메뉴 건너뛰기




Volumn 47, Issue 4, 2016, Pages 259-268

Effect of obesity on the pharmacokinetics of antimicrobials in critically ill patients: A structured review

Author keywords

Antifungal; Fluconazole; Morbidly obese patients; Non obese patients; Obesity; Pharmacodynamics

Indexed keywords

AMIKACIN; ANTIINFECTIVE AGENT; BETA LACTAM ANTIBIOTIC; CEFAZOLIN; CEFEPIME; CEFTAZIDIME; CIPROFLOXACIN; COLISTIN; DAPTOMYCIN; DORIPENEM; ERTAPENEM; FLUCONAZOLE; GENTAMICIN; LEVOFLOXACIN; LINEZOLID; MEROPENEM; MICAFUNGIN; MOXIFLOXACIN; PIPERACILLIN; TOBRAMYCIN; VANCOMYCIN;

EID: 84960510918     PISSN: 09248579     EISSN: 18727913     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2016.01.009     Document Type: Review
Times cited : (97)

References (90)
  • 1
    • 84944029009 scopus 로고    scopus 로고
    • The dose-response relationship between body mass index and mortality in subjects admitted to the ICU with and without mechanical ventilation
    • Y. Sasabuchi, H. Yasunaga, H. Matsui, A.T. Lefor, H. Horiguchi, K. Fushimi, and et al. The dose-response relationship between body mass index and mortality in subjects admitted to the ICU with and without mechanical ventilation Respir Care 60 2015 983 991
    • (2015) Respir Care , vol.60 , pp. 983-991
    • Sasabuchi, Y.1    Yasunaga, H.2    Matsui, H.3    Lefor, A.T.4    Horiguchi, H.5    Fushimi, K.6
  • 2
    • 84902300629 scopus 로고    scopus 로고
    • Contrasting effects of preexisting hyperglycemia and higher body size on hospital mortality in critically ill patients: A prospective cohort study
    • M.V. Viana, R.B. Moraes, A.R. Fabbrin, M.F. Santos, V.B. Torman, S.R. Vieira, and et al. Contrasting effects of preexisting hyperglycemia and higher body size on hospital mortality in critically ill patients: a prospective cohort study BMC Endocr Disord 14 2014 50
    • (2014) BMC Endocr Disord , vol.14 , pp. 50
    • Viana, M.V.1    Moraes, R.B.2    Fabbrin, A.R.3    Santos, M.F.4    Torman, V.B.5    Vieira, S.R.6
  • 4
    • 1842788874 scopus 로고    scopus 로고
    • Obesity-related excess mortality rate in an adult intensive care unit: A risk-adjusted matched cohort study
    • N. Bercault, T. Boulain, K. Kuteifan, M. Wolf, I. Runge, and J-C. Fleury Obesity-related excess mortality rate in an adult intensive care unit: a risk-adjusted matched cohort study Crit Care Med 32 2004 998 1003
    • (2004) Crit Care Med , vol.32 , pp. 998-1003
    • Bercault, N.1    Boulain, T.2    Kuteifan, K.3    Wolf, M.4    Runge, I.5    Fleury, J.-C.6
  • 5
    • 84875228575 scopus 로고    scopus 로고
    • Obesity and the risk and outcome of infection
    • R. Huttunen, and J. Syrjänen Obesity and the risk and outcome of infection Int J Obes (Lond) 37 2013 333 340
    • (2013) Int J Obes (Lond) , vol.37 , pp. 333-340
    • Huttunen, R.1    Syrjänen, J.2
  • 7
    • 0034645435 scopus 로고    scopus 로고
    • A prospective study of age and lifestyle factors in relation to community-acquired pneumonia in US men and women
    • I. Baik, G.C. Curhan, E.B. Rimm, A. Bendich, W.C. Willett, and W.W. Fawzi A prospective study of age and lifestyle factors in relation to community-acquired pneumonia in US men and women Arch Intern Med 160 2000 3082 3088
    • (2000) Arch Intern Med , vol.160 , pp. 3082-3088
    • Baik, I.1    Curhan, G.C.2    Rimm, E.B.3    Bendich, A.4    Willett, W.C.5    Fawzi, W.W.6
  • 9
    • 62849095029 scopus 로고    scopus 로고
    • Pharmacokinetic issues for antibiotics in the critically ill patient
    • quiz 859
    • J.A. Roberts, and J. Lipman Pharmacokinetic issues for antibiotics in the critically ill patient Crit Care Med 37 2009 840 851 quiz 859
    • (2009) Crit Care Med , vol.37 , pp. 840-851
    • Roberts, J.A.1    Lipman, J.2
  • 10
    • 84888203416 scopus 로고    scopus 로고
    • Clinical implications of antibiotic pharmacokinetic principles in the critically ill
    • A.A. Udy, J.A. Roberts, and J. Lipman Clinical implications of antibiotic pharmacokinetic principles in the critically ill Intensive Care Med 39 2013 2070 2082
    • (2013) Intensive Care Med , vol.39 , pp. 2070-2082
    • Udy, A.A.1    Roberts, J.A.2    Lipman, J.3
  • 11
    • 0023629587 scopus 로고
    • Influence of obesity on drug disposition
    • R.A. Blouin, J.H. Kolpek, and H.J. Mann Influence of obesity on drug disposition Clin Pharm 6 1987 706 714
    • (1987) Clin Pharm , vol.6 , pp. 706-714
    • Blouin, R.A.1    Kolpek, J.H.2    Mann, H.J.3
  • 13
    • 77954078062 scopus 로고    scopus 로고
    • Insufficient β-lactam concentrations in the early phase of severe sepsis and septic shock
