The melanocortin receptor accessory protein 2 promotes food intake through inhibition of the prokineticin receptor-1

eLife

Volumn 5, Issue FEBRUARY2016, 2016, Pages

  Chaly, Anna L ^a   Srisai, Dollada ^a   Gardner, Ellen E ^a   Sebag, Julien A ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOCRINE GLAND DERIVED VASCULAR ENDOTHELIAL GROWTH FACTOR; INOSITOL PHOSPHATE; MELANOCORTIN RECEPTOR; MELANOCORTIN RECEPTOR ACCESSORY PROTEIN 2; UNCLASSIFIED DRUG; G PROTEIN COUPLED RECEPTOR; MRAP2 PROTEIN, MOUSE; PKR1 PROTEIN, MOUSE; RECEPTOR ACTIVITY MODIFYING PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLUORESCENCE MICROSCOPY; FLUORESCENCE RESONANCE ENERGY TRANSFER; FOOD INTAKE; HISTOLOGY; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; EATING; KNOCKOUT MOUSE; METABOLISM; NERVE CELL;

ANIMALS; EATING; MICE; MICE, KNOCKOUT; NEURONS; RECEPTOR ACTIVITY-MODIFYING PROTEINS; RECEPTORS, G-PROTEIN-COUPLED;

EID: 84961282432     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.12397     Document Type: Article

References (32)

