIN, MOUSE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CONTROLLED STUDY; ENZYME ACTIVITY; FEEDBACK SYSTEM; GENE EXPRESSION PROFILING; HORMONE SUBSTITUTION; HYPOTHALAMUS; IN VITRO STUDY; IN VIVO STUDY; LIOTHYRONINE BLOOD LEVEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; SENSITIVITY ANALYSIS; THYROID FUNCTION TEST; THYROIDECTOMY; THYROXINE BLOOD LEVEL; TISSUE SPECIFICITY; UBIQUITINATION; ANIMAL; ENZYMOLOGY; GENE DELETION; GENE EXPRESSION REGULATION; GENETICS; HUMAN; HYPOTHALAMUS HYPOPHYSIS SYSTEM; HYPOTHYROIDISM; KNOCKOUT MOUSE; METABOLISM; MOUSE; PATHOLOGY; PHYSIOLOGY;

ANIMALS; GENE DELETION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; HYPOTHYROIDISM; IODIDE PEROXIDASE; MICE; MICE, KNOCKOUT; RATS; THYROTROPIN; THYROXINE; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84961291426     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI77588     Document Type: Article

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