메뉴 건너뛰기




Volumn 79, Issue 8, 2016, Pages 650-656

Translating neurogenomics into new medicines

Author keywords

Brain disorders; Circuits; Genes; Genomics; GWAS; Human genetics; Psychiatry; Translational medicine

Indexed keywords

BRAIN DISEASE; DISEASE SEVERITY; GENE LOCUS; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOMICS; MEDICINE; NEUROGENOMICS; PERSONALIZED MEDICINE; PHENOTYPE; PRIORITY JOURNAL; REVIEW; TRANSLATIONAL RESEARCH; BRAIN DISEASES; GENETICS; HUMAN; PROCEDURES;

EID: 84961187134     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2015.04.027     Document Type: Review
Times cited : (10)

References (62)
  • 1
    • 84867439307 scopus 로고    scopus 로고
    • Revolution stalled
    • 155cm111
    • Hyman SE (2012): Revolution stalled. Sci Transl Med 4:155cm111.
    • (2012) Sci Transl Med , vol.4
    • Hyman, S.E.1
  • 2
    • 84886999278 scopus 로고    scopus 로고
    • Progress in the genetics of polygenic brain disorders: Significant new challenges for neurobiology
    • S.A. McCarroll, and S.E. Hyman Progress in the genetics of polygenic brain disorders: Significant new challenges for neurobiology Neuron 80 2013 578 587
    • (2013) Neuron , vol.80 , pp. 578-587
    • McCarroll, S.A.1    Hyman, S.E.2
  • 3
    • 84879628020 scopus 로고    scopus 로고
    • Opportunities and limitations of intrinsic functional connectivity MRI
    • R.L. Buckner, F.M. Krienen, and B.T. Yeo Opportunities and limitations of intrinsic functional connectivity MRI Nat Neurosci 16 2013 832 837
    • (2013) Nat Neurosci , vol.16 , pp. 832-837
    • Buckner, R.L.1    Krienen, F.M.2    Yeo, B.T.3
  • 4
    • 0029741063 scopus 로고    scopus 로고
    • The future of genetic studies of complex human diseases
    • N. Risch, and K. Merikangas The future of genetic studies of complex human diseases Science 273 1996 1516 1517
    • (1996) Science , vol.273 , pp. 1516-1517
    • Risch, N.1    Merikangas, K.2
  • 5
    • 42249087793 scopus 로고    scopus 로고
    • Estimation of significance thresholds for genomewide association scans
    • F. Dudbridge, and A. Gusnanto Estimation of significance thresholds for genomewide association scans Genet Epidemiol 32 2008 227 234
    • (2008) Genet Epidemiol , vol.32 , pp. 227-234
    • Dudbridge, F.1    Gusnanto, A.2
  • 6
    • 84863338087 scopus 로고    scopus 로고
    • What should the genome-wide significance threshold be? Empirical replication of borderline genetic associations
    • Genome-Wide Significance Project
    • Panagiotou OA, Ioannidis JP, Genome-Wide Significance Project (2012): What should the genome-wide significance threshold be? Empirical replication of borderline genetic associations. Int J Epidemiol 41:273-286.
    • (2012) Int J Epidemiol , vol.41 , pp. 273-286
    • Panagiotou, O.A.1    Ioannidis, J.P.2
  • 7
    • 80055088241 scopus 로고    scopus 로고
    • Believe it or not: How much can we rely on published data on potential drug targets?
    • F. Prinz, T. Schlange, and K. Asadullah Believe it or not: How much can we rely on published data on potential drug targets? Nat Rev Drug Discov 10 2011 712
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 712
    • Prinz, F.1    Schlange, T.2    Asadullah, K.3
  • 8
    • 84897425769 scopus 로고    scopus 로고
    • Preclinical research: Make mouse studies work
    • S. Perrin Preclinical research: Make mouse studies work Nature 507 2014 423 425
    • (2014) Nature , vol.507 , pp. 423-425
    • Perrin, S.1
  • 9
    • 84897126113 scopus 로고    scopus 로고
    • Psychiatric disorders: Diagnosis to therapy
    • Krystal JH, State MW (2014): Psychiatric disorders: Diagnosis to therapy. Cell 157:201-214.
