Binding to and inhibition of insulin-regulated aminopeptidase by macrocyclic disulfides enhances spine density

Molecular Pharmacology

Volumn 89, Issue 4, 2016, Pages 413-424

  Diwakarla, Shanti ^a   Nylander, Erik ^a   Grönbladh, Alfhild ^a   Vanga, Sudarsana Reddy ^b   Khan, Yasmin Shamsudin ^b   Gutiérrez De Terán, Hugo ^b   Ng, Leelee ^f,g   Pham, Vi ^f,g   Sävmarker, Jonas ^c   Lundbäck, Thomas ^d,e   Jenmalm Jensen, Annika ^a   Andersson, Hanna ^b   Engen, Karin ^b   Rosenström, Ulrika ^b   Larhed, Mats ^d   Aqvist, Johan ^b,d,e   Chai, Siew Yeen ^f,g   Hallberg, Mathias ^a  

^a Department of Pharmaceutical Biosciences   (Sweden)

^b Department of Cell and Molecular Biology ^*  (Sweden)

^c Beijer Laboratory   (Sweden)

^d SCIENCE FOR LIFE LABORATORY   (Sweden)

^e UPPSALA UNIVERSITY   (Sweden)

^f KAROLINSKA INSTITUTE   (Sweden)

^g MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOPEPTIDASE; ANGIOTENSIN II [3-8]; CYCLOPEPTIDE; DISULFIDE; ENZYME INHIBITOR; GLUTAMIC ACID; HA 08; HA 09; INSULIN; INSULIN REGULATED AMINOPEPTIDASE; LEUKOTRIENE A4 HYDROLASE; MICROSOMAL AMINOPEPTIDASE; OXYTOCIN; UNCLASSIFIED DRUG; VASOPRESSIN; CYSTYL AMINOPEPTIDASE; LEUCYL-CYSTINYL AMINOPEPTIDASE; MACROCYCLIC COMPOUND; PROTEIN BINDING;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DENDRITIC SPINE; DRUG POTENCY; DRUG PROTEIN BINDING; EPIMER; HIPPOCAMPUS; IMAGE ANALYSIS; IMMUNOCYTOCHEMISTRY; MEMORY; MOLECULAR DYNAMICS; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CHEMISTRY; CRYSTALLOGRAPHY; FEMALE; HEK293 CELL LINE; HUMAN; METABOLISM; PHYSIOLOGY; PREGNANCY; SPRAGUE DAWLEY RAT;

ANIMALS; CELLS, CULTURED; CRYSTALLOGRAPHY; CYSTINYL AMINOPEPTIDASE; DENDRITIC SPINES; DISULFIDES; ENZYME INHIBITORS; FEMALE; HEK293 CELLS; HUMANS; MACROCYCLIC COMPOUNDS; PREGNANCY; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84961212120     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.115.102533     Document Type: Article

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