Factorial design formulation optimization and in vitro characterization of curcumin-loaded PLGA nanoparticles for colon delivery

Journal of Drug Delivery Science and Technology

Volumn 32, Issue , 2016, Pages 10-20

  Akl, Mohamed A ^a,b   Kartal Hodzic, Alma ^a   Oksanen, Timo ^a   Ismael, Hatem R ^b   Afouna, Mohsen M ^b   Yliperttula, Marjo ^a   Samy, Ahmed M ^b   Viitala, Tapani ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b Cairo University   (Egypt)

Author keywords

Colon targeting; Curcumin; Factorial design; PLGA nanoparticles; Poly vinyl alcohol

Indexed keywords

CURCUMIN; NANOPARTICLE; POLYGLACTIN;

ARTICLE; CANCER CELL; COLON; COLON ADENOCARCINOMA; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; DRUG STABILITY; DRUG UPTAKE; EMULSION; ENCAPSULATION; EVAPORATION; HUMAN; HUMAN CELL; IN VITRO STUDY; INFRARED SPECTROSCOPY; PARTICLE SIZE; ZETA POTENTIAL;

EID: 84960907106     PISSN: 17732247     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jddst.2016.01.007     Document Type: Article

References (58)

1. American Cancer Society http://www.cancer.org/cancer/colonandrectumcancer/detailedguide/colorectal-cancer-key-statistics 2015 Last accessed 21.10.2015
2. M. Das, C. Mohanty, and S.K. Sahoo Ligand-based targeted therapy for cancer tissue Expert Opin. Drug. Deliv. 6 2009 285 304
3. S.K. Sahoo, S. Parveen, and J. Panda The present and future of nanotechnology in human health care Nanomedicine 3 2007 20 31
4. B.B. Aggarwal, and K.B. Harikumar Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases Int. J. Biochem. Cell Biol. 41 2009 40 59
5. R.A. Fryer, C. Galustian, and A.G. Dalgelish Recent advances and developments in treatment strategies against pancreatic cancer Curr. Clin. Pharmacol. 4 2009 102 112
6. X. Gao, J. Kuo, H. Jiang, D. Deeb, Y. Liu, G. Divine, R.A. Chapman, S.A. Dulchavsky, and S.C. Gautam Immunomodulatory activity of curcumin: suppression of lymphocyte proliferation, development of cell-mediated cytotoxicity, and cytokine production in vitro Biochem. Pharmacol. 68 2004 51 61
7. A.P. Lakshmanan, K. Watanabe, R.A. Thandavarayan, F.R. Sari, H. Meilei, V. Soetikno, S. Arumugam, V.V. Giridharan, K. Suzuki, and M. Kodama Curcumin attenuates hyperglycaemia-mediated AMPK activation and oxidative stress in cerebrum of streptozotocin-induced diabetic rat Free Radic. Res. 45 2011 788 795
8. R. De, P. Kundu, S. Swarnakar, T. Ramamurthy, A. Chowdhury, G.B. Nair, and A.K. Mukhopadhyay Antimicrobial activity of curcumin against Helicobacter pylori isolates from India and during infections in mice Antimicrob. Agents Chemother. 53 2009 1592 1597
9. Z.M. Shao, Z.Z. Shen, C.H. Liu, M.R. Sartippour, V.L. Go, D. Heber, and M. Nguyen Curcumin exerts multiple suppressive effects on human breast carcinoma cells Int. J. Cancer 98 2002 234 240
10. S. Bisht, G. Feldmann, S. Soni, R. Ravi, C. Karikar, A. Maitra, and A. Maitra Polymeric nanoparticle-encapsulated curcumin ('nanocurcumin'): a novel strategy for human cancer therapy J. Nanobiotechnol. 5 2007 3
