메뉴 건너뛰기




Volumn 101, Issue 3, 2016, Pages 804-814

Lipids, lipoproteins, and cardiovascular disease: Clinical pharmacology now and in the future

Author keywords

[No Author keywords available]

Indexed keywords

ALIROCUMAB; ANTISENSE OLIGONUCLEOTIDE; APABETALONE; APOLIPOPROTEIN A; ATORVASTATIN; BEMPEDOIC ACID; BOCOCIZUMAB; EZETIMIBE PLUS SIMVASTATIN; FIBRIC ACID DERIVATIVE; GEMFIBROZIL; HIGH DENSITY LIPOPROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ICOSAPENTAENOIC ACID; LAROPIPRANT; LIPID; LIPOPROTEIN; LIPOPROTEIN LIPASE; LOMITAPIDE; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MIPOMERSEN; OMEGA 3 FATTY ACID; PLACEBO; PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9; ROSUVASTATIN; SERINE PROTEINASE; SIMVASTATIN; TORCETRAPIB; UNCLASSIFIED DRUG; UNINDEXED DRUG; VERY LOW DENSITY LIPOPROTEIN; ADENOSINE TRIPHOSPHATE CITRATE SYNTHASE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; PCSK9 PROTEIN, HUMAN; TRIACYLGLYCEROL;

EID: 84960926720     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2015-3940     Document Type: Article
Times cited : (41)

References (124)
  • 1
    • 76949111355 scopus 로고
    • Cholesterol, "giant molecules, " and atherosclerosis
    • Keys A. Cholesterol, "giant molecules, " and atherosclerosis. J Am Med Assoc. 1951;147:1514-1519.
    • (1951) J Am Med Assoc. , vol.147 , pp. 1514-1519
    • Keys, A.1
  • 2
    • 37049244034 scopus 로고
    • The role of lipids and lipoproteins in atherosclerosis
    • Gofman JW, Lindgren F. The role of lipids and lipoproteins in atherosclerosis. Science. 1950;111:166-171.
    • (1950) Science. , vol.111 , pp. 166-171
    • Gofman, J.W.1    Lindgren, F.2
  • 3
    • 0020899787 scopus 로고
    • Mevinolin stimulates receptor-mediated clearance of low density lipoprotein from plasmainfamilial hypercholesterolemia heterozygotes
    • Bilheimer DW, Grundy SM, Brown MS, Goldstein JL. Mevinolin stimulates receptor-mediated clearance of low density lipoprotein from plasmainfamilial hypercholesterolemia heterozygotes. Trans Assoc Am Physicians. 1983;96:1-9.
    • (1983) Trans Assoc Am Physicians. , vol.96 , pp. 1-9
    • Bilheimer, D.W.1    Grundy, S.M.2    Brown, M.S.3    Goldstein, J.L.4
  • 4
    • 0030716524 scopus 로고    scopus 로고
    • Decreased production of low density lipoprotein by atorvastatin after apheresis in homozygous familial hypercho-lesterolemia
    • Marais AD, Naoumova RP, Firth JC, Penny C, Neuwirth CK, Thompson GR. Decreased production of low density lipoprotein by atorvastatin after apheresis in homozygous familial hypercho-lesterolemia. J Lipid Res. 1997;38:2071-2078.
    • (1997) J Lipid Res. , vol.38 , pp. 2071-2078
    • Marais, A.D.1    Naoumova, R.P.2    Firth, J.C.3    Penny, C.4    Neuwirth, C.K.5    Thompson, G.R.6
  • 5
    • 84864832599 scopus 로고    scopus 로고
    • The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: Meta-analysis of individual data from 27 randomised trials
    • Cholesterol Treatment Trialists (CTT) Collaborators, Mihaylova B, Emberson J, Blackwell L, et al. The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials. Lancet. 2012;380:581-590.
    • (2012) Lancet. , vol.380 , pp. 581-590
    • Mihaylova, B.1    Emberson, J.2    Blackwell, L.3
  • 6
    • 84933673677 scopus 로고    scopus 로고
    • Efficacy and safety of LDL-lowering therapy among men and women: Meta-analysis of individual data from 174, 000 participants in 27 randomised trials
    • Cholesterol Treatment Trialists (CTT) Collaborators, Fulcher J, O'Connell R, Voysey M, et al. Efficacy and safety of LDL-lowering therapy among men and women: meta-analysis of individual data from 174, 000 participants in 27 randomised trials. Lancet. 2015; 385:1397-1405.
    • (2015) Lancet. , vol.385 , pp. 1397-1405
    • Fulcher, J.1    O'Connell, R.2    Voysey, M.3
  • 7
    • 29444456377 scopus 로고    scopus 로고
    • Effect of statins in stroke prevention
    • Amarenco P. Effect of statins in stroke prevention. Curr Opin Lipidol. 2005;16:614-618.
    • (2005) Curr Opin Lipidol. , vol.16 , pp. 614-618
    • Amarenco, P.1
  • 8
    • 84864753387 scopus 로고    scopus 로고
    • Lipid-altering efficacy of ezetimibe plus statin and statin monotherapy and identification of factors associated with treatment response: A pooled analysis of over 21, 000 subjects from 27 clinical trials
    • Morrone D, Weintraub WS, Toth PP, et al. Lipid-altering efficacy of ezetimibe plus statin and statin monotherapy and identification of factors associated with treatment response: a pooled analysis of over 21, 000 subjects from 27 clinical trials. Atherosclerosis. 2012; 223:251-261.
    • (2012) Atherosclerosis. , vol.223 , pp. 251-261
    • Morrone, D.1    Weintraub, W.S.2    Toth, P.P.3
  • 9
    • 70549098831 scopus 로고    scopus 로고
    • Coronary heart disease in moderately hypercholesterolemic, hypertensive black and non-black patients randomized to pravastatin versus usual care: The antihyper-tensive and lipid lowering to prevent heart attack trial (ALLHAT-LLT)
    • Margolis KL, Dunn K, Simpson LM, et al. Coronary heart disease in moderately hypercholesterolemic, hypertensive black and non-black patients randomized to pravastatin versus usual care: the antihyper-tensive and lipid lowering to prevent heart attack trial (ALLHAT-LLT). Am Heart J. 2009;158:948-955.
    • (2009) Am Heart J. , vol.158 , pp. 948-955
    • Margolis, K.L.1    Dunn, K.2    Simpson, L.M.3
  • 10
    • 1842326783 scopus 로고    scopus 로고
    • Cholesterol lowering with simvastatin improves prognosis of diabetic patients with coronary heart disease. A subgroup analysis of the Scandinavian Simvastatin Survival Study (4S) [published erratum appears in Diabetes Care 1997; Jun;20(6): 1048]
    • Pyörälä K, Pedersen TR, Kjekshus J, Faergeman O, Olsson AG, Thorgeirsson G. Cholesterol lowering with simvastatin improves prognosis of diabetic patients with coronary heart disease. A subgroup analysis of the Scandinavian Simvastatin Survival Study (4S) [published erratum appears in Diabetes Care 1997 Jun;20(6): 1048]. Diabetes Care. 1997;20:614-620.
    • (1997) Diabetes Care. , vol.20 , pp. 614-620
    • Pyörälä, K.1    Pedersen, T.R.2    Kjekshus, J.3    Faergeman, O.4    Olsson, A.G.5    Thorgeirsson, G.6
  • 11
    • 0033611310 scopus 로고    scopus 로고
    • Reduced coronary events in simvastatin-treated subjects with coronary heart disease and diabetes or impaired fasting glucose: Findings from the Scandinavian Simvastatin Survival Study (4S)
    • Haffner S, Alexander C, Cook T, et al. Reduced coronary events in simvastatin-treated subjects with coronary heart disease and diabetes or impaired fasting glucose: findings from the Scandinavian Simvastatin Survival Study (4S). Arch Int Med. 1999;159:2661-2667.
    • (1999) Arch Int Med. , vol.159 , pp. 2661-2667
    • Haffner, S.1    Alexander, C.2    Cook, T.3
  • 12
    • 0027987849 scopus 로고
    • Randomized trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study (4S)
    • Scandinavian Simvastatin Survival Study Group. Randomized trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet. 1994;344:1383-1389.
