Phenotypic maturation of porcine NK- and T-cell subsets

Developmental and Comparative Immunology

Volumn 40, Issue 1, 2013, Pages 51-68

  Talker, Stephanie C ^a   Käser, Tobias ^a   Reutner, Katharina ^a   Sedlak, Corinna ^a   Mair, Kerstin H ^a   Koinig, Hanna ^a   Graage, Robert ^a   Viehmann, Miriam ^a   Klingler, Eva ^a   Ladinig, Andrea ^a   Ritzmann, Mathias ^a   Saalmüller, Armin ^a   Gerner, Wilhelm ^a  

^a UNIVERSITY OF VETERINARY MEDICINE   (Austria)

Author keywords

NK cells; Phenotypic maturation; Swine; T cell subsets

Indexed keywords

CD27 ANTIGEN; CD3 ANTIGEN; CD45RC ANTIGEN; CD8ALPHA ANTIGEN; LEUKOCYTE ANTIGEN; PERFORIN; SWINE LEUKOCYTE ANTIGEN DR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; CELL COUNT; CELL LINEAGE; CELL MATURATION; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; EFFECTOR CELL; FLOW CYTOMETRY; GAMMA DELTA T LYMPHOCYTE; HELPER CELL; LYMPHOCYTE COUNT; LYMPHOCYTE DIFFERENTIATION; MEMORY T LYMPHOCYTE; NATURAL KILLER CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SWINE; T LYMPHOCYTE SUBPOPULATION;

SUIDAE; SUS;

EID: 84875633332     PISSN: 0145305X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dci.2013.01.003     Document Type: Article

References (56)

