Design and synthesis of nitrate esters of aromatic heterocyclic compounds as pharmacological preconditioning agents

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 8, 2008, Pages 4523-4531

  Fotopoulou, Theano ^a,b   Iliodromitis, Efstathios K ^c   Koufaki, Maria ^a   Tsotinis, Andrew ^b   Zoga, Anastasia ^c   Gizas, Vassilis ^c   Pyriochou, Anastasia ^d   Papapetropoulos, Andreas ^d   Andreadou, Ioanna ^b   Kremastinos, Dimitrios Th ^c  

^a INSTITUTE OF BIOLOGY   (Greece)

^b UNIVERSITY OF ATHENS   (Greece)

^c UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^d UNIVERSITY OF PATRAS   (Greece)

Author keywords

Adenosine; Infarct size; KATP channel openers; Pharmacological preconditioning

Indexed keywords

3 (11 BROMOUNDECYL) 6 (PIPERIDIN 1 YL) PURINE; 5 HYDROXYDECANOIC ACID; 8 (4 SULFOPHENYL)THEOPHYLLINE; 9 (11 BROMOUNDECYL) 6 (PIPERIDIN 1 YL) PURINE; 9 (11 NITROOXYUNDECYL) 6 PIPERIDIN 1 YL) PURINE; 9 (6 BROMOHEXYL) 6 (PIPERIDIN 1 YL) PURINE; 9 (6 NITROOXYHEXYL) 6 (PIPERIDIN 1 YL) PURINE; ADENOSINE; CYCLIC GMP; ESTER DERIVATIVE; INDOLE DERIVATIVE; MALONALDEHYDE; N (2 BROMOETHYL) 1H INDOL 2 CARBOXAMIDE; N (2 NITROOXYETHYL) 1H INDOL 2 CARBOXAMIDE; N (2 NITROOXYETHYL) QUINOLINE 2 CARBOXAMIDE; N [2 (6 PIPERIDINE 1 YL PURINE 3 YL) ETHYL] NICOTINAMIDE; N [2 (6 PIPERIDINE 1 YL PURINE 9 YL) ETHYL] NICOTINAMIDE; NICORANDIL; NITRATE ESTER DERIVATIVE; PURINE DERIVATIVE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG EFFECT; DRUG STRUCTURE; DRUG SYNTHESIS; HEART INFARCTION; HEART INFARCTION SIZE; HEART PROTECTION; ISCHEMIA; MALE; NONHUMAN; RISK FACTOR;

ANIMALS; CYCLIC GMP; DRUG DESIGN; ESTERS; HETEROCYCLIC COMPOUNDS; ISCHEMIC PRECONDITIONING; MALE; MALONDIALDEHYDE; MOLECULAR STRUCTURE; NITRATES; RABBITS; REPERFUSION INJURY; STRUCTURE-ACTIVITY RELATIONSHIP;

ORYCTOLAGUS CUNICULUS;

EID: 42249094702     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.02.051     Document Type: Article

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