Mutations in a highly conserved motif of nsp1β protein attenuate the innate immune suppression function of porcine reproductive and respiratory syndrome virus

Journal of Virology

Volumn 90, Issue 7, 2016, Pages 3584-3599

  Li, Yanhua ^a   Shyu, Duan Liang ^b   Shang, Pengcheng ^a   Bai, Jianfa ^a   Ouyang, Kang ^b   Dhakal, Santosh ^b   Hiremath, Jagadish ^b   Binjawadagi, Basavaraj ^b   Renukaradhya, Gourapura J ^b   Fang, Ying ^a  

^a KANSAS STATE UNIVERSITY   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; GAMMA INTERFERON; MESSENGER RNA; NONSTRUCTURAL PROTEIN 1; NONSTRUCTURAL PROTEIN 1BETA; UNCLASSIFIED DRUG; MUTANT PROTEIN; VIRAL PROTEIN;

ADAPTIVE IMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE; GENE EXPRESSION; GENE MUTATION; GENETIC STABILITY; IN VITRO STUDY; INNATE IMMUNITY; INTERFERON STIMULATED GENE; NONHUMAN; NONSTRUCTURAL PROTEIN 1BETA GENE; PIG; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS; PRIORITY JOURNAL; PROTEIN MOTIF; SITE DIRECTED MUTAGENESIS; VIREMIA; VIROGENESIS; VIRUS RECOMBINANT; WILD TYPE; AMINO ACID SUBSTITUTION; ANIMAL; CELL LINE; DNA MUTATIONAL ANALYSIS; GENETICS; HOST PATHOGEN INTERACTION; IMMUNE EVASION; IMMUNOLOGY; METABOLISM; MISSENSE MUTATION;

AMINO ACID SUBSTITUTION; ANIMALS; CELL LINE; DNA MUTATIONAL ANALYSIS; HOST-PATHOGEN INTERACTIONS; IMMUNE EVASION; IMMUNITY, INNATE; INTERFERON-BETA; MUTAGENESIS, SITE-DIRECTED; MUTANT PROTEINS; MUTATION, MISSENSE; PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS; SWINE; VIRAL NONSTRUCTURAL PROTEINS;

EID: 84960977459     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.03069-15     Document Type: Article

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