4-Aminopyridine restores impaired hypoxic pulmonary vasoconstriction in endotoxemic mice

Anesthesiology

Volumn 107, Issue 4, 2007, Pages 597-604

  Spöhr, Fabian ^a   Busch, Cornelius J ^a   Reich, Christian ^b   Motsch, Johann ^a   Gebhard, Martha M ^a   Kuebler, Wolfgang M ^b   Bloch, Kenneth D ^c   Weimann, Jörg ^d  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOPYRIDINE; ANGIOTENSIN II; LIPOPOLYSACCHARIDE; PENTOBARBITAL; VOLTAGE GATED POTASSIUM CHANNEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; BLOOD VESSEL REACTIVITY; BLOOD VESSEL TONE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG INHIBITION; ENDOTOXEMIA; ESCHERICHIA COLI; HYPOXIC LUNG VASOCONSTRICTION; LOW DRUG DOSE; LUNG VASCULAR RESISTANCE; LUNG VENTILATION; MALE; MOUSE; NONHUMAN; NONLINEAR REGRESSION ANALYSIS; PERFUSION PRESSURE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

4-AMINOPYRIDINE; ALGORITHMS; ANGIOTENSIN II; ANIMALS; ANOXIA; BODY WEIGHT; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTOXEMIA; LIPOPOLYSACCHARIDES; MALE; MICE; ORGAN SIZE; PERFUSION; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; PULMONARY ARTERY; PULMONARY CIRCULATION; RNA, MESSENGER; VASOCONSTRICTION;

EID: 34748862959     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/01.anes.0000281897.13703.fd     Document Type: Article

References (49)