    • (1994) Lancet. , vol.344 , pp. 1383-1389
  • 13
    • 84893853699 scopus 로고    scopus 로고
    • Lipoprotein(a) concentrations, rosuvastatin therapy, and residual vascular risk: An analysis from the JUPITER Trial (Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin)
    • Khera AV, Everett BM, Caulfield MP, et al. Lipoprotein(a) concentrations, rosuvastatin therapy, and residual vascular risk: an analysis from the JUPITER Trial (Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin). Circulation. 2014;129:635-642.
    • (2014) Circulation. , vol.129 , pp. 635-642
    • Khera, A.V.1    Everett, B.M.2    Caulfield, M.P.3
  • 14
    • 0034687604 scopus 로고    scopus 로고
    • Trends and disparities in coronary heart disease, stroke, and other cardiovascular diseases in the United States: Findings of the national conference on cardiovascular disease prevention
    • Cooper R, Cutler J, Desvigne-Nickens P, et al. Trends and disparities in coronary heart disease, stroke, and other cardiovascular diseases in the United States: findings of the national conference on cardiovascular disease prevention. Circulation. 2000;102:3137-3147.
    • (2000) Circulation. , vol.102 , pp. 3137-3147
    • Cooper, R.1    Cutler, J.2    Desvigne-Nickens, P.3
  • 15
    • 84871758936 scopus 로고    scopus 로고
    • Contributions of treatment and lifestyle to declining CVD mortality: Why have CVD mortality rates declined so much since the 1960s?
    • O'Flaherty M, Buchan I, Capewell S. Contributions of treatment and lifestyle to declining CVD mortality: why have CVD mortality rates declined so much since the 1960s? Heart. 2013;99:159-162.
    • (2013) Heart. , vol.99 , pp. 159-162
    • O'Flaherty, M.1    Buchan, I.2    Capewell, S.3
  • 16
    • 26844468578 scopus 로고    scopus 로고
    • Can low-density lipoprotein be too low? the safety and efficacy of achieving very low low-density lipoprotein with intensive statin therapy: A PROVE IT-TIMI22 substudy
    • Wiviott SD, Cannon CP, Morrow DA, et al. Can low-density lipoprotein be too low? The safety and efficacy of achieving very low low-density lipoprotein with intensive statin therapy: a PROVE IT-TIMI22 substudy. J Am Coll Cardiol. 2005;46:1411-1416.
    • (2005) J Am Coll Cardiol. , vol.46 , pp. 1411-1416
    • Wiviott, S.D.1    Cannon, C.P.2    Morrow, D.A.3
  • 17
    • 2542461241 scopus 로고    scopus 로고
    • Optimal low-density lipoprotein is 50 to 70 mg/dl: Lower is better and physiologically normal
    • O'Keefe JH, Jr., Cordain L, Harris WH, Moe RM, Vogel R. Optimal low-density lipoprotein is 50 to 70 mg/dl: lower is better and physiologically normal. J Am Coll Cardiol. 2004;43:2142-2146.
    • (2004) J Am Coll Cardiol. , vol.43 , pp. 2142-2146
    • O'Keefe, J.H.1    Cordain, L.2    Harris, W.H.3    Moe, R.M.4    Vogel, R.5
  • 18
    • 20444371945 scopus 로고    scopus 로고
    • The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)
    • Garcia-Calvo M, Lisnock J, Bull HG, et al. The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1). Proc Natl Acad Sci USA. 2005;102:8132-8137.
    • (2005) Proc Natl Acad Sci USA. , vol.102 , pp. 8132-8137
    • Garcia-Calvo, M.1    Lisnock, J.2    Bull, H.G.3
  • 19
    • 84931411520 scopus 로고    scopus 로고
    • Ezetimibe added to statin therapy after acute coronary syndromes
    • Cannon CP, Blazing MA, Giugliano RP et al; IMPROVE-IT Investigators. Ezetimibe added to statin therapy after acute coronary syndromes. N Engl J Med. 2015;372:2387-2397.
    • (2015) N Engl J Med. , vol.372 , pp. 2387-2397
    • Cannon, C.P.1    Blazing, M.A.2    Giugliano, R.P.3
  • 20
    • 84931375227 scopus 로고    scopus 로고
    • Proof that lower is better-LDL cholesterol and IMPROVE-IT
    • Jarcho JA, Keaney JF, Jr. Proof that lower is better-LDL cholesterol and IMPROVE-IT. N Engl J Med. 2015;372:2448-2450.
    • (2015) N Engl J Med. , vol.372 , pp. 2448-2450
    • Jarcho, J.A.1    Keaney, J.F.2
  • 21
    • 0037417807 scopus 로고    scopus 로고
    • The secretory propro-tein convertase neural apoptosis-regulated convertase 1 (NARC-1): Liver regeneration and neuronal differentiation
    • Seidah NG, Benjannet S, Wickham L, et al. The secretory propro-tein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation. Proc Natl Acad Sci USA. 2003;100:928-933.
    • (2003) Proc Natl Acad Sci USA. , vol.100 , pp. 928-933
    • Seidah, N.G.1    Benjannet, S.2    Wickham, L.3
  • 22
    • 0037603589 scopus 로고    scopus 로고
    • Mutations in PCSK9 cause autosomal dominant hypercholesterolemia
    • Abifadel M, Varret M, Rabes JP, et al. Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. Nat Genet. 2003;34: 154-156.
    • (2003) Nat Genet. , vol.34 , pp. 154-156
    • Abifadel, M.1    Varret, M.2    Rabes, J.P.3
  • 23
    • 38349117118 scopus 로고    scopus 로고
    • The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and Apo ER2
    • Poirier S, Mayer G, Benjannet S, et al. The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and Apo ER2. J Biol Chem. 2008;283:2363-2372.
    • (2008) J Biol Chem. , vol.283 , pp. 2363-2372
    • Poirier, S.1    Mayer, G.2    Benjannet, S.3
  • 24
    • 84885072023 scopus 로고    scopus 로고
    • The biology of PCSK9 from the endoplasmic reticulum to lysosomes: New and emerging therapeutics to control low-density lipoprotein cholesterol
    • Poirier S, Mayer G. The biology of PCSK9 from the endoplasmic reticulum to lysosomes: new and emerging therapeutics to control low-density lipoprotein cholesterol. Drug Des Devel Ther. 2013; 7:1135-1148.
    • (2013) Drug des Devel Ther. , vol.7 , pp. 1135-1148
    • Poirier, S.1    Mayer, G.2
  • 25
    • 84921323646 scopus 로고    scopus 로고
    • Efficacy and safety of alirocumab, a fully human PCSK9 monoclonal antibody, in high cardiovascular risk patients with poorly controlled hypercholesterolemia on maximally tolerated doses of statins: Rationale and design of the ODYSSEY COMBO i and II trials
    • Colhoun HM, Robinson JG, Farnier M, et al. Efficacy and safety of alirocumab, a fully human PCSK9 monoclonal antibody, in high cardiovascular risk patients with poorly controlled hypercholesterolemia on maximally tolerated doses of statins: rationale and design of the ODYSSEY COMBO I and II trials. BMC Cardiovasc Disord. 2014;14:121.
    • (2014) BMC Cardiovasc Disord. , vol.14 , pp. 121
    • Colhoun, H.M.1    Robinson, J.G.2    Farnier, M.3
  • 26
    • 84870494510 scopus 로고    scopus 로고
    • Efficacy, safety, and tolerability of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 as monotherapy in patients with hypercholesterolaemia (MENDEL): A randomised, double-blind, placebo-controlled, phase 2 study
    • Koren MJ, Scott R, Kim JB, et al. Efficacy, safety, and tolerability of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 as monotherapy in patients with hypercholesterolaemia (MENDEL): a randomised, double-blind, placebo-controlled, phase 2 study. Lancet. 2012;380:1995-2006.
    • (2012) Lancet. , vol.380 , pp. 1995-2006
    • Koren, M.J.1    Scott, R.2    Kim, J.B.3
  • 27
    • 84931849550 scopus 로고    scopus 로고
    • Effects of proprotein convertase subtilisin/kexin type 9 antibodies in adults with hypercholesterolemia: A systematic review and meta-analysis
    • Navarese EP, Kolodziejczak M, Schulze V, et al. Effects of proprotein convertase subtilisin/kexin type 9 antibodies in adults with hypercholesterolemia: a systematic review and meta-analysis. Ann Intern Med. 2015;163:40-51.