    • F.S. Taccone, P.F. Laterre, T. Dugernier, H. Spapen, I. Delattre, X. Wittebole, and et al. Insufficient β-lactam concentrations in the early phase of severe sepsis and septic shock Crit Care 14 2010 R126
    • (2010) Crit Care , vol.14 , pp. R126
    • Taccone, F.S.1    Laterre, P.F.2    Dugernier, T.3    Spapen, H.4    Delattre, I.5    Wittebole, X.6
  • 14
    • 2142760947 scopus 로고    scopus 로고
    • Antimicrobial pharmacodynamics: Critical interactions of 'bug and drug'
    • G.L. Drusano Antimicrobial pharmacodynamics: critical interactions of 'bug and drug' Nat Rev Microbiol 2 2004 289 300
    • (2004) Nat Rev Microbiol , vol.2 , pp. 289-300
    • Drusano, G.L.1
  • 15
    • 33746784161 scopus 로고    scopus 로고
    • Antibacterial dosing in intensive care
    • J.A. Roberts, and J. Lipman Antibacterial dosing in intensive care Clin Pharmacokinet 45 2006 755 773
    • (2006) Clin Pharmacokinet , vol.45 , pp. 755-773
    • Roberts, J.A.1    Lipman, J.2
  • 16
    • 84919463993 scopus 로고    scopus 로고
    • The effect of pathophysiology on pharmacokinetics in the critically ill patient - Concepts appraised by the example of antimicrobial agents
    • S.I. Blot, F. Pea, and J. Lipman The effect of pathophysiology on pharmacokinetics in the critically ill patient - concepts appraised by the example of antimicrobial agents Adv Drug Deliv Rev 77 2014 3 11
    • (2014) Adv Drug Deliv Rev , vol.77 , pp. 3-11
    • Blot, S.I.1    Pea, F.2    Lipman, J.3
  • 17
    • 84926232888 scopus 로고    scopus 로고
    • A comparison of albumin and saline for fluid resuscitation in the intensive care unit
    • S. Finfer, R. Bellomo, N. Boyce, J. French, J. Myburgh, and R. Norton A comparison of albumin and saline for fluid resuscitation in the intensive care unit N Engl J Med 350 2004 2247 2256
    • (2004) N Engl J Med , vol.350 , pp. 2247-2256
    • Finfer, S.1    Bellomo, R.2    Boyce, N.3    French, J.4    Myburgh, J.5    Norton, R.6
  • 18
    • 78751558968 scopus 로고    scopus 로고
    • The effects of hypoalbuminaemia on optimizing antibacterial dosing in critically ill patients
    • M. Ulldemolins, J.A. Roberts, J. Rello, D.L. Paterson, and J. Lipman The effects of hypoalbuminaemia on optimizing antibacterial dosing in critically ill patients Clin Pharmacokinet 50 2011 99 110
    • (2011) Clin Pharmacokinet , vol.50 , pp. 99-110
    • Ulldemolins, M.1    Roberts, J.A.2    Rello, J.3    Paterson, D.L.4    Lipman, J.5
  • 19
    • 84948566450 scopus 로고    scopus 로고
    • Population pharmacokinetics and dosing simulations of cefepime in septic shock patients receiving continuous renal replacement therapy
    • M. Carlier, F.S. Taccone, M. Beumier, L. Seyler, F. Cotton, F. Jacobs, and et al. Population pharmacokinetics and dosing simulations of cefepime in septic shock patients receiving continuous renal replacement therapy Int J Antimicrob Agents 46 2015 413 419
    • (2015) Int J Antimicrob Agents , vol.46 , pp. 413-419
    • Carlier, M.1    Taccone, F.S.2    Beumier, M.3    Seyler, L.4    Cotton, F.5    Jacobs, F.6
  • 20
    • 84894437155 scopus 로고    scopus 로고
    • Augmented renal clearance in the ICU: Results of a multicenter observational study of renal function in critically ill patients with normal plasma creatinine concentrations
    • A.A. Udy, J.P. Baptista, N.L. Lim, G.M. Joynt, P. Jarrett, L. Wockner, and et al. Augmented renal clearance in the ICU: results of a multicenter observational study of renal function in critically ill patients with normal plasma creatinine concentrations Crit Care Med 42 2014 520 527
    • (2014) Crit Care Med , vol.42 , pp. 520-527
    • Udy, A.A.1    Baptista, J.P.2    Lim, N.L.3    Joynt, G.M.4    Jarrett, P.5    Wockner, L.6
  • 22
    • 84883558584 scopus 로고    scopus 로고
    • Augmented renal clearance is a common finding with worse clinical outcome in critically ill patients receiving antimicrobial therapy
    • B.O. Claus, E.A. Hoste, K. Colpaert, H. Robays, J. Decruyenaere, and J.J. De Waele Augmented renal clearance is a common finding with worse clinical outcome in critically ill patients receiving antimicrobial therapy J Crit Care 28 2013 695 700
    • (2013) J Crit Care , vol.28 , pp. 695-700
    • Claus, B.O.1    Hoste, E.A.2    Colpaert, K.3    Robays, H.4    Decruyenaere, J.5    De Waele, J.J.6
  • 23
    • 84878668181 scopus 로고    scopus 로고
    • Obesity-related physiological changes and their pharmacokinetic consequences
    • S.-J. Cho, I.-S. Yoon, and D.-D. Kim Obesity-related physiological changes and their pharmacokinetic consequences J Pharm Investig 43 2013 161 169