11. R.K. Maheshwari, A.K. Singh, J. Gaddipati, and R.C. Srimal Multiple biological activities of curcumin: a short review Life Sci. 78 2006 2081 2087
12. S. Lev-Ari, L. Strier, D. Kazanov, L. Madar-Shapiro, H. Dvory-Sobol, I. Pinchuk, B. Marian, D. Lichtenberg, and N. Arber Celecoxib and curcumin synergistically inhibit the growth of colorectal cancer cells Clin. Cancer Res. 11 2005 6738 6744
13. W.W. Quitschke M. Diederich, K. Noworyta, Ch 5, Bioavailability and metabolism of curcuminoids in Natural Compounds as Inducers of Cell Death vol. 1 2012 Springer
14. H. Kharkwal, K. Bala, D.D. Joshi, and D. Pande Katare Bioavailability enhancement of curcuminoids using natural polymer Der Pharm. Lett. 4 2012 1698 1711
15. P. Anand, H.B. Nair, B. Sung, A.B. Kunnumakkara, V.R. Yadav, R.R. Tekmal, and B.B. Aggarwal Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo Biochem. Pharmacol. 79 2010 330 338
16. A. Lazar, S. Mourtas, I. Youssef, C. Parizot, A. Dauphin, B. Delatour, S.G. Antimisiaris, and C. Duyckaerts Curcumin-conjugated nanoliposomes with high affinity for Ab deposits: possible applications to Alzheimer disease Nanomed. Nanotechnol. 9 2013 712 721
17. M.M. Yallapu, M. Jaggi, and S.C. Chauhan Curcumin nanoformulations: a future nanomedicine for cancer Drug Discov. Today 17 2012 71 80
18. M. Gou, K. Men, H. Shi, M. Xiang, J. Zhang, J. Song, J. Long, Y. Wan, F. Luo, X. Zhao, and Z. Qian Curcumin-loaded biodegradable polymeric micelles for colon cancer therapy in vitro and in vivo Nanoscale 3 2011 1558 1567
19. A.O. Elzoghby, W.M. Samy, and N.A. Elgindy Albumin-based nanoparticles as potential controlled release drug delivery systems J. Control. Release 157 2012 168 182
20. Y.M. Tsai, C.F. Chien, L.C. Lina, and T.H. Tsai Curcumin and its nano-formulation: the kinetics of tissue distribution and blood-brain barrier penetration Int. J. Pharm. 416 2011 331 338
21. K. Ganguly, T.M. Aminabhavi, and A.R. Kulkarni Colon targeting of 5-Fluorouracil using polyethylene glycol cross-linked chitosan microspheres enteric coated with cellulose acetate phthalate Ind. Eng. Chem. Res. 50 2011 11797 11807
22. D. Peer, J.M. Karp, S. Hong, O.C. Farokhzad, R. Margalit, and R. Langer Nanocarriers as an emerging platform for cancer therapy Nat. Nanotech 2 2007 751 760
23. K.S. Soppimath, T.M. Aminabhavi, A.R. Kulkarni, and W.E. Rudzinski Biodegradable polymeric nanoparticles as drug delivery devices J. Control. Release 70 2001 1 20
24. N.M. Khalil, T.C. do Nascimento, D.M. Casa, L.F. Dalmolin, A.C. de Mattos, I. Hoss, M.A. Romano, and R.M. Mainardes Pharmacokinetics of curcumin-loaded PLGA and PLGA-PEG blend nanoparticles after oral administration in rats Coll. Surf. B Biointerface 101 2013 353 360
25. R.C. Mundargi, V.R. Babu, V. Rangaswamy, P. Patel, and T.M. Aminabhavi Nano/micro technologies for delivering macromolecular therapeutics using poly(D, L-lactide-co-glycolide) and its derivatives J. Control. Release 125 2008 193 209
26. F. Danhier, E. Ansorena, J.M. Silva, R. Coco, A. Le Breton, and V. Préat PLGA-based nanoparticles: an overview of biomedical applications J. Control. Release 161 2012 505 522
