-
1
-
-
85026995148
-
-
The impact of inflammatory bowel disease in Canada: 2012 final report and recommendations. 2012. Available from: http://www.isupportibd.ca/pdf/ccfc-ibd-impact-report-2012.pdf. Accessed July 4, 2015.
-
(2012)
Final Report and Recommendations. 2012
-
-
-
2
-
-
85026993936
-
-
Fast facts: the impact of IBD in Canada 2012. 2012. Available from: http://isupportibd.ca/pdf/ccfc.ca-impact-report-fast-facts.pdf. Accessed July 4, 2015.
-
(2012)
-
-
-
3
-
-
83755219473
-
Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review
-
Molodecky NA, Soon IS, Rabi DM, et al. Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review. Gastroenterology. 2012;142:46-54. e42; quiz e30.
-
(2012)
Gastroenterology
, vol.142
, pp. 46-54
-
-
Molodecky, N.A.1
Soon, I.S.2
Rabi, D.M.3
-
4
-
-
79953805710
-
An evidence-based systematic review on medical therapies for inflammatory bowel disease. American College of Gastroenterology IBD Task Force
-
Talley NJ, Abreu MT, Achkar JP, et al. An evidence-based systematic review on medical therapies for inflammatory bowel disease. American College of Gastroenterology IBD Task Force. Am J Gastroenterol. 2011; 106:S2-S25.
-
(2011)
Am J Gastroenterol
, vol.106
-
-
Talley, N.J.1
Abreu, M.T.2
Achkar, J.P.3
-
5
-
-
84975103797
-
Updated incidence and prevalence of Crohn’s disease and ulcerative colitis in Olmsted County, Minnesota (1970-2011)
-
Loftus EV Jr, Shivashankar R, Tremaine W, Harmsen WS, Zinsmeister AR. Updated incidence and prevalence of Crohn’s disease and ulcerative colitis in Olmsted County, Minnesota (1970-2011). ACG 2014 Annual Scientific Meeting; October 2014.
-
(2014)
ACG 2014 Annual Scientific Meeting
-
-
Loftus, E.V.1
Shivashankar, R.2
Tremaine, W.3
Harmsen, W.S.4
Zinsmeister, A.R.5
-
6
-
-
84868514758
-
Inflammatory bowel disease: A Canadian burden of illness review
-
Rocchi A, Benchimol EI, Bernstein CN, et al. Inflammatory bowel disease: a Canadian burden of illness review. Can J Gastroenterol. 2012;26:811-817.
-
(2012)
Can J Gastroenterol
, vol.26
, pp. 811-817
-
-
Rocchi, A.1
Benchimol, E.I.2
Bernstein, C.N.3
-
7
-
-
26444529476
-
Course of disease, drug treatment and health-related quality of life in patients with inflammatory bowel disease 5 years after initial diagnosis
-
Bernklev T, Jahnsen J, Schulz T, et al. Course of disease, drug treatment and health-related quality of life in patients with inflammatory bowel disease 5 years after initial diagnosis. Eur J Gastroenterol Hepatol. 2005;17:1037-1045.
-
(2005)
Eur J Gastroenterol Hepatol
, vol.17
, pp. 1037-1045
-
-
Bernklev, T.1
Jahnsen, J.2
Schulz, T.3
-
8
-
-
84973115876
-
The impact of endoscopic inflammation and mucosal healing on health- related quality of life in ulcerative colitis patients
-
Theede K, Kiszka-Kanowitz M, Nordgaard-Lassen I, Mertz Nielsen A. The impact of endoscopic inflammation and mucosal healing on health- related quality of life in ulcerative colitis patients. J Crohn s Colitis. 2015;9:625-632.
-
(2015)
J Crohn S Colitis
, vol.9
, pp. 625-632
-
-
Theede, K.1
Kiszka-Kanowitz, M.2
Nordgaard-Lassen, I.3
Mertz Nielsen, A.4
-
9
-
-
84929076272
-
Impact of drug therapy and surgery on qual ity of life in Crohn’s disease: A systematic review
-
Wright EK, Kamm MA. Impact of drug therapy and surgery on qual ity of life in Crohn’s disease: a systematic review. Inflamm Bowel Dis. 2015;21:1187-1194.
-
(2015)
Inflamm Bowel Dis
, vol.21
, pp. 1187-1194
-
-
Wright, E.K.1
Kamm, M.A.2
-
10
-
-
84867359637
-
Vedolizumab for the treat ment of ulcerative colitis and Crohn’s disease
-
McLean LP, Shea-Donohue T, Cross RK. Vedolizumab for the treat ment of ulcerative colitis and Crohn’s disease. Immunotherapy. 2012;4:883-898.
-
(2012)
Immunotherapy
, vol.4
, pp. 883-898
-
-
McLean, L.P.1
Shea-Donohue, T.2
Cross, R.K.3
-
11
-
-
85015482501
-
What is the role of vedolizumab in the era of anti-TNF agents?
-
Cheng FK, McLean LP, Cross RK. What is the role of vedolizumab in the era of anti-TNF agents? Ann Transl Med. 2014;2:4.