    • (2013) J Pharm Investig , vol.43 , pp. 161-169
    • Cho, S.-J.1    Yoon, I.-S.2    Kim, D.-D.3
  • 24
    • 0020529272 scopus 로고
    • Lean body mass in obesity
    • G.B. Forbes, and S.L. Welle Lean body mass in obesity Int J Obes 7 1983 99 107
    • (1983) Int J Obes , vol.7 , pp. 99-107
    • Forbes, G.B.1    Welle, S.L.2
  • 25
    • 84879446413 scopus 로고    scopus 로고
    • Haemodynamic monitoring of morbidly obese intensive care unit patients
    • W.K. Lagrand, E.R. van Slobbe-Bijlsma, and M.J. Schultz Haemodynamic monitoring of morbidly obese intensive care unit patients Neth J Med 71 2013 234 242
    • (2013) Neth J Med , vol.71 , pp. 234-242
    • Lagrand, W.K.1    Van Slobbe-Bijlsma, E.R.2    Schultz, M.J.3
  • 26
    • 33644850953 scopus 로고    scopus 로고
    • Obesity and cardiovascular disease: Pathophysiology, evaluation, and effect of weight loss: An update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease from the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism
    • P. Poirier, T.D. Giles, G.A. Bray, Y. Hong, J.S. Stern, F.X. Pi-Sunyer, and et al. Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss: an update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease from the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism Circulation 113 2006 898 918
    • (2006) Circulation , vol.113 , pp. 898-918
    • Poirier, P.1    Giles, T.D.2    Bray, G.A.3    Hong, Y.4    Stern, J.S.5    Pi-Sunyer, F.X.6
  • 27
    • 84863934524 scopus 로고    scopus 로고
    • Subcutaneous adipose tissue blood flow and vasomotion in morbidly obese patients: Long term effect of gastric bypass surgery
    • M. Rossi, M. Nannipieri, M. Anselmino, D. Guarino, F. Franzoni, and M. Pesce Subcutaneous adipose tissue blood flow and vasomotion in morbidly obese patients: long term effect of gastric bypass surgery Clin Hemorheol Microcirc 51 2011 159 167
    • (2011) Clin Hemorheol Microcirc , vol.51 , pp. 159-167
    • Rossi, M.1    Nannipieri, M.2    Anselmino, M.3    Guarino, D.4    Franzoni, F.5    Pesce, M.6
  • 28
    • 84945184672 scopus 로고    scopus 로고
    • Pharmacokinetic considerations and dosing strategies of antibiotics in the critically ill patient
    • S. Shah, G. Barton, and A. Fischer Pharmacokinetic considerations and dosing strategies of antibiotics in the critically ill patient J Intensive Care Soc 16 2015 147 153
    • (2015) J Intensive Care Soc , vol.16 , pp. 147-153
    • Shah, S.1    Barton, G.2    Fischer, A.3
  • 29
    • 0021678857 scopus 로고
    • Serum protein binding and the role of increased α1-acid glycoprotein in moderately obese male subjects
    • I. Benedek, R. Blouin, and P. McNamara Serum protein binding and the role of increased α1-acid glycoprotein in moderately obese male subjects Br J Clin Pharmacol 18 1984 941 946
    • (1984) Br J Clin Pharmacol , vol.18 , pp. 941-946
    • Benedek, I.1    Blouin, R.2    McNamara, P.3
  • 30
    • 0019508408 scopus 로고
    • Effect of free fatty acids on protein binding of antimicrobial agents
    • B. Suh, W.A. Craig, A.C. England, and R.L. Elliott Effect of free fatty acids on protein binding of antimicrobial agents J Infect Dis 143 1981 609 616
    • (1981) J Infect Dis , vol.143 , pp. 609-616
    • Suh, B.1    Craig, W.A.2    England, A.C.3    Elliott, R.L.4
  • 31
    • 0028954717 scopus 로고
    • Changes in the serum protein binding of vancomycin in patients with methicillin-resistant Staphylococcus aureus infection: The role of serum α1-acid glycoprotein levels
    • K. Morita, and A. Yamaji Changes in the serum protein binding of vancomycin in patients with methicillin-resistant Staphylococcus aureus infection: the role of serum α1-acid glycoprotein levels Ther Drug Monit 17 1995 107 112
    • (1995) Ther Drug Monit , vol.17 , pp. 107-112
    • Morita, K.1    Yamaji, A.2
  • 32
    • 0024416651 scopus 로고
    • The influence of serum albumin and α1-acid glycoprotein on vancomycin protein binding in patients with burn injuries
    • H.Z. Zokufa, L.D. Solem, K.A. Rodvold, K.B. Crossley, J. Fischer, and J.C. Rotschafer The influence of serum albumin and α1-acid glycoprotein on vancomycin protein binding in patients with burn injuries J Burn Care Rehabil 10 1989 425 428
    • (1989) J Burn Care Rehabil , vol.10 , pp. 425-428
    • Zokufa, H.Z.1    Solem, L.D.2    Rodvold, K.A.3    Crossley, K.B.4    Fischer, J.5    Rotschafer, J.C.6
  • 33
    • 84902285097 scopus 로고    scopus 로고
    • Obesity and perioperative acute kidney injury: A focused review