    • (2015) Ann Intern Med. , vol.163 , pp. 40-51
    • Navarese, E.P.1    Kolodziejczak, M.2    Schulze, V.3
  • 28
    • 0022980592 scopus 로고
    • Serum cholesterol, blood pressure, and mortality: Implications from a cohort of 361, 662 men
    • Martin MJ, Hulley SB, Browner WS, Kuller LH, Wentworth D. Serum cholesterol, blood pressure, and mortality: implications from a cohort of 361, 662 men. Lancet. 1986;2:933-936.
    • (1986) Lancet. , vol.2 , pp. 933-936
    • Martin, M.J.1    Hulley, S.B.2    Browner, W.S.3    Kuller, L.H.4    Wentworth, D.5
  • 29
    • 79953836812 scopus 로고    scopus 로고
    • Cardiovascular event reduction and adverse events among subjects attaining low-density lipoprotein cholesterol <50 mg/dl with rosuvastatin. The JUPITER trial (Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin)
    • Hsia J, Mac Fadyen JG, Monyak J, Ridker PM. Cardiovascular event reduction and adverse events among subjects attaining low-density lipoprotein cholesterol <50 mg/dl with rosuvastatin. The JUPITER trial (Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin). J Am Coll Cardiol. 2011; 57: 1666-1675.
    • (2011) J Am Coll Cardiol. , vol.57 , pp. 1666-1675
    • Hsia, J.1    Mac Fadyen, J.G.2    Monyak, J.3    Ridker, P.M.4
  • 30
    • 84926191670 scopus 로고    scopus 로고
    • Efficacy and safetyof alirocumabin reducing lipids and cardiovascular events
    • Robinson JG, Farnier M, Krempf M, etal;Investigators ODYSSEY LONGTERM. Efficacy and safetyof alirocumabin reducing lipids and cardiovascular events. N Engl J Med. 2015;372:1489-1499.
    • (2015) N Engl J Med. , vol.372 , pp. 1489-1499
    • Robinson, J.G.1    Farnier, M.2    Krempf, M.3
  • 31
    • 84926206074 scopus 로고    scopus 로고
    • Efficacy and safety of evolocumab in reducing lipids and cardiovascular events
    • Sabatine MS, Giugliano RP, Wiviott SD, et al; Open-Label Study of Long-Term Evaluation against LDL Cholesterol (OSLER) Investigators. Efficacy and safety of evolocumab in reducing lipids and cardiovascular events. N Engl J Med. 2015;372:1500-1509.
    • (2015) N Engl J Med. , vol.372 , pp. 1500-1509
    • Sabatine, M.S.1    Giugliano, R.P.2    Wiviott, S.D.3
  • 32
    • 84903311389 scopus 로고    scopus 로고
    • Abetalipoproteinemia and homozygous hypo-betalipoproteinemia: A framework for diagnosis and management
    • Lee J, Hegele RA. Abetalipoproteinemia and homozygous hypo-betalipoproteinemia: a framework for diagnosis and management. J Inherit Metab Dis. 2014;37:333-339.
    • (2014) J Inherit Metab Dis. , vol.37 , pp. 333-339
    • Lee, J.1    Hegele, R.A.2
  • 33
    • 84891527956 scopus 로고    scopus 로고
    • How low an LDL-C should we go with statin therapy?
    • Kostis WJ. How low an LDL-C should we go with statin therapy? Curr Atheroscler Rep. 2014;16:388.
    • (2014) Curr Atheroscler Rep. , vol.16 , pp. 388
    • Kostis, W.J.1
  • 34
    • 84900524103 scopus 로고    scopus 로고
    • Hypobetalipoproteinemia and abetalipoproteinemia
    • Welty FK. Hypobetalipoproteinemia and abetalipoproteinemia. Curr Opin Lipidol. 2014;25:161-168.
    • (2014) Curr Opin Lipidol. , vol.25 , pp. 161-168
    • Welty, F.K.1
  • 36
    • 0015466387 scopus 로고
    • Abetalipoproteinemia
    • Kayden HJ. Abetalipoproteinemia. Annu Rev Med. 1972;23:285-296.
    • (1972) Annu Rev Med. , vol.23 , pp. 285-296
    • Kayden, H.J.1
  • 37
    • 84884366154 scopus 로고    scopus 로고
    • Efficacy and safety of a novel dual modulator of adenosine triphosphate-citrate lyase and adenosine monophosphate-activated protein kinase in patients with hypercholesterolemia: Results of a multicenter, randomized, double-blind, placebo-controlled, parallel-group trial
    • Ballantyne CM, Davidson MH, Macdougall DE, et al. Efficacy and safety of a novel dual modulator of adenosine triphosphate-citrate lyase and adenosine monophosphate-activated protein kinase in patients with hypercholesterolemia: results of a multicenter, randomized, double-blind, placebo-controlled, parallel-group trial. J Am Coll Cardiol. 2013;62:1154-1162.
    • (2013) J Am Coll Cardiol. , vol.62 , pp. 1154-1162
    • Ballantyne, C.M.1    Davidson, M.H.2    Macdougall, D.E.3
  • 38
    • 84931570425 scopus 로고    scopus 로고
    • Adenosine triphosphate citrate lyase: Emerging target in the treatment of dyslipidemia
    • Lemus HN, Mendivil CO. Adenosine triphosphate citrate lyase: emerging target in the treatment of dyslipidemia. J Clin Lipidol. 2015; 9:384-389.
    • (2015) J Clin Lipidol. , vol.9 , pp. 384-389
    • Lemus, H.N.1    Mendivil, C.O.2
  • 39
    • 84894573802 scopus 로고    scopus 로고
    • Efficacy and safety of ETC-1002, a novel investigational low-density lipoprotein-cholesterol-lowering therapy for the treatment of patients with hy-percholesterolemia and type 2 diabetes mellitus
    • Gutierrez MJ, Rosenberg NL, Macdougall DE, et al. Efficacy and safety of ETC-1002, a novel investigational low-density lipoprotein-cholesterol-lowering therapy for the treatment of patients with hy-percholesterolemia and type 2 diabetes mellitus. Arterioscler Thromb Vasc Biol. 2014;34:676-683.
    • (2014) Arterioscler Thromb Vasc Biol. , vol.34 , pp. 676-683
    • Gutierrez, M.J.1    Rosenberg, N.L.2    Macdougall, D.E.3
  • 40
    • 84931466071 scopus 로고    scopus 로고
    • Useof ETC-1002 to treat hypercholesterolemia in patients with statin intolerance
    • Thompson PD, Rubino J, Janik MJ, et al. Useof ETC-1002 to treat hypercholesterolemia in patients with statin intolerance. J Clin Lipidol. 2015;9:295-304.
    • (2015) J Clin Lipidol. , vol.9 , pp. 295-304
    • Thompson, P.D.1    Rubino, J.2    Janik, M.J.3
  • 41
    • 84871226706 scopus 로고    scopus 로고
    • AMP-activated protein kinase and ATP-citrate lyase are two distinct molecular targets for ETC-1002, a novel small molecule regulator of lipid and carbohydrate metabolism
    • Pinkosky SL, Filippov S, Srivastava RA, et al. AMP-activated protein kinase and ATP-citrate lyase are two distinct molecular targets for ETC-1002, a novel small molecule regulator of lipid and carbohydrate metabolism. J Lipid Res. 2013;54:134-151.
    • (2013) J Lipid Res. , vol.54 , pp. 134-151
    • Pinkosky, S.L.1    Filippov, S.2    Srivastava, R.A.3
  • 42
    • 33750207033 scopus 로고    scopus 로고
    • Potent reduction of apo-lipoprotein B and low-density lipoprotein cholesterol by short-term administration of an antisense inhibitor of apolipoprotein B
    • Kastelein JJ, Wedel MK, Baker BF, et al. Potent reduction of apo-lipoprotein B and low-density lipoprotein cholesterol by short-term administration of an antisense inhibitor of apolipoprotein B. Circulation. 2006;114:1729-1735.
    • (2006) Circulation. , vol.114 , pp. 1729-1735
    • Kastelein, J.J.1    Wedel, M.K.2    Baker, B.F.3
  • 43
    • 33846151732 scopus 로고    scopus 로고
    • Inhibition of micro-somal triglyceride transfer protein in familial hypercholesterol-emia
    • Cuchel M, Bloedon LT, Szapary PO, et al. Inhibition of micro-somal triglyceride transfer protein in familial hypercholesterol-emia. N Engl J Med. 2007;356:148-156.