    • (2014) Cell , vol.157 , pp. 201-214
    • Krystal, J.H.1    State, M.W.2
  • 10
    • 84884671572 scopus 로고    scopus 로고
    • What psychiatric genetics has taught us about the nature of psychiatric illness and what is left to learn
    • K.S. Kendler What psychiatric genetics has taught us about the nature of psychiatric illness and what is left to learn Mol Psychiatry 18 2013 1058 1066
    • (2013) Mol Psychiatry , vol.18 , pp. 1058-1066
    • Kendler, K.S.1
  • 11
    • 84863980709 scopus 로고    scopus 로고
    • Genetic architectures of psychiatric disorders: The emerging picture and its implications
    • Sullivan PF, Daly MJ, OEDonovan M (2012): Genetic architectures of psychiatric disorders: The emerging picture and its implications. Nat Rev Genet 13:537-551.
    • (2012) Nat Rev Genet , vol.13 , pp. 537-551
    • Sullivan, P.F.1    Daly, M.J.2    O'Donovan, M.3
  • 12
    • 84877704720 scopus 로고    scopus 로고
    • Genetics of bipolar disorder
    • N. Craddock, and P. Sklar Genetics of bipolar disorder Lancet 381 2013 1654 1662
    • (2013) Lancet , vol.381 , pp. 1654-1662
    • Craddock, N.1    Sklar, P.2
  • 13
    • 84879892380 scopus 로고    scopus 로고
    • A mega-analysis of genome-wide association studies for major depressive disorder
    • Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium S. Ripke, N.R. Wray, C.M. Lewis, S.P. Hamilton, M.M. Weissman, and et al. A mega-analysis of genome-wide association studies for major depressive disorder Mol Psychiatry 18 2013 497 511
    • (2013) Mol Psychiatry , vol.18 , pp. 497-511
    • Ripke, S.1    Wray, N.R.2    Lewis, C.M.3    Hamilton, S.P.4    Weissman, M.M.5
  • 15
    • 84904804929 scopus 로고    scopus 로고
    • Biological insights from 108 schizophrenia-associated genetic loci
    • Schizophrenia Working Group of the Psychiatric Genomics Consortium
    • Schizophrenia Working Group of the Psychiatric Genomics Consortium Biological insights from 108 schizophrenia-associated genetic loci Nature 511 2014 421 427
    • (2014) Nature , vol.511 , pp. 421-427
  • 16
    • 84893814574 scopus 로고    scopus 로고
    • A genome-wide association analysis of a broad psychosis phenotype identifies three loci for further investigation
    • Psychosis Endophenotypes International Consortium, Wellcome Trust Case-Control Consortium E. Bramon, M. Pirinen, A. Strange, K. Lin, and et al. A genome-wide association analysis of a broad psychosis phenotype identifies three loci for further investigation Biol Psychiatry 75 2014 386 397
    • (2014) Biol Psychiatry , vol.75 , pp. 386-397
    • Bramon, E.1    Pirinen, M.2    Strange, A.3    Lin, K.4
  • 17
    • 84930368102 scopus 로고    scopus 로고
    • Knowns and unknowns for psychophysiological endophenotypes: Integration and response to commentaries
    • W.G. Iacono, U. Vaidyanathan, S.I. Vrieze, and S.M. Malone Knowns and unknowns for psychophysiological endophenotypes: Integration and response to commentaries Psychophysiology 51 2014 1339 1347
    • (2014) Psychophysiology , vol.51 , pp. 1339-1347
    • Iacono, W.G.1    Vaidyanathan, U.2    Vrieze, S.I.3    Malone, S.M.4
  • 18
    • 84930318143 scopus 로고    scopus 로고
    • The missing heritability of behavior: The search continues
    • D. Goldman The missing heritability of behavior: The search continues Psychophysiology 51 2014 1327 1328
    • (2014) Psychophysiology , vol.51 , pp. 1327-1328
    • Goldman, D.1
  • 19
    • 84883465830 scopus 로고    scopus 로고
    • Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