    • M. Suneja, and A.B. Kumar Obesity and perioperative acute kidney injury: a focused review J Crit Care 29 2014 694.e1-6
    • (2014) J Crit Care , vol.29 , pp. 694.e1-694.e6
    • Suneja, M.1    Kumar, A.B.2
  • 34
    • 0032896059 scopus 로고    scopus 로고
    • Effects of obesity on the cytochrome P450 enzyme system
    • M. Kotlyar, and S.W. Carson Effects of obesity on the cytochrome P450 enzyme system Int J Clin Pharmacol Ther 37 1999 8 19
    • (1999) Int J Clin Pharmacol Ther , vol.37 , pp. 8-19
    • Kotlyar, M.1    Carson, S.W.2
  • 36
    • 0033841371 scopus 로고    scopus 로고
    • The origin of the 'ideal' body weight equations
    • M.P. Pai, and F.P. Paloucek The origin of the 'ideal' body weight equations Ann Pharmacother 34 2000 1066 1069
    • (2000) Ann Pharmacother , vol.34 , pp. 1066-1069
    • Pai, M.P.1    Paloucek, F.P.2
  • 37
    • 84962930873 scopus 로고
    • Clinical pharmacy: Case studies case number 25 gentamicin therapy
    • M.M. McCarron, and B.J. Devine Clinical pharmacy: case studies case number 25 gentamicin therapy Ann Pharmacother 8 1974 650 655
    • (1974) Ann Pharmacother , vol.8 , pp. 650-655
    • McCarron, M.M.1    Devine, B.J.2
  • 38
    • 0029444220 scopus 로고
    • Formulaic methods of estimating calorie requirements in mechanically ventilated obese patients: A reappraisal
    • P. Amato, K.P. Keating, R.A. Quercia, and J. Karbonic Formulaic methods of estimating calorie requirements in mechanically ventilated obese patients: a reappraisal Nutr Clin Pract 10 1995 229 232
    • (1995) Nutr Clin Pract , vol.10 , pp. 229-232
    • Amato, P.1    Keating, K.P.2    Quercia, R.A.3    Karbonic, J.4
  • 40
    • 33744839368 scopus 로고
    • Clinical calorimetry. Tenth paper. A formula to estimate the approximate surface area if height and weight be known
    • D. Du Bois, and E. Du Bois Clinical calorimetry. Tenth paper. A formula to estimate the approximate surface area if height and weight be known Arch Intern Med 17 1916 863 871
    • (1916) Arch Intern Med , vol.17 , pp. 863-871
    • Du Bois, D.1    Du Bois, E.2
  • 41
    • 0021813909 scopus 로고
    • Quetelet's index (W/H2) as a measure of fatness
    • J.S. Garrow, and J. Webster Quetelet's index (W/H2) as a measure of fatness Int J Obes 9 1984 147 153
    • (1984) Int J Obes , vol.9 , pp. 147-153
    • Garrow, J.S.1    Webster, J.2
  • 42
    • 0003588157 scopus 로고
    • Physical status: The use and interpretation of anthropometry
    • WHO Geneva, Switzerland Technical Report Series No. 854
    • World Health Organization Physical status: the use and interpretation of anthropometry. Report of a WHO Expert Committee 1995 WHO Geneva, Switzerland Technical Report Series No. 854
    • (1995) Report of a WHO Expert Committee
    • World Health Organization1
  • 44
    • 3843141820 scopus 로고    scopus 로고
    • What is the best size descriptor to use for pharmacokinetic studies in the obese?
    • B. Green, and S.B. Duffull What is the best size descriptor to use for pharmacokinetic studies in the obese? Br J Clin Pharmacol 58 2004 119 133
    • (2004) Br J Clin Pharmacol , vol.58 , pp. 119-133
    • Green, B.1    Duffull, S.B.2
  • 45
    • 0023943265 scopus 로고
    • Predicting creatinine clearance and renal drug clearance in obese patients from estimated fat-free body mass
    • D.E. Salazar, and G.B. Corcoran Predicting creatinine clearance and renal drug clearance in obese patients from estimated fat-free body mass Am J Med 84 1988 1053 1060
    • (1988) Am J Med , vol.84 , pp. 1053-1060
    • Salazar, D.E.1    Corcoran, G.B.2
  • 46
    • 63449109827 scopus 로고    scopus 로고
    • Estimation of creatinine clearance in morbidly obese patients
    • J.A. Demirovic, A.B. Pai, and M.P. Pai Estimation of creatinine clearance in morbidly obese patients Am J Health Syst Pharm 66 2009 642 648
    • (2009) Am J Health Syst Pharm , vol.66 , pp. 642-648
    • Demirovic, J.A.1    Pai, A.B.2    Pai, M.P.3
  • 47
    • 77954658979 scopus 로고    scopus 로고
    • Pitfalls of using estimations of glomerular filtration rate in an intensive care population
    • J.H. Martin, M.F. Fay, A. Udy, J. Roberts, C. Kirkpatrick, J. Ungerer, and et al. Pitfalls of using estimations of glomerular filtration rate in an intensive care population Intern Med J 41 2011 537 543
    • (2011) Intern Med J , vol.41 , pp. 537-543
    • Martin, J.H.1    Fay, M.F.2    Udy, A.3    Roberts, J.4    Kirkpatrick, C.5    Ungerer, J.6
  • 49
    • 84960798509 scopus 로고    scopus 로고
    • What is the effect of obesity on piperacillin and meropenem trough concentrations in critically ill patients?