-
(2014)
Ann Transl Med
, vol.2
, pp. 4
-
-
Cheng, F.K.1
McLean, L.P.2
Cross, R.K.3
-
12
-
-
84928623552
-
Clinical practice guidelines for the medical management of nonhospitalized ulcerative colitis: The Toronto consensus
-
Bressler B, Marshall JK, Bernstein CN, et al. Clinical practice guidelines for the medical management of nonhospitalized ulcerative colitis: the Toronto consensus. Gastroenterology. 2015;148:1035-1058. e3.
-
(2015)
Gastroenterology
, vol.148
, pp. 1035-1058
-
-
Bressler, B.1
Marshall, J.K.2
Bernstein, C.N.3
-
13
-
-
84902659142
-
Defining quality indicators for best-practice management of inflammatory bowel disease in Canada
-
Nguyen GC, Devlin SM, Afif W, et al. Defining quality indicators for best-practice management of inflammatory bowel disease in Canada. Can J Gastroenterol Hepatol. 2014;28:275-285.
-
(2014)
Can J Gastroenterol Hepatol
, vol.28
, pp. 275-285
-
-
Nguyen, G.C.1
Devlin, S.M.2
Afif, W.3
-
14
-
-
84870857072
-
Decreasing colectomy rates for ulcerative colitis: A population-based time trend study
-
Kaplan GG, Seow CH, Ghosh S, et al. Decreasing colectomy rates for ulcerative colitis: a population-based time trend study. Am J Gastroenterol. 2012;107:1879-1887.
-
(2012)
Am J Gastroenterol
, vol.107
, pp. 1879-1887
-
-
Kaplan, G.G.1
Seow, C.H.2
Ghosh, S.3
-
15
-
-
84857798954
-
Hospitalisations and surgery in Crohn’s disease
-
Bernstein CN, Loftus EV Jr, Ng SC, et al. Hospitalisations and surgery in Crohn’s disease. Gut. 2012;61:622-629.
-
(2012)
Gut
, vol.61
, pp. 622-629
-
-
Bernstein, C.N.1
Loftus, E.V.2
Ng, S.C.3
-
16
-
-
84942372008
-
Post operative mortality among patients with inflammatory bowel diseases: A systematic review and meta-analysis of population-based studies
-
Singh S, Al-Darmaki A, Frolkis AD, et al. Post operative mortality among patients with inflammatory bowel diseases: a systematic review and meta-analysis of population-based studies. Gastroenterology. 2015;149:928-937.
-
(2015)
Gastroenterology
, vol.149
, pp. 928-937
-
-
Singh, S.1
Al-Darmaki, A.2
Frolkis, A.D.3
-
17
-
-
0029050742
-
Treatment of Crohn’s disease with anti-tumor necrosis factor chimeric monoclonal antibody (CA2)
-
van Dullemen HM, van Deventer SJ, Hommes DW, et al. Treatment of Crohn’s disease with anti-tumor necrosis factor chimeric monoclonal antibody (cA2). Gastroenterology. 1995;109:129-135.
-
(1995)
Gastroenterology
, vol.109
, pp. 129-135
-
-
Van Dullemen, H.M.1
Van Deventer, S.J.2
Hommes, D.W.3
-
18
-
-
85026985123
-
-
Janssen. Remicade® (infliximab) Product monograph. 2014. Available from: http://www.janssen.ca/subcategory_docdownload?id=2263. Accessed July 15, 2015.
-
(2014)
-
-
-
19
-
-
85026986982
-
-
Abbvie. Humira® (adalimumab) Product monograph. 2015. Available from: http://www.abbvie.ca/content/dam/abbviecorp/ca/english/docs/HUMIRA_PM_EN.pdf. Accessed July 15, 2015.
-
(2015)
-
-
-
20
-
-
85026991479
-
-
Janssen. Simponi® (golimumab) Product monograph. 2014. Available from: http://www.janssen.ca/subcategory_docdownload?id=2278. Accessed July 15, 2015.
-
(2014)
-
-
-
21
-
-
85026989859
-
-
UCB Canada. Cimzia® (certolizumab pegol) Product monograph. 2014. Available from: http://www.ucb-canada.ca/_up/ucbpharma_ca_en/documents/cimzia_pm_en_15jan2014.pdf. Accessed July 15, 2015.
-
(2014)
-
-
-
22
-
-
0037018761
-
Maintenance inflix imab for Crohn’s disease: The ACCENT I randomised trial
-
Hanauer SB, Feagan BG, Lichtenstein GR, et al. Maintenance inflix imab for Crohn’s disease: the ACCENT I randomised trial. Lancet. 2002;359:1541-1549.
-
(2002)
Lancet
, vol.359
, pp. 1541-1549
-
-
Hanauer, S.B.1
Feagan, B.G.2
Lichtenstein, G.R.3
-
23
-
-
77950988234
-
Infliximab, aza- thioprine, or combination therapy for Crohn’s disease
-
Colombel JF, Sandborn WJ, Reinisch W, et al. Infliximab, aza- thioprine, or combination therapy for Crohn’s disease. N Engl J Med. 2010;362:1383-1395.