    • (2007) N Engl J Med. , vol.356 , pp. 148-156
    • Cuchel, M.1    Bloedon, L.T.2    Szapary, P.O.3
  • 44
    • 84880133265 scopus 로고    scopus 로고
    • Microsomal transfer protein inhibition in humans
    • Cuchel M, Rader DJ. Microsomal transfer protein inhibition in humans. Curr Opin Lipidol. 2013;24:246-250.
    • (2013) Curr Opin Lipidol. , vol.24 , pp. 246-250
    • Cuchel, M.1    Rader, D.J.2
  • 45
    • 0024449985 scopus 로고
    • High-density lipoprotein- The clinical implications of recent studies
    • Gordon DJ, Rifkind BM. High-density lipoprotein-the clinical implications of recent studies. N Engl J Med. 1989;321:1311-1316.
    • (1989) N Engl J Med. , vol.321 , pp. 1311-1316
    • Gordon, D.J.1    Rifkind, B.M.2
  • 46
    • 0013019310 scopus 로고
    • Plasma high density lipoprotein concentration and development of ischaemic heart disease
    • Miller GJ, Miller NE. Plasma high density lipoprotein concentration and development of ischaemic heart disease. Lancet. 1974;1: 16-20.
    • (1974) Lancet. , vol.1 , pp. 16-20
    • Miller, G.J.1    Miller, N.E.2
  • 47
    • 84864845456 scopus 로고    scopus 로고
    • Plasma HDL cholesterol and risk of myocardial infarction: A mendelian randomisation study
    • Voight BF, Peloso GM, Orho-Melander M, et al. Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet. 2012;380:572-580.
    • (2012) Lancet. , vol.380 , pp. 572-580
    • Voight, B.F.1    Peloso, G.M.2    Orho-Melander, M.3
  • 48
    • 36348975228 scopus 로고    scopus 로고
    • Effects of torcetrapib in patients at high risk for coronary events
    • Barter PJ, Caulfield M, Eriksson M, et al; ILLUMINATE Investigators. Effects of torcetrapib in patients at high risk for coronary events. N Engl J Med. 2007;357:2109-2122.
    • (2007) N Engl J Med. , vol.357 , pp. 2109-2122
    • Barter, P.J.1    Caulfield, M.2    Eriksson, M.3
  • 49
    • 48149106322 scopus 로고    scopus 로고
    • Torcetrapib-induced blood pressure elevation is independent of CETP inhibition and is accompanied by increased circulating levels of aldosterone
    • Forrest MJ, Bloomfield D, Briscoe RJ, et al. Torcetrapib-induced blood pressure elevation is independent of CETP inhibition and is accompanied by increased circulating levels of aldosterone. Br J Pharmacol. 2008;154:1465-1473.
    • (2008) Br J Pharmacol. , vol.154 , pp. 1465-1473
    • Forrest, M.J.1    Bloomfield, D.2    Briscoe, R.J.3
  • 50
    • 84870045994 scopus 로고    scopus 로고
    • Effects of dalcetrapib in patients with a recent acute coronary syndrome
    • Schwartz GG, Olsson AG, Abt M, et al. Effects of dalcetrapib in patients with a recent acute coronary syndrome. N Engl J Med 2012;367:2089-2099.
    • (2012) N Engl J Med , vol.367 , pp. 2089-2099
    • Schwartz, G.G.1    Olsson, A.G.2    Abt, M.3
  • 51
    • 79952452422 scopus 로고    scopus 로고
    • The role of niacin in raising high-density lipo-protein cholesterolto reduce cardiovascular events in patients with atherosclerotic cardiovascular disease and optimally treated low-density lipoprotein cholesterol rationale and study design. The Atherothrombosis Intervention in Metabolic syndrome with low HDL/high triglycerides: Impact on Global Health outcomes (AIM-HIGH)
    • Investigators A-H.
    • Investigators A-H. The role of niacin in raising high-density lipo-protein cholesterolto reduce cardiovascular events in patients with atherosclerotic cardiovascular disease and optimally treated low-density lipoprotein cholesterol rationale and study design. The Atherothrombosis Intervention in Metabolic syndrome with low HDL/high triglycerides: Impact on Global Health outcomes (AIM-HIGH). Am Heart J. 2011;161:471-477.
    • (2011) Am Heart J. , vol.161 , pp. 471-477
  • 52
    • 84904252744 scopus 로고    scopus 로고
    • Effects of extended-release niacin with la-ropiprant in high-risk patients
    • HPS2-THRIVE Collaborative Group, Landray MJ, Haynes R, Hopewell JC, et al. Effects of extended-release niacin with la-ropiprant in high-risk patients. N Engl J Med. 2014;371:203-212.
    • (2014) N Engl J Med. , vol.371 , pp. 203-212
    • Landray, M.J.1    Haynes, R.2    Hopewell, J.C.3
  • 53
    • 0023001772 scopus 로고
    • Fifteen year mortality in Coronary Drug Project patients: Long-term benefit with niacin
    • Canner PL, Berge KG, Wenger NK, et al. Fifteen year mortality in Coronary Drug Project patients: long-term benefit with niacin. J Am Coll Cardiol. 1986;8:1245-1255.
    • (1986) J Am Coll Cardiol. , vol.8 , pp. 1245-1255
    • Canner, P.L.1    Berge, K.G.2    Wenger, N.K.3
  • 54
    • 0017991943 scopus 로고
    • Coronary Drug Project report on clofibrate and niacin
    • Coronary Drug Project report on clofibrate and niacin. Atherosclerosis. 1978;30:239-240.
    • (1978) Atherosclerosis. , vol.30 , pp. 239-240
  • 55
    • 0026057848 scopus 로고
    • Expression of human apolipoprotein A-I in transgenic mice results in reduced plasma levels of murine apolipoprotein A-I and the appearance of two new high density lipoprotein size subclasses
    • Rubin EM, Ishida BY, Clift SM, Krauss RM. Expression of human apolipoprotein A-I in transgenic mice results in reduced plasma levels of murine apolipoprotein A-I and the appearance of two new high density lipoprotein size subclasses. Proc Natl Acad Sci USA. 1991;88:434-438.
    • (1991) Proc Natl Acad Sci USA. , vol.88 , pp. 434-438
    • Rubin, E.M.1    Ishida, B.Y.2    Clift, S.M.3    Krauss, R.M.4
  • 56
    • 0032706442 scopus 로고    scopus 로고
    • Regression of atherosclerosis induced by liver-directed gene transfer of apolipoprotein A-I in mice
    • Tangirala RK, Tsukamoto K, Chun SH, Usher D, Pure E, Rader DJ. Regression of atherosclerosis induced by liver-directed gene transfer of apolipoprotein A-I in mice. Circulation. 1999;100:1816-1822.
    • (1999) Circulation. , vol.100 , pp. 1816-1822
    • Tangirala, R.K.1    Tsukamoto, K.2    Chun, S.H.3    Usher, D.4    Pure, E.5    Rader, D.J.6
  • 57
    • 0030865194 scopus 로고    scopus 로고
    • HDL deficiency in genetically engineered mice requires elevated LDL to accelerate atherogenesis
    • Hughes SD, Verstuyft J, Rubin EM. HDL deficiency in genetically engineered mice requires elevated LDL to accelerate atherogenesis. Arterioscler Thromb Vasc Biol. 1997;17:1725-1729.
    • (1997) Arterioscler Thromb Vasc Biol. , vol.17 , pp. 1725-1729
    • Hughes, S.D.1    Verstuyft, J.2    Rubin, E.M.3
  • 58
    • 0022638992 scopus 로고
    • Atherosclerosis and lipoprotein metabolism: Role of reverse cholesterol transport
    • Roheim PS. Atherosclerosis and lipoprotein metabolism: role of reverse cholesterol transport. Am J Cardiol 1986;57:3C-10C.
    • (1986) Am J Cardiol , vol.57 , pp. 3C-10C
    • Roheim, P.S.1
  • 59
    • 0026487748 scopus 로고
    • Roleofhigh density lipoproteins in the regression of atherosclerosis
    • Badimon JJ, Fuster V, Badimon L. Roleofhigh density lipoproteins in the regression of atherosclerosis. Circulation. 1992;86:III86-III94.