    • A.S. Alobaid, A. Brinkmann, O.R. Frey, A.C. Roehr, S. Luque, S. Grau, and et al. What is the effect of obesity on piperacillin and meropenem trough concentrations in critically ill patients? J Antimicrob Chemother 71 2016 696 702
    • (2016) J Antimicrob Chemother , vol.71 , pp. 696-702
    • Alobaid, A.S.1    Brinkmann, A.2    Frey, O.R.3    Roehr, A.C.4    Luque, S.5    Grau, S.6
  • 50
    • 33645790070 scopus 로고    scopus 로고
    • Comparative pharmacokinetics and pharmacodynamic target attainment of ertapenem in normal-weight, obese, and extremely obese adults
    • M. Chen, A.N. Nafziger, G.L. Drusano, L. Ma, and J.S. Bertino Jr. Comparative pharmacokinetics and pharmacodynamic target attainment of ertapenem in normal-weight, obese, and extremely obese adults Antimicrob Agents Chemother 50 2006 1222 1227
    • (2006) Antimicrob Agents Chemother , vol.50 , pp. 1222-1227
    • Chen, M.1    Nafziger, A.N.2    Drusano, G.L.3    Ma, L.4    Bertino, J.S.5
  • 51
    • 84884238899 scopus 로고    scopus 로고
    • Evaluation of extended interval dosing aminoglycosides in the morbidly obese population
    • A.L. Ross, J.L. Tharp, G.R. Hobbs, R. McKnight, and A. Cumpston Evaluation of extended interval dosing aminoglycosides in the morbidly obese population Adv Pharmacol Sci 2013 2013 194389
    • (2013) Adv Pharmacol Sci , vol.2013 , pp. 194389
    • Ross, A.L.1    Tharp, J.L.2    Hobbs, G.R.3    McKnight, R.4    Cumpston, A.5
  • 52
    • 77950524429 scopus 로고    scopus 로고
    • Revisiting the loading dose of amikacin for patients with severe sepsis and septic shock
    • F.S. Taccone, P.-F. Laterre, H. Spapen, T. Dugernier, I. Delattre, B. Layeux, and et al. Revisiting the loading dose of amikacin for patients with severe sepsis and septic shock Crit Care 14 2010 R53
    • (2010) Crit Care , vol.14 , pp. R53
    • Taccone, F.S.1    Laterre, P.-F.2    Spapen, H.3    Dugernier, T.4    Delattre, I.5    Layeux, B.6
  • 53
    • 80051820779 scopus 로고    scopus 로고
    • Simplified estimation of aminoglycoside pharmacokinetics in underweight and obese adult patients
    • M.P. Pai, A.N. Nafziger, and J.S. Bertino Jr. Simplified estimation of aminoglycoside pharmacokinetics in underweight and obese adult patients Antimicrob Agents Chemother 55 2011 4006 4011
    • (2011) Antimicrob Agents Chemother , vol.55 , pp. 4006-4011
    • Pai, M.P.1    Nafziger, A.N.2    Bertino, J.S.3
  • 55
    • 80052878641 scopus 로고    scopus 로고
    • Pharmacokinetics of moxifloxacin in plasma and tissue of morbidly obese patients
    • M.G. Kees, S. Weber, F. Kees, and T. Horbach Pharmacokinetics of moxifloxacin in plasma and tissue of morbidly obese patients J Antimicrob Chemother 66 2011 2330 2335
    • (2011) J Antimicrob Chemother , vol.66 , pp. 2330-2335
    • Kees, M.G.1    Weber, S.2    Kees, F.3    Horbach, T.4
  • 56
    • 79959220301 scopus 로고    scopus 로고
    • Pharmacokinetics of intravenous levofloxacin administered at 750 milligrams in obese adults
    • A.M. Cook, C. Martin, V.R. Adams, and R.S. Morehead Pharmacokinetics of intravenous levofloxacin administered at 750 milligrams in obese adults Antimicrob Agents Chemother 55 2011 3240 3243
    • (2011) Antimicrob Agents Chemother , vol.55 , pp. 3240-3243
    • Cook, A.M.1    Martin, C.2    Adams, V.R.3    Morehead, R.S.4
  • 57
    • 84905051119 scopus 로고    scopus 로고
    • 2) should be guided by creatinine clearance estimates based on ideal body weight and optimized by therapeutic drug monitoring
    • 2) should be guided by creatinine clearance estimates based on ideal body weight and optimized by therapeutic drug monitoring Clin Pharmacokinet 53 2014 753 762
    • (2014) Clin Pharmacokinet , vol.53 , pp. 753-762
    • Pai, M.1    Cojutti, P.2    Pea, F.3
  • 60
    • 84890366083 scopus 로고    scopus 로고
    • Serum and urine pharmacokinetics of tigecycline in obese class III and normal weight adults
    • M.P. Pai Serum and urine pharmacokinetics of tigecycline in obese class III and normal weight adults J Antimicrob Chemother 69 2014 190 199
    • (2014) J Antimicrob Chemother , vol.69 , pp. 190-199
    • Pai, M.P.1
  • 61
    • 16644367133 scopus 로고    scopus 로고
    • The pharmacokinetics of daptomycin in moderately obese, morbidly obese, and matched nonobese subjects