-
(2010)
N Engl J Med
, vol.362
, pp. 1383-1395
-
-
Colombel, J.F.1
Sandborn, W.J.2
Reinisch, W.3
-
24
-
-
32044451548
-
Human anti-tumor necro-sis factor monoclonal antibody (Adalimumab) in Crohn’s disease: The CLASSIC-I trial
-
Hanauer SB, Sandborn WJ, Rutgeerts P, et al. Human anti-tumor necro-sis factor monoclonal antibody (adalimumab) in Crohn’s disease: the CLASSIC-I trial. Gastroenterology. 2006;130:323-333; quiz 591.
-
Gastroenterology
, vol.130
, pp. 323-333
-
-
Hanauer, S.B.1
Sandborn, W.J.2
Rutgeerts, P.3
-
25
-
-
34249281002
-
Adalimumab for main-tenance treatment of Crohn’s disease: Results of the CLASSIC II trial
-
Sandborn WJ, Hanauer SB, Rutgeerts P, et al. Adalimumab for main-tenance treatment of Crohn’s disease: results of the CLASSIC II trial. Gut. 2007;56:1232-1239.
-
(2007)
Gut
, vol.56
, pp. 1232-1239
-
-
Sandborn, W.J.1
Hanauer, S.B.2
Rutgeerts, P.3
-
26
-
-
33846242958
-
Adalimumab for main-tenance of clinical response and remission in patients with Crohn’s disease: The CHARM trial
-
Colombel JF, Sandborn WJ, Rutgeerts P, et al. Adalimumab for main-tenance of clinical response and remission in patients with Crohn’s disease: the CHARM trial. Gastroenterology. 2007;132:52-65.
-
(2007)
Gastroenterology
, vol.132
, pp. 52-65
-
-
Colombel, J.F.1
Sandborn, W.J.2
Rutgeerts, P.3
-
27
-
-
33947397636
-
Induction and maintenance inf liximab therapy for the treatment of moderate-to-severe Crohn’s disease in children
-
Hyams J, Crandall W, Kugathasan S, et al. Induction and maintenance inf liximab therapy for the treatment of moderate-to-severe Crohn’s disease in children. Gastroenterology. 2007;132:863-873; quiz 1165-1166.
-
(2007)
Gastroenterology
, vol.132
, pp. 863-873
-
-
Hyams, J.1
Crandall, W.2
Kugathasan, S.3
-
28
-
-
84864287281
-
Safety and efficacy of adalimumab for moderate to severe Crohn’s disease in children
-
Hyams JS, Griffiths A, Markowitz J, et al. Safety and efficacy of adalimumab for moderate to severe Crohn’s disease in children. Gastroenterology. 2012;143:365-374. e2.
-
(2012)
Gastroenterology
, vol.143
, pp. 365-374
-
-
Hyams, J.S.1
Griffiths, A.2
Markowitz, J.3
-
29
-
-
10744221312
-
Infliximab maintenance therapy for fistulizing Crohn’s disease
-
Sands BE, Anderson FH, Bernstein CN, et al. Infliximab maintenance therapy for fistulizing Crohn’s disease. N Engl J Med. 2004;350: 876-885.
-
(2004)
N Engl J Med
, vol.350
, pp. 876-885
-
-
Sands, B.E.1
Erson, F.H.2
Bernstein, C.N.3
-
30
-
-
0030954732
-
A short-term study of chimeric monoclonal antibody cA2 to tumor necrosing factor a for Crohn’s disease
-
Targan SR, Hanauer SB, van Deventer SJH, et al. A short-term study of chimeric monoclonal antibody cA2 to tumor necrosing factor a for Crohn’s disease. N Engl J Med. 1997;337(15):1029-1035.
-
(1997)
N Engl J Med
, vol.337
, Issue.15
, pp. 1029-1035
-
-
Targan, S.R.1
Hanauer, S.B.2
Van Deventer, S.3
-
31
-
-
34347402306
-
Adalimumab induction therapy for Crohn disease previously treated with infliximab
-
Sandborn WJ, Rutgeerts P, Enns R, et al. Adalimumab induction therapy for Crohn disease previously treated with infliximab. Ann Intern Med. 2007;146(12):829-838.
-
(2007)
Ann Intern Med
, vol.146
, Issue.12
, pp. 829-838
-
-
Sandborn, W.J.1
Rutgeerts, P.2
Enns, R.3
-
32
-
-
24144483087
-
A randomized, placebo- controlled trial of certolizumab pegol (CDP870) for treatment of Crohn’s disease
-
Schreiber S, Rutgeerts P, Fedorak RN, et al. A randomized, placebo- controlled trial of certolizumab pegol (CDP870) for treatment of Crohn’s disease. Gastroenterology. 2005;129(3):807-818.