    • (1992) Circulation. , vol.86 , pp. III86-III94
    • Badimon, J.J.1    Fuster, V.2    Badimon, L.3
  • 60
    • 84859760161 scopus 로고    scopus 로고
    • Cholesterol efflux and atheroprotection: Advancing the concept of reverse cholesterol transport
    • Rosenson RS, Brewer HB, Jr., Davidson WS, et al. Cholesterol efflux and atheroprotection: advancing the concept of reverse cholesterol transport. Circulation. 2012;125:1905-1919.
    • (2012) Circulation. , vol.125 , pp. 1905-1919
    • Rosenson, R.S.1    Brewer, H.B.2    Davidson, W.S.3
  • 61
    • 78651379500 scopus 로고    scopus 로고
    • Cholesterol efflux capacity high-density lipoprotein function and atherosclerosis
    • Khera AV, Cuchel M, delaLlera-Moya M, et al. Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis. N Engl J Med. 2011;364:127-135.
    • (2011) N Engl J Med. , vol.364 , pp. 127-135
    • Khera, A.V.1    Cuchel, M.2    DelaLlera-Moya, M.3
  • 62
    • 84919343998 scopus 로고    scopus 로고
    • HDL cholesterol efflux capacity and incident cardiovascular events
    • Rohatgi A, Khera A, Berry JD, et al. HDL cholesterol efflux capacity and incident cardiovascular events. N Engl J Med. 2014; 371:2383-2393.
    • (2014) N Engl J Med. , vol.371 , pp. 2383-2393
    • Rohatgi, A.1    Khera, A.2    Berry, J.D.3
  • 63
    • 84934437744 scopus 로고    scopus 로고
    • Association of HDL cholesterol efflux capacity with incident coronary heart disease events: A prospective case-control study
    • Saleheen D, Scott R, Javad S, et al. Association of HDL cholesterol efflux capacity with incident coronary heart disease events: a prospective case-control study. Lancet Diabetes Endocrinol. 2015;3: 507-513.
    • (2015) Lancet Diabetes Endocrinol. , vol.3 , pp. 507-513
    • Saleheen, D.1    Scott, R.2    Javad, S.3
  • 64
    • 0041662117 scopus 로고    scopus 로고
    • Overexpression of apolipoprotein A-I promotes reverse transport of cholesterol from macrophages to feces in vivo
    • Zhang Y, Zanotti I, Reilly MP, Glick JM, Rothblat GH, Rader DJ. Overexpression of apolipoprotein A-I promotes reverse transport of cholesterol from macrophages to feces in vivo. Circulation. 2003;108:661-663.
    • (2003) Circulation. , vol.108 , pp. 661-663
    • Zhang, Y.1    Zanotti, I.2    Reilly, M.P.3    Glick, J.M.4    Rothblat, G.H.5    Rader, D.J.6
  • 65
    • 0030878533 scopus 로고    scopus 로고
    • High density lipoprotein and coronary heart disease: Insights from mutations leading to low high density lipoprotein
    • Calabresi L, Franceschini G. High density lipoprotein and coronary heart disease: insights from mutations leading to low high density lipoprotein. Curr Opin Lipidol. 1997;8:219-224.
    • (1997) Curr Opin Lipidol. , vol.8 , pp. 219-224
    • Calabresi, L.1    Franceschini, G.2
  • 66
    • 0022272843 scopus 로고
    • Almilano apopro-tein: Identification of the complete kindred and evidence of a dominant genetic transmission
    • Gualandri V, Franceschini G, Sirtori CR, et al. Almilano apopro-tein: identification of the complete kindred and evidence of a dominant genetic transmission. Am J Hum Genet. 1985;37:1083-1097.
    • (1985) Am J Hum Genet. , vol.37 , pp. 1083-1097
    • Gualandri, V.1    Franceschini, G.2    Sirtori, C.R.3
  • 67
    • 0242577955 scopus 로고    scopus 로고
    • Effect of recombinant Apo A-I Milano on coronary atherosclerosis in patients with acute coronary syndromes: A randomized controlled trial
    • Nissen SE, Tsunoda T, Tuzcu EM, et al. Effect of recombinant Apo A-I Milano on coronary atherosclerosis in patients with acute coronary syndromes: a randomized controlled trial. JAMA. 2003; 290:2292-2300.
    • (2003) JAMA , vol.290 , pp. 2292-2300
    • Nissen, S.E.1    Tsunoda, T.2    Tuzcu, E.M.3
  • 68
    • 84906934506 scopus 로고    scopus 로고
    • CSL112 enhances biomarkers of reverse cholesterol transport after single and multiple infusions in healthy subjects
    • Gille A, Easton R, D'Andrea D, Wright SD, Shear CL. CSL112 enhances biomarkers of reverse cholesterol transport after single and multiple infusions in healthy subjects. Arterioscler Thromb Vasc Biol. 2014;34:2106-2114.
    • (2014) Arterioscler Thromb Vasc Biol. , vol.34 , pp. 2106-2114
    • Gille, A.1    Easton, R.2    D'Andrea, D.3    Wright, S.D.4    Shear, C.L.5
  • 69
    • 84875867425 scopus 로고    scopus 로고
    • A novel approach to oral apoA-I mimetic therapy
    • Chattopadhyay A, Navab M, Hough G, et al. A novel approach to oral apoA-I mimetic therapy. J Lipid Res. 2013;54:995-1010.
    • (2013) J Lipid Res. , vol.54 , pp. 995-1010
    • Chattopadhyay, A.1    Navab, M.2    Hough, G.3
  • 70
    • 0037154287 scopus 로고    scopus 로고
    • Oral administra-tionofanApo A-I mimetic Peptide synthesized from D-amino acids dramatically reduces atherosclerosisinmice independentofplasma cholesterol
    • Navab M, Anantharamaiah GM, Hama S, et al. Oral administra-tionofanApo A-I mimetic Peptide synthesized from D-amino acids dramatically reduces atherosclerosisinmice independentofplasma cholesterol. Circulation. 2002;105:290-292.
    • (2002) Circulation. , vol.105 , pp. 290-292
    • Navab, M.1    Anantharamaiah, G.M.2    Hama, S.3
  • 71
    • 20844445969 scopus 로고    scopus 로고
    • Differential effects of apolipoprotein A-I-mimetic peptide on evolving and established atherosclerosis in apolipoprotein E-null mice
    • Li X, Chyu KY, Faria Neto JR, Yano J, et al. Differential effects of apolipoprotein A-I-mimetic peptide on evolving and established atherosclerosis in apolipoprotein E-null mice. Circulation. 2004; 110:1701-1705.
    • (2004) Circulation. , vol.110 , pp. 1701-1705
    • Li, X.1    Chyu, K.Y.2    Faria Neto, J.R.3    Yano, J.4
  • 72
    • 77954930317 scopus 로고    scopus 로고
    • 5A apolipoprotein mimetic peptide promotes cholesterol efflux and reduces atherosclerosis in mice
    • Amar MJ, D'Souza W, Turner S, et al. 5A apolipoprotein mimetic peptide promotes cholesterol efflux and reduces atherosclerosis in mice. J Pharmacol Exp Ther. 2010;334:634-641.
    • (2010) J Pharmacol Exp Ther. , vol.334 , pp. 634-641
    • Amar, M.J.1    D'Souza, W.2    Turner, S.3
  • 73
    • 79251573524 scopus 로고    scopus 로고
    • 4F Peptide reduces nascent atherosclerosis and induces natural antibody production in apoli-poprotein E-null mice
    • Wool GD, Cabana VG, Lukens J, et al. 4F Peptide reduces nascent atherosclerosis and induces natural antibody production in apoli-poprotein E-null mice. FASEB J. 2011;25:290-300.
    • (2011) FASEB J. , vol.25 , pp. 290-300
    • Wool, G.D.1    Cabana, V.G.2    Lukens, J.3
  • 74
    • 84896878003 scopus 로고    scopus 로고
    • The structure/function of apoprotein A-I mimetic peptides: An update
    • Getz GS, Reardon CA. The structure/function of apoprotein A-I mimetic peptides: an update. Curr Opin Endocrinol Diabetes Obes. 2014;21:129-133.
    • (2014) Curr Opin Endocrinol Diabetes Obes. , vol.21 , pp. 129-133
    • Getz, G.S.1    Reardon, C.A.2
  • 75
    • 84889663966 scopus 로고    scopus 로고
    • RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodo-main
    • Picaud S, Wells C, Felletar I, et al. RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodo-main. Proc Natl Acad Sci USA. 2013;110:19754-19759.
