Involvement of melanocortin receptor accessory proteins (MRAPs) in the function of melanocortin receptors

General and Comparative Endocrinology

Volumn 188, Issue 1, 2012, Pages 133-136

  Cerda Reverter J M ^a   Agulleiro, M J ^a   Cortes R ^a   Sanchez E ^a   Guillot, R ^a   Leal, E ^a   Fernandez Duran B ^a   Puchol, S ^a   Eley, M ^a  

^a CSIC Instituto de Acuicultura de Torre de la Sal IATS   (Spain)

Author keywords

Accessory protein; ACTH; HPA axis; Melanocortin; MRAP; MSH

Indexed keywords

CORTICOTROPIN; CYCLIC AMP; HYDROCORTISONE; MELANOCORTIN 2 RECEPTOR; MELANOCORTIN RECEPTOR; MELANOCORTIN RECEPTOR ACCESSORY PROTEIN; MELANOCORTIN RECEPTOR ACCESSORY PROTEIN 1; MELANOCORTIN RECEPTOR ACCESSORY PROTEIN 2; NUCLEOPORIN; NUCLEOPORIN 50; UNCLASSIFIED DRUG;

ADRENAL CORTEX; ADRENAL GLAND; AMINO TERMINAL SEQUENCE; ANIMAL GENETICS; ARTICLE; AUTOSOMAL DISORDER; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE; CELL SURFACE; CHROMOSOME 21; CLINICAL FEATURE; CONFORMATIONAL TRANSITION; CORTICOTROPIN BLOOD LEVEL; CYTOPLASM; DIMERIZATION; DISEASE SEVERITY; ENDOPLASMIC RETICULUM; FAMILIAL GLUCOCORTICOID DEFICIENCY TYPE 2; GENE; GENE CONTROL; GENE LOCATION; GENE LOCUS; GENE MUTATION; GLYCOSYLATION; GOLGI COMPLEX; HORMONE DEFICIENCY; HORMONE RECEPTOR INTERACTION; HORMONE SYNTHESIS; HORMONE TRANSPORT; HUMAN; MC2R GENE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; RARE DISEASE; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; ZEBRA FISH;

EID: 84879003701     PISSN: 00166480     EISSN: 10956840     Source Type: Journal    
DOI: 10.1016/j.ygcen.2013.01.017     Document Type: Article

References (37)