-
(2005)
Gastroenterology
, vol.129
, Issue.3
, pp. 807-818
-
-
Schreiber, S.1
Rutgeerts, P.2
Fedorak, R.N.3
-
33
-
-
79960498782
-
Certolizumab pegol for active Crohn’s disease: A placebo-controlled randomized trial
-
Sandborn WJ, Schreiber S, Feagan BG, et al. Certolizumab pegol for active Crohn’s disease: A placebo-controlled randomized trial. Clin Gastroenterol Hepatol. 2011;9(8):670-678.
-
(2011)
Clin Gastroenterol Hepatol
, vol.9
, Issue.8
, pp. 670-678
-
-
Sandborn, W.J.1
Schreiber, S.2
Feagan, B.G.3
-
34
-
-
34447515607
-
Maintenance therapy with certolizumab for Crohn’s disease
-
Schreiber S, Khaliq-Kareemi M, Lawrance IC, et al. Maintenance therapy with certolizumab for Crohn’s disease. NEngl J Med. 2007;357: 239-250.
-
(2007)
Nengl J Med
, vol.357
, pp. 239-250
-
-
Schreiber, S.1
Khaliq-Kareemi, M.2
Lawrance, I.C.3
-
35
-
-
79960498782
-
Certolizumab pegol for active Crohn’s disease: A placebo-controlled, randomized trial
-
Sandborn WJ, Schreiber S, Feagan BG, et al. Certolizumab pegol for active Crohn’s disease: a placebo-controlled, randomized trial. Clin Gastroenterol Hepatol. 2011;9:670-678.
-
(2011)
Clin Gastroenterol Hepatol
, vol.9
, pp. 670-678
-
-
Sandborn, W.J.1
Schreiber, S.2
Feagan, B.G.3
-
36
-
-
28844473957
-
Infliximab for induction and maintenance therapy for ulcerative colitis
-
Rutgeerts P, Sandborn WJ, Feagan BG, et al. Infliximab for induction and maintenance therapy for ulcerative colitis. N Engl J Med. 2005;353: 2462-2476.
-
(2005)
N Engl J Med
, vol.353
, pp. 2462-2476
-
-
Rutgeerts, P.1
Sandborn, W.J.2
Feagan, B.G.3
-
37
-
-
79955859430
-
Adalimumab for induction of clinical remission in moderately to severely active ulcer ative colitis: Results of a randomised controlled trial
-
Reinisch W, Sandborn WJ, Hommes DW, et al. Adalimumab for induction of clinical remission in moderately to severely active ulcer ative colitis: results of a randomised controlled trial. Gut. 2011;60: 780-787.
-
(2011)
Gut
, vol.60
, pp. 780-787
-
-
Reinisch, W.1
Sandborn, W.J.2
Hommes, D.W.3
-
38
-
-
84856163835
-
Adalimumab induces and maintains clinical remission in patients with moderate-to-severe ulcerative colitis
-
Sandborn WJ, van Assche G, Reinisch W, et al. Adalimumab induces and maintains clinical remission in patients with moderate-to-severe ulcerative colitis. Gastroenterology. 2012;142:257-2565. e1-e3.
-
(2012)
Gastroenterology
, vol.142
, pp. 257-2565
-
-
Sandborn, W.J.1
Van Assche, G.2
Reinisch, W.3
-
39
-
-
84890620601
-
Subcutaneous golimumab induces clinical response and remission in patients with moderate- to-severe ulcerative colitis
-
Sandborn WJ, Feagan BG, Marano C, et al. Subcutaneous golimumab induces clinical response and remission in patients with moderate- to-severe ulcerative colitis. Gastroenterology. 2014;146:85-95; quiz e14-e15.
-
(2014)
Gastroenterology
, vol.146
, pp. 85-95
-
-
Sandborn, W.J.1
Feagan, B.G.2
Marano, C.3
-
40
-
-
84890629055
-
Subcutaneous golimumab maintains clinical response in patients with moderate-to-severe ulcer ative colitis
-
Sandborn WJ, Feagan BG, Marano C, et al. Subcutaneous golimumab maintains clinical response in patients with moderate-to-severe ulcer ative colitis. Gastroenterology. 2014;146:96-109. e1.
-
(2014)
Gastroenterology
, vol.146
, pp. 96-109
-
-
Sandborn, W.J.1
Feagan, B.G.2
Marano, C.3
-
41
-
-
84858700602
-
Induction and maintenance therapy with infliximab for children with moderate to severe ulcerative colitis
-
Hyams J, Damaraju L, Blank M, et al. Induction and maintenance therapy with infliximab for children with moderate to severe ulcerative colitis. Clin Gastroenterol Hepatol. 2012;10:391-399. e1.
-
(2012)
Clin Gastroenterol Hepatol
, vol.10
, pp. 391-399
-
-
Hyams, J.1
Damaraju, L.2
Blank, M.3
-
42
-
-
0038460945
-
Infliximab in moderately severe glucocorticoid resistant ulcerative colitis: A randomised con trolled trial
-
Probert CSJ, Hearing SD, Schreiber S, et al. Infliximab in moderately severe glucocorticoid resistant ulcerative colitis: a randomised con trolled trial. Gut. 2003;52:998-1002.
