2,3 Butanediol production in an obligate photoautotrophic cyanobacterium in dark conditions via diverse sugar consumption

Metabolic Engineering

Volumn 36, Issue , 2016, Pages 28-36

  McEwen, Jordan T ^a   Kanno, Masahiro ^a,b   Atsumi, Shota ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b ASAHI KASEI CORPORATION   (Japan)

Author keywords

2,3 Butanediol; Cyanobacteria; Metabolic engineering; Obligate photoautotrophy

Indexed keywords

CARBON DIOXIDE; CHEMICAL COMPOUNDS; METABOLIC ENGINEERING;

2 ,3-BUTANEDIOL; CHEMICAL PRODUCTION; CONTINUOUS LIGHT; CYANOBACTERIA; NATURAL SUNLIGHT; OBLIGATE PHOTOAUTOTROPHY; PHOTOSYNTHETIC PRODUCTION; PRODUCTION TIME;

LIGHT;

2,3 BUTANEDIOL; CARBON 13; GLUCOSE; XYLOSE; 2,3-BUTYLENE GLYCOL; BUTANEDIOL; CARBOHYDRATE;

ALCOHOL PRODUCTION; ARTICLE; BACTERIAL CELL; BACTERIAL STRAIN; BACTERIUM CULTURE; BIOMASS; CELL DENSITY; CHEMICAL PHENOMENA; CONTROLLED STUDY; CYANOBACTERIUM; DIURNAL CONDITION; GAS CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLIC ENGINEERING; NONHUMAN; PRIORITY JOURNAL; BIOSYNTHESIS; DARKNESS; GENETIC ENHANCEMENT; ISOLATION AND PURIFICATION; LIGHT; METABOLISM; PHOTOSYNTHESIS; PHYSIOLOGY; PROCEDURES; RADIATION RESPONSE;

BIOSYNTHETIC PATHWAYS; BUTYLENE GLYCOLS; CYANOBACTERIA; DARKNESS; GENETIC ENHANCEMENT; LIGHT; METABOLIC ENGINEERING; METABOLIC NETWORKS AND PATHWAYS; PHOTOSYNTHESIS; SUGARS;

EID: 84961173840     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2016.03.004     Document Type: Article

References (44)

