Ezh2 regulates the Lin28/let-7 pathway to restrict activation of fetal gene signature in adult hematopoietic stem cells

Experimental Hematology

Volumn 44, Issue 4, 2016, Pages 282-296.e3

  Oshima, Motohiko ^a,b   Hasegawa, Nagisa ^a   Mochizuki Kashio, Makiko ^a,b   Muto, Tomoya ^a   Miyagi, Satoru ^a,b   Koide, Shuhei ^a,b   Yabata, Shogo ^a   Wendt, George Russel ^a   Saraya, Atsunori ^a,b   Wang, Changshan ^a,b,c   Shimoda, Kazuya ^d   Suzuki, Yutaka ^e   Iwama, Atsushi ^a,b  

^a CHIBA UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c INNER MONGOLIA UNIVERSITY   (China)

^d UNIVERSITY OF MIYAZAKI   (Japan)

^e UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BMI1 PROTEIN; CD19 ANTIGEN; CD1D ANTIGEN; CD23 ANTIGEN; CD45 ANTIGEN; CD5 ANTIGEN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HIGH MOBILITY GROUP A2 PROTEIN; LET 7 PROTEIN; LET28 PROTEIN; MICRORNA; PROTEIN BCL 2; PROTEIN BCL XL; TAMOXIFEN; TRANSCRIPTION FACTOR EZH2; UNCLASSIFIED DRUG; EZH2 PROTEIN, MOUSE; LIN-28 PROTEIN, MOUSE; MIRNLET7 MICRORNA, MOUSE; POLYCOMB REPRESSIVE COMPLEX 2; RNA BINDING PROTEIN; TRANSCRIPTOME;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW CELL; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; FETUS; FLOW CYTOMETRY; GENE; GENE DELETION; GENE SILENCING; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; LIN28 GENE; MOUSE; NONHUMAN; NUCLEAR REPROGRAMMING; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; UPREGULATION; ANIMAL; BIOLOGICAL MODEL; BIOLOGY; DEFICIENCY; DISEASE COURSE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; HEMATOLOGIC DISEASE; LYMPHOPOIESIS; METABOLISM; PATHOLOGY; PROCEDURES; RNA INTERFERENCE; TRANSGENIC MOUSE;

ANIMALS; COMPUTATIONAL BIOLOGY; DISEASE PROGRESSION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE SILENCING; HEMATOLOGIC NEOPLASMS; HEMATOPOIETIC STEM CELLS; LYMPHOPOIESIS; MICE; MICE, TRANSGENIC; MICRORNAS; MODELS, BIOLOGICAL; POLYCOMB REPRESSIVE COMPLEX 2; RNA INTERFERENCE; RNA-BINDING PROTEINS; TRANSCRIPTOME;

EID: 84960805796     PISSN: 0301472X     EISSN: 18732399     Source Type: Journal    
DOI: 10.1016/j.exphem.2015.12.009     Document Type: Article

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