-
(2003)
Gut
, vol.52
, pp. 998-1002
-
-
Probert, C.1
Hearing, S.D.2
Schreiber, S.3
-
43
-
-
84882454346
-
Review article: A clinician’s guide for therapeutic drug monitoring of infliximab in inflammatory bowel disease
-
Khanna R, Sattin BD, Afif W, et al. Review article: a clinician’s guide for therapeutic drug monitoring of infliximab in inflammatory bowel disease. Aliment Pharmacol Ther. 2013;38:447-459.
-
(2013)
Aliment Pharmacol Ther
, vol.38
, pp. 447-459
-
-
Khanna, R.1
Sattin, B.D.2
Afif, W.3
-
44
-
-
85028955683
-
Current and future status of therapeutic drug monitoring in the treatment of IBD
-
Khanna R, Feagan BG. Current and future status of therapeutic drug monitoring in the treatment of IBD. Curr Treat Options Gastroenterol. 2014;12:76-89.
-
(2014)
Curr Treat Options Gastroenterol
, vol.12
, pp. 76-89
-
-
Khanna, R.1
Feagan, B.G.2
-
45
-
-
84871701834
-
Ustekinumab induction and maintenance therapy in refractory Crohn’s disease
-
Sandborn WJ, Gasink C, Gao LL, et al. Ustekinumab induction and maintenance therapy in refractory Crohn’s disease. N Engl J Med. 2012;367:1519-1528.
-
(2012)
N Engl J Med
, vol.367
, pp. 1519-1528
-
-
Sandborn, W.J.1
Gasink, C.2
Gao, L.L.3
-
46
-
-
53049091561
-
A randomized trial of Ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with moderate-to-severe Crohn’s disease
-
Sandborn WJ, Feagan BG, Fedorak RN, et al. A randomized trial of Ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with moderate-to-severe Crohn’s disease. Gastroenterology. 2008;135:1130-1141.
-
(2008)
Gastroenterology
, vol.135
, pp. 1130-1141
-
-
Sandborn, W.J.1
Feagan, B.G.2
Fedorak, R.N.3
-
48
-
-
51049092467
-
Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans
-
Jaensson E, Uronen-Hansson H, Pabst O, et al. Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans. J Exp Med. 2008;205:2139-2149.
-
(2008)
J Exp Med
, vol.205
, pp. 2139-2149
-
-
Jaensson, E.1
Uronen-Hansson, H.2
Pabst, O.3
-
49
-
-
74649087060
-
Generation of gut-homing T cells and their localization to the small intestinal mucosa
-
Agace W. Generation of gut-homing T cells and their localization to the small intestinal mucosa. Immunol Lett. 2010;128:21-23.
-
(2010)
Immunol Lett
, vol.128
, pp. 21-23
-
-
Agace, W.1
-
50
-
-
33748030455
-
Tissue-tropic effector T cells: Generation and targeting opportunities
-
Agace WW. Tissue-tropic effector T cells: generation and targeting opportunities. Nat Rev Immunol. 2006;6:682-692.
-
(2006)
Nat Rev Immunol
, vol.6
, pp. 682-692
-
-
Agace, W.W.1
-
51
-
-
5644300399
-
Song SY Retinoic acid imprints gut-homing specificity on T cells
-
Iwata M, Hirakiyama A, Eshima Y, Kagechika H, Kato C, Song SY Retinoic acid imprints gut-homing specificity on T cells. Immunity. 2004;21:527-538.
-
(2004)
Immunity
, vol.21
, pp. 527-538
-
-
Iwata, M.1
Hirakiyama, A.2
Eshima, Y.3
Kagechika, H.4
Kato, C.5
-
52
-
-
33751223544
-
Generation of gut-homing IgA- secreting B cells by intestinal dendritic cells
-
Mora JR, Iwata M, Eksteen B, et al. Generation of gut-homing IgA- secreting B cells by intestinal dendritic cells. Science. 2006;314: 1157-1160.
-
(2006)
Science
, vol.314
, pp. 1157-1160
-
-
Mora, J.R.1
Iwata, M.2
Eksteen, B.3
-
53
-
-
53849098346
-
T-cell recruitment to the intestinal mucosa
-
Agace WW. T-cell recruitment to the intestinal mucosa. Trends Immunol. 2008;29(11):541-552.
-
(2008)
Trends Immunol
, vol.29
, Issue.11
, pp. 541-552
-
-
Agace, W.W.1
-
54
-
-
0026342111
-
Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversity
-
Butcher EC. Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. Cell. 1991;67:1033-1036.
-
(1991)
Cell
, vol.67
, pp. 1033-1036
-
-
Butcher, E.C.1
-
55
-
-
0027248939
-
Attenuation of colitis in the cotton-top tamarin by anti-alpha 4 integrin monoclonal antibody
-
Podolsky DK, Lobb R, King N, et al. Attenuation of colitis in the cotton-top tamarin by anti-alpha 4 integrin monoclonal antibody. J Clin Invest. 1993;92:372-380.