27. M.S. Cartiera, E.C. Ferreira, C. Caputo, M.E. Egan, M.J. Caplan, and W.M. Saltzman Partial correction of cystic fibrosis defects with PLGA nanoparticles encapsulating curcumin Mol. Pharm. 7 2009 86 93
28. S. Jain, and S. Saraf Influence of processing variables and in vitro characterization of glipizide loaded biodegradable nanoparticles Diab. Metabol. Syndr. Clin. Res. Rev. 3 2009 113 117
29. T. Ma, L. Wang, T. Yang, G. Ma, and S. Wang Homogeneous PLGA-lipid nanoparticles as a promising oral vaccine delivery system for ovalbumin Asian J. Pharm. Sci. 9 2014 129 136
30. A. Zanotto-Filho, K. Coradini, E. Braganhol, R. Schröder, C.M. de Oliveiram, A. Simões-Pires, A.M. Battastini, A.R. Pohlmann, S.S. Guterres, C.M. Forcelini, R.C. Beck, and J.C. Moreira Curcumin-loaded lipid-core nanocapsules as a strategy to improve pharmacological efficacy of curcumin in glioma treatment Eur. J. Pharm. Biopharm. 83 2013 156 167
31. USP 36 NF 31. United State Pharmacopeia and National Formulary, 2013.
32. N.T. Paragkumar, D. Edith, and J.-L. Six Surface characteristics of PLA and PLGA films Appl. Surf. Sci. 253 2006 2758 2764
33. R. Benassi, E. Ferrari, S. Lazzari, F. Spagnolo, and M. Saladini Theoretical study on Curcumin: a comparison of calculated spectroscopic properties with NMR, UV-vis and IR experimental data J. Mol. Struct. 892 2008 168 176
34. T.M. Kolev, E.A. Velcheva, B.A. Stamboliyska, and M. Spiteller DFT and experimental studies of the structure and vibrational spectra of curcumin, Int J. Quantum Chem. 102 2005 1069 1079
35. A. Anitha, M. Sreeranganathan, K.P. Chennazhi, V.K. Lakshmanan, and R. Jayakumar In vitro combinatorial anticancer effects of 5-fluorouracil and curcumin loaded N, O-carboxymethyl chitosan nanoparticles toward colon cancer and in vivo pharmacokinetic studies Eur. J. Pharm. Biopharm. 88 2014 238 251
36. K. Renuka, M. Ramakant, V. Ashwni, D. Pankaj, K. Vivek, G. Varsha, K.P. Sarvesh, R.M. Prabhat, and K.D. Anil Colon-specific delivery of curcumin by exploiting Eudragit-decorated chitosan nanoparticles in vitro and in vivo J. Nanopart. Res. 15 2013 1893
37. A. Mukerjee, and J.K. Vishwanatha Formulation, characterization and evaluation of curcumin-loaded PLGA nanospheres for cancer therapy Anticancer Res. 29 2009 3867 3875
38. X. Xie, Q. Tao, Y. Zou, F. Zhang, M. Guo, Y. Wang, H. Wang, Q. Zhou, and S. Yu PLGA nanoparticles improve the oral bioavailability of curcumin in rats: characterizations and mechanisms J. Agric. Food Chem. 59 2011 9280 9289
39. C. Wang, P.C. Ho, and L.Y. Lim Wheat germ agglutinin-conjugated PLGA nanoparticles for enhanced intracellular delivery of paclitaxel to colon cancer cells Int. J. Pharm. 400 2010 201 210
40. D.P. Lankveld, A.G. Oomen, P. Krystek, A. Neigh, A. Troost-de Jong, C.W. Noorlander, J.C. Van Eijkeren, R.E. Geertsma, and W.H. De Jong The kinetics of the tissue distribution of silver nanoparticles of different sizes Biomaterials 31 2010 8350 8361
41. S.A. Kulkarni, and S.-S. Feng Effects of particle size and surface modification on cellular uptake and biodistribution of polymeric nanoparticles for drug delivery Pharm. Res. 30 2013 2512 2522