    • Cross-Disorder Group of the Psychiatric Genomics Consortium S.H. Lee, S. Ripke, B.M. Neale, S.V. Faraone, SM Purcell, and et al. Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs Nat Genet 45 2013 984 994
    • (2013) Nat Genet , vol.45 , pp. 984-994
    • Lee, S.H.1    Ripke, S.2    Neale, B.M.3    Faraone, S.V.4    Purcell, S.M.5
  • 20
    • 84876296688 scopus 로고    scopus 로고
    • Identification of risk loci with shared effects on five major psychiatric disorders: A genome-wide analysis
    • Cross-Disorder Group of the Psychiatric Genomics Consortium, Genetic Risk Outcome of Psychosis Consortium
    • Cross-Disorder Group of the Psychiatric Genomics Consortium, Genetic Risk Outcome of Psychosis Consortium Identification of risk loci with shared effects on five major psychiatric disorders: A genome-wide analysis Lancet 381 2013 1371 1379
    • (2013) Lancet , vol.381 , pp. 1371-1379
  • 21
    • 0003472502 scopus 로고    scopus 로고
    • 5th ed. American Psychiatric Association Washington, DC
    • American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders 5th ed. 2013 American Psychiatric Association Washington, DC
    • (2013) Diagnostic and Statistical Manual of Mental Disorders
  • 22
    • 84870465485 scopus 로고
    • 4th ed. American Psychiatric Association Washington, DC
    • American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders 4th ed. 1994 American Psychiatric Association Washington, DC
    • (1994) Diagnostic and Statistical Manual of Mental Disorders
  • 24
    • 0027194791 scopus 로고
    • Gene dose of apolipoprotein e type 4 allele and the risk of Alzheimer's disease in late onset families
    • E.H. Corder, A.M. Saunders, W.J. Strittmatter, D.E. Schmechel, P.C. Gaskell, G.W. Small, and et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families Science 261 1993 921 923
    • (1993) Science , vol.261 , pp. 921-923
    • Corder, E.H.1    Saunders, A.M.2    Strittmatter, W.J.3    Schmechel, D.E.4    Gaskell, P.C.5    Small, G.W.6
  • 25
    • 80055046548 scopus 로고    scopus 로고
    • An improved model for disease progression in patients from the Alzheimer's disease neuroimaging initiative
    • M.N. Samtani, M. Farnum, V. Lobanov, E. Yang, N. Raghavan, A. Dibernardo, and et al. An improved model for disease progression in patients from the Alzheimer's disease neuroimaging initiative J Clin Pharmacol 52 2012 629 644
    • (2012) J Clin Pharmacol , vol.52 , pp. 629-644
    • Samtani, M.N.1    Farnum, M.2    Lobanov, V.3    Yang, E.4    Raghavan, N.5    Dibernardo, A.6
  • 26
    • 84871179111 scopus 로고    scopus 로고
    • Disease progression model in subjects with mild cognitive impairment from the Alzheimer's disease neuroimaging initiative: CSF biomarkers predict population subtypes
    • M.N. Samtani, N. Raghavan, Y. Shi, G. Novak, M. Farnum, V. Lobanov, and et al. Disease progression model in subjects with mild cognitive impairment from the Alzheimer's disease neuroimaging initiative: CSF biomarkers predict population subtypes Br J Clin Pharmacol 75 2013 146 161
    • (2013) Br J Clin Pharmacol , vol.75 , pp. 146-161
    • Samtani, M.N.1    Raghavan, N.2    Shi, Y.3    Novak, G.4    Farnum, M.5    Lobanov, V.6
  • 28
    • 84879762685 scopus 로고    scopus 로고
    • An audience with ... Luca Santarelli. Interview by Alexandra Flemming
    • L. Santarelli An audience with... Luca Santarelli. Interview by Alexandra Flemming Nat Rev Drug Discov 12 2013 14 15
    • (2013) Nat Rev Drug Discov , vol.12 , pp. 14-15
    • Santarelli, L.1
  • 29
    • 84889564072 scopus 로고    scopus 로고