-
(1993)
J Clin Invest
, vol.92
, pp. 372-380
-
-
Podolsky, D.K.1
Lobb, R.2
King, N.3
-
56
-
-
85026985901
-
-
Biogen Canada. Tysabri® (natalizumab) Product Monograph 2015. Available from: http://www.biogen.ca/Admin/Public/DWSDownload.aspx?File=Files%2fFiler%2fCanada%2fProduct_Information%2fTYSABRI%2f2015_04_07-TYSABRI-PM-E.pdf Accessed July 15, 2015.
-
(2015)
-
-
-
57
-
-
0027768713
-
The alpha 4 beta 1/VCAM-1 adhesion pathway in physiology and disease
-
Postigo AA, Teixido J, Sanchez-Madrid F. The alpha 4 beta 1/VCAM-1 adhesion pathway in physiology and disease. Res Immunol. 1993;144:723-735; discussion 54-62.
-
(1993)
Res Immunol
, vol.144
, pp. 723-735
-
-
Postigo, A.A.1
Teixido, J.2
Sanchez-Madrid, F.3
-
58
-
-
0037413468
-
Natalizumab for active Crohn’s disease
-
Ghosh S, Goldin E, Gordon FH, et al. Natalizumab for active Crohn’s disease. N Engl J Med. 2003;348:24-32.
-
(2003)
N Engl J Med
, vol.348
, pp. 24-32
-
-
Ghosh, S.1
Goldin, E.2
Gordon, F.H.3
-
59
-
-
0026506799
-
Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha4beta1 integrin
-
Yednock TA, Cannon C, Fritz LC, Sanchez-Madrid F, Steinman L, Karin N. Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha4beta1 integrin. Nature. 1992;356:63-66.
-
(1992)
Nature
, vol.356
, pp. 63-66
-
-
Yednock, T.A.1
Cannon, C.2
Fritz, L.C.3
Sanchez-Madrid, F.4
Steinman, L.5
Karin, N.6
-
60
-
-
83455212000
-
The link between VLA-4 and JC virus reactivation
-
Monaco MC, Major EO. The link between VLA-4 and JC virus reactivation. Expert Rev Clin Immunol. 2012;8:63-72.
-
(2012)
Expert Rev Clin Immunol
, vol.8
, pp. 63-72
-
-
Monaco, M.C.1
Major, E.O.2
-
61
-
-
27644441529
-
Natalizumab induction and maintenance therapy for Crohn’s disease
-
Sandborn WJ, Colombel JF, Enns R, et al. Natalizumab induction and maintenance therapy for Crohn’s disease. N Engl J Med. 2005;353: 1912-1925.
-
(2005)
N Engl J Med
, vol.353
, pp. 1912-1925
-
-
Sandborn, W.J.1
Colombel, J.F.2
Enns, R.3
-
62
-
-
70349086185
-
The binding specificity and selective antagonism of vedolizumab, an anti- {alpha}4{beta}7 integrin therapeutic antibody in development for inflam matory bowel diseases
-
Soler D, Chapman T, Yang LL, Wyant T, Egan R, Fedyk ER. The binding specificity and selective antagonism of vedolizumab, an anti- {alpha}4{beta}7 integrin therapeutic antibody in development for inflam matory bowel diseases. J Pharmacol Exp Ther. 2009;330(3):864-875.
-
(2009)
J Pharmacol Exp Ther
, vol.330
, Issue.3
, pp. 864-875
-
-
Soler, D.1
Chapman, T.2
Yang, L.L.3
Wyant, T.4
Egan, R.5
Fedyk, E.R.6
-
63
-
-
0034903450
-
A randomized placebo- controlled trial of a humanized monoclonal antibody to a4 integrin in active Crohn’s disease
-
Gordon FH, Lai CWY, Hamilton MI, et al. A randomized placebo- controlled trial of a humanized monoclonal antibody to a4 integrin in active Crohn’s disease. Gastroenterology. 2001;121(2):268-274.
-
(2001)
Gastroenterology
, vol.121
, Issue.2
, pp. 268-274
-
-
Gordon, F.H.1
Lai, C.2
Hamilton, M.I.3
-
64
-
-
34247884424
-
Et at. Natalizumab for the treatment of active Crohn’s disease: Results of the ENCORE trial
-
Targan SR, Feagan BG, Fedorak RN, et at. Natalizumab for the treatment of active Crohn’s disease: results of the ENCORE trial. Gastroenterology. 2007;132(5):1672-1683.
-
(2007)
Gastroenterology
, vol.132
, Issue.5
, pp. 1672-1683
-
-
Targan, S.R.1
Feagan, B.G.2
Fedorak, R.N.3
-
65
-
-
33846184129
-
Safety and tolerability of con-current natalizumab treatment for patients with Crohn’s disease not in remission while receiving infliximab
-
Sands BE, Korazek R, Spainhour J, et al. Safety and tolerability of con-current natalizumab treatment for patients with Crohn’s disease not in remission while receiving infliximab. Inflamm Bowel Dis. 2007;13(1): 2-11.