1. Anderson S.L., McIntosh L. Light-activated heterotrophic growth of the cyanobacterium Synechocystis sp. strain PCC 6803: a blue-light-requiring process. J. Bacteriol. 1991, 173:2761-2767.
2. Atsumi S., et al. Direct photosynthetic recycling of carbon dioxide to isobutyraldehyde. Nat. Biotechnol. 2009, 27:1177-1180.
3. Berla B.M., et al. Synthetic biology of cyanobacteria: unique challenges and opportunities. Front. Microbiol. 2013, 4:246.
4. Cohen S.E., Golden S.S. Circadian rhythms in cyanobacteria. Microbiol. Mol. Biol. Rev. 2015, 79:373-385.
5. Deng M.D., Coleman J.R. Ethanol synthesis by genetic engineering in cyanobacteria. Appl. Environ. Microbiol. 1999, 65:523-528.
6. Desai S.H., Atsumi S. Photosynthetic approaches to chemical biotechnology. Curr. Opin. Biotechnol. 2013, 24:1031-1036.
7. Diamond S., et al. The circadian oscillator in Synechococcus elongatus controls metabolite partitioning during diurnal growth. Proc. Natl. Acad. Sci. USA 2015, 112:1916-1925.
8. Díez B., Ininbergs K. Ecological importance of cyanobacteria. Cyanobacteria 2014, 41-63. John Wiley & Sons, Ltd., Hoboken, NJ. N.K. Sharma (Ed.).
9. Ducat D.C., et al. Rerouting carbon flux to enhance photosynthetic productivity. Appl. Environ. Microbiol. 2012, 78:2660-2668.
10. Elias-Arnanz M., et al. Light-dependent gene regulation in nonphototrophic bacteria. Curr. Opin. Microbiol. 2011, 14:128-135.
11. Gan F., et al. Extensive remodeling of a cyanobacterial photosynthetic apparatus in far-red light. Science 2014, 345:1312-1317.
12. Golden S.S., et al. Genetic engineering of the cyanobacterial chromosome. Methods Enzymol. 1987, 153:215-231.
13. Guerrero F., et al. Ethylene synthesis and regulated expression of recombinant protein in Synechocystis sp. PCC 6803. PLoS One 2012, 7:e50470.
14. Hays S.G., Ducat D.C. Engineering cyanobacteria as photosynthetic feedstock factories. Photosynth. Res. 2015, 123:285-295.
15. Heidorn T., et al. Synthetic biology in cyanobacteria engineering and analyzing novel functions. Methods Enzymol. 2011, 497:539-579.
16. Hirose Y., et al. Green/red cyanobacteriochromes regulate complementary chromatic acclimation via a protochromic photocycle. Proc. Natl. Acad. Sci. USA 2013, 110:4974-4979.
17. Ito H., et al. Cyanobacterial daily life with Kai-based circadian and diurnal genome-wide transcriptional control in Synechococcus elongatus. Proc. Natl. Acad. Sci. USA 2009, 106:14168-14173.
18. Kaiser B.K., et al. Fatty aldehydes in cyanobacteria are a metabolically flexible precursor for a diversity of biofuel products. PLoS One 2013, 8:e58307.
19. Lee T.C., et al. Engineered xylose utilization enhances bio-products productivity in the cyanobacterium Synechocystis sp. PCC 6803. Metab. Eng. 2015, 30:179-189.
20. Lindberg P., et al. Engineering a platform for photosynthetic isoprene production in cyanobacteria, using Synechocystis as the model organism. Metab. Eng. 2010, 12:70-79.
21. Liu X., et al. Fatty acid production in genetically modified cyanobacteria. Proc. Natl. Acad. Sci. USA 2011, 108:6899-6904.
22. Machado I.M., Atsumi S. Cyanobacterial biofuel production. J. Biotechnol. 2012, 162:50-56.
23. Markson J.S., et al. Circadian control of global gene expression by the cyanobacterial master regulator RpaA. Cell 2013, 155:1396-1408.
24. McEwen J.T., et al. Engineering Synechococcus elongatus PCC 7942 for continuous growth under diurnal conditions. Appl. Environ. Microbiol. 2013, 79:1668-1675.
25. Nair U., et al. Roles for sigma factors in global circadian regulation of the cyanobacterial genome. J. Bacteriol. 2002, 184:3530-3538.
26. Nakajima T., et al. Integrated metabolic flux and omics analysis of Synechocystis sp. PCC 6803 under mixotrophic and photoheterotrophic conditions. Plant Cell Physiol. 2014, 55:1605-1612.
27. Narainsamy K., et al. High performance analysis of the cyanobacterial metabolism via liquid chromatography coupled to a LTQ-Orbitrap mass spectrometer: evidence that glucose reprograms the whole carbon metabolism and triggers oxidative stress. Metabolomics 2013, 9:21-32.
28. Nozzi N.E., et al. Cyanobacteria as a platform for biofuel production. Front. Bioeng. Biotechnol 2013, 1:7.
29. Oliver J.W., Atsumi S. Metabolic design for cyanobacterial chemical synthesis. Photosynth. Res. 2014, 120:249-261.
30. Oliver J.W., et al. Cyanobacterial conversion of carbon dioxide to 2,3-butanediol. Proc. Natl. Acad. Sci. USA 2013, 110:1249-1254.
31. Osanai T., et al. Genetic engineering of group 2 sigma factor SigE widely activates expressions of sugar catabolic genes in Synechocystis species PCC 6803. J. Biol. Chem. 2011, 286:30962-30971.
32. Pinkerton K.E., Rom W.N. Global Climate Change and Public Health 2014, Humana Press, New York.
33. Schirmer A., et al. Microbial biosynthesis of alkanes. Science 2010, 329:559-562.
34. Schmidt G., Archer D. Climate change: too much of a bad thing. Nature 2009, 458:1117-1118.
35. Schwarz D., et al. Metabolic and transcriptomic phenotyping of inorganic carbon acclimation in the cyanobacterium Synechococcus elongatus PCC 7942. Plant Physiol. 2011, 155:1640-1655.
36. Sharif D.I., et al. Quorum sensing in cyanobacteria: N-octanoyl-homoserine lactone release and response, by the epilithic colonial cyanobacterium Gloeothece PCC6909. ISME J. 2008, 2:1171-1182.
37. Takahama K., et al. Construction and analysis of a recombinant cyanobacterium expressing a chromosomally inserted gene for an ethylene-forming enzyme at the psbAI locus. J. Biosci. Bioeng. 2003, 95:302-305.
38. Takahashi H., et al. Difference in metabolite levels between photoautotrophic and photomixotrophic cultures of Synechocystis sp. PCC 6803 examined by capillary electrophoresis electrospray ionization mass spectrometry. J. Exp. Bot. 2008, 59:3009-3018.
39. 2 to ethylene in recombinant cyanobacterium Synechocystis 6803. Energy Environ Sci 2012, 5:8998-9006.
40. Varman A.M., et al. Metabolic engineering of Synechocystis sp. strain PCC 6803 for isobutanol production. Appl. Environ. Microbiol. 2013, 79:908-914.
41. Varman A.M., et al. Photoautotrophic production of d-lactic acid in an engineered cyanobacterium. Microb. Cell Fact. 2013, 12:117.
42. Vijayan V., et al. Oscillations in supercoiling drive circadian gene expression in cyanobacteria. Proc. Natl. Acad. Sci. USA 2009, 106:22564-22568.
43. 13C-labeled glucose. Metab. Eng. 2002, 4:202-216.
44. 13C flux analysis. Metab. Eng. 2011, 13:656-665.