    • The "dGPPN-Cohort": A national collaboration initiative by the German Association for Psychiatry and Psychotherapy (DGPPN) for establishing a large-scale cohort of psychiatric patients
    • H. Anderson-Schmidt, L. Adler, C. Aly, I.G. Anghelescu, M. Bauer, J. Baumgartner, and et al. The "DGPPN-Cohort": A national collaboration initiative by the German Association for Psychiatry and Psychotherapy (DGPPN) for establishing a large-scale cohort of psychiatric patients Eur Arch Psychiatry Clin Neurosci 263 2013 695 701
    • (2013) Eur Arch Psychiatry Clin Neurosci , vol.263 , pp. 695-701
    • Anderson-Schmidt, H.1    Adler, L.2    Aly, C.3    Anghelescu, I.G.4    Bauer, M.5    Baumgartner, J.6
  • 30
    • 0037219738 scopus 로고    scopus 로고
    • Getting what you ask for: On the selectivity of depression rating scales
    • K. Demyttenaere, and J. De Fruyt Getting what you ask for: On the selectivity of depression rating scales Psychother Psychosom 72 2003 61 70
    • (2003) Psychother Psychosom , vol.72 , pp. 61-70
    • Demyttenaere, K.1    De Fruyt, J.2
  • 31
    • 84858108170 scopus 로고    scopus 로고
    • Symptom rating scales and outcome in schizophrenia
    • A.M. Mortimer Symptom rating scales and outcome in schizophrenia Br J Psychiatry Suppl 50 2007 s7 14
    • (2007) Br J Psychiatry Suppl , vol.50 , pp. s7-14
    • Mortimer, A.M.1
  • 32
  • 34
    • 84886252097 scopus 로고    scopus 로고
    • Pharmacogenetics of antidepressants, mood stabilizers, and antipsychotics in diverse human populations
    • E. Murphy, and F.J. McMahon Pharmacogenetics of antidepressants, mood stabilizers, and antipsychotics in diverse human populations Discov Med 16 2013 113 122
    • (2013) Discov Med , vol.16 , pp. 113-122
    • Murphy, E.1    McMahon, F.J.2
  • 35
    • 84877626914 scopus 로고    scopus 로고
    • Toward the future of psychiatric diagnosis: The seven pillars of RDoC
    • B.N. Cuthbert, and T.R. Insel Toward the future of psychiatric diagnosis: The seven pillars of RDoC BMC Med 11 2013 126
    • (2013) BMC Med , vol.11 , pp. 126
    • Cuthbert, B.N.1    Insel, T.R.2
  • 36
    • 2342597739 scopus 로고    scopus 로고
    • Neuroimaging studies of working memory: A meta-analysis
    • T.D. Wager, and E.E. Smith Neuroimaging studies of working memory: A meta-analysis Cogn Affect Behav Neurosci 3 2003 255 274
    • (2003) Cogn Affect Behav Neurosci , vol.3 , pp. 255-274
    • Wager, T.D.1    Smith, E.E.2
  • 37
    • 0037277598 scopus 로고    scopus 로고
    • Neuroimaging studies of amygdala function in anxiety disorders
    • S.L. Rauch, L.M. Shin, and C.I. Wright Neuroimaging studies of amygdala function in anxiety disorders Ann N Y Acad Sci 985 2003 389 410
    • (2003) Ann N y Acad Sci , vol.985 , pp. 389-410
    • Rauch, S.L.1    Shin, L.M.2    Wright, C.I.3
  • 38
    • 84862676392 scopus 로고    scopus 로고
    • Psychopathology and the human connectome: Toward a transdiagnostic model of risk for mental illness
    • J.W. Buckholtz, and A. Meyer-Lindenberg Psychopathology and the human connectome: Toward a transdiagnostic model of risk for mental illness Neuron 74 2012 990 1004
    • (2012) Neuron , vol.74 , pp. 990-1004
    • Buckholtz, J.W.1    Meyer-Lindenberg, A.2
  • 39
    • 84856472879 scopus 로고    scopus 로고
    • Cognitive dysfunction in psychiatric disorders: Characteristics, causes and the quest for improved therapy
    • M.J. Millan, Y. Agid, M. Brune, E.T. Bullmore, C.S. Carter, N.S. Clayton, and et al. Cognitive dysfunction in psychiatric disorders: Characteristics, causes and the quest for improved therapy Nat Rev Drug Discov 11 2012 141 168