    • (2013) Proc Natl Acad Sci USA. , vol.110 , pp. 19754-19759
    • Picaud, S.1    Wells, C.2    Felletar, I.3
  • 76
    • 84862765834 scopus 로고    scopus 로고
    • Apo A-I induction as a potential cardioprotective strategy: Rationale for the SUSTAIN and ASSURE studies
    • Nicholls SJ, Gordon A, Johannson J, et al. Apo A-I induction as a potential cardioprotective strategy: rationale for the SUSTAIN and ASSURE studies. Cardiovasc Drugs Ther. 2012;26:181-187.
    • (2012) Cardiovasc Drugs Ther. , vol.26 , pp. 181-187
    • Nicholls, S.J.1    Gordon, A.2    Johannson, J.3
  • 77
    • 84960856349 scopus 로고    scopus 로고
    • Effect of the BET protein inhibitor, RVX-208, on progression of coronary atherosclerosis: Results of the phase 2b, randomized, double-blind, multicenter, ASSURE Trial
    • In press
    • Nicholls SJ, Puri R, Wolski K, et al. Effect of the BET protein inhibitor, RVX-208, on progression of coronary atherosclerosis: results of the phase 2b, randomized, double-blind, multicenter, ASSURE Trial. Am J Cardiovasc Drugs. In press.
    • Am J Cardiovasc Drugs
    • Nicholls, S.J.1    Puri, R.2    Wolski, K.3
  • 78
    • 0014384871 scopus 로고
    • Interrelationships of hyperinsulinism and hypertriglyceridemia in young patients with coronary heart disease
    • Tzagournis M, Chiles R, Ryan JM, Skillman TG. Interrelationships of hyperinsulinism and hypertriglyceridemia in young patients with coronary heart disease. Circulation. 1968;38:1156-1163.
    • (1968) Circulation. , vol.38 , pp. 1156-1163
    • Tzagournis, M.1    Chiles, R.2    Ryan, J.M.3    Skillman, T.G.4
  • 79
    • 0014482955 scopus 로고
    • Hypertriglyceridemia, diabetes mellitus, and coronary vessel disease
    • Levy RI, Glueck CJ. Hypertriglyceridemia, diabetes mellitus, and coronary vessel disease. Arch Intern Med. 1969;123:220-228.
    • (1969) Arch Intern Med. , vol.123 , pp. 220-228
    • Levy, R.I.1    Glueck, C.J.2
  • 80
    • 0019780478 scopus 로고
    • High density lipoprotein and other lipo-proteins in normolipidaemic and hypertriglyceridaemic (type IV) men with coronary artery disease
    • Moberg B, Wallentin L. High density lipoprotein and other lipo-proteins in normolipidaemic and hypertriglyceridaemic (type IV) men with coronary artery disease. Eur J Clin Invest. 1981;11:433-440.
    • (1981) Eur J Clin Invest. , vol.11 , pp. 433-440
    • Moberg, B.1    Wallentin, L.2
  • 81
    • 33846637379 scopus 로고    scopus 로고
    • Triglycerides and the risk of coronary heart disease: 10, 158 incident cases among 262, 525 participants in 29 Western prospective studies
    • Sarwar N, Danesh J, Eiriksdottir G, et al. Triglycerides and the risk of coronary heart disease: 10, 158 incident cases among 262, 525 participants in 29 Western prospective studies. Circulation. 2007; 115:450-458.
    • (2007) Circulation. , vol.115 , pp. 450-458
    • Sarwar, N.1    Danesh, J.2    Eiriksdottir, G.3
  • 82
    • 0024497540 scopus 로고
    • Particle size distribution of lipoproteins from human atherosclerotic plaque: A preliminary report
    • Rapp JH, Harris HW, Hamilton RL, et al. Particle size distribution of lipoproteins from human atherosclerotic plaque: a preliminary report. J Vasc Surg. 1989;9:81-88.
    • (1989) J Vasc Surg. , vol.9 , pp. 81-88
    • Rapp, J.H.1    Harris, H.W.2    Hamilton, R.L.3
  • 84
    • 70350245011 scopus 로고    scopus 로고
    • Harmonizing the metabolic syndrome: A joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; And International Association for the Study of Obesity
    • Alberti KG, Eckel RH, Grundy SM, et al; International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; International Association for the Study of Obesity. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation. 2009;120:1640-1645.
    • (2009) Circulation. , vol.120 , pp. 1640-1645
    • Alberti, K.G.1    Eckel, R.H.2    Grundy, S.M.3
  • 85
    • 34447511196 scopus 로고    scopus 로고
    • Non-fasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women
    • Nordestgaard BG, Benn M, Schnohr P, Tybjaerg-Hansen A. Non-fasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women. JAMA. 2007;298: 299-308.
    • (2007) JAMA , vol.298 , pp. 299-308
    • Nordestgaard, B.G.1    Benn, M.2    Schnohr, P.3    Tybjaerg-Hansen, A.4
  • 86
    • 52149109922 scopus 로고    scopus 로고
    • Fasting compared with nonfasting lipids and apolipoproteins for predicting incident cardiovascular events
    • Mora S, Rifai N, Buring JE, Ridker PM. Fasting compared with nonfasting lipids and apolipoproteins for predicting incident cardiovascular events. Circulation. 2008;118:993-1001.
    • (2008) Circulation. , vol.118 , pp. 993-1001
    • Mora, S.1    Rifai, N.2    Buring, J.E.3    Ridker, P.M.4
  • 87
    • 0034898391 scopus 로고    scopus 로고
    • Association of the Sst-I polymorphism at the APOC3 gene locus with variations in lipid levels, lipoprotein subclass profiles and coronary heart disease risk: The Framingham offspring study
    • Russo GT, Meigs JB, Cupples LA, et a;. Association of the Sst-I polymorphism at the APOC3 gene locus with variations in lipid levels, lipoprotein subclass profiles and coronary heart disease risk: the Framingham offspring study. Atherosclerosis. 2001;158:173-181.
    • (2001) Atherosclerosis. , vol.158 , pp. 173-181
    • Russo, G.T.1    Meigs, J.B.2    Cupples, L.A.3
  • 89
    • 0023232216 scopus 로고
    • Helsinki Heart Study: Primary-prevention trial with gemfibrozil in middle-aged men with dyslip-idemia. Safety of treatment, changes in risk factors, and incidence of coronary heart disease
    • Frick MH, Elo O, Haapa K, et al. Helsinki Heart Study: primary-prevention trial with gemfibrozil in middle-aged men with dyslip-idemia. Safety of treatment, changes in risk factors, and incidence of coronary heart disease. N Engl J Med. 1987;317:1237-1245.
    • (1987) N Engl J Med. , vol.317 , pp. 1237-1245
    • Frick, M.H.1    Elo, O.2    Haapa, K.3
  • 90
    • 33646683337 scopus 로고    scopus 로고
    • Contrast-induced nephropathy: A clinical and evidence-based approach
    • Tepel M, Aspelin P, Lameire N. Contrast-induced nephropathy: a clinical and evidence-based approach. Circulation. 2006;113:1799-1806.
    • (2006) Circulation. , vol.113 , pp. 1799-1806
    • Tepel, M.1    Aspelin, P.2    Lameire, N.3
  • 91
    • 0033527030 scopus 로고    scopus 로고
    • Gemfibrozil for the secondary prevention ofcoronary heart disease in men with low levels of high-density lipoprotein cholesterol. Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group
    • Rubins HB, Robins SJ, Collins D, et al. Gemfibrozil for the secondary prevention ofcoronary heart disease in men with low levels of high-density lipoprotein cholesterol. Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group. N Engl J Med. 1999;341:410-418.
    • (1999) N Engl J Med. , vol.341 , pp. 410-418
    • Rubins, H.B.1    Robins, S.J.2    Collins, D.3
  • 92
    • 0035962048 scopus 로고    scopus 로고
    • Validation of a clinical decision aid to discontinue in-hospital cardiac arrest resuscitations
    • van Walraven C, Forster AJ, Parish DC, et al. Validation of a clinical decision aid to discontinue in-hospital cardiac arrest resuscitations. JAMA. 2001;285:1602-1606.