    • B.H. Dvorchik, and D. Damphousse The pharmacokinetics of daptomycin in moderately obese, morbidly obese, and matched nonobese subjects J Clin Pharmacol 45 2005 48 56
    • (2005) J Clin Pharmacol , vol.45 , pp. 48-56
    • Dvorchik, B.H.1    Damphousse, D.2
  • 64
    • 80054678278 scopus 로고    scopus 로고
    • Plasma and tissue pharmacokinetics of cefazolin in patients undergoing elective and semielective abdominal aortic aneurysm open repair surgery
    • A. Douglas, A.A. Udy, S.C. Wallis, P. Jarrett, J. Stuart, M. Lassig-Smith, and et al. Plasma and tissue pharmacokinetics of cefazolin in patients undergoing elective and semielective abdominal aortic aneurysm open repair surgery Antimicrob Agents Chemother 55 2011 5238 5242
    • (2011) Antimicrob Agents Chemother , vol.55 , pp. 5238-5242
    • Douglas, A.1    Udy, A.A.2    Wallis, S.C.3    Jarrett, P.4    Stuart, J.5    Lassig-Smith, M.6
  • 65
    • 84929720221 scopus 로고    scopus 로고
    • Plasma and target-site subcutaneous tissue population pharmacokinetics and dosing simulations of cefazolin in post-trauma critically ill patients
    • J.A. Roberts, A.A. Udy, P. Jarrett, S.C. Wallis, W.W. Hope, R. Sharma, and et al. Plasma and target-site subcutaneous tissue population pharmacokinetics and dosing simulations of cefazolin in post-trauma critically ill patients J Antimicrob Chemother 70 2015 1495 1502
    • (2015) J Antimicrob Chemother , vol.70 , pp. 1495-1502
    • Roberts, J.A.1    Udy, A.A.2    Jarrett, P.3    Wallis, S.C.4    Hope, W.W.5    Sharma, R.6
  • 66
    • 84898664892 scopus 로고    scopus 로고
    • Steady-state pharmacokinetics and pharmacodynamics of meropenem in morbidly obese patients hospitalized in an intensive care unit
    • S.C. Cheatham, M.R. Fleming, D.P. Healy, E.K. Chung, K.M. Shea, M.L. Humphrey, and et al. Steady-state pharmacokinetics and pharmacodynamics of meropenem in morbidly obese patients hospitalized in an intensive care unit J Clin Pharmacol 54 2014 324 330
    • (2014) J Clin Pharmacol , vol.54 , pp. 324-330
    • Cheatham, S.C.1    Fleming, M.R.2    Healy, D.P.3    Chung, E.K.4    Shea, K.M.5    Humphrey, M.L.6
  • 69
    • 84873390207 scopus 로고    scopus 로고
    • Optimal doripenem dosing simulations in critically ill nosocomial pneumonia patients with obesity, augmented renal clearance, and decreased bacterial susceptibility
    • J.A. Roberts, and J. Lipman Optimal doripenem dosing simulations in critically ill nosocomial pneumonia patients with obesity, augmented renal clearance, and decreased bacterial susceptibility Crit Care Med 41 2013 489 495
    • (2013) Crit Care Med , vol.41 , pp. 489-495
    • Roberts, J.A.1    Lipman, J.2
  • 70
    • 84898020642 scopus 로고    scopus 로고
    • Pharmacokinetic analysis of piperacillin administered with tazobactam in critically ill, morbidly obese surgical patients
    • A.W. Sturm, N. Allen, K.D. Rafferty, D.N. Fish, E. Toschlog, M. Newell, and et al. Pharmacokinetic analysis of piperacillin administered with tazobactam in critically ill, morbidly obese surgical patients Pharmacotherapy 34 2014 28 35
    • (2014) Pharmacotherapy , vol.34 , pp. 28-35
    • Sturm, A.W.1    Allen, N.2    Rafferty, K.D.3    Fish, D.N.4    Toschlog, E.5    Newell, M.6
  • 71
    • 84871667901 scopus 로고    scopus 로고
    • Steady-state pharmacokinetics and pharmacodynamics of piperacillin and tazobactam administered by prolonged infusion in obese patients
    • S.C. Cheatham, M.R. Fleming, D.P. Healy, C.E. Chung, K.M. Shea, M.L. Humphrey, and et al. Steady-state pharmacokinetics and pharmacodynamics of piperacillin and tazobactam administered by prolonged infusion in obese patients Int J Antimicrob Agents 41 2013 52 56
    • (2013) Int J Antimicrob Agents , vol.41 , pp. 52-56
    • Cheatham, S.C.1    Fleming, M.R.2    Healy, D.P.3    Chung, C.E.4    Shea, K.M.5    Humphrey, M.L.6
  • 72
    • 7444254040 scopus 로고    scopus 로고
    • Pharmacodynamics of vancomycin and other antimicrobials in patients with Staphylococcus aureus lower respiratory tract infections
    • P.A. Moise-Broder, A. Forrest, M.C. Birmingham, and J.J. Schentag Pharmacodynamics of vancomycin and other antimicrobials in patients with Staphylococcus aureus lower respiratory tract infections Clin Pharmacokinet 43 2004 925 942
    • (2004) Clin Pharmacokinet , vol.43 , pp. 925-942
