Myh11R247C/R247C mutations increase thoracic aorta vulnerability to intramural damage despite a general biomechanical adaptivity

Journal of Biomechanics

Volumn 48, Issue 1, 2015, Pages 113-121

  Bellini, Chiara ^a   Wang, Shanzhi ^b   Milewicz, Dianna M ^b   Humphrey, Jay D ^a  

^a Yale University   (United States)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

Actomyosin functionality; Familial thoracic aortic aneurysms and dissections; Smooth muscle myosin heavy chain; Wall stress and stiffness

Indexed keywords

BIOMECHANICS; CELLS; DISSECTION; HEMODYNAMICS; MAMMALS; MUSCLE; PROTEINS;

ACTOMYOSIN FUNCTIONALITY; AORTIC ANEURYSMS; AORTIC DISSECTIONS; BIAXIAL MECHANICAL PROPERTIES; MYOSIN HEAVY CHAIN; SMOOTH MUSCLE CELLS; STRUCTURE AND PROPERTIES; WALL STRESS;

BLOOD VESSELS;

CONTRACTILE PROTEIN; GLYCOSAMINOGLYCAN; PROTEOGLYCAN; MYOSIN 11, MOUSE; MYOSIN HEAVY CHAIN;

ACTA2 GENE; ANEURYSM SURGERY; ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA DISSECTION; ARTICLE; ASCENDING AORTA; ASCENDING THORACIC AORTA; BIOMECHANICS; CLINICAL OBSERVATION; CONTROLLED STUDY; DESCENDING AORTA; EPIGENETICS; GENE; GENE MUTATION; HEART HEMODYNAMICS; HISTOPATHOLOGY; HYPERTENSION; MALE; MOUSE; MYH11 GENE; NONHUMAN; PHENOTYPE; PROXIMAL DESCENDING THORACIC AORTA; RISK FACTOR; THORACIC AORTA; THORACIC AORTA ANEURYSM; ANIMAL; AORTA; DISEASE MODEL; GENETICS; HEMODYNAMICS; HUMAN; MUTATION; PATHOLOGY; PATHOPHYSIOLOGY; SMOOTH MUSCLE CELL; TRANSGENIC MOUSE;

ANIMALS; AORTA; AORTA, THORACIC; AORTIC ANEURYSM, THORACIC; DISEASE MODELS, ANIMAL; HEMODYNAMICS; HUMANS; HYPERTENSION; MALE; MICE; MICE, TRANSGENIC; MUTATION; MYOCYTES, SMOOTH MUSCLE; MYOSIN HEAVY CHAINS; PHENOTYPE;

EID: 84921947571     PISSN: 00219290     EISSN: 18732380     Source Type: Journal    
DOI: 10.1016/j.jbiomech.2014.10.031     Document Type: Article

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