    • (2001) JAMA , vol.285 , pp. 1602-1606
    • Van Walraven, C.1    Forster, A.J.2    Parish, D.C.3
  • 93
    • 0034604225 scopus 로고    scopus 로고
    • Secondary prevention by raising HDL cholesterol and reducing triglycerides in patients with coronary artery disease
    • Bezafibrate Infarction Prevention Study. Secondary prevention by raising HDL cholesterol and reducing triglycerides in patients with coronary artery disease. Circulation. 2000;102:21-27.
    • (2000) Circulation. , vol.102 , pp. 21-27
  • 94
    • 28044452217 scopus 로고    scopus 로고
    • Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): Randomised controlled trial
    • Keech A, Simes RJ, Barter P, et al. Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial. Lancet. 2005;366:1849-1861.
    • (2005) Lancet. , vol.366 , pp. 1849-1861
    • Keech, A.1    Simes, R.J.2    Barter, P.3
  • 95
    • 77951704587 scopus 로고    scopus 로고
    • Effects of combination lipid therapy in type 2 diabetes mellitus
    • ACCORD Study Group, Ginsberg HN, Elam MB, Lovato LC, et al. Effects of combination lipid therapy in type 2 diabetes mellitus. N Engl J Med. 2010;362:1563-1574.
    • (2010) N Engl J Med. , vol.362 , pp. 1563-1574
    • Ginsberg, H.N.1    Elam, M.B.2    Lovato, L.C.3
  • 96
    • 0034526070 scopus 로고    scopus 로고
    • Results of the low-dose (20 mg) pravastatin GISSI Prevenzione trial in 4271 patients with recent myocardial infarction: Do stopped trials contribute to overall knowledge? GISSI Prevenzione Investigators (Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Mio-cardico)
    • Results of the low-dose (20 mg) pravastatin GISSI Prevenzione trial in 4271 patients with recent myocardial infarction: do stopped trials contribute to overall knowledge? GISSI Prevenzione Investigators (Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Mio-cardico). Ital Heart J. 2000;1:810-820.
    • (2000) Ital Heart J. , vol.1 , pp. 810-820
  • 97
    • 33947583493 scopus 로고    scopus 로고
    • Effects of eicosapenta-enoic acid on major coronary events in hypercholesterolaemic patients (JELIS): A randomised open-label, blinded endpoint analysis
    • Yokoyama M, Origasa H, Matsuzaki M, et al; Japan EPA lipid intervention study (JELIS) Investigators. Effects of eicosapenta-enoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis. Lancet. 2007;369:1090-1098.
    • (2007) Lancet. , vol.369 , pp. 1090-1098
    • Yokoyama, M.1    Origasa, H.2    Matsuzaki, M.3
  • 98
    • 49749128376 scopus 로고    scopus 로고
    • Effects of EPA on coronary artery disease in hypercholesterolemic patients with multiple risk factors: Sub-analysis of primary prevention cases from the Japan EPA Lipid Intervention Study (JELIS)
    • Saito Y, Yokoyama M, Origasa H, et al; Japan JELIS Investigators. Effects of EPA on coronary artery disease in hypercholesterolemic patients with multiple risk factors: sub-analysis of primary prevention cases from the Japan EPA Lipid Intervention Study (JELIS). Atherosclerosis. 2008;200:135-140.
    • (2008) Atherosclerosis. , vol.200 , pp. 135-140
    • Saito, Y.1    Yokoyama, M.2    Origasa, H.3
  • 99
    • 84861128254 scopus 로고    scopus 로고
    • Efficacy of omega-3 fatty acid supplements (eicosapen-taenoic acid and docosahexaenoic acid) in the secondary preven-tionofcardiovascular disease:ameta-analysisofrandomized, double-blind, placebo-controlled trials
    • Kwak SM, Myung SK, Lee YJ, Seo HG, Korean Meta-analysis Study G. Efficacy of omega-3 fatty acid supplements (eicosapen-taenoic acid and docosahexaenoic acid) in the secondary preven-tionofcardiovascular disease:ameta-analysisofrandomized, double-blind, placebo-controlled trials. Arch Intern Med. 2012;172: 686-694.
    • (2012) Arch Intern Med. , vol.172 , pp. 686-694
    • Kwak, S.M.1    Myung, S.K.2    Lee, Y.J.3    Seo, H.G.4
  • 100
    • 84897970506 scopus 로고    scopus 로고
    • 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines
    • Stone NJ, Robinson JG, Lichtenstein AH, et al; American College of Cardiology/American Heart Association Task Forceon Practice Guideline Panel. 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation. 2014;129:S1-S45.
    • (2014) Circulation. , vol.129 , pp. S1-S45
    • Stone, N.J.1    Robinson, J.G.2    Lichtenstein, A.H.3
  • 103
    • 84903727023 scopus 로고    scopus 로고
    • Loss-of-function mutations in APOC3, triglycerides, and coronary disease
    • TG and HDL Working Group of the Exome Sequencing Project, National Heart, Lung, Blood Institute, Crosby J, Peloso GM, Auer PL, et al. Loss-of-function mutations in APOC3, triglycerides, and coronary disease. N Engl J Med. 2014;371:22-31.
    • (2014) N Engl J Med. , vol.371 , pp. 22-31
    • Crosby, J.1    Peloso, G.M.2    Auer, P.L.3
  • 104
    • 0015530365 scopus 로고
    • Inhibition of lipoprotein lipase by an apoprotein of human very low density lipoprotein
    • Brown WV, Baginsky ML. Inhibition of lipoprotein lipase by an apoprotein of human very low density lipoprotein. Biochem Bio-phys Res Commun. 1972;46:375-382.
    • (1972) Biochem Bio-phys Res Commun. , vol.46 , pp. 375-382
    • Brown, W.V.1    Baginsky, M.L.2
  • 105
    • 0026443622 scopus 로고
    • Mechanism of hypertri-glyceridemia in human apolipoprotein (apo) CIII transgenic mice. Diminished very low density lipoprotein fractional catabolic rate associated with increased apo CIII and reduced apo e on the particles
    • Aalto-Setala K, Fisher EA, Chen X, et al. Mechanism of hypertri-glyceridemia in human apolipoprotein (apo) CIII transgenic mice. Diminished very low density lipoprotein fractional catabolic rate associated with increased apo CIII and reduced apo E on the particles. J Clin Invest. 1992;90:1889-1900.
    • (1992) J Clin Invest. , vol.90 , pp. 1889-1900
    • Aalto-Setala, K.1    Fisher, E.A.2    Chen, X.3
  • 106
    • 84918803944 scopus 로고    scopus 로고
    • Targeting APOC3 in the familial chylomicronemia syndrome
    • Gaudet D, Brisson D, Tremblay K, et al. Targeting APOC3 in the familial chylomicronemia syndrome. N Engl J Med. 2014;371: 2200-2206.
    • (2014) N Engl J Med. , vol.371 , pp. 2200-2206
    • Gaudet, D.1    Brisson, D.2    Tremblay, K.3
  • 107
    • 84894387971 scopus 로고    scopus 로고
    • Regulation of lipoprotein lipase by Angptl4
    • Dijk W, Kersten S. Regulation of lipoprotein lipase by Angptl4. Trends Endocrinol Metab. 2014;25:146-155.
    • (2014) Trends Endocrinol Metab. , vol.25 , pp. 146-155
    • Dijk, W.1    Kersten, S.2
  • 108
    • 67649389843 scopus 로고    scopus 로고
    • Identification of a new functional domain in angiopoietin-like 3 (ANGPTL3) and angiopoi-etin-like 4 (ANGPTL4) involved in binding and inhibition of lipo-protein lipase (LPL)
    • Lee EC, Desai U, Gololobov G, et al. Identification of a new functional domain in angiopoietin-like 3 (ANGPTL3) and angiopoi-etin-like 4 (ANGPTL4) involved in binding and inhibition of lipo-protein lipase (LPL). J Biol Chem. 2009;284:13735-13745.
    • (2009) J Biol Chem. , vol.284 , pp. 13735-13745
    • Lee, E.C.1    Desai, U.2    Gololobov, G.3
  • 109
    • 34547444929 scopus 로고    scopus 로고
    • Lipid-lowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin-like 4 knockout mice
    • Desai U, Lee EC, Chung K, et al. Lipid-lowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin-like 4 knockout mice. Proc Natl Acad Sci USA. 2007; 104:11766-11771.
