Enhanced cardiac Akt/protein kinase B signaling contributes to pathological cardiac hypertrophy in part by impairing mitochondrial function via transcriptional repression of mitochondrion-targeted nuclear genes

Molecular and Cellular Biology

Volumn 35, Issue 5, 2015, Pages 831-846

  Wende, Adam R ^a,b   O'Neill, Brian T ^a,c   Bugger, Heiko ^a,d   Riehle, Christian ^a,e   Tuinei, Joseph ^a   Buchanan, Jonathan ^a   Tsushima, Kensuke ^a,e   Wang, Li ^a   Caro, Pilar ^a   Guo, Aili ^a,f   Sloan, Crystal ^a   Kim, Bum Jun ^a   Wang, Xiaohui ^a   Pereira, Renata O ^a,e   McCrory, Mark A ^b   Nye, Brenna G ^b   Benavides, Gloria A ^b   Darley Usmar, Victor M ^b   Shioi, Tetsuo ^g   Weimer, Bart C ^h   Abela, E Dale ^e   more..

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b University of Alabama at Birmingham   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF FREIBURG   (Germany)

^e UNIVERSITY OF IOWA   (United States)

^f OHIO UNIVERSITY   (United States)

^g KYOTO UNIVERSITY   (Japan)

^h UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PROTEIN KINASE B; TRANSCRIPTION FACTOR FKHR; TRANSCRIPTION FACTOR FKHRL1; ADENOSINE TRIPHOSPHATE; AKT1 PROTEIN, MOUSE; OXYGEN;

ANIMAL EXPERIMENT; ARTICLE; BIOENERGY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVATION; ENZYME INHIBITION; FATTY ACID OXIDATION; FEMALE; GENE REPRESSION; GLYCOLYSIS; HEART VENTRICLE HYPERTROPHY; HEMODYNAMIC PARAMETERS; MALE; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; PROTEOMICS; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; ANIMAL; CARDIOMEGALY; CELL NUCLEUS; CYTOLOGY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HEART; HEMODYNAMICS; HYPERTROPHY; METABOLISM; MITOCHONDRION; MUSCLE CELL; PHYSIOLOGY; TRANSGENE;

ADENOSINE TRIPHOSPHATE; ANIMALS; CARDIOMEGALY; CELL NUCLEUS; FATTY ACIDS; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GLYCOLYSIS; HEART; HEMODYNAMICS; HYPERTROPHY; MALE; MICE; MITOCHONDRIA; MUSCLE CELLS; OXYGEN; PPAR ALPHA; PROTEOMICS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; TRANSGENES;

EID: 84961290849     PISSN: 02707306     EISSN: 10985549     Source Type: Journal    
DOI: 10.1128/MCB.01109-14     Document Type: Article

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