1. Agulleiro M.J., Roy S., Sánchez E., Puchol S., Gallo-Payet N., Cerdá-Reverter J.M. Role of accessory proteins in the function of zebrafish melanocortin receptor type 2. Mol. Cell. Endocrinol. 2010, 320:145-152.
2. Bangol D., Lu X.-Y., Kaelin C.D., Day H.E.W., Ollmann M., Gantz I., Akil H., Barsh G.S., Watson S.J.J. Anatomy of an endogenous antagonist: relationship between agouti-related protein and proopiomelanocortin in bran. J. Neurosci. 1999, 19:1-7.
3. Castro M.G., Morrison E. Post-translational processing of proopiomelanocortin in the pituitary and the brain. Crit. Rev. Neurobiol. 1997, 11:35-57.
4. Cerdá-Reverter J.M., Peter R.E. Endogenous melanocortin antagonist in fish: structure, brain mapping, and regulation by fasting of the goldfish agouti-related protein gene. Endocrinology 2003, 144:4552-4561.
5. Cerdá-Reverter J.M., Haitina T., Schiöth H.S., Peter R.E. Gene structure of the goldfish agouti-signaling protein: a putative role in the dorsal-ventral pigment pattern of fish. Endocrinology 2005, 146:1597-161026.
6. Cerdá-Reverter J.M., Agulleiro M.J., Sánchez E., Guillot R. Fish melanocortin system. Eur. J. Pharmacol. 2011, 660:53-60.
7. Chai B.X., Neubig R.R., Millhauser G.L., Thompson D.A., Jackson P.J., Barsh G.S., Dickinson C.J., Li J.Y., Lai Y.M., Gantz I. Inverse agonist activity of agouti and agouti-related protein. Peptides 2003, 24:603-609.
8. Chan L.F., Webb T.R., Chung T.T., Meimaridou E., Cooray S.N., Guasti L., Chapple J.P., Egertová M., Elphick M.R., Cheetham M.E., Metherell L.A., Clark A.J. MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family. Proc. Natl. Acad. Sci. 2009, 106:6146-6151.
9. Chan L.F., Metherell L.A., Clark A.J. Effects of melanocortins on adrenal gland physiology. Eur. J. Pharmacol. 2011, 660:171-180.
10. Cone R.D. Studies on the physiological functions of the melanocortin system. Endocr. Rev. 2006, 27:736-749.
11. Cooray S.N., Clark A.J. Melanocortin receptors and their accessory proteins. Mol. Cell. Endocrinol. 2011, 331:215-221.
12. Cooray S.N., Almiro Do Vale I., Leung K.Y., Webb T.R., Chapple J.P., Egertová M., Cheetham M.E., Elphick M.R., Clark A.J. The melanocortin 2 receptor accessory protein exists as a homodimer and is essential for the function of the melanocortin 2 receptor in the mouse y1 cell line. Endocrinology 2008, 149:1935-1941.
13. Cooray S.N., Chung T.T., Mazhar K., Szidonya L., Clark A.J. Bioluminescence resonance energy transfer reveals the adrenocorticotropin (ACTH)-induced conformational change of the activated ACTH receptor complex in living cells. Endocrinology 2011, 152:495-502.5.
14. Doufexis M., Storr H.L., King P.J., Clark A.J. Interaction of the melanocortin 2 receptor with nucleoporin 50: evidence for a novel pathway between a G-protein-coupled receptor and the nucleus. FASEB J. 2007, 21:4095-4100.
15. Fridmanis D., Petrovska R., Kalnina I., Slaidina M., Peculis R., Schiöth h.B., Klovins J. Identification of domains responsible for specific membrane transport and ligand specificity of the ACTH receptor (MC2R). Mol. Cell. Endocrinol. 2010, 321:175-183.
16. Gerets H.H.J., Peeters K., Arckens L., Vandesande R., Berghman L.R. Sequence and distribution of proopiomelanocortin in the pituitary and brain of the chicken (Gallus gallus). J. Comp. Neurol. 2000, 417:250-262.
17. Hinkle P.M., Serasinghe M.N., Jakabowski A., Sebag J.A., Wilson K.R., Haskell-Luevano C. Use of chimeric melanocortin-2 and -4 receptors to identify regions responsible for ligand specificity and dependence on melanocortin 2 receptor accessory protein. Eur. J. Pharmacol. 2011, 660:94-102.
18. Kurokawa T., Murashita K., Uji S. Characterization and tissue distribution of multiple agouti-family genes in pufferfish, Takifugu rubripes. Peptides 2006, 27:3165-3175.
19. Metherell L.A., Chapple J.P., Cooray S., David A., Becker C., Rüschendorf F., Naville D., Begeot M., Khoo B., Nürnberg P., Huebner A., Cheetham M.E., Clark A.J. Mutations in MRAP, encoding a new interacting partner of the ACTH receptor, cause familial glucocorticoid deficiency type 2. Nat. Genet. 2005, 37:166-170.
