Life without thyroxine to 3,5,3′-triiodothyronine conversion: Studies in mice devoid of the 5′-deiodinases

Endocrinology

Volumn 150, Issue 6, 2009, Pages 2957-2963

  Galton, Valerie Anne ^a   Schneider, Mark J ^a   Clark, Ann S ^b   St Germain, Donald L ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

^b DARTMOUTH COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIOTHYRONINE; THYROTROPIN; THYROXINE; THYROXINE DEIODINASE;

AGILITY; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN METABOLISM; CONTROLLED STUDY; DEIODINATION; ENZYME DEFICIENCY; GENE EXPRESSION REGULATION; KNOCKOUT MOUSE; LEARNING; LIOTHYRONINE BLOOD LEVEL; LIOTHYRONINE METABOLISM; LOCOMOTION; MAZE TEST; MEMORY; MOTOR PERFORMANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REPRODUCTIVE HEALTH; THYROID FUNCTION;

ANIMALS; BRAIN; HOMEOSTASIS; IODIDE PEROXIDASE; IODINE; LEARNING; LOCOMOTION; MEMORY; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RNA, MESSENGER; THYROID GLAND; THYROTROPIN; THYROXINE; TRIIODOTHYRONINE;

EID: 66649091781     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2008-1572     Document Type: Article

References (39)

