CFTR and sphingolipids mediate hypoxic pulmonary vasoconstriction

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 13, 2015, Pages E1614-E1623

  Tabeling, Christoph ^a   Yu, Hanpo ^a,b   Wang, Liming ^a,b   Ranke, Hannes ^a,b   Goldenberg, Neil M ^b,c   Zabini, Diana ^b   Noe, Elena ^a   Krauszman, Adrienn ^a,b   Gutbier, Birgitt ^a   Yin, Jun ^a,b   Schaefer, Michael ^d   Arenz, Christoph ^e   Hocke, Andreas C ^a   Suttorp, Norbert ^a   Proiag, Richard L ^f   Witzenrath, Martin ^a   Kuebler, Wolfgang M ^a,b,c  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b ST MICHAEL'S HOSPITAL   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d UNIVERSITY OF LEIPZIG   (Germany)

^e HUMBOLDT UNIVERSITY   (Germany)

^f NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

Ceramide; Neutral sphingomyelinase; Pulmonary hypertension; Transient receptor potential canonical 6

Indexed keywords

CALCIUM ION; CERAMIDE; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; PHOSPHOLIPASE C; RHO KINASE; SPHINGOLIPID; SPHINGOMYELIN PHOSPHODIESTERASE; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE KINASE 1; TRANSIENT RECEPTOR POTENTIAL CHANNEL 6; CALCIUM; CFTR PROTEIN, HUMAN; NEUTRAL SPHINGOMYELINASE-1, HUMAN; OXYGEN; PHOSPHOTRANSFERASE; SPHINGOSINE KINASE; TRANSIENT RECEPTOR POTENTIAL CHANNEL C; TRPC6 PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM MOBILIZATION; CAVEOLA; CELL HYPOXIA; CONTROLLED STUDY; CORONARY ARTERY SMOOTH MUSCLE CELL; ENZYME ACTIVATION; ENZYME INHIBITION; HYPOXIC LUNG VASOCONSTRICTION; LUNG CIRCULATION; LUNG PRESSURE; LUNG VASOCONSTRICTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; PULMONARY ARTERY SMOOTH MUSCLE CELL; PULMONARY HYPERTENSION; SMOOTH MUSCLE FIBER; ANIMAL; ANOXIA; C57BL MOUSE; CALCIUM SIGNALING; CHEMISTRY; CORONARY BLOOD VESSEL; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR MOUSE; HUMAN; LUNG; METABOLISM; PATHOLOGY; PULMONARY ARTERY; SIGNAL TRANSDUCTION; VASOCONSTRICTION;

HUMAN PAPILLOMAVIRUS;

ANIMALS; ANOXIA; CALCIUM; CALCIUM SIGNALING; CERAMIDES; CORONARY VESSELS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; HUMANS; HYPERTENSION, PULMONARY; LUNG; MICE; MICE, INBRED C57BL; MICE, INBRED CFTR; MYOCYTES, SMOOTH MUSCLE; OXYGEN; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN TRANSPORT; PULMONARY ARTERY; RECEPTORS, LYSOSPHINGOLIPID; RHO-ASSOCIATED KINASES; SIGNAL TRANSDUCTION; SPHINGOMYELIN PHOSPHODIESTERASE; TRPC CATION CHANNELS; TYPE C PHOSPHOLIPASES; VASOCONSTRICTION;

EID: 84961289697     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1421190112     Document Type: Article

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