-
(2007)
Inflamm Bowel Dis
, vol.13
, Issue.1
, pp. 2-11
-
-
Sands, B.E.1
Korazek, R.2
Spainhour, J.3
-
66
-
-
84882769357
-
Vedolizumab as induc tion and maintenance therapy for ulcerative colitis
-
Feagan BG, Rutgeerts P, Sands BE, et al. Vedolizumab as induc tion and maintenance therapy for ulcerative colitis. N Engl J Med. 2013;369:699-710.
-
(2013)
N Engl J Med
, vol.369
, pp. 699-710
-
-
Feagan, B.G.1
Rutgeerts, P.2
Sands, B.E.3
-
67
-
-
84882749768
-
Vedolizumab as induction and maintenance therapy for Crohn’s disease
-
Sandborn WJ, Feagan BG, Rutgeerts P, et al. Vedolizumab as induction and maintenance therapy for Crohn’s disease. N Engl J Med. 2013;369: 711-721.
-
(2013)
N Engl J Med
, vol.369
, pp. 711-721
-
-
Sandborn, W.J.1
Feagan, B.G.2
Rutgeerts, P.3
-
68
-
-
84906569062
-
Effects of vedolizumab induction therapy for patients with Crohn’s disease in whom tumor necrosis factor antagonist treatment failed
-
Sands BE, Feagan BG, Rutgeerts P, et al. Effects of vedolizumab induction therapy for patients with Crohn’s disease in whom tumor necrosis factor antagonist treatment failed. Gastroenterology. 2014;147: 618-627. e3.
-
(2014)
Gastroenterology
, vol.147
, pp. 618-627
-
-
Sands, B.E.1
Feagan, B.G.2
Rutgeerts, P.3
-
69
-
-
0000788815
-
An ascending dose trial of a humanized alpha4 beta7 antibody in ulcerative colitis (UC)
-
Feagan BG, McDonald J, Greenberg G, et al. An ascending dose trial of a humanized alpha4 beta7 antibody in ulcerative colitis (UC). Gastroenterology. 2000;118(4):AB74.
-
(2000)
Gastroenterology
, vol.118
, Issue.4
-
-
Feagan, B.G.1
McDonald, J.2
Greenberg, G.3
-
70
-
-
20444469332
-
Treatment of ulcerative colitis with a humanized antibody to the a4p7 integrin
-
Feagan BG, Greenberg G, Wild G, et al. 2005. Treatment of ulcerative colitis with a humanized antibody to the a4p7 integrin. N Engl J Med. 2005;352(24):2499-2507.
-
(2005)
N Engl J Med
, vol.352
, Issue.24
, pp. 2499-2507
-
-
Feagan, B.G.1
Greenberg, G.2
Wild, G.3
-
71
-
-
57249089077
-
Treatment of active Crohn’s disease with MLN0002, a humanized antibody to the a4p7 integrin
-
Feagan BG, Greenberg GR, Wild G, et al. Treatment of active Crohn’s disease with MLN0002, a humanized antibody to the a4p7 integrin. Clin Gastroenterol Hepatol. 2008;6(12):1370-1377.
-
(2008)
Clin Gastroenterol Hepatol
, vol.6
, Issue.12
, pp. 1370-1377
-
-
Feagan, B.G.1
Greenberg, G.R.2
Wild, G.3
-
72
-
-
84863984524
-
Vedolizumab for the treatment of active ulcerative colitis: A randomized controlled phase 2 dose-ranging study
-
Parikh A, Leach T, Wyant T, et al. Vedolizumab for the treatment of active ulcerative colitis: a randomized controlled phase 2 dose-ranging study. Inflamm Bowel Dis. 2012;18(8):1470-1479.
-
(2012)
Inflamm Bowel Dis
, vol.18
, Issue.8
, pp. 1470-1479
-
-
Parikh, A.1
Leach, T.2
Wyant, T.3
-
73
-
-
84921325308
-
Comparative effectiveness of immunosuppressants and biologics for inducing and maintaining remis-sion in Crohn’s disease: A network meta-analysis
-
Hazlewood GS, Rezaie A, Borman M, et al. Comparative effectiveness of immunosuppressants and biologics for inducing and maintaining remis-sion in Crohn’s disease: a network meta-analysis. Gastroenterology. 2015;148:344-354. e5; quiz e14-e5.
-
(2015)
Gastroenterology
, vol.148
, pp. 344-354
-
-
Hazlewood, G.S.1
Rezaie, A.2
Borman, M.3
-
74
-
-
85026988680
-
-
Takeda. Entyvio® (vedolizumab) Product monograph. 2015. Available from: http://www.takedacanada.com/entyviopm7~/media/countries/ca/files/product%20pdfs/entyviopm_eng_2015jan25.pdf. Accessed July 15, 2015.
