Mitigation of myocardial fibrosis by molecular cardiac surgery-mediated gene overexpression

Journal of Thoracic and Cardiovascular Surgery

Volumn 151, Issue 4, 2016, Pages 1191-1200.e3

  Katz, Michael G ^a,b   Brandon Warner, Elizabeth ^c   Fargnoli, Anthony S ^a,b   Williams, Richard D ^a   Kendle, Andrew P ^a   Hajjar, Roger J ^b   Schrum, Laura W ^c   Bridges, Charles R ^a  

^a Sanger Heart and Vascular Institute ^*  (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c CAROLINAS MEDICAL CENTER   (United States)

Author keywords

fibrosis; gene therapy; myocardial infarction; TGFbeta

Indexed keywords

ADENOVIRUS VECTOR; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN II; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE ISOFORM 2A; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; CALCIUM; COLLAGEN; FIBRONECTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; GENE OVEREXPRESSION; GENE TRANSFER; HEART FAILURE; HEART INFARCTION; HEART MUSCLE FIBROSIS; HEART SURGERY; MALE; NONHUMAN; PRIORITY JOURNAL; ANIMAL; BIOSYNTHESIS; CARDIAC MUSCLE; CARDIOMYOPATHIES; DISEASE MODEL; ENZYME INDUCTION; ENZYMOLOGY; FIBROSIS; GENE THERAPY; GENETICS; HEMODYNAMICS; METABOLISM; MYOCARDIAL INFARCTION; MYOFIBROBLAST; PATHOLOGY; PATHOPHYSIOLOGY; PROCEDURES; SHEEP; TIME FACTOR;

ANGIOTENSIN II; ANIMALS; CALCIUM; CARDIOMYOPATHIES; COLLAGEN; DISEASE MODELS, ANIMAL; ENZYME INDUCTION; FIBRONECTINS; FIBROSIS; GENETIC THERAPY; HEART FAILURE; HEMODYNAMICS; MALE; MYOCARDIAL INFARCTION; MYOCARDIUM; MYOFIBROBLASTS; RECEPTOR, ANGIOTENSIN, TYPE 1; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; SHEEP; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA;

EID: 84961146893     PISSN: 00225223     EISSN: 1097685X     Source Type: Journal    
DOI: 10.1016/j.jtcvs.2015.11.031     Document Type: Article

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