1. Oppenheimer JH, Koerner D, Schwartz HL, Surks MI 1972 Specific nuclear triidothyronine binding sites in rat liver and kidney. J Clin Endocrinol Metab 35:330-333
2. Bianco AC, Salvatore D, Gereben B, Berry MJ, Larsen PR 2002 Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases. Endocr Rev 23:38-89
3. Leonard JL, Visser TJ 1986 Biochemistry of deiodination. In: Hennemann G, ed. Thyroid hormone metabolism. New York: Marcel Dekker; 189-229
4. Visser TJ 1988 Metabolism of thyroid hormones. In: Cooke BA, King RJB, van der Molen HJ, eds. Hormones and their action, part 1. New York: Elsevier Science Publishers; 81-103
5. Chopra IL 1996 Nature, source and relative significance of circulating thyroid hormones. In: Braverman LE, Utiger RD, eds. Werner and Ingbar's the thyroid. 7th ed. Philadelphia: Lippincott-Raven; 111-124
6. Chanoine JP, Braverman LE, Farwell AP, Safran M, Alex S, Dubord S, Leonard JL 1993 The thyroid gland is a major source of circulating T3 in the rat. J Clin Invest 91:2709-2713
7. Berry MJ, Grieco D, Taylor BA, Maia AL, Kieffer JD, Beamer W, Glover E, Poland A, Larsen PR 1993 Physiological and genetic analysis of inbred mouse strains with a type I iodothyronine 5′ deiodinase deficiency. J Clin Invest 92:1517-1528
8. Streckfuss F, Hamann I, Schomburg L, Michaelis M, Sapin R, Klein MO, Köhrle J, Schweizer U 2005 Hepatic deiodinase activity is dispensable for the maintenance of normal circulating thyroid hormone levels in mice. Biochem Biophys Res Commun 337:739-745
9. Schneider MJ, Fiering SN, Thai B, Wu SY, St. Germain E, Parlow AF, St. Germain DL, Galton VA 2006 Targeted disruption of the type1 selenodeiodinase gene (Dio1) results in marked changes in thyroid hormone economy in mice. Endocrinology 147:580-589
10. Nguyen TT, Chapa F, DiStefano 3rd JJ 1998 Direct measurement of the contributions of type I and type II 5′-deiodinases to whole body steady state 3,5,3′-triiodothyronine production from thyroxine in the rat. Endocrinology 139:4626-4633
11. Maia AL, Kim BW, Huang SA, Harney JW, Larsen PR 2005 Type 2 deiodinase is the major source of plasma T3 in euthyroid humans. J Clin Invest 115:2524-2533
12. 4. Mol Endocrinol 15:2137-2148
13. de Jesus LA, Carvalho SD, Ribeiro MO, Schneider M, Kim SW, Harney JW, Larsen PR, Bianco AC 2001 The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue. J Clin Invest 108:1379-1385
14. Ng L, Goodyear RJ, Woods CA, Schneider MJ, Diamond E, Richardson GP, Kelley MW, St. Germain DL, Galton VA, Forrest D 2004 Hearing loss and retarded cochlear development in mice lacking type 2 iodothyronine deiodinase. Proc Natl Acad Sci USA 101:3473-3479
15. Galton VA, Wood ET, St. Germain EA, Withrow CA, Aldrich G, St. Germain GM, Clark AS, St. Germain DL 2007 Thyroid hormone homeostasis and action in the type 2 deiodinase-deficient brain during development. Endocrinology 148: 3080-3088
16. Anthony A, Adams PM, Stein SA 1993 The effects of congenital hypothyroidism using the hyt/hyt mouse on locomotor activity and learned behavior. Horm Behav 27:418-433
17. m activity. J Biol Chem 267:12539-12544
18. Galton VA, Martinez E, Hernandez A, St. Germain EA, Bates JM, St. Germain DL 1999 Pregnant rat uterus expresses high levels of the type 3 iodothyronine deiodinase. J Clin Invest 103:979-987
19. St. Germain DL, Galton VA 1985 Comparative study of pituitary-thyroid hormone economy in fasting and hypothyroid rats. J Clin Invest 75:679-688
20. Roti E, Gnudi A, Braverman LE, Robuschi G, Emanuele R, Bandini P, Benassi L, Pagliani A, Emerson CH 1981 Human cord blood concentrations of thyrotropin, thyroglobulin, and iodothyronines after maternal administration of thyrotropin-releasing hormone. J Clin Endocrinol Metab 53:813-817
21. Thompson CC, Potter GB 2000 Thyroid hormone action in neural development. Cereb Cortex 10:939-945
22. Bernal J, Guadaño-Ferraz A, Morte B 2003 Perspectives in the study of thyroid hormone action on brain development and function. Thyroid 13:1005-1012
23. Engler D, Burger AG 1984 The deiodination of the iodothyronines and their derivatives in man. Endocr Rev 5:151-184
24. Erickson VJ, Cavalieri RR, Rosenberg LL 1981 Phenolic and non-phenolic ring deiodinase from rat thyroid gland. Endocrinology 108:1257-1264
25. Ishii H, Inada M, Tanaka K, Mashio Y, Naito K, Nishikawa M, Matsuzuka F, Kuma K, Imura H 1982 Sequential deiodination of thyroxine in human thyroid gland. J Clin Endocrinol Metab 55:890-896
26. Chiu SC, Kubota K, Kuzuya N, Ikeda H, Uchimura H, Nagataki S 1983 Effects of prolonged administration of thyrotrophin on serum concentration, release and synthesis of thyroid hormones in mice. Acta Endocrinol 103:68-75
27. Tegler L, Gillquist J, Lindvall R, Almqvist S, Roos P 1983 Thyroid hormone secretion rates: response to endogenous and exogenous TSH in man during surgery. Clin Endocrinol (Oxf) 18:1-9
28. Kubota K, Uchimura H, Mitsuhashi T, Chiu SC, Kuzuya N, Nagataki S 1984 Effects of intrathyroidal metabolism of thyroxine on thyroid hormone secretion: increased degradation of thyroxine in mouse thyroids stimulated chronically with thyrotrophin. Acta Endocrinol 105:57-65
29. Fukuda H, Yasuda N, Greer MA, Kutas M, Greer SE 1975 Changes in plasma thyroxine, triiodothyronine, and TSH during adaptation to iodine deficiency in the rat. Endocrinology 97:307-314
30. Silva JE, Matthews P 1984 Thyroid hormone metabolism and the source of plasma triiodothyronine in 2-week-old rats: effects of thyroid status. Endocrinology 114:2394-2405
31. Rutgers M, Heusdens FA, Bonthuis F, Visser TJ 1989 Metabolism of triiodothyroacetic acid (TA3) in rat liver. II. Deiodination and conjugation of TA3 by rat hepatocytes and in rats in vivo. Endocrinology 125:433-443
32. Moreno M, Berry MJ, Horst C, Thoma R, Goglia F, Harney JW, Larsen PR, Visser TJ 1994 Activation and inactivation of thyroid hormone by type I iodothyronine deiodinase. FEBS Let 344:143-146
33. Riesco G, Taurog A, Larsen PR 1976 Variations in the response of the thyroid gland of the rat to different low-iodine diets: correlation with the iodine content of the diet. Endocrinology 99:270-280
34. Stanbury JB 1960 Deiodination of the iodinated amino acids. Ann NY Acad Sci 86:417-439
35. Gnidehou S, Caillou B, Talbot M, Ohayon R, Kaniewski J, Noël-Hudson MS, Morand S, Agnangji D, Sezan A, Courtin F, Virion A, Dupuy C 2004 Iodotyrosine dehalogenase 1 (DEHAL1) is a transmembrane protein involved in the recycling of iodide close to the thyroglobulin iodination site. FASEB J 18: 1574-1576
36. Solís-S JC, Villalobos P, Orozco A, Valverde-R C 2004 Comparative kinetic characterization of rat thyroid iodotyrosine dehalogenase and iodothyronine deiodinase type 1. J Endocrinol 181:385-392
37. Christoffolete MA, Arrojo e Drigo R, Gazoni F, Tente SM, Goncalves V, Amorim BS, Larsen PR, Bianco AC, Zavacki AM 2007 Mice with impaired extrathyroidal thyroxine to 3,5,3′-triiodothyronine conversion maintain normal serum 3,5,3′-triiodothyronine concentrations. Endocrinology 148:954-960
38. Laurberg P, Vestergaard H, Nielsen S, Christensen SE, Seefeldt T, Helleberg K, Pedersen KM 2007 Sources of circulating 3,5,3′- triiodothyronine in hyperthyroidism estimated after blocking of type 1 and type 2 iodothyronine deiodinases. J Clin Endocrinol Metab 92:2149-2156
39. Dumitrescu AM, Liao XH, Abdullah MS, Lado-Abeal J, Majed FA, Moeller LC, Boran G, Schomburg L, Weiss RE, Refetoff S 2005 Mutations in SECISBP2 result in abnormal thyroid hormone metabolism. Nat Genet 37:1247-1252