-
(2015)
-
-
-
75
-
-
84904747073
-
Vedolizumab affects antibody responses to immunisation selectively in the gastrointestinal tract: Randomised controlled trial results
-
Wyant T, Leach T, Sankoh S, et al. Vedolizumab affects antibody responses to immunisation selectively in the gastrointestinal tract: randomised controlled trial results. Gut. 2015;64:77-83.
-
(2015)
Gut
, vol.64
, pp. 77-83
-
-
Wyant, T.1
Leach, T.2
Sankoh, S.3
-
77
-
-
84902014339
-
Advances and controversies in the pathogenesis and management of primary sclerosing cholangitis
-
Eksteen B. Advances and controversies in the pathogenesis and management of primary sclerosing cholangitis. Br Med Bull. 2014;110:89-98.
-
(2014)
Br Med Bull
, vol.110
, pp. 89-98
-
-
Eksteen, B.1
-
78
-
-
4043099125
-
Lymphocyte homing in the pathogenesis of extra-intestinal manifestations of inflammatory bowel disease
-
Eksteen B, Miles AE, Grant AJ, Adams DH. Lymphocyte homing in the pathogenesis of extra-intestinal manifestations of inflammatory bowel disease. Clin Med. 2004;4:173-180.
-
(2004)
Clin Med
, vol.4
, pp. 173-180
-
-
Eksteen, B.1
Miles, A.E.2
Grant, A.J.3
Adams, D.H.4
-
79
-
-
10644245899
-
Hepatic endothelial CCL25 medi-ates the recruitment of CCR9+ gut-homing lymphocytes to the liver in primary sclerosing cholangitis
-
Eksteen B, Grant AJ, Miles A, et al. Hepatic endothelial CCL25 medi-ates the recruitment of CCR9+ gut-homing lymphocytes to the liver in primary sclerosing cholangitis. J Exp Med. 2004;200:1511-1517.
-
(2004)
J Exp Med
, vol.200
, pp. 1511-1517
-
-
Eksteen, B.1
Grant, A.J.2
Miles, A.3
-
80
-
-
33344478734
-
Aberrant homing of mucosal T cells and extra-intestinal manifestations of inflammatory bowel disease
-
Adams DH, Eksteen B. Aberrant homing of mucosal T cells and extra-intestinal manifestations of inflammatory bowel disease. Nat Rev Immunol. 2006;6:244-251.
-
(2006)
Nat Rev Immunol
, vol.6
, pp. 244-251
-
-
Adams, D.H.1
Eksteen, B.2
-
81
-
-
0028898488
-
Dual binding capac ity of mucosal immunoblasts to mucosal and synovial endothelium in humans: Dissection of the molecular mechanisms
-
Salmi M, Andrew DP, Butcher EC, Jalkanen S. Dual binding capac ity of mucosal immunoblasts to mucosal and synovial endothelium in humans: dissection of the molecular mechanisms. J Exp Med. 1995;181:137-149.
-
(1995)
J Exp Med
, vol.181
, pp. 137-149
-
-
Salmi, M.1
Rew, D.P.2
Butcher, E.C.3
Jalkanen, S.4
-
82
-
-
0032064008
-
Endothelial ligands and homing of mucosal leu-kocytes in extraintestinal manifestations of IBD
-
Salmi M, Jalkanen S. Endothelial ligands and homing of mucosal leu-kocytes in extraintestinal manifestations of IBD. Inflamm Bowel Dis. 1998;4:149-156.
-
(1998)
Inflamm Bowel Dis
, vol.4
, pp. 149-156
-
-
Salmi, M.1
Jalkanen, S.2
-
83
-
-
84865013186
-
Tofacitinib, an oral Janus kinase inhibitor, in active ulcerative colitis
-
Sandborn WJ, Ghosh S, Panes J, et al. Tofacitinib, an oral Janus kinase inhibitor, in active ulcerative colitis. N Engl J Med. 2012;367: 616-624.
-
(2012)
N Engl J Med
, vol.367
, pp. 616-624
-
-
Sandborn, W.J.1
Ghosh, S.2
Panes, J.3
-
84
-
-
84919419135
-
New targeted therapies such as anti-adhesion molecules, anti-IL-12/23 and anti-Janus kinases are looking toward a more effective treatment of inflammatory bowel disease
-
Bravata I, Fiorino G, Allocca M, Repici A, Danese S. New targeted therapies such as anti-adhesion molecules, anti-IL-12/23 and anti-Janus kinases are looking toward a more effective treatment of inflammatory bowel disease. Scand J Gastroenterol. 2015;50:113-120.
-
(2015)
Scand J Gastroenterol
, vol.50
, pp. 113-120
-
-
Bravata, I.1
Fiorino, G.2
Allocca, M.3
Repici, A.4
Danese, S.5
-
85
-
-
84943599564
-
Strategies that target leukocyte traffic in inflamma tory bowel diseases: Recent developments
-
Rivera-Nieves J. Strategies that target leukocyte traffic in inflamma tory bowel diseases: recent developments. Curr Opin Gastroenterol. 2015;31:441-448.
-
(2015)
Curr Opin Gastroenterol
, vol.31
, pp. 441-448
-
-
Rivera-Nieves, J.1
|