1. Almeida-Oliveira A., Smith-Carvalho M., Porto L.C., Cardoso-Oliveira J., Ribeiro A.d.S., Falcao R.R., Abdelhay E., Bouzas L.F., Santos Thuler L.C., Ornellas M.H., Diamond H.R. Age-related changes in natural killer cell receptors from childhood through old age. Hum. Immunol. 2011, 72:319-329.
2. Appay V., van Lier R.A.W., Sallusto F., Roederer M. Phenotype and function of human T lymphocyte subsets: consensus and issues. Cytometry Part A 2008, 73A:975-983.
3. + T cells vary in differentiation phenotype in different persistent virus infections. Nat. Med. 2002, 8:379-385.
4. Bjorkstrom N.K., Lindgren T., Stoltz M., Fauriat C., Braun M., Evander M., Michaelsson J., Malmberg K., Klingström J., Ahlm C., Ljunggren H. Rapid expansion and long-term persistence of elevated NK cell numbers in humans infected with hantavirus. J. Exp. Med. 2011, 208:13-21.
5. Blanco E., McCullough K., Summerfield A., Fiorini J., Andreu D., Chiva C., Borras E., Barnett P., Sobrino F. Interspecies major histocompatibility complex-restricted Th cell epitope on foot-and-mouth disease virus capsid protein VP4. J. Virol. 2000, 74:4902-4907.
6. Borghetti P., De Angelis E., Saleri R., Cavalli V., Cacchioli A., Corradi A., Mocchegiani E., Martelli P. Peripheral T lymphocyte changes in neonatal piglets: Relationship with growth hormone (GH), prolactin (PRL) and cortisol changes. Vet. Immunol. Immunopathol. 2006, 110:17-25.
7. Boysen P., Eide D.M., Storset A.K. Natural killer cells in free-living Mus musculus have a primed phenotype. Mol. Ecol. 2011, 20:5103-5110.
8. deBarros A., Chaves-Ferreira M., d'Orey F., Ribot J.C., Silva-Santos B. CD70-CD27 interactions provide survival and proliferative signals that regulate T cell receptor-driven activation of human γδ peripheral blood lymphocytes. Eur. J. Immunol. 2011, 41:195-201.
9. Denyer M.S., Wileman T.E., Stirling C.M.A., Zuber B., Takamatsu H.H. Perforin expression can define CD8 positive lymphocyte subsets in pigs allowing phenotypic and functional analysis of natural killer, cytotoxic T, natural killer T and MHC un-restricted cytotoxic T-cells. Vet. Immunol. Immunopathol. 2006, 110:279-292.
10. Dieli F., Poccia F., Lipp M., Sireci G., Caccamo N., Di Sano C., Salerno A. Differentiation of effector/memory Vδ2 T cells and migratory routes in lymph nodes or inflammatory sites. J. Exp. Med. 2003, 198:391-397.
11. Gerner W., Käser T., Saalmüller A. Porcine T lymphocytes and NK cells - an update. Dev. Comp. Immunol. 2009, 33:310-320.
12. Gerner W., Käser T., Pintaric M., Groiss S., Saalmüller A. Detection of intracellular antigens in porcine PBMC by flow cytometry: a comparison of fixation and permeabilisation reagents. Vet. Immunol. Immunopathol. 2008, 121:251-259.
13. Gerner W., Denyer M.S., Takamatsu H., Wileman T.E., Wiesmüller K., Pfaff E., Saalmüller A. Identification of novel foot-and-mouth disease virus specific T-cell epitopes in c/c and d/d haplotype miniature swine. Virus Res. 2006, 121:251-259.
14. Graham E.M., Thom M.L., Howard C.J., Boysen P., Storset A.K., Sopp P., Hope J.C. Natural killer cell number and phenotype in bovine peripheral blood is influenced by age. Vet. Immunol. Immunopathol. 2009, 132:101-108.
15. Grierson S.S., King D.P., Tucker A.W., Donadeu M., Mellencamp M.A., Haverson K., Banks M., Bailey M. Ontogeny of systemic cellular immunity in the neonatal pig: correlation with the development of post-weaning multisystemic wasting syndrome. Vet. Immunol. Immunopathol. 2007, 119:254-268.
16. Juul-Madsen H.R., Jensen K.H., Nielsen J., Damgaard B.M. Ontogeny and characterization of blood leukocyte subsets and serum proteins in piglets before and after weaning. Vet. Immunol. Immunopathol. 2010, 133:95-108.
17. Käser T., Gerner W., Mair K., Hammer S.E., Patzl M., Saalmüller A. Current knowledge on porcine regulatory T cells. Vet. Immunol. Immunopathol. 2012, 148:136-138.
18. Käser T., Gerner W., Saalmüller A. Porcine regulatory T cells: mechanisms and T-cell targets of suppression. Dev. Comp. Immunol. 2011, 35:1166-1172.
19. high regulatory T cells. Vet. Immunol. Immunopathol. 2008, 122:153-158.
20. Käser T., Gerner W., Hammer S.E., Patzl M., Saalmüller A. Detection of Foxp3 protein expression in porcine T lymphocytes. Vet. Immunol. Immunopathol. 2008, 125:92-101.
21. Labbok M.H., Clark D., Goldman A.S. Breastfeeding: maintaining an irreplaceable immunological resource. Nat. Rev. Immunol. 2004, 4:565-572.
22. Lunney J.K., Walker K., Goldman T., Aasted B., Bianchi A., Binns R., Licence S., Bischof R., Brandon M., Blecha F., Kielian T.L., McVey D.S., Chu R.M., Carr M., Howard C., Sopp P., Davis W., Dvorak P., Dominguez J., Canals A., Vizcaino J.M.S., Kim Y.B., Laude H., Mackay C.R., Magnusson U., Mccullough K., Misfeldt M., Murtaugh M., Molitor T., Choi C., Pabst R., Parkhouse R.M., Denham S., Yang H., Pescovitz M., Pospisil R., Tlaskalova H., Saalmüller A., Weiland E., Salmon H., Sachs D., Arn S., Shimizu M., Stokes C., Stevens K., Valpotic I., Zuckermann F., Husmann R. Overview of the first international workshop to define swine leukocyte cluster of differentiation (CD) antigens. Vet. Immunol. Immunopathol. 1994, 43:193-206.
23. Ma L.J., Walter B., DeGuzman A., Muller H.K., Walker A.M. Trans-epithelial immune cell transfer during suckling modulates delayed-type hypersensitivity in recipients as a function of gender. PLoS ONE 2008, 3:e3562.
24. Mair K.H., Essler S.E., Patzl M., Storset A.K., Saalmüller A., Gerner W. NKp46 expression discriminates porcine NK cells with different functional properties. Eur. J. Immunol. 2012, 42:1261-1271.
25. Marchant A., Goldman M. T cell-mediated immune responses in human newborns: ready to learn?. Clin. Exp. Immunol. 2005, 141:10-18.