    • Moise-Broder, P.A.1    Forrest, A.2    Birmingham, M.C.3    Schentag, J.J.4
  • 73
    • 84861180225 scopus 로고    scopus 로고
    • Altered vancomycin pharmacokinetics in obese and morbidly obese patients: What we have learned over the past 30 years
    • E. Grace Altered vancomycin pharmacokinetics in obese and morbidly obese patients: what we have learned over the past 30 years J Antimicrob Chemother 67 2012 1305 1310
    • (2012) J Antimicrob Chemother , vol.67 , pp. 1305-1310
    • Grace, E.1
  • 74
  • 75
    • 42049113605 scopus 로고    scopus 로고
    • Larger vancomycin doses (at least four grams per day) are associated with an increased incidence of nephrotoxicity
    • T.P. Lodise, B. Lomaestro, J. Graves, and G.L. Drusano Larger vancomycin doses (at least four grams per day) are associated with an increased incidence of nephrotoxicity Antimicrob Agents Chemother 52 2008 1330 1336
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 1330-1336
    • Lodise, T.P.1    Lomaestro, B.2    Graves, J.3    Drusano, G.L.4
  • 76
    • 0034801826 scopus 로고    scopus 로고
    • Pharmacokinetics of levofloxacin and ciprofloxacin during continuous renal replacement therapy in critically ill patients
    • R.S. Malone, D.N. Fish, E. Abraham, and I. Teitelbaum Pharmacokinetics of levofloxacin and ciprofloxacin during continuous renal replacement therapy in critically ill patients Antimicrob Agents Chemother 45 2001 2949 2954
    • (2001) Antimicrob Agents Chemother , vol.45 , pp. 2949-2954
    • Malone, R.S.1    Fish, D.N.2    Abraham, E.3    Teitelbaum, I.4
  • 77
    • 77957659759 scopus 로고    scopus 로고
    • High-dose ciprofloxacin for serious Gram-negative infection in an obese, critically ill patient receiving continuous venovenous hemodiafiltration
    • T.R. Utrup, E.W. Mueller, D.P. Healy, R.A. Callcut, J.D. Peterson, and W.E. Hurford High-dose ciprofloxacin for serious Gram-negative infection in an obese, critically ill patient receiving continuous venovenous hemodiafiltration Ann Pharmacother 44 2010 1660 1664
    • (2010) Ann Pharmacother , vol.44 , pp. 1660-1664
    • Utrup, T.R.1    Mueller, E.W.2    Healy, D.P.3    Callcut, R.A.4    Peterson, J.D.5    Hurford, W.E.6
  • 79
    • 79959248672 scopus 로고    scopus 로고
    • Population pharmacokinetics of colistin methanesulfonate and formed colistin in critically ill patients from a multicenter study provide dosing suggestions for various categories of patients
    • S.M. Garonzik, J. Li, V. Thamlikitkul, D.L. Paterson, S. Shoham, J. Jacob, and et al. Population pharmacokinetics of colistin methanesulfonate and formed colistin in critically ill patients from a multicenter study provide dosing suggestions for various categories of patients Antimicrob Agents Chemother 55 2011 3284 3294
    • (2011) Antimicrob Agents Chemother , vol.55 , pp. 3284-3294
    • Garonzik, S.M.1    Li, J.2    Thamlikitkul, V.3    Paterson, D.L.4    Shoham, S.5    Jacob, J.6
  • 80
    • 45149094778 scopus 로고    scopus 로고
    • Colistin serum concentrations after intravenous administration in critically ill patients with serious multidrug-resistant, Gram-negative bacilli infections: A prospective, open-label, uncontrolled study
    • N. Markou, S.L. Markantonis, E. Dimitrakis, D. Panidis, E. Boutzouka, S. Karatzas, and et al. Colistin serum concentrations after intravenous administration in critically ill patients with serious multidrug-resistant, Gram-negative bacilli infections: a prospective, open-label, uncontrolled study Clin Ther 30 2008 143 151
    • (2008) Clin Ther , vol.30 , pp. 143-151
    • Markou, N.1    Markantonis, S.L.2    Dimitrakis, E.3    Panidis, D.4    Boutzouka, E.5    Karatzas, S.6
  • 81
    • 67749145541 scopus 로고    scopus 로고
    • Population pharmacokinetic analysis of colistin methanesulfonate and colistin after intravenous administration in critically ill patients with infections caused by Gram-negative bacteria
    • D. Plachouras, M. Karvanen, L.E. Friberg, E. Papadomichelakis, A. Antoniadou, I. Tsangaris, and et al. Population pharmacokinetic analysis of colistin methanesulfonate and colistin after intravenous administration in critically ill patients with infections caused by Gram-negative bacteria Antimicrob Agents Chemother 53 2009 3430 3436
    • (2009) Antimicrob Agents Chemother , vol.53 , pp. 3430-3436