    • (2012) Nat Rev Drug Discov , vol.11 , pp. 141-168
    • Millan, M.J.1    Agid, Y.2    Brune, M.3    Bullmore, E.T.4    Carter, C.S.5    Clayton, N.S.6
  • 41
    • 57749195712 scopus 로고    scopus 로고
    • RNA-Seq: A revolutionary tool for transcriptomics
    • Z. Wang, M. Gerstein, and M. Snyder RNA-Seq: A revolutionary tool for transcriptomics Nat Rev Genet 10 2009 57 63
    • (2009) Nat Rev Genet , vol.10 , pp. 57-63
    • Wang, Z.1    Gerstein, M.2    Snyder, M.3
  • 42
    • 84878682420 scopus 로고    scopus 로고
    • The Genotype-Tissue Expression (GTEx) project
    • GTEx Consortium
    • GTEx Consortium The Genotype-Tissue Expression (GTEx) project Nat Genet 45 2013 580 585
    • (2013) Nat Genet , vol.45 , pp. 580-585
  • 43
    • 79959262465 scopus 로고    scopus 로고
    • Transcriptomic analysis of autistic brain reveals convergent molecular pathology
    • I. Voineagu, X. Wang, P. Johnston, J.K. Lowe, Y. Tian, S. Horvath, and et al. Transcriptomic analysis of autistic brain reveals convergent molecular pathology Nature 474 2011 380 384
    • (2011) Nature , vol.474 , pp. 380-384
    • Voineagu, I.1    Wang, X.2    Johnston, P.3    Lowe, J.K.4    Tian, Y.5    Horvath, S.6
  • 44
    • 84961162081 scopus 로고    scopus 로고
    • Accessed April 24, 2014
    • Common Mind Consortium. Available at: http://commonmind.org/. Accessed April 24, 2014.
  • 45
    • 84926152584 scopus 로고    scopus 로고
    • Developmental regulation of human cortex transcription and its clinical relevance at single base resolution
    • A.E. Jaffe, J. Shin, L. Collado-Torres, J.T. Leek, R. Tao, C. Li, and et al. Developmental regulation of human cortex transcription and its clinical relevance at single base resolution Nat Neurosci 18 2015 154 161
    • (2015) Nat Neurosci , vol.18 , pp. 154-161
    • Jaffe, A.E.1    Shin, J.2    Collado-Torres, L.3    Leek, J.T.4    Tao, R.5    Li, C.6
  • 46
    • 84868336049 scopus 로고    scopus 로고
    • Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
    • L. Jostins, S. Ripke, R.K. Weersma, R.H. Duerr, D.P. McGovern, K.Y. Hui, and et al. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease Nature 491 2012 119 124
    • (2012) Nature , vol.491 , pp. 119-124
    • Jostins, L.1    Ripke, S.2    Weersma, R.K.3    Duerr, R.H.4    McGovern, D.P.5    Hui, K.Y.6
  • 47
    • 78649573450 scopus 로고    scopus 로고
    • Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease
    • L. Jones, P.A. Holmans, M.L. Hamshere, D. Harold, V. Moskvina, D. Ivanov, and et al. Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease PloS One 5 2010 e13950
    • (2010) PloS One , vol.5 , pp. e13950
    • Jones, L.1    Holmans, P.A.2    Hamshere, M.L.3    Harold, D.4    Moskvina, V.5    Ivanov, D.6
  • 49
    • 0035289779 scopus 로고    scopus 로고
    • Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
    • C.A. Lipinski, F. Lombardo, B.W. Dominy, and P.J. Feeney Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings Adv Drug Deliv Rev 46 2001 3 26
    • (2001) Adv Drug Deliv Rev , vol.46 , pp. 3-26
    • Lipinski, C.A.1    Lombardo, F.2    Dominy, B.W.3    Feeney, P.J.4
  • 50
    • 79960985571 scopus 로고    scopus 로고
    • Structure-based druggability assessment - Identifying suitable targets for small molecule therapeutics
    • E.B. Fauman, B.K. Rai, and E.S. Huang Structure-based druggability assessment - identifying suitable targets for small molecule therapeutics Curr Opin Chem Biol 15 2011 463 468
    • (2011) Curr Opin Chem Biol , vol.15 , pp. 463-468
    • Fauman, E.B.1    Rai, B.K.2    Huang, E.S.3
  • 51