1. Marshall BE, Hanson CW, Frasch F, Marshall C: Role of hypoxic pulmonary vasoconstriction in pulmonary gas exchange and blood flow distribution: 2. Pathophysiology. Intensive Care Med 1994; 20:379-89
2. Ogasawara H, Koizumi T, Yamamoto H, Kubo K: Effects of a selective nitric oxide synthase inhibitor on endotoxin-induced alteration in hypoxic pulmonary vasoconstriction in sheep. J Cardiovasc Pharmacol 2003; 42:521-6
3. Fischer SR, Deyo DJ, Bone HG, McGuire R, Traber LD, Traber DL: Nitric oxide synthase inhibition restores hypoxic pulmonary vasoconstriction in sepsis. Am J Respir Crit Care Med 1997; 156:833-9
4. Graham LM, Vasil A, Vasil ML, Voelkel NF, Stenmark KR: Decreased pulmonary vasoreactivity in an animal model of chronic Pseudomonas pneumonia. Am Rev Respir Dis 1990; 142:221-9
5. Reeves JT, Grover RF: Blockade of acute hypoxic pulmonary hypertension by endotoxin. J Appl Physiol 1974; 36:328-32
6. Frank DU, Lowson SM, Roos CM, Rich GF: Endotoxin alters hypoxic pulmonary vasoconstriction in isolated rat lungs. J Appl Physiol 1996; 81:1316-22
7. Theissen JL, Loick HM, Curry BB, Traber LD, Herndon DN, Traber DL: Time course of hypoxic pulmonary vasoconstriction after endotoxin infusion in unanesthetized sheep. J Appl Physiol 1991; 70:2120-5
8. Ullrich R, Bloch KD, Ichinose F, Steudel W, Zapol WM: Hypoxic pulmonary blood flow redistribution and arterial oxygenation in endotoxin-challenged NOS2-deficient mice. J Clin Invest 1999; 104:1421-9
9. Chang SW, Feddersen CO, Henson PM, Voelkel NF: Platelet-activating factor mediates hemodynamic changes and lung injury in endotoxin-treated rats. J Clin Invest 1987; 79:1498-509
10. Weir EK, Mlczoch J, Reeves JT, Grover RF: Endotoxin and prevention of hypoxic pulmonary vasoconstriction. J Lab Clin Med 1976; 88:975-83
11. Hales CA, Sonne L, Peterson M, Kong D, Miller M, Watkins WD: Role of thromboxane and prostacyclin in pulmonary vasomotor changes after endotoxin in dogs. J Clin Invest 1981; 68:497-505
12. Ichinose F, Zapol WM, Sapirstein A, Ullrich R, Tager AM, Coggins K, Jones R, Bloch KD: Attenuation of hypoxic pulmonary vasoconstriction by endotoxemia requires 5-lipoxygenase in mice. Circ Res 2001; 88:832-8
13. Spöhr F, Cornelissen AJ, Busch C, Gebhard MM, Motsch J, Martin EO, Weimann J: Role of endogenous nitric oxide in endotoxin-induced alteration of hypoxic pulmonary vasoconstriction in mice. Am J Physiol Heart Circ Physiol 2005; 289:H823-31
14. Weimann J, Bloch KD, Takata M, Steudel W, Zapol WM: Congenital NOS2 deficiency protects mice from LPS-induced hyporesponsiveness to inhaled nitric oxide. ANESTHESIOLOGY 1999; 91:1744-53
15. Lopez-Barneo J, Lopez-Lopez J, Urena J, Gonzalez C: Chemotransduction in the carotid body: K+- current modulated by PO2 in type I chemoreceptor cells. Science 1988; 242:580-2
16. Post JM, Hume JR, Archer SL, Weir EK: Direct role for potassium channel inhibition in hypoxic pulmonary vasoconstriction. Am J Physiol 1992; 262:C882-90
17. Weir EK, Archer SL: The mechanism of acute hypoxic pulmonary vasoconstriction: the tale of two channels. FASEB J 1995; 9:183-9
18. Osipenko ON, Tate RJ, Gurney AM: Potential role for Kv3.1b channels as oxygen sensors. Circ Res 2000; 86:534-40
19. Waypa GB, Chandel NS, Schumacker PT: Model for hypoxic pulmonary vasoconstriction involving mitochondrial oxygen sensing. Circ Res 2001; 88:1259-66
20. Sylvester JT: Hypoxic pulmonary vasoconstriction: A radical view. Circ Res 2001; 88:1228-30
21. Sweeney M, Yuan JXJ: Hypoxic pulmonary vasoconstriction: Role of voltage-gated potassium channels. Respir Res 2000; 1:40-8
22. Archer S, Michelakis E: The mechanism(s) of hypoxic pulmonary vasoconstriction: potassium channels, redox O(2) sensors, and controversies. News Physiol Sci 2002; 17:131-7
23. Archer S: The role of potassium channels in the control of the pulmonary circulation, Potassium Channels in Cardiovascular Biology. Edited by Archer SL, Rusch NJ. New York, Kluwer Academic/Plenum Publishers, 2001, pp 543-70
24. Linehan JH, Haworth ST, Nelin LD, Krenz GS, Dawson CA: A simple distensible vessel model for interpreting pulmonary vascular pressure-flow curves. J Appl Physiol 1992; 73:987-94
25. Permutt S, Riley RL: Hemodynamics of collapsible vessels with tone: The vascular waterfall. J Appl Physiol 1963; 18:924-32
26. Spaan JA: Response to the article by Klocke on "Coronary pressure-flow relationships: Controversial issues and probable implications." Circ Res 1985; 56:789-92
27. Klocke FJ, Mates RE, Canty JM Jr, Ellis AK: Coronary pressure-flow relationships: Controversial issues and probable implications. Circ Res 1985; 56:310-23