42. V.J. Mohanraj, and Y. Chen Nanoparticles: a review Trop. J. Pharm. Res. 5 2006 561 573
43. M.P. Desai, V. Labhasetwar, E. Walter, R.J. Levy, and G.L. Amidon The mechanism of uptake of biodegradable microparticles in Caco-2 cells is size dependent Pharm. Res. 14 1997 1568 1573
44. S. Prabha, W.-Z. Zhou, J. Panyam, and V. Labhasetwar Size-dependency of nanoparticle-mediated gene transfection: studies with fractionated nanoparticles Int. J. Pharm. 244 2002 105 115
45. C. He, Y. Hu, L. Yin, C. Tang, and C. Yin Effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles Biomaterials 31 2010 3657 3666
46. F. Akhtar, M.A. Rizvi, and S.K. Kar Oral delivery of curcumin bound to chitosan nanoparticles cured Plasmodium yoelii infected mice Biotech. Adv. 30 2012 310 320
47. S. Abbas, E. Karangwa, M. Bashari, K. Hayat, X. Hong, H.R. Sharif, and X. Zhang Fabrication of polymeric nanocapsules from curcumin-loaded nanoemulsion templates by self-assembly Ultrason. Sonochem. 23 2014 81 92
48. K.L. Nair, A.K. Thulasidasan, G. Deepa, R.J. Anto, and G.S. Kumar Purely aqueous PLGA nanoparticulate formulations of curcumin exhibit enhanced anticancer activity with dependence on the combination of the carrier Int. J. Pharm. 425 2012 44 52
49. J. Vandervoort, and A. Ludwig Biocompatible stabilizers in the preparation of PLGA nanoparticles: a factorial design study Int. J. Pharm. 238 2002 77 92
50. J. Panyam, W.Z. Zhou, S. Prabha, S.K. Sahoo, and V. Labhasetwar Rapid endo-lysosomal escape of poly (D, L-lactide-co-glycolide) nanoparticles: implications for drug and gene delivery FASEB J. 16 2002 1217 1226
51. C.E. Astete, and C.M. Sabliov Synthesis and characterization of PLGA nanoparticles J. Biomater. Sci. Polym. Ed. 17 2006 247 289
52. C. Wischke, and S.P. Schwendeman Principles of encapsulating hydrophobic drugs in PLA/PLGA microparticles Int. J. Pharm. 364 2008 298 327
53. T. Niwa, H. Takeuchi, T. Hino, N. Kunou, and Y. Kawashima Preparations of biodegradable nanospheres of water-soluble and insoluble drugs with D, L-lactide/glycolide copolymer by a novel spontaneous emulsification solvent diffusion method, and the drug release behaviour J. Control. Release 25 1993 89 98
54. K.K. Chereddy, R. Coco, P.B. Memvanga, B. Ucakar, A. des Rieux, G. Vandermeulen, and V. Préat Combined effect of PLGA and curcumin on wound healing activity J. Control. Release 171 2013 208 215
55. Y. Duan, S. Xu, Q. Wang, J. Liu, and Z. Zhang Optimization of preparation of DHAQ-loaded PEG-PLGA-PEG nonaparticles using central composite design J. Mater. Sci. Mater. Med. 17 2006 559 563
56. M. Sampath, R. Lakra, P. Korrapati, and B. Sengottuvelan Curcumin loaded poly (lactic-co-glycolic) acid nanofiber for the treatment of carcinoma Coll. Surf. B Biointerface 117 2014 128 134
57. M. Polakovc, T. Görner, R. Gref, and E. Dellacherie Lidocaine loaded biodegradable nanospheres II. Modelling of drug release J. Control. Release 60 1999 169 177
58. J.K. Vasir, and V. Labhasetwar Biodegradable nanoparticles for cytosolic delivery of therapeutics Adv. Drug. Deliv. Rev. 59 2007 718 728