    • 84902574209 scopus 로고    scopus 로고
    • Neurodevelopmental and neurodegenerative models of schizophrenia: White matter at the center stage
    • P. Kochunov, and L.E. Hong Neurodevelopmental and neurodegenerative models of schizophrenia: White matter at the center stage Schizophr Bull 40 2014 721 728
    • (2014) Schizophr Bull , vol.40 , pp. 721-728
    • Kochunov, P.1    Hong, L.E.2
  • 52
    • 84905460411 scopus 로고    scopus 로고
    • Distribution and medical impact of loss-of-function variants in the Finnish founder population
    • E.T. Lim, P. Wurtz, A.S. Havulinna, P. Palta, T. Tukiainen, K. Rehnstrom, and et al. Distribution and medical impact of loss-of-function variants in the Finnish founder population PLoS Geneti 10 2014 e1004494
    • (2014) PLoS Geneti , vol.10 , pp. e1004494
    • Lim, E.T.1    Wurtz, P.2    Havulinna, A.S.3    Palta, P.4    Tukiainen, T.5    Rehnstrom, K.6
  • 53
    • 0033968306 scopus 로고    scopus 로고
    • Molecular genetics of Alzheimer's disease
    • P.H. St George-Hyslop Molecular genetics of Alzheimer's disease Biol Psychiatry 47 2000 183 199
    • (2000) Biol Psychiatry , vol.47 , pp. 183-199
    • St George-Hyslop, P.H.1
  • 54
    • 84864471159 scopus 로고    scopus 로고
    • A mutation in APP protects against Alzheimer's disease and age-related cognitive decline
    • T. Jonsson, J.K. Atwal, S. Steinberg, J. Snaedal, P.V. Jonsson, S. Bjornsson, and et al. A mutation in APP protects against Alzheimer's disease and age-related cognitive decline Nature 488 2012 96 99
    • (2012) Nature , vol.488 , pp. 96-99
    • Jonsson, T.1    Atwal, J.K.2    Steinberg, S.3    Snaedal, J.4    Jonsson, P.V.5    Bjornsson, S.6
  • 55
    • 5344223383 scopus 로고    scopus 로고
    • Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism
    • I. Splawski, K.W. Timothy, L.M. Sharpe, N. Decher, P. Kumar, R. Bloise, and et al. Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism Cell 119 2004 19 31
    • (2004) Cell , vol.119 , pp. 19-31
    • Splawski, I.1    Timothy, K.W.2    Sharpe, L.M.3    Decher, N.4    Kumar, P.5    Bloise, R.6
  • 56
    • 33846627787 scopus 로고    scopus 로고
    • Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death
    • C. Antzelevitch, G.D. Pollevick, J.M. Cordeiro, O. Casis, M.C. Sanguinetti, Y. Aizawa, and et al. Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death Circulation 115 2007 442 449
    • (2007) Circulation , vol.115 , pp. 442-449
    • Antzelevitch, C.1    Pollevick, G.D.2    Cordeiro, J.M.3    Casis, O.4    Sanguinetti, M.C.5    Aizawa, Y.6
  • 57
    • 84897567720 scopus 로고    scopus 로고
    • Drug development: The modelling challenge
    • A. Katsnelson Drug development: The modelling challenge Nature 508 2014 S8 S9
    • (2014) Nature , vol.508 , pp. S8-S9
    • Katsnelson, A.1
  • 58
    • 77957914609 scopus 로고    scopus 로고
    • The psychiatric GWAS consortium: Big science comes to psychiatry
    • P.F. Sullivan The psychiatric GWAS consortium: Big science comes to psychiatry Neuron 68 2010 182 186
    • (2010) Neuron , vol.68 , pp. 182-186
    • Sullivan, P.F.1
  • 61
    • 84961169470 scopus 로고    scopus 로고
    • Accessed April 24, 2014
    • Wikimedia Commons. Available at: http://commons.wikimedia.org/wiki/File:MRI-Location-Amygdala-up.png. Accessed April 24, 2014.
  • 62
    • 84961187528 scopus 로고    scopus 로고
    • Accessed April 24, 2014
    • Wikimedia Commons. Available at: http://commons.wikimedia.org/wiki/File:H1-Receptor-with-Doxepin.png. Accessed April 24, 2014.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.