28. Archer SL, Souil E, Dinh-Xuan AT, Schremmer B, Mercier JC, El Yaagoubi A, Nguyen-Huu L, Reeve HL, Hampl V: Molecular identification of the role of voltage-gated K+- channels, Kv1.5 and Kv2.1, in hypoxic pulmonary vasoconstriction and control of resting membrane potential in rat pulmonary artery myocytes. J Clin Invest 1998; 101:2319-30
29. Tristani-Firouzi M, Reeve HL, Tolarova S, Weir EK, Archer SL: Oxygen-induced constriction of rabbit ductus arteriosus occurs via inhibition of a 4-aminopyridine-, voltage-sensitive potassium channel. J Clin Invest 1996; 98:1959-65
30. Barman SA: Potassium channels modulate hypoxic pulmonary vasoconstriction. Am J Physiol 1998; 275:L64-70
31. Sham JS, Crenshaw BRJ, Deng LH, Shimoda LA, Sylvester JT: Effects of hypoxia in porcine pulmonary arterial myocytes: Roles of K(V) channel and endothelin-1. Am J Physiol Lung Cell Mol Physiol 2000; 279:L262-72
32. Hulme JT, Coppock EA, Felipe A, Martens JR, Tamkun MM: Oxygen sensitivity of cloned voltage-gated K(+-) channels expressed in the pulmonary vasculature. Circ Res 1999; 85:489-97
33. Patel AJ, Lazdunski M, Honore E: Kv2.1/Kv9.3, a novel ATP-dependent delayed-rectifier K+- channel in oxygen-sensitive pulmonary artery myocytes. EMBO J 1997; 16:6615-25
34. Archer SL, London B, Hampl V, Wu X, Nsair A, Puttagunta L, Hashimoto K, Waite RE, Michelakis ED: Impairment of hypoxic pulmonary vasoconstriction in mice lacking the voltage-gated potassium channel Kv1.5. FASEB J 2001; 15:1801-3
35. Archer SL, Wu XC, Thebaud B, Nsair A, Bonnet S, Tyrrell B, McMurtry MS, Hashimoto K, Harry G, Michelakis ED: Preferential expression and function of voltage-gated, O2-sensitive K-+ channels in resistance pulmonary arteries explains regional heterogeneity in hypoxic pulmonary vasoconstriction: ionic diversity in smooth muscle cells. Circ Res 2004; 95:308-18
36. Hasunuma K, Rodman DM, McMurtry IF: Effects of K-+ channel blockers on vascular tone in the perfused rat lung. Am Rev Respir Dis 1991; 144:884-7
37. Littler CM, Morris KG Jr, Fagan KA, McMurtry IF, Messing RO, Dempsey EC: Protein kinase C-epsilon-null mice have decreased hypoxic pulmonary vasoconstriction. Am J Physiol Heart Circ Physiol 2003; 284:H1321-31
38. Yuan XJ, Wang J, Juhaszova M, Golovina VA, Rubin LJ: Molecular basis and function of voltage-gated K+- channels in pulmonary arterial smooth muscle cells. Am J Physiol 1998; 274:L621-35
39. Platoshyn O, Remillard CV, Fantozzi I, Mandegar M, Sison TT, Zhang S, Burg E, Yuan JX: Diversity of voltage-dependent K+- channels in human pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 2004; 287:L226-38
40. Coppock EA, Martens JR, Tamkun MM: Molecular basis of hypoxia-induced pulmonary vasoconstriction: Role of voltage-gated K+- channels. Am J Physiol Lung Cell Mol Physiol 2001; 281:L1-12
41. Pozeg ZI, Michelakis ED, McMurtry MS, Thebaud B, Wu XC, Dyck JR, Hashimoto K, Wang S, Moudgil R, Harry G, Sultanian R, Koshal A, Archer SL: In vivo gene transfer of the O2-sensitive potassium channel Kv1.5 reduces pulmonary hypertension and restores hypoxic pulmonary vasoconstriction in chronically hypoxic rats. Circulation 2003; 107:2037-44
42. Reeve HL, Michelakis E, Nelson DP, Weir EK, Archer SL: Alterations in a redox oxygen sensing mechanism in chronic hypoxia. J Appl Physiol 2001; 90:2249-56
43. Sakai M, Unemoto K, Solari V, Puri P: Decreased expression of voltage-gated K-+ channels in pulmonary artery smooth muscles cells in nitrogeninduced congenital diaphragmatic hernia in rats. Pediatr Surg Int 2004; 20:192-6
44. Doering EB, Hanson CW, Reily DJ, Marshall C, Marshall BE: Improvement in oxygenation by phenylephrine and nitric oxide in patients with adult respiratory distress syndrome. ANESTHESIOLOGY 1997; 87:18-25
45. Mourgeon E, Puybasset L, Law-Koune JD, Lu Q, Abdennour L, Gallart L, Malassine P, Rao GU, Cluzel P, Bennani A, Coriat P, Rouby JJ: Inhaled nitric oxide in acute respiratory distress syndrome with and without septic shock requiring norepinephrine administration: A dose-response study. Crit Care (Lond) 1997; 1:25-39
46. Payen DM, Gatecel C, Plaisance P: Almitrine effect on nitric oxide inhalation in adult respiratory distress syndrome. Lancet 1993; 341:1664
47. Gallart L, Lu Q, Puybasset L, Umamaheswara RG, Coriat P, Rouby JJ: Intravenous almitrine combined with inhaled nitric oxide for acute respiratory distress syndrome. The NO Almitrine Study Group. Am J Respir Crit Care Med 1998; 158:1770-7
48. Papazian L, Roch A, Bregeon F, Thirion X, Gaillat F, Saux P, Fulachier V, Jammes Y, Auffray JP: Inhaled nitric oxide and vasoconstrictors in acute respiratory distress syndrome. Am J Respir Crit Care Med 1999; 160:473-9
49. Dembinski R, Max M, Lopez F, Kuhlen R, Kurth R, Rossaint R: Effect of inhaled prostacyclin in combination with almitrine on ventilation-perfusion distributions in experimental lung injury. ANESTHESIOLOGY 2001; 94:461-7