20. Murashita K., Kurokawa T., Ebbesson L.O., Stefansson S.O., Rønnestad I. Characterization, tissue distribution, and regulation of agouti-related protein (AgRP), cocaine- and amphetamine-regulated transcript (CART) and neuropeptide Y (NPY) in Atlantic salmon (Salmo salar). Gen. Comp. Endocrinol. 2009, 162:160-171.
21. Nakanishi S., Inoue A., Kita T., Nakamura M., Chang A.C.Y., Cohen S.N., Numa S. Nucleotide sequence of cloned cDNA for bovine corticotropin-β-lipotropin precursor. Nature 1979, 288:610-613.
22. Nijenhuis W.A., Oosterom J., Adan R.A. AgRP(83-132) acts as an inverse agonist on the human-melanocortin-4 receptor. Mol. Endocrinol. 2001, 15:164-171.
23. Noon L.A., Franklin J.M., King P.J., Goulding N.J., Hunyady L., Clark A.J. Failed export of the adrenocorticotrophin receptor from the endoplasmic reticulum in non-adrenal cells: evidence in support of a requirement for a specific adrenal accessory factor. J. Endocrinol. 2002, 174:17-25.
24. Reinick C.L., Liang L., Angleson J.K., Dores R.M. Functional expression of Squalus acanthias melanocortin-5 receptor in CHO cells: ligand selectivity and interaction with MRAP. Eur. J. Pharmacol. 2012, 680:1-7.
25. Reinick C.L., Liang L., Angleson J.K., Dores R.M. Identification of an MRAP-independent melanocortin 2 receptor: functional expression of the cartilaginous fish, Callorhinchus milii, melanocortin-2 receptor in CHO cells. Endocrinology 2012, 153:4757-4765.
26. Roy S., Rached M., Gallo-Payet N. Differential regulation of the human adrenocorticotropin receptor [melanocortin-2 receptor (MC2R)] by human MC2R accessory protein isoforms alpha and beta in isogenic human embryonic kidney 293 cells. Mol. Endocrinol. 2007, 21:1656-1669.
27. Roy S., Roy S.J., Agulleiro M.J., Cerdá-Reverter J.M., Parent J.L., Gallo-Payet N. The C-terminal domain of melanocortin 2 receptor accessory proteins (MRAP) determines its localization and fine tunes ACTH-induced signaling. Gen. Comp. Endocrinol. 2012, 76:265-274.
28. Schimmer B.P., Kwan W.K., Tsao J., Qiu R. Adrenocorticotropin-resistant mutants of the Y1 adrenal cell line fail to express the adrenocorticotropin receptor. J. Cell. Physiol. 1995, 163:164-171.
29. Schiöth H.B., Haitina T., Ling M.K., Ringholm A., Fredriksson R., Cerdá-Reverter J.M., Klovins J. Evolutionary conservation of the structural, pharmacological and genomic characteristics of the melanocortin receptors subtypes. Peptides 2005, 26:1886-1900.
30. Sebag J.A., Hinkle P.M. Melanocortin-2 receptor accessory protein MRAP forms antiparallel homodimers. Proc. Natl. Acad. Sci. USA 2007, 104:20244-20249.
31. Sebag J.A., Hinkle P.M. Opposite effects of the melanocortin-2 receptor accessory protein MRAP on MC2 and MC5 receptor dimerization and trafficking. J. Biol. Chem. 2009, 284:22641-22648.
32. Sebag J.A., Hinkle P.M. Regions of melanocortin 2 (MC2) receptor accessory protein necessary for dual topology and MC2 receptor trafficking and signaling. J. Biol. Chem. 2009, 284:610-618.
33. Sebag J.A., Hinkle P.M. Regulation of G protein-coupled receptor signaling: specific dominant-negative effects of melanocortin 2 receptor accessory protein 2. Sci. Signal. 2010, 3:116:ra28.
34. Song Y., Golling G., Thacker T.L., Cone R.D. Agouti-related protein (AGRP) is conserved and regulated by metabolic state in the zebrafish, Danio rerio. Endocrine 2003, 22:257-265.
35. Tuinhof R., Ubink R., Tanaka S., Atzori C., van Strien F.J.C., Roubos E.W. Distribution of proopiomelanocortin and its peptide end products in the brain and hypophysis of the aquatic toad, Xenopus laevis. Cell Tissue Res. 1998, 292:251-265.
36. Webb T.R., Chan L., Cooray S.N., Cheetham M.E., Chapple J.P., Clark A.J. Distinct melanocortin 2 receptor accessory protein domains are required for melanocortin 2 receptor interaction and promotion of receptor trafficking. Endocrinology 2009, 150:720-726.
37. Xu A., Choi K.L., Wang Y., Permana P.A., Xu L.Y., Bogardus C., Cooper G.J. Identification of novel putative membrane proteins selectively expressed during adipose conversion of 3T3-L1 cells. Biochem. Biophys. Res. Commun. 2002, 293:1161-1167.