Population pharmacokinetics and dosing simulations of cefepime in septic shock patients receiving continuous renal replacement therapy

International Journal of Antimicrobial Agents

Volumn 46, Issue 4, 2015, Pages 413-419

  Carlier, Mieke ^a   Taccone, Fabio S ^b   Beumier, Majorie ^b   Seyler, Lucie ^b   Cotton, Frédéric ^b   Jacobs, Frédérique ^b   Roberts, Jason A ^c,d,e  

^a GHENT UNIVERSITY   (Belgium)

^b ERASME HOSPITAL   (Belgium)

^c UNIVERSITY OF QUEENSLAND   (Australia)

^d ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

^e UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Critical care; Dialysis Lactam antibiotics; Dosing; ICU

Indexed keywords

CEFEPIME; ANTIINFECTIVE AGENT; CEPHALOSPORIN DERIVATIVE;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTINUOUS HEMODIAFILTRATION; CONTINUOUS HEMOFILTRATION; CONTINUOUS RENAL REPLACEMENT THERAPY; CONTROLLED STUDY; CREATININE CLEARANCE; DRUG CLEARANCE; DRUG DISTRIBUTION; FEMALE; FLOW RATE; HUMAN; MALE; MINIMUM INHIBITORY CONCENTRATION; MONTE CARLO METHOD; OBSERVATIONAL STUDY; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; SEPTIC SHOCK; ULTRAFILTRATION; CHEMISTRY; MICROBIAL SENSITIVITY TEST; MIDDLE AGED; PLASMA; PROCEDURES; RENAL REPLACEMENT THERAPY; SHOCK, SEPTIC; STATISTICAL MODEL; VERY ELDERLY; YOUNG ADULT;

ADULT; AGED; AGED, 80 AND OVER; ANTI-BACTERIAL AGENTS; CEPHALOSPORINS; FEMALE; HUMANS; MALE; MICROBIAL SENSITIVITY TESTS; MIDDLE AGED; MODELS, STATISTICAL; PLASMA; RENAL REPLACEMENT THERAPY; SHOCK, SEPTIC; YOUNG ADULT;

EID: 84948566450     PISSN: 09248579     EISSN: 18727913     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2015.05.020     Document Type: Article

References (22)

1. Esteban A, Frutos-Vivar F, Ferguson ND, Peñuelas O, Lorente JÁ, Gordo F, et al. Sepsis incidence and outcome: contrasting the intensive care unit with thehospital ward. Crit Care Med 2007;35:1284-9.
2. Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, et al. SurvivingSepsis Campaign: international guidelines for management of severe sepsis andseptic shock, 2012. Intensive Care Med 2013;39:165-228.
3. Ferrer R, Martin-Loeches I, Phillips G, Osborn TM, Townsend S, Dellinger RP,et al. Empiric antibiotic treatment reduces mortality in severe sepsis and septicshock from the first hour: results from a guideline-based performance improve-ment program. Crit Care Med 2014;42:1749-55.
4. Kollef M, Sherman G, Ward S, Fraser V. Inadequate antimicrobial treatment ofinfections: a risk factor for hospital mortality among critically ill patients. Chest1999;115:462-74.
5. Craig WA. Interrelationship between pharmacokinetics and pharmacodynam-ics in determining dosage regimens for broad-spectrum cephalosporins. DiagnMicrobiol Infect Dis 1995;22:89-96.
6. McKinnon P, Paladino J, Schentag J. Evaluation of area under the inhibitory curve(AUIC) and time above the minimum inhibitory concentration (T > MIC) as pre-dictors of outcome for cefepime and ceftazidime in serious bacterial infections.Int J Antimicrob Agents 2008;31:345-51.
7. Li C, Du X, Kuti JL, Nicolau DP. Clinical pharmacodynamics of meropenem inpatients with lower respiratory tract infections. Antimicrob Agents Chemother2007;51:1725-30.
8. Aitken SL, Altshuler J, Guervil DJ, Hirsch EB, Ostrosky-Zeichner LL, Ericsson CD,et al. Cefepime free minimum concentration to minimum inhibitory concentra-tion (fCmin/MIC) ratio predicts clinical failure in patients with Gram-negativebacterial pneumonia. Int J Antimicrob Agents 2015;45:541-4.
9. Roberts J, Lipman J. Pharmacokinetic issues for antibiotics in the critically illpatient. Crit Care Med 2009;37:840-51.
10. Taccone FS, Laterre PF, Dugernier T, Spapen H, Delattre I, Wittebole X, et al. Insufficient β-lactam concentrations in the early phase of severe sepsis andseptic shock. Crit Care 2010;14:R126.
11. Beumier M, Casu GS, Hites M, Seyler L, Cotton F, Vincent J-L, et al. β-Lactamantibiotic concentrations during continuous renal replacement therapy. CritCare 2014;18:R105.
12. Seyler L, Cotton F, Taccone FS, De Backer D, Macours P, Vincent JL, et al. Rec-ommended β-lactam regimens are inadequate in septic patients treated withcontinuous renal replacement therapy. Crit Care 2011;15:R137.
13. Roberts DM, Roberts JA, Roberts MS, Liu X, Nair P, Cole L, et al. Variability ofantibiotic concentrations in critically ill patients receiving continuous renalreplacement therapy: a multicentre pharmacokinetic study. Crit Care Med2012;40:1523-8.
14. Trotman RL, Williamson JC, Shoemaker DM, Salzer WL. Antibiotic dosing incritically ill adult patients receiving continuous renal replacement therapy. ClinInfect Dis 2005;41:1159-66.
15. Malone RS, Fish DN, Abraham E, Teitelbaum I. Pharmacokinetics of cefepimeduring continuous renal replacement therapy in critically ill patients. Antimi-crob Agents Chemother 2001;45:3148-55.
16. Allaouchiche B, Breilh D, Jaumain H, Gaillard B, Renard S, Saux MC. Phar-macokinetics of cefepime during continuous venovenous hemodiafiltration.Antimicrob Agents Chemother 1997;41:2424-7.
17. Parke J, Holford NH, Charles BG. A procedure for generating bootstrap sam-ples for the validation of nonlinear mixed-effects population models. ComputMethods Programs Biomed 1999;59:19-29.
18. European Committee on Antimicrobial Susceptibility Testing. Antimicrobialwild type distributions of microorganisms. EUCAST; 2012 http://mic.eucast.org/Eucast2/SearchController/search.jsp?action=init [accessed 29.06.15].
19. Smith NL, Freebairn RC, Park MA, Wallis SC, Roberts JA, Lipman J. Therapeu-tic drug monitoring when using cefepime in continuous renal replacementtherapy: seizures associated with cefepime. Crit Care Resusc 2012;14:312-5.
20. Wilson FP, Bachhuber MA, Caroff D, Adler R, Fish D, Berns J. Low cefepimeconcentrations during high blood and dialysate flow continuous venovenoushemodialysis. Antimicrob Agents Chemother 2012;56:2178-80.
21. Beumier M, Casu GS, Hites M, Wolff F, Cotton F, Vincent JL, et al. Elevated β-lactam concentrations associated with neurological deterioration in ICU septicpatients. Minerva Anestesiol 2015;81:497-506.
22. Lamoth F, Buclin T, Pascual A, Vora S, Bolay S, Decosterd LA, et al. Highcefepime plasma concentrations and neurological toxicity in febrile neu-tropenic patients with mild impairment of renal function. Antimicrob AgentsChemother 2010;54:4360-7.