26. Meurens F., Summerfield A., Nauwynck H., Saif L., Gerdts V. The pig: a model for human infectious diseases. Trends Microbiol. 2012, 20:50-57.
27. Nolte M.A., van Olffen R.W., van Gisbergen K.P.J.M., van Lier R.A.W. Timing and tuning of CD27-CD70 interactions: the impact of signal strength in setting the balance between adaptive responses and immunopathology. Immunol. Rev. 2009, 229:216-231.
28. Pescovitz M.D., Sakopoulos A.G., Gaddy J.A., Husmann R.J., Zuckermann F.A. Porcine peripheral blood CD4+/CD8+ dual expressing T-cells. Vet. Immunol. Immunopathol. 1994, 43:53-62.
29. Phillips J.H., Hori T., Nagler A., Bhat N., Spits H., Lanier L.L. Ontogeny of human natural killer (NK) cells: fetal NK cells mediate cytolytic function and express cytoplasmic CD3ε, δ proteins. J. Exp. Med. 1992, 175:1055-1066.
30. Reutner K., Leitner J., Essler S.E., Witter K., Patzl M., Steinberger P., Saalmüller A., Gerner W. Porcine CD27: identification, expression and functional aspects in lymphocyte subsets in swine. Dev. Comp. Immunol. 2012, 38:321-331.
31. + T cells. Dev. Comp. Immunol. 2005, 29:479-488.
32. Ribot J.C., deBarros A., Pang D.J., Neves J.F., Peperzak V., Roberts S.J., Girardi M., Borst J., Hayday A.C., Pennington D.J., Silva-Santos B. CD27 is a thymic determinant of the balance between interferon-γ-and interleukin 17-producing γδ T cell subsets. Nat. Immunol. 2009, 10:427-436.
33. Roederer M. Spectral compensation for flow cytometry: visualization artifacts, limitations, and caveats. Cytometry 2001, 45:194-205.
34. Rukinava D., Laskarin G., Rubesa G., Strbo N., Bedenicki I., Manestar D., Glavas M., Christmas S.E., Podack E.R. Age-related decline of perforin expression in human cytotoxic T lymphocytes and natural killer cells. Blood 1998, 92:2410-2420.
35. Saalmüller A., Werner T., Fachinger V. T-helper cells from naive to committed. Vet. Immunol. Immunopathol. 2002, 87:137-145.
36. Saalmüller A., Pauly T., Höhlich B.J., Pfaff E. Characterization of porcine T lymphocytes and their immune response against viral antigens. J. Biotechnol. 1999, 73:223-233.
37. Saalmüller A., Maurer S. Major histocompatibility antigen class II expressing resting porcine T lymphocytes are potent antigen-presenting cells in mixed leukocyte culture. Immunobiology 1994, 190:23-34.
38. Saalmüller A., Weiland F., Reddehase M.J. Resting porcine T lymphocytes expressing class II major histocompatibility antigen. Immunobiology 1991, 183:102-114.
39. Saalmüller A., Reddehase M.J., Bühring H.J., Jonjic S., Koszinowski U.H. Simultaneous expression of CD4 and CD8 antigens by a substantial proportion of resting porcine T lymphocytes. Eur. J. Immunol. 1987, 17:1297-1301.
40. Saalmüller A., Jonjic S., Bühring H.J., Reddehase M.J., Koszinowski U.H. Monoclonal antibodies reactive with swine lymphocytes. II. Detection of an antigen on resting T cells down-regulated after activation. J. Immunol. 1987, 138:1852-1857.
41. + regulatory T cells in the human immune system. Nat. Rev. Immunol. 2010, 10:490-500.
42. + regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu. Rev. Immunol. 2004, 22:531-562.
43. Sinkora M., Sinkorova J., Holtmeier W. Development of γδ thymocyte subsets during prenatal and postnatal ontogeny. Immunology 2005, 115:544-555.
44. Sinkora M., Sinkora J., Rehakova Z., Butler J.E. Early ontogeny of thymocytes in pigs: sequential colonization of the thymus by T cell progenitors. J. Immunol. 2000, 165:1832-1839.
45. Solano-Aguilar G.I., Vengroski K.G., Beshah E., Douglass L.W., Lunney J.K. Characterization of lymphocyte subsets from mucosal tissues in neonatal swine. Dev. Comp. Immunol. 2001, 25:245-263.
46. Stepanova H., Samankova P., Leva L., Sinkora J., Faldyna M. Early postnatal development of the immune system in piglets: the redistribution of T lymphocyte subsets. Cell. Immunol. 2007, 249:73-79.
47. + extrathymic T lymphocytes. Cell. Immunol. 1996, 168:291-296.
48. Takamatsu H.H., Denyer M.S., Stirling C., Cox S., Aggarwal N., Dash P., Wileman T.E., Barnett P.V. Porcine γδ T cells: possible roles on the innate and adaptive immune responses following virus infection. Vet. Immunol. Immunopathol. 2006, 112:49-61.
49. Walzer T., Blery M., Chaix J., Fuseri N., Chasson L., Robbins S.H., Jaeger S., Andre P., Gauthier L., Daniel L., Chemin K., Morel Y., Dalod M., Imbert J., Pierres M., Moretta A., Romagne F., Vivier E. Identification, activation, and selective in vivo ablation of mouse NK cells via NKp46. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:3384-3389.
50. Weiss D.J., Wardrop K.J. Schalm's Veterinary Hematology 2010, Wiley-Blackwell, Hoboken, New Jersey. sixth ed.
51. Wen K., Li G., Zhang W., Azevedo M.S.P., Saif L.J., Liu F., Bui T., Yousef A., Yuan L. Development of γδ T cell subset responses in gnotobiotic pigs infected with human rotaviruses and colonized with probiotic lactobacilli. Vet. Immunol. Immunopathol. 2011, 141:267-275.
52. Yang H.Z., Parkhouse R.M.E., Wileman T. Monoclonal antibodies that identify the CD3 molecules expressed specifically at the surface of porcine γδ-T cells. Immunology 2005, 115:189-196.
53. Yang H., Parkhouse R.M.E. Phenotypic classification of porcine lymphocyte subpopulations in blood and lymphoid tissues. Immunology 1996, 89:76-83.
54. Yang W.C., Schultz R.D. Ontogeny of natural killer cell activity and antibody dependent cell mediated cytotoxicity in pigs. Dev. Comp. Immunol. 1986, 10:405-418.
55. Zuckermann F.A. Extrathymic CD4/CD8 double positive T cells. Vet. Immunol. Immunopathol. 1999, 72:55-66.
56. Zuckermann F.A., Husmann R.J. Functional and phenotypic analysis of porcine peripheral blood CD4/CD8 double-positive T cells. Immunology 1996, 87:500-512.