1. Asai M, Ramachandrappa S, Joachim M, Shen Y, Zhang R, Nuthalapati N, Ramanathan V, Strochlic DE, Ferket P, Linhart K, Ho C, Novoselova TV, Garg S, Ridderstrale M, Marcus C, Hirschhorn JN, Keogh JM, O’Rahilly S, Chan LF, Clark AJ, Farooqi IS, Majzoub JA. 2013. Loss of function of the melanocortin 2 receptor accessory protein 2 is associated with mammalian obesity. Science 341:275-278. doi: 10.1126/science.1233000
2. Beale KEL, Gardiner JV, Bewick GA, Hostomska K, Patel NA, Hussain SS, Jayasena CN, Ebling FJP, Jethwa PH, Prosser HM, Lattanzi R, Negri L, Ghatei MA, Bloom SR, Dhillo WS. 2013. Peripheral administration of prokineticin 2 potently reduces food intake and body weight in mice via the brainstem. British Journal of Pharmacology 168:403-410. doi: 10.1111/j.1476-5381.2012.02191.x
3. Boulberdaa M, Urayama K, Nebigil CG. 2011. Prokineticin receptor 1 (pKR1) signalling in cardiovascular and kidney functions. Cardiovascular Research 92:191-198. doi: 10.1093/cvr/cvr228
4. Butler AA, Cone RD. 2002. The melanocortin receptors: lessons from knockout models. Neuropeptides 36:77-84. doi: 10.1054/npep.2002.0890
5. Butler AA, Cone RD. 2003. Knockout studies defining different roles for melanocortin receptors in energy homeostasis. Annals of the New York Academy of Sciences 994:240-245. doi: 10.1111/j.1749-6632.2003.tb03186.x
6. Cerdá-Reverter JM, Agulleiro MJ, Cortés R, Sánchez E, Guillot R, Leal E, Fernández-Durán B, Puchol S, Eley M. 2013. Involvement of melanocortin receptor accessory proteins (mRAPs) in the function of melanocortin receptors. General and Comparative Endocrinology 188:133-136. doi: 10.1016/j.ygcen.2013.01.017
7. Chan LF, Webb TR, Chung T-T, Meimaridou E, Cooray SN, Guasti L, Chapple JP, Egertova M, Elphick MR, Cheetham ME, Metherell LA, Clark AJL. 2009. MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family. Proceedings of the National Academy of Sciences of the United States of America 106:6146-6151. doi: 10.1073/pnas.0809918106
8. Cooray SN, Chan L, Webb TR, Metherell L, Clark AJL. 2009. Accessory proteins are vital for the functional expression of certain g protein-coupled receptors. Molecular and Cellular Endocrinology 300:17-24. doi: 10.1016/j.mce.2008.10.004
9. Denison FC, Battersby S, King AE, Szuber M, Jabbour HN. 2008. Prokineticin-1: a novel mediator of the inflammatory response in third-trimester human placenta. Endocrinology 149:3470-3477. doi: 10.1210/en.2007-1695
10. Dormishian M, Turkeri G, Urayama K, Nguyen TL, Boulberdaa M, Messaddeq N, Renault G, Henrion D, Nebigil CG. 2013. Prokineticin receptor-1 is a new regulator of endothelial insulin uptake and capillary formation to control insulin sensitivity and cardiovascular and kidney functions. Journal of the American Heart Association 2: e000411. doi: 10.1161/JAHA.113.000411
11. Gardiner JV, Bataveljic A, Patel NA, Bewick GA, Roy D, Campbell D, Greenwood HC, Murphy KG, Hameed S, Jethwa PH, Ebling FJP, Vickers SP, Cheetham S, Ghatei MA, Bloom SR, Dhillo WS. 2010. Prokineticin 2 is a hypothalamic neuropeptide that potently inhibits food intake. Diabetes 59:397-406. doi: 10.2337/db09-1198
12. Hoffmann P, Feige J-J, Alfaidy N. 2007. Placental expression of EG-VEGF and its receptors PKR1 (prokineticin receptor-1) and PKR2 throughout mouse gestation. Placenta 28:1049-1058. doi: 10.1016/j.placenta.2007.03.008
13. Li M, Bullock CM, Knauer DJ, Ehlert FJ, Zhou QY. 2001. Identification of two prokineticin cDNAs: recombinant proteins potently contract gastrointestinal smooth muscle. Molecular Pharmacology 59:692-698.
14. Liu J, Garza JC, Truong HV, Henschel J, Zhang W, Lu X-Y. 2007. The melanocortinergic pathway is rapidly recruited by emotional stress and contributes to stress-induced anorexia and anxiety-like behavior. Endocrinology 148:5531-5540. doi: 10.1210/en.2007-0745
15. Matsunami H, Mainland JD, Dey S. 2009. Trafficking of mammalian chemosensory receptors by receptor-transporting proteins. Annals of the New York Academy of Sciences 1170:153-156. doi: 10.1111/j.1749-6632.2009.03888.x
16. Metherell LA, Chapple JP, Cooray S, David A, Becker C, Ruschendorf F, Naville D, Begeot M, Khoo B, Nurnberg P, Huebner A, Cheetham ME, Clark AJL. 2005. Mutations in MRAP, encoding a new interacting partner of the ACTH receptor, cause familial glucocorticoid deficiency type 2. Nature Genetics 37:166-170. doi: 10.1038/ng1501
17. Negri L, Lattanzi R. 2011. Bv8-prokineticins and their receptors: modulators of pain. Current Pharmaceutical Biotechnology 12:1720-1727. doi: 10.2174/138920111798357410
18. Ngan ESW, Tam PKH. 2008. Prokineticin-signaling pathway. The International Journal of Biochemistry & Cell Biology 40:1679-1684. doi: 10.1016/j.biocel.2008.03.010
19. Parameswaran N, Spielman WS. 2006. RAMPs: the past, present and future. Trends in Biochemical Sciences 31: 631-638. doi: 10.1016/j.tibs.2006.09.006
20. Ritter SL, Hall RA. 2009. Fine-tuning of GPCR activity by receptor-interacting proteins. Nature Reviews Molecular Cell Biology 10:819-830. doi: 10.1038/nrm2803
21. Saito H, Kubota M, Roberts RW, Chi Q, Matsunami H. 2004. RTP family members induce functional expression of mammalian odorant receptors. Cell 119:679-691. doi: 10.1016/j.cell.2004.11.021
22. Sebag JA, Hinkle PM. 2007. Melanocortin-2 receptor accessory protein MRAP forms antiparallel homodimers. Proceedings of the National Academy of Sciences of the United States of America 104:20244-20249. doi: 10.1073/pnas.0708916105
23. Sebag JA, Hinkle PM. 2009a. Opposite effects of the melanocortin-2 (mC2) receptor accessory protein MRAP on MC2 and MC5 receptor dimerization and trafficking. Journal of Biological Chemistry 284:22641-22648. doi: 10.1074/jbc.M109.022400
24. Sebag JA, Hinkle PM. 2009b. Regions of melanocortin 2 (mC2) receptor accessory protein necessary for dual topology and MC2 receptor trafficking and signaling. Journal of Biological Chemistry 284:610-618. doi: 10.1074/jbc.M804413200
25. Sebag JA, Zhang C, Hinkle PM, Bradshaw AM, Cone RD. 2013. Developmental control of the melanocortin-4 receptor by MRAP2 proteins in zebrafish. Science 341:278-281. doi: 10.1126/science.1232995
26. Sexton PM, Morfis M, Tilakaratne N, Hay DL, Udawela M, Christopoulos G, Christopoulos A. 2006. Complexing receptor pharmacology: modulation of family b g protein-coupled receptor function by RAMPs. Annals of the New York Academy of Sciences 1070:90-104. doi: 10.1196/annals.1317.076
27. Szatkowski C, Vallet J, Dormishian M, Messaddeq N, Valet P, Boulberdaa M, Metzger D, Chambon P, Nebigil CG. 2013. Prokineticin receptor 1 as a novel suppressor of preadipocyte proliferation and differentiation to control obesity. PLoS ONE 8:e81175. doi: 10.1371/journal.pone.0081175
28. Urayama K, Guilini C, Messaddeq N, Hu K, Steenman M, Kurose H, Ert G, Nebigil CG. 2007. The prokineticin receptor-1 (gPR73) promotes cardiomyocyte survival and angiogenesis. The FASEB Journal 21:2980-2993. doi: 10.1096/fj.07-8116com
29. van der Westhuizen ET, Valant C, Sexton PM, Christopoulos A. 2015. Endogenous allosteric modulators of g protein-coupled receptors. Journal of Pharmacology and Experimental Therapeutics 353:246-260. doi: 10.1124/jpet.114.221606
30. Vergoni AV, Bertolini A, Wikberg JES, Schioth HB. 1999. Selective melanocortin MC4 receptor blockage reduces immobilization stress-induced anorexia in rats. European Journal of Pharmacology 369:11-15. doi: 10.1016/S0014-2999(99)00045-X
31. Xu A, Choi K-L, Wang Y, Permana PA, Yi Xu L, Bogardus C, Cooper GJS. 2002. Identification of novel putative membrane proteins selectively expressed during adipose conversion of 3T3-L1 cells. Biochemical and Biophysical Research Communications 293:1161-1167. doi: 10.1016/S0006-291X(02)00354-6
32. Zhou W, Li J-D, Hu W-P, Cheng MY, Zhou Q-Y. 2012. Prokineticin 2 is involved in the thermoregulation and energy expenditure. Regulatory Peptides 179:84-90. doi: 10.1016/j.regpep.2012.08.003