    • (2007) Proc Natl Acad Sci USA. , vol.104 , pp. 11766-11771
    • Desai, U.1    Lee, E.C.2    Chung, K.3
  • 110
    • 84906653638 scopus 로고    scopus 로고
    • Recent advances in pharmaco-therapy for hypertriglyceridemia
    • Sahebkar A, Chew GT, Watts GF. Recent advances in pharmaco-therapy for hypertriglyceridemia. Prog Lipid Res. 2014;56:47-66.
    • (2014) Prog Lipid Res. , vol.56 , pp. 47-66
    • Sahebkar, A.1    Chew, G.T.2    Watts, G.F.3
  • 111
    • 85027956925 scopus 로고    scopus 로고
    • Triglycerides and cardiovascular disease: A scientific statement from the American Heart Association
    • Miller M, Stone NJ, Ballantyne C, et al; American Heart Association Clinical Lipidology, Thrombosis, and Prevention Committee of the Council on Nutrition, Physical Activity, and Metabolism; Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Cardiovascular Nursing; Council on the Kidney in Cardiovascular Disease. Triglycerides and cardiovascular disease: a scientific statement from the American Heart Association. Circulation. 2011;123:2292-2333.
    • (2011) Circulation. , vol.123 , pp. 2292-2333
    • Miller, M.1    Stone, N.J.2    Ballantyne, C.3
  • 112
    • 0025905304 scopus 로고
    • Effects of the apolipo-protein(a) size polymorphism on the lipoprotein(a) concentration in 7 ethnic groups
    • Sandholzer C, Hallman DM, Saha N, et al. Effects of the apolipo-protein(a) size polymorphism on the lipoprotein(a) concentration in 7 ethnic groups. Hum Genet. 1991;86:607-614.
    • (1991) Hum Genet. , vol.86 , pp. 607-614
    • Sandholzer, C.1    Hallman, D.M.2    Saha, N.3
  • 113
    • 0029689736 scopus 로고    scopus 로고
    • [New drug formsofmolsidomine Corvaton-forte and Corvaton-retard and their antianginal efficacy in stenocardia patients]
    • Kukushkin SK, Shamarin VM, Manoshkina EM, Berzak NV, Petrosian K.[New drug formsofmolsidomine, Corvaton-forte and Corvaton-retard, and their antianginal efficacy in stenocardia patients]. Ter Arkh. 1996;68:29-30.
    • (1996) Ter Arkh. , vol.68 , pp. 29-30
    • Kukushkin, S.K.1    Shamarin, V.M.2    Manoshkina, E.M.3    Berzak, N.V.4    Petrosian, K.5
  • 114
    • 84902484753 scopus 로고    scopus 로고
    • Lipoprotein(a) as a therapeutic target in cardiovascular disease
    • Koschinsky M, Boffa M. Lipoprotein(a) as a therapeutic target in cardiovascular disease. Expert Opin Ther Targets. 2014;18:747-757.
    • (2014) Expert Opin Ther Targets. , vol.18 , pp. 747-757
    • Koschinsky, M.1    Boffa, M.2
  • 115
    • 78649888517 scopus 로고    scopus 로고
    • Lipoprotein(a) as a cardiovascular risk factor: Current status
    • Nordestgaard BG, Chapman MJ, Ray K, et al; European Atherosclerosis Society Consensus Panel. Lipoprotein(a) as a cardiovascular risk factor: current status. Eur Heart J. 2010;31:2844-2853.
    • (2010) Eur Heart J. , vol.31 , pp. 2844-2853
    • Nordestgaard, B.G.1    Chapman, M.J.2    Ray, K.3
  • 116
    • 67651210632 scopus 로고    scopus 로고
    • Lipoprotein(a) concentration and the risk of coronary heart disease, stroke, and nonvascular mortality
    • Emerging Risk Factors Collaboration, Erqou S, Kaptoge S, Perry PL, et al. Lipoprotein(a) concentration and the risk of coronary heart disease, stroke, and nonvascular mortality. JAMA. 2009; 302:412-423.
    • (2009) JAMA , vol.302 , pp. 412-423
    • Emerging Risk Factors Collaboration Erqou, S.1    Kaptoge, S.2    Perry, P.L.3
  • 117
    • 84886070404 scopus 로고    scopus 로고
    • Relationship of apolipopro-teins A-1 andB, and lipoprotein(a)tocardiovascular outcomes: The AIM-HIGH trial (Atherothrombosis Intervention in Metabolic Syndromewith Low HDL/High Triglyceride andImpacton Global Health Outcomes)
    • Albers JJ, Slee A, O'Brien KD, et al. Relationship of apolipopro-teins A-1 andB, and lipoprotein(a)tocardiovascular outcomes: the AIM-HIGH trial (Atherothrombosis Intervention in Metabolic Syndromewith Low HDL/High Triglyceride andImpacton Global Health Outcomes). J Am Coll Cardiol. 2013;62:1575-1579.
    • (2013) J Am Coll Cardiol. , vol.62 , pp. 1575-1579
    • Albers, J.J.1    Slee, A.2    O'Brien, K.D.3
  • 118
    • 84884211406 scopus 로고    scopus 로고
    • Lipoprotein(a) metabolism: Potential sites for therapeutic targets
    • Hoover-Plow J, Huang M. Lipoprotein(a) metabolism: potential sites for therapeutic targets. Metabolism. 2013;62:479-491.
    • (2013) Metabolism. , vol.62 , pp. 479-491
    • Hoover-Plow, J.1    Huang, M.2
  • 119
    • 53149102508 scopus 로고    scopus 로고
    • The role of oxidized phospholipids in mediating lipoprotein(a) atherogenicity
    • Tsimikas S, Witztum JL. The role of oxidized phospholipids in mediating lipoprotein(a) atherogenicity. Curr Opin Lipidol. 2008; 19:369-377.
    • (2008) Curr Opin Lipidol. , vol.19 , pp. 369-377
    • Tsimikas, S.1    Witztum, J.L.2
  • 120
    • 84870065743 scopus 로고    scopus 로고
    • Emerging therapeutic agents to lower lipo-protein (a) levels
    • Kolski B, Tsimikas S. Emerging therapeutic agents to lower lipo-protein (a) levels. Curr Opin Lipidol. 2012;23:560-568.
    • (2012) Curr Opin Lipidol. , vol.23 , pp. 560-568
    • Kolski, B.1    Tsimikas, S.2
  • 121
    • 45849110333 scopus 로고    scopus 로고
    • Lipoprotein(a), hormone replacement therapy, and risk of future cardiovascular events
    • Suk Danik J, Rifai N, Buring JE, Ridker PM. Lipoprotein(a), hormone replacement therapy, and risk of future cardiovascular events. J Am Coll Cardiol. 2008;52:124-131.
    • (2008) J Am Coll Cardiol. , vol.52 , pp. 124-131
    • Suk Danik, J.1    Rifai, N.2    Buring, J.E.3    Ridker, P.M.4
  • 122
    • 84944152398 scopus 로고    scopus 로고
    • Antisense therapy targeting apolipoprotein(a): A randomised, double-blind, placebo-controlled phase 1 study
    • Tsimikas S, Viney NJ, Hughes SG, et al. Antisense therapy targeting apolipoprotein(a): a randomised, double-blind, placebo-controlled phase 1 study. Lancet. 2015;386:1472-1483.
    • (2015) Lancet. , vol.386 , pp. 1472-1483
    • Tsimikas, S.1    Viney, N.J.2    Hughes, S.G.3
  • 123
    • 84863984123 scopus 로고    scopus 로고
    • Gene therapy for lipoprotein lipase deficiency
    • Gaudet D, Methot J, Kastelein J. Gene therapy for lipoprotein lipase deficiency. Curr Opin Lipidol. 2012;23:310-320.
    • (2012) Curr Opin Lipidol. , vol.23 , pp. 310-320
    • Gaudet, D.1    Methot, J.2    Kastelein, J.3
  • 124
    • 0028793489 scopus 로고
    • A pilot study of ex vivo gene therapy for homozygous familial hypercholesterolaemia
    • Grossman M, Rader DJ, Muller DW, et al. A pilot study of ex vivo gene therapy for homozygous familial hypercholesterolaemia. Nat Med. 1995;1:1148-1154.
    • (1995) Nat Med. , vol.1 , pp. 1148-1154
    • Grossman, M.1    Rader, D.J.2    Muller, D.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.