Pharmacologically improved contractility protects against aortic dissection in mice with disrupted transforming growth factor-β signaling despite compromised extracellular matrix properties

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 36, Issue 5, 2016, Pages 919-927

  Ferruzzi, Jacopo ^a   Murtada, Sae Il ^a   Li, Guangxin ^b,c   Jiao, Yang ^b,d   Uman, Selen ^a,e   Ting, Magdalene Y L ^a,e   Tellides, George ^b   Humphrey, Jay D ^a,b  

^a Yale University   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c CHINA MEDICAL UNIVERSITY   (China)

^d PEKING UNIVERSITY   (China)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

aneurysm; aorta; rapamycin; stiffness; strength; transforming growth factor beta

Indexed keywords

RAPAMYCIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA2; MTOR PROTEIN, MOUSE; PROTEIN KINASE INHIBITOR; PROTEIN SERINE THREONINE KINASE; TARGET OF RAPAMYCIN KINASE; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR-BETA TYPE II RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA DISSECTION; AORTA WALL; ARTICLE; BIOMECHANICS; CONTROLLED STUDY; ELASTICITY; EXERCISE; EXTRACELLULAR MATRIX; HYPERTENSION; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION; SMOOTH MUSCLE CONTRACTILITY; STRESS; THORACIC AORTA; ANEURYSM, DISSECTING; ANIMAL; ANTAGONISTS AND INHIBITORS; AORTIC ANEURYSM, THORACIC; ARTERIAL PRESSURE; ARTERIAL STIFFNESS; DEFICIENCY; DRUG EFFECTS; GENETIC PREDISPOSITION; GENETICS; KNOCKOUT MOUSE; MECHANICAL STRESS; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHENOTYPE; VASCULAR SMOOTH MUSCLE; VASOCONSTRICTION;

ANEURYSM, DISSECTING; ANIMALS; AORTA, THORACIC; AORTIC ANEURYSM, THORACIC; ARTERIAL PRESSURE; ELASTICITY; EXTRACELLULAR MATRIX; GENETIC PREDISPOSITION TO DISEASE; MALE; MICE, KNOCKOUT; MUSCLE, SMOOTH, VASCULAR; PHENOTYPE; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIROLIMUS; STRESS, MECHANICAL; TOR SERINE-THREONINE KINASES; VASCULAR STIFFNESS; VASOCONSTRICTION;

EID: 84961226626     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.116.307436     Document Type: Article

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