Reduced Biaxial Contractility in the Descending Thoracic Aorta of Fibulin-5 Deficient Mice

Journal of Biomechanical Engineering

Volumn 138, Issue 5, 2016, Pages

  Murtada, S I ^a,b   Ferruzzi, J ^a   Yanagisawa, H ^c   Humphrey, J D ^a  

^a Yale University   (United States)

^b KAROLINSKA INSTITUTE   (Sweden)

^c UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

active stress; artery; passive stress; smooth muscle; Wall mechanics

Indexed keywords

BLOOD VESSELS; GLYCOPROTEINS; MAMMALS; MUSCLE; STRESSES;

ACTIVE STRESS; ARTERY; PASSIVE STRESS; SMOOTH MUSCLES; WALL MECHANICS;

ELASTIN;

FIBULIN 5; POTASSIUM; FBLN5 PROTEIN, MOUSE; RECOMBINANT PROTEIN; SCLEROPROTEIN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DESCENDING AORTA; FORCE TRANSDUCER; GENE DELETION; GENOTYPE; MALE; MOUSE; MUSCLE ISOMETRIC CONTRACTION; MUSCLE RELAXATION; MUSCLE RIGIDITY; MUSCLE STRENGTH; NONHUMAN; SMOOTH MUSCLE CONTRACTILITY; THICKNESS; THORACIC AORTA; ANIMAL; DEFICIENCY; MECHANICAL STRESS; PHYSIOLOGY; VASOCONSTRICTION;

ANIMALS; AORTA, THORACIC; EXTRACELLULAR MATRIX PROTEINS; GENOTYPE; MALE; MICE; RECOMBINANT PROTEINS; STRESS, MECHANICAL; VASOCONSTRICTION;

EID: 84971254882     PISSN: 01480731     EISSN: 15288951     Source Type: Journal    
DOI: 10.1115/1.4032938     Document Type: Article

References (30)