    • Plachouras, D.1    Karvanen, M.2    Friberg, L.E.3    Papadomichelakis, E.4    Antoniadou, A.5    Tsangaris, I.6
  • 82
    • 84864386288 scopus 로고    scopus 로고
    • Application of a loading dose of colistin methanesulfonate in critically ill patients: Population pharmacokinetics, protein binding, and prediction of bacterial kill
    • A.F. Mohamed, I. Karaiskos, D. Plachouras, M. Karvanen, K. Pontikis, B. Jansson, and et al. Application of a loading dose of colistin methanesulfonate in critically ill patients: population pharmacokinetics, protein binding, and prediction of bacterial kill Antimicrob Agents Chemother 56 2012 4241 4249
    • (2012) Antimicrob Agents Chemother , vol.56 , pp. 4241-4249
    • Mohamed, A.F.1    Karaiskos, I.2    Plachouras, D.3    Karvanen, M.4    Pontikis, K.5    Jansson, B.6
  • 83
    • 33748557483 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of antifungals
    • D. Andes Pharmacokinetics and pharmacodynamics of antifungals Infect Dis Clin North Am 20 2006 679 697
    • (2006) Infect Dis Clin North Am , vol.20 , pp. 679-697
    • Andes, D.1
  • 84
    • 84907984358 scopus 로고    scopus 로고
    • Fluconazole pharmacokinetics in a morbidly obese, critically ill patient receiving continuous venovenous hemofiltration
    • N.D. Lopez, and K.M. Phillips Fluconazole pharmacokinetics in a morbidly obese, critically ill patient receiving continuous venovenous hemofiltration Pharmacotherapy 34 2014 e162 e168
    • (2014) Pharmacotherapy , vol.34 , pp. e162-e168
    • Lopez, N.D.1    Phillips, K.M.2
  • 85
    • 0034466544 scopus 로고    scopus 로고
    • Influence of continuous veno-venous haemodiafiltration and continuous veno-venous haemofiltration on the pharmacokinetics of fluconazole
    • E. Muhl, T. Martens, H. Iven, P. Rob, and H.-P. Bruch Influence of continuous veno-venous haemodiafiltration and continuous veno-venous haemofiltration on the pharmacokinetics of fluconazole Eur J Clin Pharmacol 56 2000 671 678
    • (2000) Eur J Clin Pharmacol , vol.56 , pp. 671-678
    • Muhl, E.1    Martens, T.2    Iven, H.3    Rob, P.4    Bruch, H.-P.5
  • 86
    • 0030770456 scopus 로고    scopus 로고
    • Fluconazole serum concentrations and pharmacokinetics in an obese patient
    • L.G. Cohen, A. DiBiasio, S.J. Lisco, and W.E. Hurford Fluconazole serum concentrations and pharmacokinetics in an obese patient Pharmacotherapy 17 1997 1023 1026
    • (1997) Pharmacotherapy , vol.17 , pp. 1023-1026
    • Cohen, L.G.1    DiBiasio, A.2    Lisco, S.J.3    Hurford, W.E.4
  • 88
    • 16244367425 scopus 로고    scopus 로고
    • Pharmacokinetic and maximum tolerated dose study of micafungin in combination with fluconazole versus fluconazole alone for prophylaxis of fungal infections in adult patients undergoing a bone marrow or peripheral stem cell transplant
    • J. Hiemenz, P. Cagnoni, D. Simpson, S. Devine, N. Chao, J. Keirns, and et al. Pharmacokinetic and maximum tolerated dose study of micafungin in combination with fluconazole versus fluconazole alone for prophylaxis of fungal infections in adult patients undergoing a bone marrow or peripheral stem cell transplant Antimicrob Agents Chemother 49 2005 1331 1336
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 1331-1336
    • Hiemenz, J.1    Cagnoni, P.2    Simpson, D.3    Devine, S.4    Chao, N.5    Keirns, J.6
  • 89
    • 84943738569 scopus 로고    scopus 로고
    • Plasma and peritoneal fluid population pharmacokinetics of micafungin in post-surgical patients with severe peritonitis
    • S. Grau, S. Luque, N. Campillo, E. Samsó, U. Rodríguez, C. García-Bernedo, and et al. Plasma and peritoneal fluid population pharmacokinetics of micafungin in post-surgical patients with severe peritonitis J Antimicrob Chemother 70 2015 2854 2861
    • (2015) J Antimicrob Chemother , vol.70 , pp. 2854-2861
    • Grau, S.1    Luque, S.2    Campillo, N.3    Samsó, E.4    Rodríguez, U.5    García-Bernedo, C.6
  • 90
    • 84928399468 scopus 로고    scopus 로고
    • Optimization of antibiotic therapy in the obese, critically ill patient
    • M. Hites, and F.S. Taccone Optimization of antibiotic therapy in the obese, critically ill patient Réanimation 24 2015 278 294
    • (2015) Réanimation , vol.24 , pp. 278-294
    • Hites, M.1    Taccone, F.S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.