1. Yanagisawa, H., Davis, E. C., Starcher, B. C., Ouchi, T., Yanagisawa, M., Richardson, J. A., Olson, E. N., 2002, "Fibulin-5 is an Elastin-Binding Protein Essential for Elastic Fiber Development In Vivo," Nature, 415(6868), pp. 168-171.
2. Le, V. P., Cheng, J. K., Kim, J., Staiculescu, M. C., Ficker, S. W., Sheth, S. C., Bhayani, S. A., Mecham, R. P., Yanagisawa, H., Wagenseil, J. E., 2015, "Mechanical Factors Direct Mouse Aortic Remodeling During Early Maturation," J. R. Soc. Interface., 12(104), p. 20141350.
3. Ferruzzi, J., Bersi, M. R., Uman, S., Yanagisawa, H., Humphrey, J. D., "Decreased Energy Storage, Not Increased Material Stiffness, Characterizes Central Artery Dysfunction in Fibulin-5 Deficiency Independent of Sex," ASME J. Biomech. Eng., 137(3), p. 031007.
4. Pereira, L., Lee, S. Y., Gayraud, B.,rikopoulos, K., Shapiro, S. D., Bunton, T., Biery, N. J., Dietz, H. C., Sakai, L. Y., Ramirez, F., 1999, "Pathogenetic Sequence for Aneurysm Revealed in Mice Under Expressing Fibrillin-1," Proc. Natl. Acad. Sci. USA, 96(7), pp. 3819-3823.
5. Huang, J., Davis, E. C., Chapman, S. L., Budatha, M., Marmorstein, L. Y., Word, R. A., Yanagisawa, H., 2010, "Fibulin-4 Deficiency Results in Ascending Aortic Aneurysms: A Potential Link Between Abnormal Smooth Muscle Cell Phenotype and Aneurysm Progression," Circ. Res., 106(3), pp. 583-592.
6. Wang, X., LeMaire, S. A., Chen, L., Carter, S. A., Shen, Y. H., Gan, Y., Bartsch, H., Wilks, J. A., Utama, B., Ou, H., Thompson, R. W., Coselli, J. S., Wang, X. L., 2005, "Decreased Expression of Fibulin-5 Correlates With Reduced Elastin in Thoracic Aortic Dissection," Surgery, 138(2), pp. 352-359.
7. Humphrey, J. D., Schwartz, M. A., Tellides, G., Milewicz, D. M., 2015, "Role of Mechanotransduction in Vascular Biology: Focus on Thoracic Aortic Aneurysms and Dissections," Circ. Res., 116(8), pp. 1448-1461.
8. Kim, H. R., Appel, S., Betterkind, S., Gangopadhyay, S. S., Morgan, K. G., 2008, "Smooth Muscle Signaling Pathways in Health and Disease," J. Cell. Mol. Med., 12(6a), pp. 2165-2180.
9. Putz, S., Lubomirov, L. T., Pfitzer, G., 2009, "Regulation of Smooth Muscle Contraction by Small GTPases," Physiology, 24(6), pp. 324-356.
10. Ferruzzi, J., Bersi, M. R., Humphrey, J. D., 2013, "Biomechanical Phenotyping of Central Arteries in Health and Disease: Advantages of and Methods for Murine Models," Ann. Biomed. Eng., 41(7), pp. 1311-1330.
11. Gleason, R. L., Gray, S. P.,Wilson, E., Humphrey, J. D., 2004, "A Multiaxial Computer-Controlled Organ Culture and Biomechanical Device for Mouse Carotid Arteries," ASME J. Biomech. Eng., 126(6), pp. 787-795.
12. Agianniotis, A., Rachev, A., Stergiopulos, N., 2012, "Active Axial Stress in Mouse Aorta," J. Biomech., 26(45), pp. 1924-1927.
13. Humphrey, J. D., 2002, Cardiovascular Solid Mechanics: Cells, Tissues, Organs, Springer, New York.
14. Wagner, H. P., Humphrey, J. D., 2011, "Differential Passive and Active Biaxial Mechanical Behaviors of Muscular and Elastic Arteries: Basilar Versus Common Carotid," ASME J. Biomech. Eng., 133(5), p. 051009.
15. Van Loon, P., Klip, W., Bradley, E. L., 1977, "Length-Force and Volume-Pressure Relationships of Arteries," Biorheology, 14(4), pp. 181-201.
16. Dobrin, P. B., Schwarcz, T. H., Mrkvicka, R., 1990, "Longitudinal Retractive Force in Pressurized Dog and Human Arteries," J. Surg. Res., 48(2), pp. 116-120.
17. Humphrey, J. D., Eberth, J. F., Dye, W. W., Gleason, R. L., 2009, "Fundamental Role of Axial Stress in Compensatory Adaptations by Arteries," J. Biomech., 42(1), pp. 1-8.
18. Dye, W. W., Gleason, R. L., Wilson, E., Humphrey, J. D., 2007, "Altered Biomechanical Properties of Carotid Arteries in Two Mouse Models of Muscular Dystrophy," J. Appl. Physiol., 103(2), pp. 664-672.
19. Humphrey, J. D., Na, S., 2002, "Elastodynamics and Arterial Wall Stress," Ann. Biomed. Eng., 30(4), pp. 509-523.
20. Zulliger, M. A., Kwak, N. T., Tsapikouni, T., Stergiopulos, N., 2002, "Effects of Longitudinal Stretch on VSM Tone and Distensibility of Muscular Conduit Arteries," Am. J. Physiol. Heart Circ. Physiol., 283(6), pp. H2599-H2605.
21. Knapp, J., Aleth, S., Balzer, F., Gergs, U., Schmitz, W., Neumann, J., 2006, "Comparison of Contractile Responses in Isolated Mouse Aorta and Pulmonary Artery: Influence of Strain and Sex," J. Cardiovasc. Pharmacol., 48(1), pp. 820-826.
22. Cyron, C., Humphrey, J. D., 2015, "Preferred Fiber Orientations in Healthy Arteries and Veins Understood from Netting Analysis," Math. Mech. Solids., 20(6), pp. 680-696.
23. Humphrey, J. D., Wilson, E., 2003, "A Potential Role of Smooth Muscle Tone in Early Hypertension: A Theoretical Study," J. Biomech., 36(11), pp. 1595-1601.
24. Takamizawa, K., Hayashi, K., Matsuda, T., 1992, "Isometric Biaxial Tension of Smooth Muscle in Isolated Cylindrical Segments of Rabbit Arteries," Am. J. Physiol., 263(1), pp. H30-H34.
25. Humphrey, J. D., 2003, "Continuum Thermomechanics and the Treatment of Disease and Injury," ASME Appl. Mech. Rev., 56(2), pp. 231-260.
26. Murtada, S.-I., Kroon, M., Holzapfel, G. A., 2010, "A Calcium-Driven Mechanochemical Model for Prediction of Force Generation in Smooth Muscle," Biomech. Model. Mechanobiol., 9(6), pp. 749-762.
27. Murtada, S.-I., Arner, A., Holzapfel, G. A., 2012, "Experiments and Mechanochemical Modeling of Smooth Muscle Contraction: Significance of Filament Overlap," J. Theor. Biol., 297, pp. 176-186.
28. Murtada, S.-I., Lewin, S., Arner, A., Humphrey, J. D., "Adaptation of Active Tone in the Mouse Descending Thoracic Aorta Under Acute Changes in Loading," Biomech. Model. Mechanobiol. (in press).
29. Milewicz, D. M., Gou, D. C., Fadulu, V. T., Lafont, A. L., Papke, C. L., Inamoto, S., Kwartler, C. S., Pannu, H., 2008, "Genetic Basis of Thoracic Aortic Aneurysms and Dissections: Focus on Smooth Muscle Cell Contractile Dysfunction," Annu. Rev. Genomics. Hum. Genet., 9(1), pp. 283-302.
30. Ferruzzi, J., Murtada, S.-I., Li, G., Jiao, Y., Uman, S., Ting, M. Y.-L., Tellides, G., Humphrey, J. D., 2016, "Pharmacologically Improved Contractility Protects Against Aortic Dissection in Mice With Disrupted TGFb Signaling Despite Compromised ECM Properties," Arterioscl. Thromb. Vasc. Biol. (in press).